293 results on '"P. Castelnau"'
Search Results
2. Investigation of the mechanical work during ultrasonic fatigue loading using pulsed time-resolved X-ray diffraction
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Vincent Jacquemain, Christophe Cheuleu, Nicolas Ranc, Olivier Castelnau, Vincent Michel, Doriana Vinci, Véronique Favier, Cristian Mocuta, and Dominique Thiaudiere
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x-ray diffraction ,ultrasonic fatigue machine ,very high cycle fatigue ,pump–probe method ,pulsed x-ray source ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Crystallography ,QD901-999 - Abstract
In the energy production and transportation industries, numerous metallic structures may be subjected to at least several billions of cycles, i.e. loaded in the very high cycle fatigue domain (VHCF). Therefore, to design structures in the VHCF domain, a reliable methodology is necessary. One useful quantity to characterize plastic activity at the microscopic scale and fatigue damage evolution is the mechanical work supplied to a material. However, the estimation of this mechanical work in a metal during ultrasonic fatigue tests remains challenging. This paper aims to present an innovative methodology to quantify this. An experimental procedure was developed to estimate the mechanical work from stress and total strain evolution measurements during one loading cycle with a time accuracy of about 50 ns. This was achieved by conducting time-resolved X-ray diffraction coupled to strain gauge measurements at a synchrotron facility working in pulsed mode (single-bunch mode).
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- 2024
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3. Borderline Personality Disorder in Mothers, Maternal Sensitivity, and Infant Social Withdrawal: A Study on Clinical Dyads Referred to Perinatal Mental Health Units
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Jaqueline Wendland, Charlotte Castelnau, Alexandra Déprez, Didier Rabain, Claire de Carmantrand, and Antoine Guédeney
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Behavioural, cognitive and emotional dysregulation related to parent borderline personality disorder (BPD) may have a major impact on parent-infant interactions. We investigated the ways in which infant social withdrawal and mother sensitivity may be associated to a BPD diagnosis in mothers. Two groups of clinic-referred mother-infant dyads were set up: one in which consulting mothers were diagnosed with BPD. Infant social withdrawal and maternal sensitivity were assessed during free-play interactions videotaped within a clinical setting. Mothers with BPD showed lower maternal sensitivity, while their infants displayed higher levels of social withdrawal behaviour when compared to dyads with no maternal psychiatric diagnosis. Infants of mothers with BPD appear at particular risk of adverse developmental outcomes from their very first months of life. Early interventions should concentrate on improving maternal interpretation and response to infant cues, such as identifying nonverbal behaviours and regulating the infant's emotional states, and on promoting mentalization.
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- 2023
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4. Corpus callosum in children with neurodevelopmental delay: MRI standard qualitative assessment versus automatic quantitative analysis
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Natacha Mandine, Elsa Tavernier, Till Hülnhagen, Bénédicte Maréchal, Tobias Kober, Clovis Tauber, Marine Guichard, Pierre Castelnau, and Baptiste Morel
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Brain ,Child ,Corpus callosum ,Segmentation ,Magnetic resonance imaging ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background The corpus callosum (CC) is a key brain structure. In children with neurodevelopmental delay, we compared standard qualitative radiological assessments with an automatic quantitative tool. Methods We prospectively enrolled 73 children (46 males, 63.0%) with neurodevelopmental delay at single university hospital between September 2020 and September 2022. All of them underwent 1.5-T brain magnetic resonance imaging (MRI) including a magnetization-prepared 2 rapid acquisition gradient echoes − MP2RAGE sequence. Two radiologists blindly reviewed the images to classify qualitatively the CC into normal, hypoplasic, hyperplasic, and/or dysgenetic classes. An automatic tool (QuantiFIRE) was used to provide brain volumetry and T1 relaxometry automatically as well as deviations of those parameters compared