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Nanophotonic structures have shown promising routes to controlling and enhancing nonlinear optical processes at the nanoscale. However, most nonlinear nanostructures require a handling substrate, reducing their application scope. Due to the underwhelming heat dissipation, it has been a challenge to evaluate the nonlinear optical properties of free-standing nanostructures. Here, we overcome this challenge by performing shot-controlled fifth harmonic generation (FHG) measurements on a SiC meta-membrane - a free-standing transmission metasurface with pronounced optical resonances in the mid-infrared (λ res ≈ 4,000 nm). Back focal plane imaging of the FHG diffraction orders and rigorous finite-difference time-domain simulations reveal at least two orders of magnitude enhancement of the FHG from the meta-membrane, compared to the unstructured SiC film of the same thickness. Single-shot measurements of the meta-membrane with varying resonance positions reveal an unusual spectral behavior that we explain with Kerr-driven intensity-dependent resonance dynamics. This work paves the way for novel substrate-less nanophotonic architectures.

In today’s context of growing volumes of personal data and the increasing number of legally significant actions that can be conducted with access to such data, the importance of legal protection for personal data has become more pronounced. This paper aims to examine the nature of the right to personal data. Based on an analysis of Russian legislation, the Author concludes that there exists an unnamed, independent subjective right, which serves to enable the data subject to control and define the conditions for data processing, as well as to protect personal data from unauthorized use. The study critically evaluates the current scientific debate regarding the nature of this right. Three primary approaches in the academic discourse on the autonomy of this right are identified, tentatively categorized as the “ignoring”, “denying”, and “recognizing” approaches. The Author notes the lack of a uniform scientific approach to naming this right and suggests designating it as “the right to the inviolability of personal data”. This right is characterized as an independent, subjective, personal non-property, and absolute civil right. The paper further explores the conditions under which this right arises and terminates. Specifically, it originates at the birth of an individual and terminates when the purpose of personal data processing ceases, typically upon the death of the individual whose data was processed. The need for legal succession is justified to allow heirs to ensure the inviolability of the testator’s personal data if its processing continues posthumously. In distinguishing between the right to the inviolability of personal data and the right to privacy, the Author argues that these are distinct subjective rights. They are interconnected only in theoretical frameworks that enable the use of protective measures for one right when the other is infringed. A trend in judicial practice has been identified, where courts recognize the existence of a right to personal data. Although not explicitly named, this right is nonetheless afforded legal protection.

Infectious mononucleosis is a current problem of pediatric practice, which tends to increase the incidence in the Russian Federation and other countries. Liver dysfunction of varying severity in infectious mononucleosis occur with a frequency of 17—90% of cases while Epstein-Barr neuroinfections of viral etiology occur in no more than 5% of patients. This article presents a clinical case of infectious mononucleosis with liver damage and right facial neuropathy in a 15-year-old child.

The objective of this study is to elucidate the challenges inherent in the prevention of military-economic crime under martial law in Ukraine. In the light of the study's findings, the authors proceed to analyse the measures to prevent military-economic crimes under martial law in Ukraine. This analysis enables the identification and detailed characterisation of three principal levels: general social, special criminological and individual preventive. In the context of studying the general social prevention of military-economic crime, it has been demonstrated that the formation of patriotism among servicemen of the Armed Forces of Ukraine and other military formations is unfeasible without the implementation of an appropriate set of state and social measures aimed at fostering the consciousness and behaviour of the individual in anticipation of their future role as a serviceman. These measures must be designed to cultivate a range of qualities, including civil, socio-psychological, moral, physical, military professional and volitional qualities, in order to ensure the fulfilment of both the constitutional duty of Ukrainian citizens to protect the Motherland and the effective execution of combat missions in any circumstances. Within the framework of special criminological prevention of military-economic crime, the study substantiates and proves the need to create mental health units at the level of divisions and brigades, which should be headed by psychiatrists and include mental health officers (licensed psychologists and/or social workers with specialised education who have at least one year of experience in relevant medical institutions). The article establishes that the main purpose of individual prevention of military-economic crime is a positive correction of a serviceman's personality aimed at changing his behaviour from anti-social to law-abiding, and therefore the main measures of individual prevention of military-economic crime in the Armed Forces of Ukraine and other military formations should be the following: identification of sources of negative influence that contribute to the commission of military economic criminal offences; examination of the personality of typical offenders; forecasting the individual behaviour of persons prone to commit military economic criminal offences; planning individual preventive measures for identified persons; implementation of appropriate corrective influence on the personality of a typical offender aimed at avoiding the commission of military economic criminal offences; control over the behaviour of typical offenders.

