11 results on '"P. Bordwine"'
Search Results
2. Development and implementation of a scalable and versatile test for COVID-19 diagnostics in rural communities
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Ceci, A., Muñoz-Ballester, C., Tegge, A. N., Brown, K. L., Umans, R. A., Michel, F. M., Patel, D., Tewari, B., Martin, J., Alcoreza, O., Maynard, T., Martinez-Martinez, D., Bordwine, P., Bissell, N., Friedlander, M. J., Sontheimer, H., and Finkielstein, C. V.
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- 2021
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3. Development and implementation of a scalable and versatile test for COVID-19 diagnostics in rural communities
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Robyn A. Umans, N. Bissell, Harald Sontheimer, F. M. Michel, Dipan C. Patel, Carmen Muñoz-Ballester, Carla V. Finkielstein, Oscar B. Alcoreza, Michael J. Friedlander, T. Maynard, P. Bordwine, Bhanu P. Tewari, Allison N. Tegge, A. Ceci, Daniel Martinez-Martinez, Joelle Martin, and K. L. Brown
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0301 basic medicine ,Emergency Use Authorization ,medicine.medical_specialty ,Public land ,Computer science ,Science ,Supply chain ,General Physics and Astronomy ,Real-Time Polymerase Chain Reaction ,Sensitivity and Specificity ,General Biochemistry, Genetics and Molecular Biology ,Article ,Specimen Handling ,Genomic analysis ,03 medical and health sciences ,0302 clinical medicine ,Limit of Detection ,Nasopharynx ,Pandemic ,medicine ,Humans ,Pandemics ,Health policy ,Multidisciplinary ,SARS-CoV-2 ,Public health ,COVID-19 ,General Chemistry ,Equipment Design ,Gene expression profiling ,Test (assessment) ,Identification (information) ,030104 developmental biology ,Risk analysis (engineering) ,COVID-19 Nucleic Acid Testing ,Communicable Disease Control ,Printing, Three-Dimensional ,RNA, Viral ,Reagent Kits, Diagnostic ,Rural Health Services ,Rural area ,030217 neurology & neurosurgery - Abstract
Rapid and widespread testing of severe acute respiratory coronavirus 2 (SARS-CoV-2) is essential for an effective public health response aimed at containing and mitigating the coronavirus disease 2019 (COVID-19) pandemic. Successful health policy implementation relies on early identification of infected individuals and extensive contact tracing. However, rural communities, where resources for testing are sparse or simply absent, face distinctive challenges to achieving this success. Accordingly, we report the development of an academic, public land grant University laboratory-based detection assay for the identification of SARS-CoV-2 in samples from various clinical specimens that can be readily deployed in areas where access to testing is limited. The test, which is a quantitative reverse transcription polymerase chain reaction (RT-qPCR)-based procedure, was validated on samples provided by the state laboratory and submitted for FDA Emergency Use Authorization. Our test exhibits comparable sensitivity and exceeds specificity and inclusivity values compared to other molecular assays. Additionally, this test can be re-configured to meet supply chain shortages, modified for scale up demands, and is amenable to several clinical specimens. Test development also involved 3D engineering critical supplies and formulating a stable collection media that allowed samples to be transported for hours over a dispersed rural region without the need for a cold-chain. These two elements that were critical when shortages impacted testing and when personnel needed to reach areas that were geographically isolated from the testing center. Overall, using a robust, easy-to-adapt methodology, we show that an academic laboratory can supplement COVID-19 testing needs and help local health departments assess and manage outbreaks. This additional testing capacity is particularly germane for smaller cities and rural regions that would otherwise be unable to meet the testing demand., Here, the authors report the development of a versatile academic, SARSCoV-2 RT-qPCR molecular diagnostic test that uses 3D printed technology for sample collection, is implemented in rural setting in the US state of Virginia and validated in its population.
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- 2021
4. The Role of Coping in Mediating the Relationship Between Positive Affect and School Satisfaction in Adolescents
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Bordwine, Vanessa C. and Huebner, E. Scott
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- 2010
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5. Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives
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Dorratoltaj, Nargesalsadat, O’Dell, Margaret L., Bordwine, Paige, Kerkering, Thomas M., Redican, Kerry J., and Abbas, Kaja M.
- Abstract
AbstractObjectiveWe evaluated the effectiveness and cost of a fungal meningitis outbreak response in the New River Valley of Virginia during 2012-2013 from the perspective of the local public health department and clinical facilities. The fungal meningitis outbreak affected 23 states in the United States with 751 cases and 64 deaths in 20 states; there were 56 cases and 5 deaths in Virginia.MethodsWe conducted a partial economic evaluation of the fungal meningitis outbreak response in New River Valley. We collected costs associated with the local health department and clinical facilities in the outbreak response and estimated the epidemiological effectiveness by using disability-adjusted life years (DALYs) averted.ResultsWe estimated the epidemiological effectiveness of this outbreak response to be 153 DALYs averted among the patients, and the costs incurred by the local health department and clinical facilities to be $30,413 and $39,580, respectively.ConclusionsWe estimated the incremental cost-effectiveness ratio of $198 per DALY averted and $258 per DALY averted from the local health department and clinical perspectives, respectively, thereby assisting in impact evaluation of the outbreak response by the local health department and clinical facilities. (Disaster Med Public Health Preparedness. 2018;12:38–46)
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- 2018
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6. Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review
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Abbas, Kaja M., Dorratoltaj, Nargesalsadat, O’Dell, Margaret L., Bordwine, Paige, Kerkering, Thomas M., and Redican, Kerry J.
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AbstractWe conducted a systematic review of the 2012–2013 multistate fungal meningitis epidemic in the United States from the perspectives of clinical response, outbreak investigation, and epidemiology. Articles focused on clinical response, outbreak investigation, and epidemiology were included, whereas articles focused on compounding pharmacies, legislation and litigation, diagnostics, microbiology, and pathogenesis were excluded. We reviewed 19 articles by use of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework. The source of the fungal meningitis outbreak was traced to the New England Compounding Center in Massachusetts, where injectable methylprednisolone acetate products were contaminated with the predominant pathogen, Exserohilum rostratum. As of October 23, 2013, the final case count stood at 751 patients and 64 deaths, and no additional cases are anticipated. The multisectoral public health response to the fungal meningitis epidemic from the hospitals, clinics, pharmacies, and the public health system at the local, state, and federal levels led to an efficient epidemiological investigation to trace the outbreak source and rapid implementation of multiple response plans. This systematic review reaffirms the effective execution of a multisectoral public health response and efficient delivery of the core functions of public health assessment, policy development, and service assurances to improve population health.(Disaster Med Public Health Preparedness. 2016;10:145–151)
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- 2016
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7. Symantec on Cybersecurity.
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Bordwine, John
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COMPUTER security ,COMPUTER hacking ,DATA protection - Abstract
An interview with John Bordwine, public sector chief technology officer (CTO) of Symantec, is presented. When asked about the cybersecurity threat at present, he says the complexity behind the attack structures is at a much higher level. He believes that the biggest challenge of the federal government in cybersecurity is data protection. According to Bordwine, protection and management of data and information reduces risk greatly.
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- 2010
8. Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States
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Rachel A. Silverman, Alessandro Ceci, Alasdair Cohen, Meagan Helmick, Erica Short, Paige Bordwine, Michael J. Friedlander, and Carla V. Finkielstein
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COVID-19 ,SARS-CoV-2 ,incarcerated persons ,prisons ,correctional facilities ,vaccine effectiveness ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
In April 2021, a COVID-19 outbreak occurred at a correctional facility in rural Virginia, USA. Eighty-four infections were identified among 854 incarcerated persons by facilitywide testing with reverse transcription quantitative PCR (qRT-PCR). We used whole-genome sequencing to link all infections to 2 employees infected with the B.1.1.7α (UK) variant. The relative risk comparing unvaccinated to fully vaccinated persons (mRNA-1273 [Moderna, https://www.modernatx.com]) was 7.8 (95% CI 4.8–12.7), corresponding to a vaccine effectiveness of 87.1% (95% CI 79.0%–92.1%). Average qRT-PCR cycle threshold values were lower, suggesting higher viral loads, among unvaccinated infected than vaccinated cases for the nucleocapsid, envelope, and spike genes. Vaccination was highly effective at preventing SARS-CoV-2 infection in this high-risk setting. This approach can be applied to similar settings to estimate vaccine effectiveness as variants emerge to guide public health strategies during the ongoing pandemic.
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- 2022
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9. Widespread Community Transmission of Hepatitis A Virus Following an Outbreak at a Local Restaurant - Virginia, September 2021-September 2022.
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Helmick MJ, Morrow CB, White JH, and Bordwine P
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- Male, Humans, United States, Virginia epidemiology, Homosexuality, Male, Restaurants, Disease Outbreaks, Hepatitis A virus, Hepatitis A prevention & control, Sexual and Gender Minorities
- Abstract
Hepatitis A is a vaccine-preventable liver infection caused by the hepatitis A virus (HAV); it is transmitted through ingestion of food or drink that has been contaminated by small amounts of infected stool, or through direct contact, including sexual contact, with a person who is infected (1). After years of historically low rates of hepatitis A in the United States, the incidence began increasing in 2016, with outbreaks characterized by person-to-person HAV transmission among persons who use drugs, persons experiencing homelessness, and men who have sex with men (2,3). As of September 2022, 13 states were experiencing outbreaks, including Virginia (3). In September 2021, the Roanoke City and Alleghany Health Districts (RCAHD) in southwestern Virginia investigated an outbreak of hepatitis A. The outbreak, which resulted in 51 cases, 31 hospitalizations, and three deaths, was associated with a food handler who was infected. After the outbreak, the community experienced ongoing person-to-person transmission of HAV, predominantly among persons who use injection drugs. As of September 30, 2022,* an additional 98 cases had been reported to RCAHD. The initial outbreak and community transmission have exceeded US$3 million in estimated direct costs (4,5). This report describes the initial outbreak and the ongoing community transmission of HAV. Increasing vaccination coverage among persons with risk factors for hepatitis A infection is important, including among those who use drugs. Strengthening community partnerships between public health officials and organizations that employ persons with risk factors for acquisition of HAV could help to prevent infections and outbreaks., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.
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- 2023
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10. Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men's Correctional Facility, United States.
- Author
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Silverman RA, Ceci A, Cohen A, Helmick M, Short E, Bordwine P, Friedlander MJ, and Finkielstein CV
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- Correctional Facilities, Disease Outbreaks prevention & control, Humans, Male, SARS-CoV-2 genetics, United States epidemiology, Vaccine Efficacy, COVID-19 epidemiology, COVID-19 prevention & control
- Abstract
In April 2021, a COVID-19 outbreak occurred at a correctional facility in rural Virginia, USA. Eighty-four infections were identified among 854 incarcerated persons by facilitywide testing with reverse transcription quantitative PCR (qRT-PCR). We used whole-genome sequencing to link all infections to 2 employees infected with the B.1.1.7α (UK) variant. The relative risk comparing unvaccinated to fully vaccinated persons (mRNA-1273 [Moderna, https://www.modernatx.com]) was 7.8 (95% CI 4.8-12.7), corresponding to a vaccine effectiveness of 87.1% (95% CI 79.0%-92.1%). Average qRT-PCR cycle threshold values were lower, suggesting higher viral loads, among unvaccinated infected than vaccinated cases for the nucleocapsid, envelope, and spike genes. Vaccination was highly effective at preventing SARS-CoV-2 infection in this high-risk setting. This approach can be applied to similar settings to estimate vaccine effectiveness as variants emerge to guide public health strategies during the ongoing pandemic.
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- 2022
- Full Text
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11. Economic Evaluation of Fungal Meningitis Outbreak Response in New River Valley: Local Health Department Perspective.
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Abbas KM, Dorratoltaj N, O'Dell ML, Bordwine P, Kerkering TM, and Redican KJ
- Abstract
Background: The multi-state fungal meningitis outbreak started in September 2012 in Tennessee. The cause of the outbreak was injection of contaminated lots of methylprednisolone acetate used in epidural spinal injections. Roanoke and New River Valley were the epicenter of this outbreak in Virginia, with two clinical centers having administered the contaminated injections to their patients. New River Health District, in coordination with hospitals, and state and federal agencies, deployed its resources to control the local impact of the outbreak., Purpose: The objective of this study was to conduct an economic evaluation of the fungal meningitis outbreak response in New River Valley of Virginia, from the local public health department perspective., Methods: The health department conducted the outbreak investigation from October 2012 until March 2013 to ascertain that all possible cases were identified and treated. Data were collected on the costs associated with the local health department in the outbreak response, and the epidemiologic effectiveness estimated, using the metric of disability adjusted life years (DALYs)., Results: The cost incurred by the local health department was estimated to be $30,493; the epidemiologic effectiveness was estimated to be 138 DALYs averted among the patients, for an incremental cost-effectiveness ratio of $221 per DALY averted., Implications: The incremental cost effectiveness ratio of the fungal meningitis outbreak response in New River Valley assists the local health department to analyze the costs and epidemiologic effectiveness of the outbreak response.
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- 2015
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