with a healthy age-matched cohort. The MRI reference standard for CC volumetry was based on the Garel et al. study. Cohen κ statistics was used for interrater agreement. The radiologists and QuantiFIRE’s diagnostic accuracy were compared with the reference standard using the Delong test. Results The CC was normal in 42 cases (57.5%), hypoplastic in 20 cases (27.4%), and hypertrophic in 11 cases (15.1%). T1 relaxometry values were abnormal in 26 children (35.6%); either abnormally high (18 cases, 24.6%) or low (8 cases, 11.0%). The interrater Cohen κ coefficient was 0.91. The diagnostic accuracy of the QuantiFIRE prototype was higher than that of the radiologists for hypoplastic and normal CC (p = 0.003 for both subgroups, Delong test). Conclusions An automated volumetric and relaxometric assessment can assist the evaluation of brain structure such as the CC, particularly in the case of subtle abnormalities. Relevance statement Automated brain MRI segmentation combined with statistical comparison to normal volume and T1 relaxometry values can be a useful diagnostic support tool for radiologists. Key points • Corpus callosum abnormality detection is challenging but clinically relevant. • Automated quantitative volumetric analysis had a higher diagnostic accuracy than that of visual appreciation of radiologists. • Quantitative T1 relaxometric analysis might help characterizing corpus callosum better. Graphical Abstract
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- 2023
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5. Corpus callosum in children with neurodevelopmental delay: MRI standard qualitative assessment versus automatic quantitative analysis
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Mandine, Natacha, Tavernier, Elsa, Hülnhagen, Till, Maréchal, Bénédicte, Kober, Tobias, Tauber, Clovis, Guichard, Marine, Castelnau, Pierre, and Morel, Baptiste
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- 2023
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6. Integrating artificial intelligence into lung cancer screening: a randomised controlled trial protocol
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Paul Hofman, Sylvie Leroy, Jonathan Benzaquen, Bernard Padovani, Charles Hugo Marquette, Fontas Eric, Eric Fontas, Stephanie Lopez, Nesrine Rouis, Jacques Boutros, Allegra Maryline, Amamou-Elhani Faten, ARFI Thierry, Baque Jean, Baque-Juston Marie, Barel Remy, Barrios Baretto Deisy, Baudin Guillaume, Beck Camille, Bellmann Laurent, Benchetrit Maxime, Benkirane Mohamed-Taib, Benyoussef Sid Ali, Benzaquen Jonathan, Berthet Jean Philippe, Bonnard Eric, Bordone Olivier, Boutros Jacques, Boyer Guy-René, Bulsei Julie, Caillon Cynthia, Castelnau Olivier, Chalmin Jérémy, Chebib Ralph, Cohen Charlotte, Cruzel Coralie, Degoutte Aurélien, Delin Margot, Diascorn Yann, Doux Nathalie, Durand Lorraine, Duval Yannick, El Hemweh Omar, Fayada Julien, Felderhoof Eric, Feliciello Stéphane:, Femenia Richard, Ferrari Victoria, Francisci Marc Paul, Ghalloussi Hannah, Gomez-Caro-Andres Abel, Gora Assia, Griffonnet Jennifer, Gubeno Marie Christine, Guigay Joël, Hamila Marame, Harrathi Mohamed-Ali, Henaut Quentin, Herin Edouard, Hofman Paul, Hofman Véronique, ILIE Marius, Korzeniewski Sylvia, Lalvee Salomé, Lassalle Sandra, Le Heron Charles, Leray Loïc, Leriche Julien, Lerousseau Lionel, Leroy Sylvie, Lespinet Fabre Virginie, Lestrez Roxane, Leyssalle Axelle, Long Mira Elodie, Lopez Stephanie, Mahler Valentin, Maniel Charlotte, Marcano Xavier, Marco Roucayrol Sabine, Marquette Charles-Hugo, Martin Nicolas, Mistri Aurélie, Nicolle Isabelle, Novellas Sébastien, Oddo Frédéric, Otto Josiane, Padovani Bernard, PERQUIS Marie Pierre, Philibert Lorène, Pop Daniel, Pottier Héloïse, Raguin Olivier, Rolland Fabien, Rouis Nesrine, Rousset Johanna, Ruitort Frédéric, Sanfiorenzo Céline, Selva Eric, Tanga Virginie, Tardy Magalie, Thomas Olivier, Varenio Sophie, Verdoire Paul, Vigny Isabelle, Washetine Kévin, Zurlinden Olivier, Tarhini Adam, and Perrotin Cédric
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Medicine - Abstract