Femtosecond-laser-assisted material restructuring employs extreme optical intensities to localize the ablation regions. To overcome the minimum feature size limit set by the wave nature of photons, there is a need for new approaches to tailored material processing at the nanoscale. Here, we report the formation of deeply-subwavelength features in silicon, enabled by localized laser-induced phase explosions in prefabricated silicon resonators. Using short trains of mid-infrared laser pulses, we demonstrate the controllable formation of high aspect ratio (>10:1) nanotrenches as narrow as [Formula: see text]. The trench geometry is shown to be scalable with wavelength, and controlled by multiple parameters of the laser pulse train, such as the intensity and polarization of each laser pulse and their total number. Particle-in-cell simulations reveal localized heating of silicon beyond its boiling point and suggest its subsequent phase explosion on the nanoscale commensurate with the experimental data. The observed femtosecond-laser assisted nanostructuring of engineered microstructures (FLANEM) expands the nanofabrication toolbox and opens exciting opportunities for high-throughput optical methods of nanoscale structuring of solid materials.

The controlled delivery of selenium nanoparticles (Se‐NPs) is promising for bone cancer treatment due to their dual benefits in bone regeneration and tumor inhibition, yet achieving an optimal dosing regimen remains challenging. Natural mesoporous biosilica (BS) beads have shown promise for drug delivery due to their microporous structure. This study explores incorporating BS beads into collagen‐chitosan (Coll‐CS) scaffolds, known for bone repair, to control Se‐NP delivery. Two approaches are compared: loading Se‐NPs into BS beads before integrating them into Coll‐CS scaffolds versus directly loading Se‐NPs into Coll‐CS scaffolds. The scaffold properties, Se release kinetics, cytocompatibility, and effects on mesenchymal stem cells (MSCs) and prostate cancer cells (LNCaP) are evaluated. BS bead‐loaded scaffolds provide controlled Se‐NP release and enhanced mechanical properties compared to directly loaded scaffolds. Higher Se‐NP concentrations in BS‐loaded scaffolds effectively promote MSC osteogenic differentiation and mineralisation while inhibiting LNCaP cell viability. In contrast, low Se‐NP concentrations not only induce early osteogenic differentiation but also promote cancer cell proliferation, underscoring the need for optimal Se‐NP concentration and release. These findings suggest that BS bead‐loaded Coll‐CS scaffolds are a promising strategy for controlled Se‐NP delivery, addressing the dual challenges of bone formation and cancer recurrence prevention in bone cancer treatment.

This study delves into the psychological effects of vocal therapy on university music students, addressing a gap in research on targeted mental health interventions for this group. Amidst the unique pressures of music education, this research examines how vocal therapy influences students' coping strategies, social connectedness, mental health, and resilience. Utilizing various validated instruments like the Kenny Music Performance Anxiety Inventory (K-MPAI), Short Form-36 (SF-36), UCLA Loneliness Scale, Coping Inventory for Stressful Situations (CISS), and the Connor-Davidson Resilience Scale (CD-RISC), the study compares students undergoing vocal therapy with those who are not. Results indicate a significant reduction in performance anxiety, improved general health and mental well-being, decreased feelings of loneliness, enhanced coping strategies, and increased resilience in students participating in vocal therapy. These findings underscore the efficacy of vocal therapy as a comprehensive intervention, advocating for its integration into university mental health services. This study contributes to the growing field of music therapy and mental health, offering essential insights for educational institutions, mental health professionals, and music educators.

The relevance of the research is substantiated by the fact that the information society can be addressed as a stage in the modern civilization formation, which is characterized by the increasing role of knowledge, information, as well as information processing technologies. The number of people employed in the information sphere is growing steadily. The information products and information services are gaining additional shares in the market. It is specifically the prerequisites for a future specialist to have high media and cultural competence to tackle current challenges. The research aims to ascertain experimentally the pedagogical conditions for media culture formation and its impact on future professionals' training. The study was conducted using such tools as questionnaires and testing. Diagnosis of cognitive interest (according to N. Kuzmina's scale), the scale for assessing students' operational skills (according to M. Chobitko), Pearson's criterion (chi-square). In the experimental group, only 1.9% of students at the control stage of the experiment corresponded to the low level of media culture according to the cognitive criterion, while in the control group there were 18.4% f students. However, in the experimental group at the control stage of the experiment more than 61% of respondents yielded a high level of media culture according to the cognitive criterion. That said, in the experimental group only 1.9% respondents at the control stage of the experiment corresponded to a low level of media culture according to the cognitive criterion. The obtained results give grounds to argue that media culture formation has a positive effect on the future professionals' training. This is due to the fact that media culture is underlying the general professional competence of the XXI century specialist. The enhancement of the students training through the use of new information and Internet technologies has all chances to be one of the prospects for further research in the relative to the issue addressed.

