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1. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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2. Enhancing sustainability education through critical reading: a qualitative study in a Spanish primary school.

Author

Muela-Bermejo, Diana and Pérez-Martínez, Laura

Subjects
*CONSCIOUSNESS raising, *PRIMARY schools, *ECOCRITICISM, *SUSTAINABILITY, *CONSCIOUSNESS
Abstract

AbstractThis research explores how picturebooks can enhance ecocritical awareness and sustainable attitudes among 97 primary school children aged 8–9 in a Spanish school. The study includes 24 reading sessions in three formats: individual, small group, and adult-mediated. The selection of the corpus for children’s readings aligns with theoretical studies focusing on an ecocritical approach to children’s literature, a scholarly perspective that has gained prominence in recent decades. Results indicate that adult-mediated sessions are more effective than individual or small-group readings, fostering greater emotional and cognitive engagement. While students generally showed an ecocentric perspective, an anthropocentric view of sustainability persisted. The study highlights that, although guided reading is beneficial, a more integrated and multidimensional educational approach is needed to cultivate a regenerative consciousness. The educator’s role is crucial for guiding students toward deeper, more meaningful ecocritical understanding. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Kinetics of formic acid dehydration on Pt electrodes by time-resolved ATR-SEIRAS.

Author

Pérez-Martínez, Laura, Herrero, Enrique, and Cuesta, Angel

Subjects
*FORMIC acid, *ATTENUATED total reflectance, *OXIDATION of formic acid, *INFRARED absorption, *DEHYDRATION, *INFRARED spectroscopy, *ELECTRODES
Abstract

The potential dependence of the rate of dehydration of formic acid to adsorbed CO (COad) on Pt at pH 1 has been studied on a polycrystalline Pt surface by time-resolved surface-enhanced infrared absorption spectroscopy in the attenuated total reflection mode (ATR-SEIRAS) with simultaneous recording of current transients after a potential step. A range of formic acid concentrations has been used to obtain a deeper insight into the mechanism of the reaction. The experiments have allowed us to confirm that the potential dependence of the rate of dehydration has a bell shape, going through a maximum around the potential of zero total charge (pztc) of the most active site. The analysis of the integrated intensity and frequency of the bands corresponding to COL and COB/M shows a progressive population of the active sites on the surface. The observed potential dependence of the rate of formation of COad is consistent with a mechanism in which the reversible electroadsorption of HCOOad is followed by its rate-determining reduction to COad. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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8. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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14. Kinetics of formic acid dehydration on Pt electrodes by time-resolved ATR-SEIRAS

Author

Universidad de Alicante. Departamento de Química Física, Universidad de Alicante. Instituto Universitario de Electroquímica, Pérez-Martínez, Laura, Herrero, Enrique, Cuesta, Angel, Universidad de Alicante. Departamento de Química Física, Universidad de Alicante. Instituto Universitario de Electroquímica, Pérez-Martínez, Laura, Herrero, Enrique, and Cuesta, Angel

Abstract

The potential dependence of the rate of dehydration of formic acid to adsorbed CO (COad) on Pt at pH 1 has been studied on a polycrystalline Pt surface by time-resolved surface-enhanced infrared absorption spectroscopy in the attenuated total reflection mode (ATR-SEIRAS) with simultaneous recording of current transients after a potential step. A range of formic acid concentrations has been used to obtain a deeper insight into the mechanism of the reaction. Our experiments have allowed us to confirm that the potential dependence of the rate of dehydration has a bell shape, going through a maximum around the potential of zero total charge (pztc) of the most active site. The analysis of the integrated intensity and frequency of the bands corresponding to COL and COB/M shows a progressive population of the active sites on the surface. The observed potential dependence of the rate of formation of COad is consistent with a mechanism in which the reversible electroadsorption of HCOOad is followed by its rate-determining reduction to COad.

Published
2023

15. Should We Expect an Increase in the Number of Cancer Cases in People with Long COVID?

Author

Amiama-Roig, Ana [0000-0003-3326-585X], Verdugo-Sivianes, Eva M. [0000-0002-0922-0371], Blanco, José Ramón [0000-0002-4268-0150], Amiama-Roig, Ana, Pérez-Martínez, Laura, Rodríguez Ledo, Pilar, Verdugo-Sivianes, Eva M., Blanco, José Ramón, Amiama-Roig, Ana [0000-0003-3326-585X], Verdugo-Sivianes, Eva M. [0000-0002-0922-0371], Blanco, José Ramón [0000-0002-4268-0150], Amiama-Roig, Ana, Pérez-Martínez, Laura, Rodríguez Ledo, Pilar, Verdugo-Sivianes, Eva M., and Blanco, José Ramón

Abstract

The relationship between viral infections and the risk of developing cancer is well known. Multiple mechanisms participate in and determine this process. The COVID-19 pandemic caused by the SARS-CoV-2 virus has resulted in the deaths of millions of people worldwide. Although the effects of COVID-19 are limited for most people, a large number of people continue to show symptoms for a long period of time (long COVID). Several studies have suggested that cancer could also be a potential long-term complication of the virus; however, the causes of this risk are not yet well understood. In this review, we investigated arguments that could support or reject this possibility.

Published
2023

16. Human Immunodeficiency Virus/Hepatits C Virus Coinfection in Spain: Elimination Is Feasible, but the Burden of Residual Cirrhosis Will Be Significant

Author

Berenguer, Juan, Jarrín, Inmaculada, Pérez-Latorre, Leire, Hontañón, Víctor, Vivancos, María J, Navarro, Jordi, Téllez, María J, Guardiola, Josep M, Iribarren, José A, Rivero-Juárez, Antonio, Márquez, Manuel, Artero, Arturo, Morano, Luis, Santos, Ignacio, Moreno, Javier, Fariñas, María C, Galindo, María J, Hernando, María A, Montero, Marta, Cifuentes, Carmen, Domingo, Pere, Sanz, José, Domíngez, Lourdes, Ferrero, Oscar L, De la Fuente, Belén, Rodríguez, Carmen, Reus, Sergio, Hernández-Quero, José, Gaspar, Gabriel, Pérez-Martínez, Laura, García, Coral, Force, Lluis, Veloso, Sergio, Losa, Juan E, Vilaró, Josep, Bernal, Enrique, Arponen, Sari, Ortí, Amat J, Chocarro, Ángel, Teira, Ramón, Alonso, Gerardo, Silvariño, Rafael, Vegas, Ana, Geijo, Paloma, Bisbe, Josep, Esteban, Herminia, and González-García, Juan

Published
2018
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18. Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study.

Author

Ramón Santos, José, Casadellà, Maria, Noguera-Julian, Marc, Micán-Rivera, Rafael, Domingo, Pere, Antela, Antonio, Portilla, Joaquin, Sanz, Jesús, Montero-Alonso, Marta, Navarro, Jordi, Masiá, Mar, Valcarce-Pardeiro, Nieves, Ocampo, Antonio, Pérez-Martínez, Laura, García-Vallecillos, Coral, Jesús Vivancos, María, Imaz, Arkaitz, Antonio Iribarren, José, Hernández-Quero, José, and Villar-García, Judit

Subjects
RESOURCE-limited settings, TERMINATION of treatment, LONGITUDINAL method, VIRAL load, SALVAGE therapy, HIV prevention
Abstract

Introduction: Second-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some resource-limited settings, these drugs are not always available. An analysis of the experience with the use of INSTIs in unselected adults living with HIV may be of help to make therapeutic decisions when second-generation INSTIs are not available. This study aimed to evaluate the real-life effectiveness and safety of dolutegravir (DTG), elvitegravir/cobicistat (EVG/c), and raltegravir (RAL) in a large Spanish cohort of HIV-1-infected patients. Methods: Real-world study of adults living with HIV who initiated integrase INSTIs DTG, EVG/c, and RAL-based regimens in three settings (ART-naïve patients, ART-switching, and ART-salvage patients). The primary endpoint was the median time to treatment discontinuation after INSTI-based regimen initiation. Proportion of patients experiencing virological failure (VF) (defined as two consecutive viral loads (VL) ≥200 copies/mL at 24 weeks or as a single determination of VL ≥1,000 copies/mL while receiving DTG, EVG/c or RAL, and at least 3 months after INSTI initiation) and time to VF were also evaluated. Results: Virological effectiveness of EVG/c- and RAL-based regimens was similar to that of DTG when given as first-line and salvage therapy. Treatment switching for reasons other than virological failure was more frequent in subjects receiving EVG/c and, in particular, RAL. Naïve patients with CD4+ nadir <100 cells/mL were more likely to develop VF, particularly if they initiated RAL or EVG/c. In the ART switching population, initiation of RAL and EVG/c was associated with both VF and INSTI discontinuation. There were no differences in the time to VF and INSTI discontinuation between DTG, EVG/c and RAL. Immunological parameters improved in the three groups and for the three drugs assessed. Safety and tolerability were consistent with expected safety profiles. Discussion: Whereas second-generation INSTIs are preferred treatment options worldwide, and DTG is one of the treatment of choices in resource-limited settings, first-generation INSTIs may still provide high virological and immunological effectiveness when DTG is not available. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Role of Maraviroc and/or Rapamycin in Aging Liver Processes

Author

Pérez-Martínez, Laura, primary, Romero, Lourdes, additional, Verdugo-Sivianes, Eva M., additional, Muñoz-Galván, Sandra, additional, Rubio-Mediavilla, Susana, additional, Amiama, Ana, additional, Carnero, Amancio, additional, and Blanco, José Ramón, additional

Published
2022
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20. Disseny i implementació de part d'un sistema automatitzat basat en deep learning per a la prevenció de riscos a les estacions de tren en temps real

Author

Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Morros Rubió, Josep Ramon, Espuga Zaragoza, Ramon, Pérez Martínez, Laura, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Morros Rubió, Josep Ramon, Espuga Zaragoza, Ramon, and Pérez Martínez, Laura

Published
2022

22. Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease

Author

Blanco, Jose-Ramon, primary, Cobos-Ceballos, María-Jesús, additional, Navarro, Francisco, additional, Sanjoaquin, Isabel, additional, Armiñanzas, Carlos, additional, Bernal, Enrique, additional, Buzon-Martin, Luis, additional, Viribay, Miguel, additional, Pérez-Martínez, Laura, additional, Espejo-Pérez, Simona, additional, Valencia, Borja, additional, Guzman-Aguilar, Jesus, additional, Ruiz-Cubillan, Juan-Jose, additional, Alcalde, Consuelo, additional, Gutierrez-Herrero, Fernando Gustavo, additional, Olalla, Julian, additional, Andres-Esteban, Eva-Maria, additional, Jurado-Gamez, Bernabe, additional, and Ugedo, Javier, additional

Published
2022
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23. Design and implementation of an automated Deep Learning-based system for real-time risk prevention at train stations

Author

Pérez Martínez, Laura, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Morros Rubió, Josep Ramon, and Espuga Zaragoza, Ramon

Subjects
redes neuronales, Visió per ordinador, visión por ordenador, inteligéncia artificial, Imatges -- Processament, artificial intelligence, neural networks, procesamiento de imágenes, computer vision, Aprendizaje automático, image processing, Machine learning, Aprenentatge automàtic, Informàtica::Intel·ligència artificial [Àrees temàtiques de la UPC]
Published
2022

24. Bases ecológicas y sociales para la restauración de los páramos

Author

Vargas-Ríos, Orlando, Melgarejo, Luz Marina, Rojas-Zamora, Óscar, Ávila-Rodríguez, Liz Alejandra, Pérez-Martínez, Laura Victoria, Insuasty-Torres, Jennyfer, Castiblanco-Álvarez, Felipe, Rodríguez-Castillo, Natalia Alejandra, Armero-Estrada, Milena, Vargas Ríos, Orlando, Meléndez, Lilian Carolina, and Grupo de Restauración Ecológica

Subjects
Ecología vegetal, 577 - Ecología [570 - Biología], Ecología de tierras húmedas, Vegetación y clima
Abstract

ilustraciones, fotografías, mapas El objetivo principal de este libro es plantear y revisar los temas más relevantes a la hora de pensar en la restauración ecológica del páramo, así como proyectar desde la experiencia adquirida las estrategias más exitosas que se pueden seguir para comenzar y alcanzar niveles cada vez más altos de recuperación después de diferentes tipos de disturbios y diferentes tipos de hábitats en el páramo. El propósito de este libro es dar una guía de los pasos a seguir para emprender el proceso de restauración en páramos e incentivar que los planes de manejo y de acción incorporen este tipo de estrategias en las áreas con alguna figura de protección. (texto tomado de la fuente) Capítulo I. Introducción a la ecología de los páramos / Orlando Vargas-Ríos; Jennyfer Insuasty-Torres -- Capítulo 2. Plantas de páramo: Formas de vida y adaptación / Felipe Castiblanco-Álvarez; Laura Victoria Pérez- Martínez; Liz Alejandra Ávila-Rodríguez; Orlando Vargas-Ríos -- Capítulo 3. Dinámica de la vegetación de los páramos / Orlando Vargas-Ríos, Liz Alejandra Ávila-Rodríguez -- Capítulo 4. Estrategias y lineamientos para la restauración ecológica de los páramos / Orlando Vargas-Ríos; Oscar Rojas-Zamora; Jennyfer Insuasty-Torres; Liz Alejandra Ávila-Rodríguez; Felipe Castiblanco-Álvarez; Laura Pérez-Martínez; Natalia Rodríguez-Castillo -- Capítulo 5. Restauración ecológica en el marco de la gobernanza adaptativa de sistemas socioecológicos: Conceptos clave e ideas para la práctica / Milena Armero-Estrada; Orlando Vargas-Ríos -- Capítulo 6. Las Semillas y la restauración ecológica de los páramos: Métodos de colecta, almacenamiento y germinación / Laura Victoria Pérez-Martínez; Natalia Rodríguez-Cas- tillo; Luz Marina Melgarejo -- Capítulo 7. Modelo de estados y transiciones para la restauración ecológica en los páramos / Orlando Vargas-Ríos; Jennyfer Insuasty-Torres; Oscar Rojas-Zamora Primera edición

Published
2021

25. HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018

Author

Pérez-Latorre, Leire, Berenguer, Juan, Micán, Rafael, Montero, Marta, Cifuentes, Carmen, Puig, Teresa, Sanz, José, Ferrero, Oscar L, De La Fuente, Belén, Rodríguez, Carmen, Reus, Sergio, Hernández-Quero, José, Gaspar, Gabriel, Pérez-Martínez, Laura, García, Coral, Force, Luis, Veloso, Sergio, De Miguel, Marta, Jarrin-Vera, Inmaculada, González-García, Juan, GeSIDA 8514 Study Group, Instituto de Salud Carlos III, European Regional Development Fund, Plan Nacional de I+D+i (España), and Red de Investigación Cooperativa en Investigación en Sida

Subjects
Hepatitis B virus, medicine.medical_specialty, Cirrhosis, Epidemiology, Human immunodeficiency virus (HIV), Patient characteristics, HIV Infections, medicine.disease_cause, 03 medical and health sciences, Hepatitis delta virus, 0302 clinical medicine, hepatitis delta virus, HIV/HBV coinfection, Virology, Internal medicine, HBV therapy, Prevalence, medicine, Humans, 030212 general & internal medicine, biology, Coinfection, business.industry, Research, Public Health, Environmental and Occupational Health, virus diseases, Hepatitis B, medicine.disease, digestive system diseases, Europe, Cross-Sectional Studies, Spain, biology.protein, 030211 gastroenterology & hepatology, Hepatitis D virus, Antibody, business, Transient elastography, HBV therapy, HIV/HBV coinfection, hepatitis delta virus
Abstract

Background Recent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking. Aim Leveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spain in 2018 and compared the results with five similar studies performed since 2002. Methods This cross-sectional prevalence study was carried out in 43 centres, and patients were selected using simple random sampling. The reference population comprised 40,322 patients and the sample size were 1,690 patients. Results The prevalence of HIV/HBV coinfection in Spain at the end of 2018 was 3.2%. The prevalence in 2002, 2009, 2015, 2016 and 2017 was 4.9%, 3.4%, 3%, 3.9% and 3%, respectively. Among the HIV/HBV-coinfected patients identified in 2018, 16.7% had cirrhosis according to transient elastography and 26.3% tested positive for antibodies against hepatitis D virus. All HIV/HBV-coinfected patients were receiving drugs with activity against HBV, and 97% of those tested for HBV DNA had an HBV DNA load Conclusions The prevalence of HIV/HBV coinfection in Spain remained stable at around 3% for a decade. Our data could facilitate the design of national programmes to control HBV infection and help identify areas of patient management that need improvement.

Published
2021

27. La investigación frente al SARS-COV-2 y la COVID-19 en el Departamento de Enfermedades Infecciosas del Hospital Universitario San Pedro-CIBIR

Author

Alba Fernández, Jorge, Blanco Ramos, José Ramón, Cervera Acedo, Cristina, García Alvarez, Lara, García García, Concepción, Ibarra Cucalón, Valvanera, Íñiguez Martínez, María, Metola, Luis, Omatos, Sonia, Palomar, Ana M., Pellejero Sagastizabal, Galadriel, Pérez-Martínez, Laura, Pérez Matute, Patricia, Portillo Barrio, Aránzazu, Recio, Emma, Romero, Lourdes, Ruiz Arrondo, Ignacio, Santibáñez Sáenz, Paula, Santibáñez Sáenz, Sonia, Sanz Sánchez, Mercedes, Villoslada Blanco, Pablo, and Oteo Revuelta, José Antonio

Abstract

Durante la pandemia provocada por el SARS-CoV-2, agente causal de la COVID-19, el Departamento de Enfermedades Infecciosas en su brazo armado o asistencial del Hospital y en su lado más científico en el Centro de Investigación Biomédica han puesto su grano de arena para dar luz a la generación de conocimiento práctico y básico necesarios para conseguir salir de la gran crisis generada. En este artículo se enumeran las diferentes aportaciones publicadas por los miembros de este equipo multidisciplinar During the pandemic caused by SARS-CoV-2, the causative agent of COVID-19, the Department of Infectious Diseases formed by its clinical team together with its more scientific side in the Center from Biomedical Research of La Rioja have worked hard to generate new knowledge to overcome this crisis from both a basic and clinic approach. This article summarizes the different scientific articles published by the members of this multidisciplinary team.

Published
2021

28. Odiar no es delito. Análisis del artículo 510 del codigo penal

Author

Pérez Martínez, Laura, López del Moral Echeverría, José Luis, and Universidad de Cantabria

Subjects
Colectivos vulnerables, Discrimination, Delito de odio, Libertad de expresión, Hate Crime, Vulnerable Groups, Freedom of Speech, Discurso del odio, Hate speech
Abstract

RESUMEN: Los delitos de odio han adquirido un importante protagonismo en la vida social, mediática, política, y, por ende, en la vida jurídica; debido al exponencial incremento de la intolerancia, hacia grupos con una fuerte tendencia a la discriminación y exclusión social. Sin embargo, no es baladí su existencia, la cual ha divido a la doctrina penal, construyendo, por un lado, un sector que defiende férreamente la libertad de expresión, y en contraposición, el sector que observa la necesaria y verdadera defensa de los colectivos diana, frente a todo discurso público hiriente, interpretando a este como discurso del odio. Es por lo que instituciones tanto europeas como extracomunitarias, reconocen este problema social y pautan sus líneas generales interpretativas. Nuestro legislador dotó al criticado artículo 510 de un amplio abanico de conductas discriminatorias, por ello, no son una cuestión inane en nuestro ordenamiento jurídico, en la gran mayoría de casos se coarta el derecho a la libertad de expresión. A través del presente trabajo se exponen las cuestiones penales más relevantes del discurso del odio y su regulación en el artículo 510 del Código Penal. ABSTRACT: Hate crimes have acquired an important role in social, media and political life, as well as, in legal life, due to the exponential increase in intolerance against groups with a strong tendency towards discrimination and social exclusion. However, its existence is not trivial, which has divided criminal doctrine, creating on the one hand, a sector that fiercely defends freedom of speech, and on the other hand, the sector that supports the necessary and true defence of target groups against all hurtful public discourse, interpreting this as hate speech. This is why both European and non-EU institutions recognise this social problem and set out their general interpretative guidelines. Althought, our legislator endowed the criticised article 510 with a wide range of discriminatory conducts, it is not a simple issue for our legal system. In the vast majority of cases the right to freedom of speech is restricted. This paper sets out the most relevant criminal issues of hate speech and its regulation in article 510 of the Criminal Code. Grado en Derecho

Published
2021

29. La investigación frente al SARS-COV-2 y la COVID-19 en el Departamento de Enfermedades Infecciosas del Hospital Universitario San Pedro-CIBIR

Author

Oteo Revuelta, José Antonio, Villoslada Blanco, Pablo, Pellejero Sagastizabal, Galadriel, Recio, Emma, Romero, Lourdes, Ruiz Arrondo, Ignacio, Sanz Sánchez, Mercedes, Alba Fernández, Jorge, Blanco Ramos, José Ramón, Cervera Acedo, Cristina, García Alvarez, Lara, García García, Concepción, Ibarra Cucalón, Valvanera, Íñiguez Martínez, María, Metola, Luis, Omatos, Sonia, Palomar, Ana M., Pérez-Martínez, Laura, Pérez Matute, Patricia, Portillo Barrio, Aránzazu, Santibáñez Sáenz, Paula, Santibáñez Sáenz, Sonia, Oteo Revuelta, José Antonio, Villoslada Blanco, Pablo, Pellejero Sagastizabal, Galadriel, Recio, Emma, Romero, Lourdes, Ruiz Arrondo, Ignacio, Sanz Sánchez, Mercedes, Alba Fernández, Jorge, Blanco Ramos, José Ramón, Cervera Acedo, Cristina, García Alvarez, Lara, García García, Concepción, Ibarra Cucalón, Valvanera, Íñiguez Martínez, María, Metola, Luis, Omatos, Sonia, Palomar, Ana M., Pérez-Martínez, Laura, Pérez Matute, Patricia, Portillo Barrio, Aránzazu, Santibáñez Sáenz, Paula, and Santibáñez Sáenz, Sonia

Abstract

During the pandemic caused by SARS-CoV-2, the causative agent of COVID-19, the Department of Infectious Diseases formed by its clinical team together with its more scientific side in the Center from Biomedical Research of La Rioja have worked hard to generate new knowledge to overcome this crisis from both a basic and clinic approach. This article summarizes the different scientific articles published by the members of this multidisciplinary team., Durante la pandemia provocada por el SARS-CoV-2, agente causal de la COVID-19, el Departamento de Enfermedades Infecciosas en su brazo armado o asistencial del Hospital y en su lado más científico en el Centro de Investigación Biomédica han puesto su grano de arena para dar luz a la generación de conocimiento práctico y básico necesarios para conseguir salir de la gran crisis generada. En este artículo se enumeran las diferentes aportaciones publicadas por los miembros de este equipo multidisciplinar

Published
2021

32. Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort study

Author

Instituto de Salud Carlos III, European Commission, Suárez-García, Inés, Moreno, Cristina, Ruiz-Algueró, Marta, Pérez-Elías, María Jesús, Navarro, Marta, Díez Martínez, Marcos, Viciana, Pompeyo, Pérez-Martínez, Laura, Górgolas-Hernández-Mora, Miguel, Amador, Concha, Zárraga, Miguel Alberto de, Jarrín, Inma, Instituto de Salud Carlos III, European Commission, Suárez-García, Inés, Moreno, Cristina, Ruiz-Algueró, Marta, Pérez-Elías, María Jesús, Navarro, Marta, Díez Martínez, Marcos, Viciana, Pompeyo, Pérez-Martínez, Laura, Górgolas-Hernández-Mora, Miguel, Amador, Concha, Zárraga, Miguel Alberto de, and Jarrín, Inma

Abstract

[Background]: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS)., [Methods]: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014–2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen)., [Results]: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure., [Conclusions]: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads.

Published
2020

33. Implications of maraviroc and/or rapamycin in a mouse model of fragility

Author

Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Pérez-Martínez, Laura, Romero, Lourdes, Muñoz-Galván, Sandra, Verdugo-Sivianes, Eva M., Rubio-Mediavilla, Susana, Oteo, José Antonio, Carnero, Amancio, Blanco, José Ramón, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Pérez-Martínez, Laura, Romero, Lourdes, Muñoz-Galván, Sandra, Verdugo-Sivianes, Eva M., Rubio-Mediavilla, Susana, Oteo, José Antonio, Carnero, Amancio, and Blanco, José Ramón

Abstract

[Background] As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because patients with frailty demonstrate an overexpression of CCR5, rapamycin (RAPA) and/or maraviroc (MVC), two molecules able to decrease CCR5 expression, were evaluated., [Results] Muscle myostatin was reduced in all the therapeutic groups but the MVC group (p <0.001 for RAPA and MVC-RAPA) and in serum samples (p <0.01 for all the groups). Serum CK levels were also significantly lower in MVC and RAPA groups (p <0.01 in both cases). Lower AST levels were observed in all the therapeutic groups (p <0.05 for all of them). The apoptotic effector caspase-3 was significantly lower in MVC and RAPA groups (p<0.05 in both cases). Combined treatment with MVC-RAPA showed a synergistic increase in p-AKT, p-mTOR and SIRT1 levels., [Conclusions] MVC and RAPA show a protective role in some factors involved in frailty. More studies are needed to prove their clinical applications., [Material and methods] Eighty male homozygous IL10KOs were randomly assigned to one of 4 groups (n= 20): i) IL10KO group (IL10KO); ii) IL10KO receiving MVC in drinking water (MVC group), iii) IL10KO receiving RAPA in drinking water (RAPA group), and finally, iv) MVC-RAPA group that received MVC and RAPA in drinking water. Blood and muscle samples were analysed. Survival analysis, frailty index calculation, and functional assessment were also performed.

Published
2020

37. Caracterización refractiva de lentes de contacto progresivas

Author

Pérez Martínez, Laura María, Ares García, Jorge, and Collados Collados, Mª Victoria

Abstract

En este trabajo se ha calibrado un banco optico para la medida del frente de onda en lentes de contacto. Se ha medido el frente de onda a la salida de diferentes diseños de lentes de contacto multifocales y se ha simulado la calidad de imagen que se obtiene con cada una.

Published
2019

40. Seed desiccation tolerance and germination of four Puya (Bromeliaceae) high-andean tropical species from Colombia

Author

CALDERÓN-HERNÁNDEZ, MANUELA and PÉREZ-MARTÍNEZ, LAURA VICTORIA

Subjects
seed storage, semillas ortodoxas, páramo, Andes, ex situ conservation, Almacenamiento de semillas, orthodox seeds, conservación ex situ
Abstract

Ex-situ seed conservation is one of the most effective tools for biodiversity and genetic diversity protection. In the context of global climate change, ex situ conservation has become an important strategy that must be strengthen and integrated with in situ conservation strategies. The main objective of this study was to document the desiccation tolerance and germination properties of four species from Puya and provide tools that allow the ex situ conservation of this and other closely related species. These species are distributed in Páramo, a threatened ecosystem despite of its value as a water reservoir and supplier for urban population. Seed morphological variables and moisture content (MC) were measured before a test of germination was conducted with three different moisture contents (fresh seeds, 10-12 % and 3-5 %). Germination percentage and the mean germination time were evaluated. The germination was above 80 % in all the species with no significant differences when decreasing MC. There were no significant differences in mean germination time. Seed viability for the four species was high, as compared to other Páramo species. The results indicate that all species are orthodox. Therefore, this genus has great potential to be conserved in seed banks, which will contribute to diversity conservation of native species from tropical Andean highlands, and can be implemented in germination protocols for their propagation and reintroduction in restoration programs. RESUMEN La conservación ex situ de semillas es una de las formas más efectivas de preservación de la biodiversidad y especialmente de la diversidad genética. En el marco del cambio climático su aplicación es una estrategia importante que se debe fortalecer e integrar con la conservación in situ. El objetivo del presente trabajo fue estudiar la tolerancia a la desecación y la germinación de cuatro especies del género Puya y proporcionar herramientas para su conservación ex situ. Estas especies están distribuidas en el páramo, un ecosistema amenazado a pesar de su valor como reservorio y proveedor de agua para la población urbana. En las semillas se realizó la toma de medidas morfológicas y del contenido de humedad (CH), se realizaron ensayos de germinación en tres contenidos de humedad (semillas frescas, 10-12 % y 3-5 %) y se evaluó el porcentaje de germinación y tiempo medio de germinación. Se registró una germinación superior al 80 % en las cuatro especies y no se encontraron diferencias significativas al disminuir el CH. El tiempo medio de germinación no varió entre especies y la viabilidad fue alta comparada con otras especies de páramo. Los resultados indican que son semillas ortodoxas y las variables morfológicas apoyan esta tendencia. Por tanto, este género presenta un gran potencial para ser conservado en bancos de germoplasma lo que contribuye a la conservación de su diversidad, con las cuales se pueden implementar protocolos de germinación para la propagación y reintroducción en programas de restauración.

Published
2018

42. Supplementary material Article 68251. Assessment of seed viability of 17 high andean tropical species by germination and tetrazolium tests

Author

Mancipe-Murillo, Carolina, Calderón-Hernández, Manuela, Pérez-Martínez, Laura Victoria, Mancipe-Murillo, Carolina, Calderón-Hernández, Manuela, and Pérez-Martínez, Laura Victoria

Abstract

Annex 1. Articles with different methods to evaluate the viability of seeds. The X shows which method was used in each study, in some articles two methods were used., Anexo 1. Artículos con diferentes métodos para evaluar la viabilidad de semillas. La X muestra que método fue utilizado en cada estudio, en algunos artículos fueron utilizados dos métodos.

Published
2018

43. Assessment of seed viability of 17 high andean tropical species by germination and tetrazolium tests

Author

Mancipe-Murillo, Carolina, Calderón-Hernández, Manuela, Pérez-Martínez, Laura Victoria, Mancipe-Murillo, Carolina, Calderón-Hernández, Manuela, and Pérez-Martínez, Laura Victoria

Abstract

Viability denotes the potential of a seed to germinate, which is linked to the reproductive success or failure of the populations and in this way is one of the first variables to evaluate when working with seeds. Our aim was to determine the best method to assess the viability in 17 high Andean species; the viability obtained by two tests was compared: Tetrazolium, for which variations in concentration, conditioning and exposure time were tested; and germination, which was worked under controlled conditions at 20/10 °C, photoperiod and thermoperiod of 12 hours. The Kruskal-Wallis test was used to evaluate differences. Differences were found between tests. In 11 species the Tetrazolium test is recommended, where the best evaluation condition was [1-1.5 %] TZ, 40 °C and 24 hours of exposure. In Puya, Hypericum, and Gaultheria, the germination was the better test for viability evaluation. The comparison of the tests allowed to detect dormancy in some species where a high viability but low germination was recorded. The results allowed to determine the most reliable method to evaluate the viability in the different species, provide information about their germinative requirements and potential for sexual propagation, as well as detect the possible presence of dormancy and the need to deepen the evaluation of the methods of rupture that allow to increase the percentage of germination in some of the species., La viabilidad denota el potencial que tiene una semilla para germinar, la cual está ligada al éxito o fracaso reproductivo de las poblaciones y de esta manera es una de las primeras variables a evaluar cuando se trabaja con semillas. Nuestro objetivo fue determinar el mejor método para evaluar la viabilidad en 17 especies altoandinas; se comparó la viabilidad mediante dos pruebas: Tetrazolio, para la cual se probaron variaciones de concentración, acondicionamiento y tiempo de exposición; y germinación, que se trabajó bajo condiciones controladas a 20/10 °C, fotoperiodo y termoperiodo de 12 horas. Se utilizó la prueba Kruskal- Wallis para evaluar diferencias. Se encontraron diferencias en el valor de viabilidad entre las pruebas. En 11 especies se recomienda la prueba de Tetrazolio, donde la mejor condición de evaluación fue [1-1,5 %] TZ, 40 °C y 24 horas de exposición. En Puya, Hypericum y Gaultheria la prueba de germinación fue mejor para evaluar la viabilidad. La comparación de las pruebas permitió detectar la presencia de dormancia en algunas especies donde se evidenció una alta viabilidad pero baja germinación. Los resultados permitieron determinar el método más confiable para evaluar la viabilidad en las diferentes especies, aportar información sobre sus requerimientos germinativos y potencial para la propagación sexual, así como detectar la posible presencia de dormancia y la necesidad de profundizar en la evaluación de los métodos de ruptura que permitan aumentar los porcentajes de germinación en algunas de las especies.

Published
2018

44. Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: a multicentre cohort study.

Author

Suárez-García, Inés, Moreno, Cristina, Ruiz-Algueró, Marta, Pérez-Elías, María Jesús, Navarro, Marta, Díez Martínez, Marcos, Viciana, Pompeyo, Pérez-Martínez, Laura, Górgolas, Miguel, Amador, Concha, de Zárraga, Miguel Alberto, Jarrín, Inma, the Cohort of the Spanish HIV/AIDS Research Network (CoRIS), Moreno, Santiago, Dalmau, David, Navarro, Maria Luisa, González, Maria Isabel, Garcia, Federico, Poveda, Eva, and Iribarren, Jose Antonio

Subjects
COMBINATION drug therapy, DRUG tolerance, HIV infections, LONGITUDINAL method, MEDICAL cooperation, MEDICAL practice, RESEARCH, VIRAL load, TREATMENT effectiveness, DARUNAVIR, EMTRICITABINE-tenofovir
Abstract

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014–2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Serrano-Villar, Sergio, Martínez-Sanz, Javier, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, Fanjul, Francisco, Portilla, Joaquín, Muñoz, Josefa, Amador, Concha, de Zárraga, Miguel Alberto, Vivancos, María J, Moreno, Santiago, Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, and Vallejo, Alejandro

Abstract

A low CD4/CD8 ratio during antiretroviral therapy (ART) identifies people with heightened immunosenescence and increased risk of mortality. We aimed to assess the effects of integrase strand transfer inhibitor (INSTI)-based, protease inhibitor-based, or non-nucleoside reverse transcriptase inhibitor (NNRTI)-based first-line ART on long-term CD4/CD8 ratio recovery.

Published
2020
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47. Estudio sobre la enseñanza aprendizaje de la argumentación en un centro educativo

Author

Pérez Martínez, Laura María and Ezpelta Aguilar, Fermín

Subjects
proyecto social, enseñanza-aprendizaje, opinión, prensa, argumentación
Abstract

Este trabajo se enmarca dentro de la línea B de los Trabajos Fin de Máster propuestos desde el Máster de Profesorado de Educación Secundaria Obligatoria y Bachillerato. Se ha elaborado un estudio de la enseñanza-aprendizaje de la argumentación en un centro educativo para hacer una propuesta de mejora. Los datos se han extraído a través de la observación directa y de encuestas. Asimismo, la propuesta consiste en un proyecto social.

Published
2014

49. Evaluación ecofisiológica de gulupa Passiflora edulis SIMS, bajo tres condiciones ambientales

Author

Pérez Martínez, Laura Victoria and Melgarejo Muñoz, Luz Marina

Subjects
ecophysiology, Estado fenológicos, Ecofisiología de la gulupa, Passiflora edulis, Ecofisiología, Plántula, Gulupa Passiflora edulis Sims, environmental factors, Ecofisiología vegetal, Juvenil, Floración, 582 - Plantas destacadas por características vegetativas y flores [580 - Plantas], Fructificación, Factores ambientales
Abstract

ilustraciones, fotografías, gráficas, tablas La ecofisiología vegetal es una herramienta importante para determinar la adaptación y el éxito de una especie a determinado sitio permitiendo hallar no sólo el óptimo para su crecimiento y desarrollo sino su tolerancia a determinadas condiciones ambientales. A su vez, la gulupa Passiflora edulis Sims, es un frutal de gran importancia económica en el país ya que constituye uno de los primeros renglones en exportación de frutales. A pesar de que en los últimos años los estudios en gulupa han aumentado, a nivel agronómico la mayor parte del conocimiento es empírica y no se registran estudios en campo de la ecofisiología de la planta. En el presente estudio se caracterizó la ecofisiología de la planta en Chía, Granada y Tena durante cuatro estado fenológicos: Plántula, Juvenil, Floración y Fructificación. Se realizaron mediciones de intercambio de gases (fotosíntesis y transpiración), conductancia estomática, eficiencia de operación del fotosistema II, tasa de transporte de electrones, potencial hídrico foliar durante el día en rangos de dos horas. Se determinó Ci/Ca y el uso eficiente del agua. A su vez, se realizaron mediciones de máxima eficiencia cuántica del fotosistema II y potencial hídrico antes del amanecer. Además se realizaron curvas de respuesta fotosintética a la luz y al CO2 para determinar la capacidad fotosintética de las plantas en cada uno de los lugares. A partir de estaciones climáticas instaladas en cada localidad se determinó cuál de los factores; radiación fotosintéticamente activa, humedad relativa, déficit de presión de vapor y temperatura, ejerce mayor influencia sobre las variables fisiológicas medidas tanto a nivel general como en cada localidad por medio del análisis por pasos. Los resultados indicaron que el déficit de presión de vapor es la variable climática que influencia más fuertemente la fisiología de la gulupa en condiciones no estresantes pero, en etapa reproductiva aumenta la sensibilidad a otras variables climáticas como temperatura y radiación. A su vez, la humedad relativa influyó directamente el potencial hídrico foliar. En condiciones estresantes, se registró una mayor influencia de la alta temperatura que ocasiona cierre estomático en horas de mayor DPV y con esto disminución de la fotosíntesis. El menor déficit de presión de vapor, temperatura adecuada (18°C en promedio) y la alta humedad relativa (85% en el día y 95% en la noche) hacen de Granada la localidad donde mejor se desempeña fisiológicamente la gulupa, hecho evidenciado en la producción. Las bajas radiaciones (por debajo de 400 μmol fotones/m2s) en Tena producto de la alta nubosidad y su poca disminución de la temperatura y poco aumento de la humedad, un DPV por encima de 0,70 KPa en ciertas horas del día en Tena y Chía, y bajas temperaturas en Chía tendrían efectos en la tasa fotosintética, en la recuperación del estado hídrico y enn el estado del fotosistema II que hacen que aunque la gulupa se desarrolle y llegue a producción, las condiciones no sean óptimas. (Texto tomado de la fuente). Plan ecophysiology is an important tool to determine the adaptation and success of specie to a site allowing finding the optimal for its growth and development and its tolerance to specific environmental conditions. In turn, the gulupa Passiflora edulis Sims is a very important economically fruit crop in Colombia because it make up one of the first lines of exportations in the country. In spite of increasing studies in the last years, at agronomical level the knowledge has been empirical and there are not ecophysiological studies of the gulupa in field. In the present study, the ecophysiology of gulupa was characterized in Chia, Granada and Tena during four phonological stages: Seedling, Juvenile, Flowering and fructification. Gas exchange, stomatal conductance, photosystem II operation efficiency, electron transport rate and leaf water potential were measured during the day in two-hour ranges. Ci/Ca and water use efficiency were calculated from data. In turn, Fv/Fm and predawn water potential were measured. Additionally, radiation and CO2 photosynthetical response curves were done in each site. The physiology was related with the production yield in each site. With climatic stations in each site, temperature, relative humidity, photosynthetically active radiation and water vapor deficit were measured and through path analysis the strength of each climatic variable on physiological variables were determined. The results shows that water vapour deficit is the most important climatic variable that has strong influence on the gulupa’s physiology in not stressful conditions, but in reproductive stages the sensibility to other climatic variables as temperature and radiation increases. Adittionaly, the relative humidity directly influences the leaf water potential. In stressful conditions, a strong influence of temperature was found which cause stomatal close in higher DPV day hours and because of that decrease in photosynthetic rate. The lower VPD, suitable temperature (18°C average) and high relative humidity (85% at day and 95 at night, average) turn Granada the best locality where the gulupa grows and develop in optimal conditions. The low radiations (below 400 μmol fotones/m2s) in Tena, result of the high cloudiness and the low temperarure decrease and humidity increase, a VPD above 0,70KPa in certain hours a day, and low temperatures in Chia would have effect in photosynthetic rate, water status recovery and photosystem II stability which make that unless the gulupa has production, the conditions are not optimal. Incluye anexos Maestría Magíster en Ciencias Agrarias Fisiología de cultivos Ciencias Agronómicas

Published
2013

50. Ecofisiología del cultivo de la gulupa (Passiflora edulis Sims)

Author

Pérez Martínez, Laura Victoria, Melgarejo, Luz Marina, Flórez Gutiérrez, Laura Marcela, Cruz Aguilar, Marisol, Hernández, María Soledad, Hoyos Carvajal, Liliana María, Guerrero, Eugenio, Potosí, Carmen Tulia, Valeryevich Magnitskiy , Stanislav, Velásquez Villamil, Juan David, Nates Parra, María Guiomar, Ospina Torres, Rodolfo, Amaya Márquez, Marisol, Ángel Coca, Catalina, Medina, Julián, and Melgarejo, Luz Marina

Subjects
63 Agricultura y tecnologías relacionadas / Agriculture, ecofisiología de la gulupa, Gulupa, cultivo de la gulupa, 57 Ciencias de la vida, Biología / Life sciences, biology, contenido nutricional de la gulupa, calendarios fenológicos
Abstract

Este libro muestra los resultados de la investigación realizada en gulupa (Passiflora edulis Sims), la cual es una de las especies incluidas en la apuesta exportadora de Colombia en la vigencia 2019. En Colombia se cultiva en los departamentos de Risaralda, Quindío, Cundinamarca y Boyacá, entre otros. La demanda por esta fruta se ha incrementado y el sector productivo frutícola colombiano se beneficia con los precios alcanzados en la ventana de exportación cuando no se provee de otras partes del mundo. Los resultados obtenidos han permitido fortalecer un paquete tecnológico con el fin de consolidar la oferta exportadora y de comercio nacional e internacional. El libro va dirigido tanto al sector productivo como a profesionales, técnicos, estudiantes universitarios o personas interesadas en el cultivo de la gulupa.

Published
2012

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