Introduction Lung cancer (LC) is the most common cause of cancer-related deaths worldwide. Its early detection can be achieved with a CT scan. Two large randomised trials proved the efficacy of low-dose CT (LDCT)-based lung cancer screening (LCS) in high-risk populations. The decrease in specific mortality is 20%–25%.Nonetheless, implementing LCS on a large scale faces obstacles due to the low number of thoracic radiologists and CT scans available for the eligible population and the high frequency of false-positive screening results and the long period of indeterminacy of nodules that can reach up to 24 months, which is a source of prolonged anxiety and multiple costly examinations with possible side effects.Deep learning, an artificial intelligence solution has shown promising results in retrospective trials detecting lung nodules and characterising them. However, until now no prospective studies have demonstrated their importance in a real-life setting.Methods and analysis This open-label randomised controlled study focuses on LCS for patients aged 50–80 years, who smoked more than 20 pack-years, whether active or quit smoking less than 15 years ago. Its objective is to determine whether assisting a multidisciplinary team (MDT) with a 3D convolutional network-based analysis of screening chest CT scans accelerates the definitive classification of nodules into malignant or benign. 2722 patients will be included with the aim to demonstrate a 3-month reduction in the delay between lung nodule detection and its definitive classification into benign or malignant.Ethics and dissemination The sponsor of this study is the University Hospital of Nice. The study was approved for France by the ethical committee CPP (Comités de Protection des Personnes) Sud-Ouest et outre-mer III (No. 2022-A01543-40) and the Agence Nationale du Medicament et des produits de Santé (Ministry of Health) in December 2023. The findings of the trial will be disseminated through peer-reviewed journals and national and international conference presentations.Trial registration number NCT05704920.
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- 2024
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7. Stereotactic ablative radiotherapy for unresectable inferior vena cava tumor thrombus in a patient with renal cell carcinoma: a case report
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Castelnau-Marchand, Pauline, Scher, Nathaniel, Bollet, Marc, Chargari, Cyrus, and Toledano, Alain
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- 2023
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8. Multiscale modeling of the effective viscoplastic behavior of Mg$_2$SiO$_4$ wadsleyite: Bridging atomic and polycrystal scales
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Castelnau, O., Derrien, K., Ritterbex, S, Carrez, P., Cordier, P., and Moulinec, H.
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Physics - Geophysics ,Condensed Matter - Materials Science - Abstract
The viscoplastic behavior of polycrystalline Mg$_2$SiO$_4$ wadsleyite aggregates, a major high pressure phase of the mantle transition zone of the Earth (depth range: 410 -- 520 km), is obtained by properly bridging several scale transition models. At the very fine nanometric scale corresponding to the disloca-tion core structure, the behavior of thermally activated plastic slip is modeled for strain-rates relevant for laboratory experimental conditions, at high pressure and for a wide range of temperatures, based on the Peierls-Nabarro-Galerkin model. Corresponding single slip reference resolved shear stresses and associated constitutive equations are deduced from Orowan's equation in order to describe the average viscoplastic behavior at the grain scale, for the easiest slip systems. These data have been implemented in two grain-polycrystal scale transition models, a mean-field one (the recent Fully-Optimized Second-Order Viscoplastic Self-Consistent scheme of [44]) allowing rapid evaluation of the effective viscosity of polycrystalline aggregates , and a full-field (FFT based [45] [33]) method allowing investigating stress and strain-rate localization in typical microstructures and heterogeneous activation of slip systems within grains. Calculations have been performed at pressure and temperatures relevant for in-situ conditions. Results are in very good agreement with available mechanical tests conducted at strain-rates typical for laboratory experiments., Comment: Comptes Rendus M\'ecanique, Elsevier Masson, In press
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- 2020
9. Periclase deforms more slowly than bridgmanite under mantle conditions
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Cordier, Patrick, Gouriet, Karine, Weidner, Timmo, Van Orman, James, Castelnau, Olivier, Jackson, Jennifer M., and Carrez, Philippe
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- 2023
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10. Modelling iceberg capsize in the open ocean
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Bonnet, P., Yastrebov, V. A., Queutey, P., Leroyer, A., Mangeney, A., Castelnau, O., Sergeant, A., Stutzmann, E., and Montagner, J. -P.
