1. Relevance of 10 Caucasian HLA haplotypes in searches for unrelated bone marrow donors for 100 patients from a single center
- Author
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E, Tron de Bouchony, C, Leberre, C, Dauriac, N, Genetet, C, Lapart, R, Fauchet, P Y, Leprisé, B, Genetet, C, Raffoux, and G, Semana
- Subjects
HLA-DP Antigens ,Tissue and Organ Procurement ,Tissue Donors ,White People ,Europe ,Gene Frequency ,Haplotypes ,HLA Antigens ,Humans ,Transplantation, Homologous ,France ,Registries ,Lymphocyte Culture Test, Mixed ,HLA-DP beta-Chains ,Bone Marrow Transplantation - Abstract
Unrelated donor searches for 100 Caucasian patients were referred to France Greffe de Moëlle Registry (FGM) from September 1987 (24,600 donors) to December 1993 (71,500 donors, 61% DR typed). After DR typing of HLA-A,B matched donors, unsuccessful searches were extended to other European Registries for 36 patients. Twenty two patients had a donor (FGM: 19, other Registries: 3) selected on: (1) HLA-A,B and DRB,DQB1 split identity; and (2) unidirectional relative response5% in MLR performed twice. Estimated probability of finding a compatible donor at 9 months in FGM was 12% (s.e. +/- 4%) and 25% at 2 years (s.e. +/- 6%). This probability was stringently dependent on a phenoidentity to one very common HLA-A,B,DR or B,DR haplotype (25% at 9 months when present, representing 19 of 19 patients with a compatible donor). Without this phenoidentity, the probability was zero per cent (P = 0.0001) in FGM searches and4% (n = 1) in extended searches. The MLR test was shown to be insensitive for screening for DPB1 mismatches. Clinical status influenced the probability of finding a compatible donor at one year ranging from 9% +/- 9% for ALL to 23% +/- 8% for CML (NS). Disregarding DPB1 mismatches is the most efficient way of increasing search efficiency.
- Published
- 1995