The purpose of the research was to adapt the Academic Motivation Scale in the context of investigating students' motivation to study physical education and sports, including the assessment of psychometric properties and experimental validation of the model tool. In this study, a combination of quantitative and qualitative research methods was used. After comparison with alternatively possible models, the seven-factor model showed the highest correspondence. The test-retest factors were above 0.7 for all subscales, indicating high reliability of the questionnaire. The analysis of the participants' results revealed that the highest indicators were for extrinsic and identified regulation and internal motivation related to knowledge acquisition. The obtained version of the Academic Motivation Scale is a valid instrument and has acceptable psychometric properties and can be used to study the learning motivation of university students, in particular future specialists in physical education and sports.

Purpose. Forming a thematic bibliographic list of English-language and Ukrainian-language publications, which highlight the issues of artificial breeding and cultivation of European grayling in Ukraine and abroad, the results of research into its population, ecological, genetic, physiological, biochemical, immunological and other characteristics. Methods. The complete and selective methods were applied in the process of the systematic search. The bibliographic core have been consisted of scientific publications in Ukrainian and English from the fund of the Institute of Fisheries NAAS Scientific Library, as well as resources available to its users. Results. There was composed the thematic list of publications with a total quantity of 200 sources covering the time interval from 1982 to 2024, and outlining issues regarding the reproduction of a representative of Salmonids — European grayling (Thymallus thymallus L.) as one of the most rare, valuable, and significant species in the ichthyofauna of Ukraine in terms of nature protection, research of its biological, morphological, ecological, genetic, physiological, biochemical and other features at various stages of ontogenesis and different living conditions. The literary sources were arranged in alphabetical order by author or title, and described according to DSTU 8302:2015 “Information and documentation. Bibliographic reference. General principles and rules of composition”, with the amendments (code UKND 01.140.40), as well as in accordance with the requirements of APA style — international standard of references. Practical value. The list may be useful for scientists, specialists, professors, and students whose area of interests includes research of rare and endangered species of fish, biological, population, genetic, ecological and other characteristics of Thymallinae, in particular in the context of their artificial reproduction.

In this article, we will begin with two almost simultaneously written paradoxes of modernism / avant-garde. The first paradox is Gertrude Stein’s miniature “Sacred Emily”, a one-line poem that reads “Rose is a rose is a rose”. The second paradox is Alexey Kruchenykh’s abstract poem “Dyr byl schyl”. Both texts suggest a transition from a negative emotional state to a positive one, creating a complex aesthetic experience. At the heart of this experience is a re-evaluation of the poetic code as a meaningful and symbolic system, a source of meaning and knowledge. The reader interacts with this code as a collaborator and co-creator, adapting it to their own reality and giving it new meaning. These texts reflect the global artistic trends of the era, which were characterized by a shift towards a different type of representation, one that emphasizes the transmission of feelings and impressions. This vector is inherent in the creative works of both Gertrude Stein and Aleksey Kruchenykh. The artist's task is to induce a complex range of reactions in the recipient, which form a cognitive and creative experience, resulting in an epistemological reconfiguration. Focusing on a new approach to imitation (imitating an experience of reality, not reality itself), both Stein and Kruchenykh sought to accomplish a cognitive recalibration of the reader's mind through experimentation with language. Both Gertrude Stein and Alexey Kruchenykh identify peripheral and associative aspects of experience, create a complex of experiences based on these elements, and recreate them through language. This process is made possible by the suggestive, associative, and connotative power of language and artistic form.

The presented material describes the results of the purposeful search for the novel hepatoprotective agents among synthetic sulfur-containing pteridines. The studied compounds were obtained using previously described synthetic procedures. SwissADME and ProTox-II services, as well as a docking study were used to predict the compounds` pharmacokinetics, drug-likeness and toxicity. The effects of sulfur-containing pteridines on lipid peroxidation in vitro and GSH/GSSG levels in vivo were studied for evaluation of their hepatoprotective potential. In silico procedures allowed us to exclude the compounds with inappropriate ADME parameters and high predicted toxicity. Molecular docking of the obtained compounds towards the active site of CYP-enzyme allowed us to clarify the specifics of ligand-enzyme interactions and predict cytochrome-inhibiting activity of the studied agents. The antioxidant activity of the studied compounds was evaluated in vitro using the linoleic acid peroxidation model. It has been found that sulfur-containing pteridines inhibit the peroxidation of linoleic acid. The structure – antioxidant activity relationships were evaluated and discussed as well. Additionally, it has been estimated that antioxidant properties of the studied pteridines directly correlate with their hydrophilicity and number of functional groups with exchangeable proton in molecules. In vivo studies showed that some of the studied sulfur-containing pteridines reduced severity of the hepatotoxic effects caused by the administration of carbon tetrachloride. (3-(7-Hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydropteridin-6-yl)propanoyl)alanine has been identified as the most active hepatoprotective agent. The above mentioned compound significantly increases the content of GSH and decreases the level of GSSG compared with non-treated experimental pathology, which reliably affirms its hepatoprotective activity. The hepatoprotective activity of the studied compounds is likely associated with their ability to increase the level of GSH, inhibit lipid peroxidation and decrease prooxidant compounds levels. The obtained results attest the reasonability of further search for hepatoprotective agents among sulfur-containing pteridine derivatives.

The aim of the article is to identify the features of modern approaches to the motivation of personnel of international projects to ensure competitiveness and establish, using statistical and econometric methods, the quantitative influence of individual socioeconomic factors on the performance of these employees. The socioeconomic and political situation in Ukraine due to the full-scale military aggression on the part of the russian federation requires the top management of business entities to search for and successfully use statistical and econometric methods to determine and model dependencies between socioeconomic indicators, as well as to provide an opportunity to be involved in international projects in order to obtain additional competitive advantages. In the course of the study with the use of system-structural analysis and synthesis, the stages of personnel management of international projects are determined, as well as the characteristics and functions performed by individual subsystems of personnel management of international projects are identified. According to the results of the review of scientific literature, considerable attention of scientists to the problems of motivation of personnel of international projects to ensure the competitiveness of enterprise has been revealed. Approbation of theoretical studies was carried out based on the results of the activities of JSC «Interpipe NMPP», the main types of products of which are pipes of medium and small assortment. The analytical study revealed a decrease in sales, net profit and the number of employees, which is a consequence of the company’s work in an unstable external environment (COVID, military aggression of the russian federation against Ukraine). With the use of statistical and econometric methods, the degree of influence of individual factors on the efficiency of the personnel of the specified enterprise is determined; in particular, with the use of regression analysis, the author has built econometric models of the impact of personnel development in the form of professional training and advanced training and material incentives (remuneration) on the efficiency of the personnel of the specified enterprise and its involvement in participation in international projects. The author’s vision boils down to the fact that the use of such tools for motivating the personnel of international projects as wages, vocational training and advanced training provide an increase in labor productivity and, accordingly, the formation of competitive advantages of both employees and products, the enterprise, and the country as a whole. Prospect for further scientific research is the formation of a system of non-material factors for increasing labor productivity and personnel evaluation.

Вступ. Вивчення передового досвіду, сильних та слабких сторін, ключових особливостей підходів до відновлення та реабілітації ветеранів у розвинутих країнах світу є актуальним завданням для врахування досягнень та уникнення поширених помилок, що буде запорукою вдосконалення підходів до надання якісних реабілітаційних послуг військовослужбовцям ЗС України. Мета. Провести аналіз передового досвіду та ключових особливостей реабілітації ветеранів в розвинутих країнах світу. Матеріали та методи. У дослідженні використано бібліосемантичний та аналітичний методи в наступних електронних базах даних: PubMed, Scopus і Google Scholar. Було проаналізовано системи реабілітації ветеранів у США, Великобританії, Німеччині, Франції, Ізраїлі та Туреччині. Результати. Проведено аналіз заходів та програм реабілітації військовослужбовців США, Ізраїлю, Канади, Великобританії, Німеччини, Франції та Туреччини. Встановлено особливості реабілітаційних заходів в різних країнах. Зокрема, звернули увагу на наявні системи реабілітації, мережі потужних спеціалізованих реабілітаційних закладів (установ), застосування в реабілітаційному процесі новітніх технологій, наявність державних програм психологічної допомоги військовослужбовцям, ветеранам, і членам їхніх родин, та соціальну реінтеграцію ветеранів. Висновки. В наявних джерелах інформації виявлено, що установи та заклади, які здійснюють реабілітацію, зазвичай поділяються на: стаціонарні, амбулаторні, санаторно-курортні, проте їх реабілітаційний статус є не завжди чітко окресленим. Також не висвітлено стрункої системи оцінки ефекту реабілітації або окремих її показників, що є негативною стороною багатьох моделей реабілітації. Проведений аналіз свідчить про те, що форми організації реабілітації в різних державах різні, але цілі, що стоять перед ними, майже тотожні. Фахівці, які займаються реабілітацією, повинні мати методологічний інструмент (способи і методи), який дозволить комплексно оцінити досягнення цілей у конкретного пацієнта та покращення його функціонального стану. При цьому слід враховувати не тільки ступінь обмеження участі реабілітанта в активному житті суспільства до і після реабілітації, алей проміжний контроль для вчасного коригування програми реабілітації. Вивчення досвіду інших країн дозволить обґрунтувати належний розвиток системи реабілітації в ЗС України та провести реформи, базуючись на найкращому міжнародному досвіді, де сучасні концепції набули чіткої реабілітаційної спрямованості.

У даній статті проаналізовано актуальну позицію Верховного Суду щодо спорів пов’язаних з зміною орендної плати внаслідок зміни нормативної грошової оцінки. Проведено аналіз норм Цивільного кодексу України та Земельного кодексу України, які регулюють загальні принципи договорів найму (оренди), в тому числі договорів оренди землі та особливостей оренди земель комунальної або державної власності. Розглянуто особливості таких договорів визначені Законом України «Про оренду землі». Зроблено висновок про цивільно-правову, диспозитивну природу договору. Акцентовано увагу на особливостях визначення розміру орендної плати, порядку сплати орендної плати за договором оренди земельних ділянок комунальної та державної власності. Детально досліджено положення Податкового кодексу України щодо плати за землю у формі орендної плати за земельну ділянку комунальної або державної власності. Досліджено взаємозв’язок між нормативною грошовою оцінкою земельної ділянки та розміром орендної плати за договором. Перелічено умови зміни нормативної грошової оцінки земельної ділянки. Зроблено висновок про наявність імперативних елементів при укладенні описаної категорії договорів. Розібрано попередню практику Великої Палати Верховного суду щодо спорів, які виникали між сторонами договору оренди земельної ділянки комунальної або державної власності, щодо зміни орендної плати внаслідок зміни нормативної грошової оцінки земельної ділянки. Вивчено також й актуальну практику Великої Палати Верховного Суду щодо зазначеної категорії спорів. На підставі порівняння позицій Великої Палати Верховного Суду складено висновки щодо особливостей зміни правової позиції та можливих передумов таких змін. Виокремлено переваги та недоліки нової практики Великої Палати Верховного Суду у описаній категорії справ. Розглянуто можливі сценарії розвитку правовідносин між орендодавцями та орендарями у світлі нових судових рішень. Обговорено також перспективи подальшого розвитку законодавства в цій сфері та можливі напрями вдосконалення нормативно-правової бази з урахуванням сучасних викликів.

The study presents a solution to maximize public investment as a growth driver for commodity-exporting economies. The solution is to compensate for the low efficiency of public investment by drawing on internal and external factors within an active fiscal and monetary policy framework. For this, the paper introduces a quantitative model that implements a golden rule of public finance in a resource boom backed by a sovereign wealth fund under an active monetary policy stance. The modeling results show that mobilizing windfall resource revenues to finance increased public investment can limit a crowding-out effect through proper resource allocation and change the sectoral structure in favor of the final goods sector. As confirmed by the sensitivity analysis, the low efficiency of public investment can be partially offset by a less restrictive monetary policy response to fiscal dominance, but this leads to excessive volatility in financial indicators. However, if the public debt burden is an issue due to a more robust fiscal dominance regime, a higher tax rate on exported raw materials can be used to maintain sustainability. By developing a policy goals domain, the paper initiates a discussion that can direct policy recommendations toward a promising growth path by maximizing the public investment driver in the complex policy environment of fiscal-monetary interaction.

Purpose. Forming a thematic bibliographic list of English-language and Ukrainian-language publications on the development of organic aquaculture in Ukraine and abroad. Methods. The complete and selective methods were applied in the process of the systematic search. The bibliographic core have been consisted of scientific publications in Ukrainian and English from the fund of the Institute of Fisheries NAAS Scientific Library, as well as resources available to its users. Results. There was composed the thematic list of publications with a total quantity of 91 sources covering the time interval from 2001 to 2024, and outlining a wide range of issues regarding the prerequisites for the development of organic aquaculture, including theoretical, legislative, economic, technological and other aspects of the functioning of this sector both on a global scale and within Ukraine.The literary sources are arranged in alphabetical order by author or title, and described according to DSTU 8302:2015 “Information and documentation. Bibliographic reference. General principles and rules of composition”, with the amendments (code UKND 01.140.40), as well as in accordance with the requirements of APA style — international standard of references. Practical value. The list may be useful for to scientists, specialists, and students whose area of interests includes research on the current state and prospects for the further development of organic aquaculture in Ukraine and the world.

Phytosanitary monitoring of forest stands is currently a relevant and important area of scientific research that ensures observation, assessment, and forecasting of the dynamics (changes) of the quantitative and qualitative (including sanitary) state of forests and underlies the development of an effective system of tree protection. The purpose of this study was to identify the species composition and distribution of dominant phytopathogen species in the Modryna tract of the Zvyagelske Forestry branch and to identify the primary factors of Larix decidua Mill. decline. This study employed phytopathological, entomological, forest inventory, and comparative methods. The study identified and registered typical symptoms of damage and the consequences of the harmful effects of pests of L. decidua trees in the Modryna tract, leading to a general weakening of their sanitary condition. Symptoms of larch needle cast (meria needle blight) and browning were recorded on the needles; on the trunks – typical manifestations of cankers and fruiting bodies of a unique basidiomycete – Lariciphomes officinalis. Apart from infectious pathologies, sporadic wind and storm damaged larch trees, as well as other negative effects of wind exposure, were recorded in the study areas. The species composition of the pests of the surveyed larch trees included the following insect species: Cephalcia lariciphila, Sacchiphantes viridis Ratz., Coleophora laricella, Zeiraphera diniana Gn., Lasiomma laricicola Karl. It was generalised that the main threat to the centuries-old larch trees is the complex effect of anthropogenic, abiotic, and biotic (including parasitic) environmental factors that constantly and to varying degrees affect the sanitary and physiological state of ancient larch trees. The findings of this study provide information for predicting the risks of spreading pathogens and pests, which allows managing these risks and preventing their further spread

Background. The antioxidant system is one of the protective cell systems. Changes in its functioning, after the introduction of xenobiotics into the body, will determine the further course of the intensity of free radical processes. Among xenobiotics, a prominent place belongs to phthalates, in particular diethyl phthalate (DEP) – the most common group of synthetic substances that are widely used as plasticizers in various industries. Materials and Methods. For a series of experiments, white outbred rats were used, and cytosolic and microsomal fractions were isolated from the liver cells. The activity of such antioxidant enzymes as superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione peroxidase (GSH-Px, EC 1.11.1.9), glutathione S-transferase (GST, EC 2.5.1.18), and the concentration of reduced glutathione (GSH) were determined in the cytosolic fraction. GST activity was also studied in the microsomal fraction. Results and Discussion. The administration of different doses of DEP for 14 days promoted the activation of antioxidant enzymes, regardless of the dose of xenobiotic administration. The use of DEP for 21 days led to a multidirectional effect of the xenobiotic on the enzymes of the antioxidant system in liver cells. The inactivation of the studied enzymes and depletion of the GSH pool were observed when DEP was administered at a dose of 5.4 mg/kg of body weight. The activity of antioxidant enzymes in liver subcellular fractions remained at a high level compared to the control when DEP was administered at a dose of 2.5 mg/kg of body weight. It was established that the same trend of changes in GST enzyme activity was found in both the microsomal and cytosolic fractions of rat liver. The activity of the enzyme increased under the influence of both studied doses under the administration of DEP for 14 days. Administration of the xenobiotic for 21 days led to a decrease in GST activity when a high dose of DEP was administered. Conclusion. The activation of antioxidant system enzymes occurs in response to a short-term intake of DEP. With an increase in the dose and duration of administration of the studied xenobiotic, inactivation of antioxidant enzymes was detected.