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Physics - Fluid Dynamics ,Physics - Geophysics - Abstract
At near-grounded glacier termini, calving can lead to the capsize of kilometer-scale unstable icebergs. The transient contact force applied by the capsizing iceberg on the glacier front generates seismic waves that propagate over teleseismic distances. The inversion of this seismic signal is of great interest to get insight into actual and past capsize dynamics. However, the iceberg size, which is of interest for geophysical and climatic studies, cannot be recovered from the seismic amplitude alone. This is because the capsize is a complex process involving interactions between the iceberg, the glacier and the surrounding water. This paper presents a first step towards the construction of a complete model, and is focused on the capsize in the open ocean without glacier front nor ice-m\'elange. The capsize dynamics of an iceberg in the open ocean is captured by computational fluid dynamics (CFD) simulations, which allows assessing the complexity of the fluid motion around a capsizing iceberg and how far the ocean is affected by iceberg rotation. Expressing the results in terms of appropriate dimensionless variables, we show that laboratory scale and field scale capsizes can be directly compared. The capsize dynamics is found to be highly sensitive to the iceberg aspect ratio and to the water and ice densities. However, dealing at the same time with the fluid dynamics and the contact between the iceberg and the deformable glacier front requires highly complex coupling that often goes beyond actual capabilities of fluid-structure interaction softwares. Therefore, we developed a semi-analytical simplified fluid-structure model (SAFIM) that can be implemented in solid mechanics computations dealing with contact dynamics of deformable solids. This model accounts for hydrodynamic forces through calibrated drag and added-mass effects, and is calibrated against the reference CFD simulations..., Comment: 31 pages, 16 figures
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- 2020
11. Deformation Mechanisms, Microstructures, and Seismic Anisotropy of Wadsleyite in the Earth's Transition Zone
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Estelle E. Ledoux, Morvarid Saki, Jeffrey P. Gay, Matthias Krug, Olivier Castelnau, Wen‐Yi Zhou, Jin S. Zhang, Julien Chantel, Nadège Hilairet, Maxim Bykov, Elena Bykova, Georgios Aprilis, Volodymyr Svitlyk, Gaston Garbarino, Carmen Sanchez‐Valle, Christine Thomas, Sergio Speziale, and Sébastien Merkel
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wadsleyite ,deformation ,lattice preferred orientations ,anisotropy ,transition zone ,multigrain X‐ray diffraction ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
Abstract Wadsleyite is the dominant mineral of the upper portion of the Earth's mantle transition zone (MTZ). As such, understanding plastic deformation of wadsleyite is relevant for the interpretation of observations of seismic signals from this region in terms of mantle flow. Despite its relevance, however, the deformation mechanisms of wadsleyite and their effects on microstructures and anisotropy are still poorly understood. Here, we present the results of new deformation experiments on polycrystalline wadsleyite at temperatures of 1400–1770 K and pressures between 12.3 and 20.3 GPa in the laser‐heated diamond anvil cell. We rely on multigrain X‐ray crystallography to follow the evolution of individual grain orientations and extract lattice preferred orientations at the sample scale at different steps of the experiments. A comparison of experimental results of our work and the literature with polycrystal plasticity simulations, indicates that 〈111〉{101} is the most active slip system of dislocations in wadsleyite at all investigated conditions. Secondary slip systems such as [001](010), [100](001), and [100]{0kl}, however, play a critical role in the resulting microstructures and their activity depends on both temperature and water content, from which we extract an updated deformation map of wadsleyite at MTZ conditions. Lastly, we propose several seismic anisotropy models of the upper part of the MTZ, depending on temperature, geophysical context, and levels of hydration that will be useful for the interpretation of seismic signals from the MTZ in terms of mantle flow and water content.
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- 2023
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12. Validity of crystal plasticity models near grain boundaries: a contribution of elastic strain measurements at the micron scale
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Plancher, Emeric, Tajdary, Pouya, Auger, Thierry, Castelnau, Olivier, Favier, Véronique, Loisnard, Dominique, Marijon, Jean-Baptiste, Maurice, Claire, Michel, Vincent, Robach, Odile, and Stodolna, Julien
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Condensed Matter - Materials Science ,Physics - Classical Physics - Abstract
Synchrotron Laue microdiffraction and Digital Image Correlation measurements were coupled to track the elastic strain field (or stress field) and the total strain field near a general grain boundary in a bent bicrystal. A 316L stainless steel bicrystal was deformed in situ into the elasto-plastic regime with a four-point bending setup. The test was then simulated using finite elements with a crystal plasticity model comprising internal variables (dislocation densities on discrete slip systems). The predictions of the model have been compared with both the total strain field and the elastic strain field obtained experimentally. While activated slip systems and total strains are reasonably well predicted, elastic strains appear overestimated next to the grain boundary. This suggests that conventional crystal plasticity models need improvement to correctly model stresses at grain boundaries.
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- 2019
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13. Multiscale modeling of the elastic behavior of architectured and nanostructured Cu-Nb composite wires
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Gu, T., Castelnau, O., Forest, S., Hervé-Luanco, E., Lecouturier, F., Proudhon, H., and Thilly, L.
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Condensed Matter - Materials Science - Abstract
Nanostructured and architectured copper niobium composite wires are excellent candidates for the generation of intense pulsed magnetic fields (>90T) as they combine both high strength and high electrical conductivity. Multi-scaled Cu-Nb wires are fabricated by accumulative drawing and bundling (a severe plastic deformation technique), leading to a multiscale, architectured, and nanostructured microstructure exhibiting a strong fiber crystallographic texture and elongated grain shapes along the wire axis. This paper presents a comprehensive study of the effective elastic behavior of this composite material by three multi-scale models accounting for different microstructural contents: two mean-field models and a full-field finite element model. As the specimens exhibit many characteristic scales, several scale transition steps are carried out iteratively from the grain scale to the macro-scale. The general agreement among the model responses allows suggesting the best strategy to estimate the effective behavior of Cu-Nb wires and save computational time. The importance of crystallographical and morphological textures in various cases is discussed. Finally, the models are validated by available experimental data with a good agreement., Comment: This paper has been published on 6 May 2017 in "International Journal of Solids and Structures"
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- 2016
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14. MIRS: an imaging spectrometer for the MMX mission
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Maria Antonietta Barucci, Jean-Michel Reess, Pernelle Bernardi, Alain Doressoundiram, Sonia Fornasier, Michel Le Du, Takahiro Iwata, Hiromu Nakagawa, Tomoki Nakamura, Yves André, Shohei Aoki, Takehiko Arai, Elisa Baldit, Pierre Beck, Jean-Tristan Buey, Elisabet Canalias, Matthieu Castelnau, Sebastien Charnoz, Marc Chaussidon, Fréderic Chapron, Valerie Ciarletti, Marco Delbo, Bruno Dubois, Stephane Gauffre, Thomas Gautier, Hidenori Genda, Rafik Hassen-Khodja, Gilles Hervet, Ryuki Hyodo, Christian Imbert, Takeshi Imamura, Laurent Jorda, Shingo Kameda, Driss Kouach, Toru Kouyama, Takeshi Kuroda, Hiroyuki Kurokawa, Laurent Lapaw, Jeremie Lasue, Laetitia Le Deit, Aurélien Ledot, Cedric Leyrat, Bertrand Le Ruyet, Moe Matsuoka, Frederic Merlin, Hideaki Miyamoto, Frederic Moynier, Napoleon Nguyen Tuong, Kazunori Ogohara, