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183 results on '"Pértega, Sonia"'

14. Impact of parental smoking on childhood asthma

Author

Gonzalez-Barcala, Francisco-Javier, Pertega, Sonia, Sampedro, Manuel, Lastres, Juan Sanchez, Gonzalez, Miguel Angel San Jose, Bamonde, Luis, Garnelo, Luciano, Castro, Teresa Perez, Valdés-Cuadrado, Luis, Carreira, Jose-M., Moure, Jose-D., and Silvarrey, Angel Lopez

Published
2013
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19. Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss

Author

Juiz-Valiña, Paula, primary, Cordido, María, additional, Outeiriño-Blanco, Elena, additional, Pértega, Sonia, additional, Urones, Paula, additional, García-Brao, María Jesús, additional, Mena, Enrique, additional, Pena-Bello, Lara, additional, Sangiao-Alvarellos, Susana, additional, and Cordido, Fernando, additional

Published
2021
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25. Long-term trends in the incidence of peritoneal dialysis-related peritonitis disclose an increasing relevance of streptococcal infections: A longitudinal study

Author

Santos, Joana Eugénio, primary, Rodríguez Magariños, Catuxa, additional, García Gago, Leticia, additional, Astudillo Jarrín, Daniela, additional, Pértega, Sonia, additional, Rodríguez-Carmona, Ana, additional, García Falcón, Teresa, additional, and Pérez Fontán, Miguel, additional

Published
2020
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26. Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation

Author

Juiz-Valiña, Paula, primary, Pena-Bello, Lara, additional, Cordido, Maria, additional, Outeiriño-Blanco, Elena, additional, Pértega, Sonia, additional, Varela-Rodriguez, Barbara, additional, Garcia-Brao, Maria Jesus, additional, Mena, Enrique, additional, Sangiao-Alvarellos, Susana, additional, and Cordido, Fernando, additional

Published
2020
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29. Central Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Loss

Author

Juiz-Valiña, Paula, primary, Cordido, María, additional, Outeiriño-Blanco, Elena, additional, Pértega, Sonia, additional, Varela-Rodríguez, Bárbara María, additional, García-Brao, María Jesús, additional, Mena, Enrique, additional, Pena-Bello, Lara, additional, Sangiao-Alvarellos, Susana, additional, and Cordido, Fernando, additional

Published
2020
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30. Results in liver transplantation using grafts from donors after controlled circulatory death: A single‐center experience comparing donor grafts harvested after controlled circulatory death to those harvested after brain death

Author

Otero, Alejandra, primary, Vázquez, María Angeles, additional, Suárez, Francisco, additional, Pértega, Sonia, additional, Rivas, Jose Ignacio, additional, Mosteiro, Fernando, additional, and Gómez, Manuel, additional

Published
2019
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31. Rhabdomyolysis and acute kidney injury in patients with traumatic spinal cord injury

Author

Galeiras, Rita, Mourelo, MóNica, Pértega, Sonia, Lista, Amanda, Ferreiro, M[Sup]A, Salvador, SebastiáN, Montoto, Antonio, and Rodríguez, Antonio

Subjects
International Business Machines Corp., Rhabdomyolysis -- Complications and side effects -- Care and treatment, Spinal cord injuries -- Complications and side effects -- Care and treatment, Medical research, Computer industry, Microcomputer industry, Computer industry, Health
Abstract

Byline: Rita. Galeiras, Mónica. Mourelo, Sonia. Pértega, Amanda. Lista, M[sup]a. Ferreiro, Sebastián. Salvador, Antonio. Montoto, Antonio. Rodríguez Background: Patients with acute traumatic spinal cord injuries (SCIs) exhibit factors that, in [...]

Published
2016

32. Tracheostomy in the management of patients with thermal injuries

Author

Mourelo, MóNica, Galeiras, Rita, Pértega, Sonia, Freire, David, López, Eugenia, Broullón, Javier, and Campos, Eva

Subjects
Burns -- Care and treatment, Tracheostomy -- Methods, Health
Abstract

Byline: Mónica. Mourelo, Rita. Galeiras, Sonia. Pértega, David. Freire, Eugenia. López, Javier. Broullón, Eva. Campos Objective: To assess the use and clinical impact of tracheostomy in burn patients. Summary Background [...]

Published
2015

34. Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Euthyroid Patients with Morbid Obesity

Author

Juiz-Valiña, Paula, primary, Outeiriño-Blanco, Elena, additional, Pértega, Sonia, additional, Varela-Rodriguez, Bárbara María, additional, García-Brao, María, additional, Mena, Enrique, additional, Pena-Bello, Lara, additional, Cordido, María, additional, Sangiao-Alvarellos, Susana, additional, and Cordido, Fernando, additional

Published
2019
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35. Long-term clinical experience with darunavir (2007-2015) in a large cohort of HIV-infected patients in Spain

Author

Pernas, Berta, Grandal, Marta, Tabernilla, Andrés, Cid, Purificacion, Pértega, Sonia, Castro-Iglesias, Angeles, Mena, Alvaro, Margusino, Luis, Pedreira, Jose D, Poveda, Eva, and Pharmaceutical and Pharmacological Sciences

Subjects
Adult, Male, HIV Infections/drug therapy, Long Term Adverse Effects, Sulfonamides/adverse effects, HIV Protease Inhibitors/administration & dosage, Drug Administration Schedule, Viral Load/drug effects, CD4 Lymphocyte Count, Anti-HIV Agents/administration & dosage, Ritonavir/administration & dosage, HIV-1/drug effects, Spain, Darunavir/administration & dosage, Humans, young adult, Drug Therapy, Combination, Female, Lopinavir/adverse effects, RNA, Viral/blood, Retrospective Studies
Abstract

The clinical experience with the protease inhibitor darunavir/ritonavir (DRV/r) was retrospectively evaluated in a cohort of 173 HIV+ patients who initiated antiretroviral treatment including DRV/r (period 2007-2015). The 43.2% had a CD4 nadir ≤100 cells/mm3 , 64.1% were treatment-experienced, and 36.5% had failed to >3 lines of antiretroviral therapy. Nonetheless, the rate of virological suppression (HIV-RNA

Published
2016

36. Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study

Author

Instituto de Salud Carlos III, European Commission, Fernández-Moreno, Mercedes, Soto-Hermida, Angel, Vázquez-Mosquera, María E., Cortés-Pereira, Estefanía, Relaño, Sara, Hermida-Gómez, Tamara, Pértega, Sonia, Oreiro-Villar, Natividad, Fernández-López, Carlos, Garesse, Rafael, Blanco, Francisco J., Rego-Pérez, Ignacio, Instituto de Salud Carlos III, European Commission, Fernández-Moreno, Mercedes, Soto-Hermida, Angel, Vázquez-Mosquera, María E., Cortés-Pereira, Estefanía, Relaño, Sara, Hermida-Gómez, Tamara, Pértega, Sonia, Oreiro-Villar, Natividad, Fernández-López, Carlos, Garesse, Rafael, Blanco, Francisco J., and Rego-Pérez, Ignacio

Abstract

[Objective]: To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential diagnostic biomarkers and therapeutic targets., [Methods]: Two prospective cohorts contributed participants. The osteoarthritis initiative (OAI) included 2579 subjects of the incidence subcohort, and the cohort hip and cohort knee (CHECK) included 635, both with 8-year follow-up. The analysis included the association of mtDNA haplogroups with the rate of incident knee OA in subjects from both cohorts followed by a subsequent meta-analysis. Transmitochondrial cybrids harbouring haplogroup J or H were constructed to detect differences between them in relation to physiological features including specific mitochondrial metabolic parameters, reactive oxygen species production, oxidative stress and apoptosis., [Results]: Compared with H, the haplogroup J associates with decreased risk of incident knee OA in subjects from OAI (HR=0.680; 95% CI 0.470 to 0.968; p<0.05) and CHECK (HR=0.728; 95% CI 0.469 to 0.998; p<0.05). The subsequent meta-analysis including 3214 cases showed that the haplogroup J associates with a lower risk of incident knee OA (HR=0.702; 95% CI 0.541 to 0.912; p=0.008). J cybrids show a lower free radical production, higher cell survival under oxidative stress conditions, lower grade of apoptosis as well as lower expression of the mitochondrially related pro-apoptotic gene BCL2 binding component 3 (BBC3). In addition, J cybrids also show a lower mitochondrial respiration and glycolysis leading to decreased ATP production., [Conclusions]: The physiological effects of the haplogroup J are beneficial to have a lower rate of incident knee OA over time. Potential drugs to treat OA could focus on emulating the mitochondrial behaviour of this haplogroup.

Published
2017

39. Characterization of chronic HCV infection in Northwest Spain: Impact of the treatment strategic plan of the Spanish National Health Service on HCV cure

Author

Grandal, Marta, primary, Pernas, Berta, additional, Mariño, Ana, additional, Álvarez, Hortensia, additional, Tabernilla, Andrés, additional, Castro-Iglesias, Ángeles, additional, Mena, Álvaro, additional, Delgado, Manuel, additional, Pértega, Sonia, additional, and Poveda, Eva, additional

Published
2017
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41. Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study

Author

Fernández-Moreno, Mercedes, primary, Soto-Hermida, Angel, additional, Vázquez-Mosquera, María E, additional, Cortés-Pereira, Estefanía, additional, Relaño, Sara, additional, Hermida-Gómez, Tamara, additional, Pértega, Sonia, additional, Oreiro-Villar, Natividad, additional, Fernández-López, Carlos, additional, Garesse, Rafael, additional, Blanco, Francisco J, additional, and Rego-Pérez, Ignacio, additional

Published
2016
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42. A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis

Author

Fernández-Moreno, Mercedes, primary, Soto-Hermida, Angel, additional, Vázquez-Mosquera, María E., additional, Cortés-Pereira, Estefanía, additional, Pértega, Sonia, additional, Relaño, Sara, additional, Oreiro-Villar, Natividad, additional, Fernández-López, Carlos, additional, Blanco, Francisco J., additional, and Rego-Pérez, Ignacio, additional

Published
2016
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43. Brief Report: European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain

Author

Tabernilla, Andres, primary, Rego-Pérez, Ignacio, additional, Grandal, Marta, additional, Pernas, Berta, additional, Pértega, Sonia, additional, Delgado, Manuel, additional, Mariño, Ana, additional, Álvarez, Hortensia, additional, Mena, Alvaro, additional, Rodríguez-Osorio, Iria, additional, Pedreira, Jose Domingo, additional, Blanco, Francisco Javier, additional, and Poveda, Eva, additional

Published
2016
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46. Emergency presentation of colorectal patients in Spain.

Author

Esteva, Magdalena, Ruiz-Díaz, Mercedes, Sánchez, M. Antonia, Pértega, Sonia, Pita-Fernández, Salvador, Macià, Francesc, Posso, Margarita, González-Luján, Luis, Boscá-Wats, Marta M., Leiva, Alfonso, Ripoll, Joana, and null, null

Subjects
COLON cancer diagnosis, HOSPITAL admission & discharge, CANCER-related mortality, OUTPATIENT medical care
Abstract

Background: Colorectal cancer (CRC) is the leading cause of cancer deaths in Europe. Survival is poorer in patients admitted to hospitals through the emergency department than in electively admitted patients. Knowledge of factors associated with a cancer diagnosis through presentation at an emergency department may reduce the likelihood of an emergency diagnosis. This study evaluated factors influencing the diagnosis of CRC in the emergency department. Methods and findings: This is a cross-sectional study in 5 Spanish regions; subjects were incident cases of CRC diagnosed in 9 public hospitals, between 2006 and 2008. Data were obtained from patient interviews and primary care and hospital clinical records. We found that approximately 40% of CRC patients first contacted a hospital for CRC through an emergency service. Women were more likely than men to be emergency presenters. The type of symptom associated with emergency presentation differed between patients with colon cancer and those with rectal cancer, in that the frequency of “alarm symptoms” was significantly lower in colon than in rectal cancer patients who initially presented to emergency services. Soon after symptom onset, some patients went to a hospital emergency service, whereas others contacted their GP. Lack of contact with a GP for CRC-related symptoms was consistently related to emergency presentation. Among patients who contacted a GP, a higher number of consultations for CRC symptoms and any referral to outpatient consultations reduced the likelihood of emergency presentation. All diagnostic time intervals were shorter in emergency presenters than in elective patients. Conclusions: Emergency presenters are not a uniform category and can be divided into categories according to their symptoms, help seeking behavior trajectory and interaction with their GPs. Time constraints for testing and delays in obtaining outpatient appointments led patients to visit a hospital service either on their own or after referral by their GP. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study.

Author

Fernández-Moreno, Mercedes, Soto-Hermida, Angel, Vázquez-Mosquera, María E., Cortés-Pereira, Estefanía, Relaño, Sara, Hermida-Gómez, Tamara, Pértega, Sonia, Oreiro-Villar, Natividad, Fernández-López, Carlos, Garesse, Rafael, Blanco, Francisco J., and Rego-Pérez, Ignacio

Abstract

Objective: To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential diagnostic biomarkers and therapeutic targets.Methods: Two prospective cohorts contributed participants. The osteoarthritis initiative (OAI) included 2579 subjects of the incidence subcohort, and the cohort hip and cohort knee (CHECK) included 635, both with 8-year follow-up. The analysis included the association of mtDNA haplogroups with the rate of incident knee OA in subjects from both cohorts followed by a subsequent meta-analysis. Transmitochondrial cybrids harbouring haplogroup J or H were constructed to detect differences between them in relation to physiological features including specific mitochondrial metabolic parameters, reactive oxygen species production, oxidative stress and apoptosis.Results: Compared with H, the haplogroup J associates with decreased risk of incident knee OA in subjects from OAI (HR=0.680; 95% CI 0.470 to 0.968; p<0.05) and CHECK (HR=0.728; 95% CI 0.469 to 0.998; p<0.05). The subsequent meta-analysis including 3214 cases showed that the haplogroup J associates with a lower risk of incident knee OA (HR=0.702; 95% CI 0.541 to 0.912; p=0.008). J cybrids show a lower free radical production, higher cell survival under oxidative stress conditions, lower grade of apoptosis as well as lower expression of the mitochondrially related pro-apoptotic gene BCL2 binding component 3 (BBC3). In addition, J cybrids also show a lower mitochondrial respiration and glycolysis leading to decreased ATP production.Conclusions: The physiological effects of the haplogroup J are beneficial to have a lower rate of incident knee OA over time. Potential drugs to treat OA could focus on emulating the mitochondrial behaviour of this haplogroup. [ABSTRACT FROM AUTHOR]

Published
2017
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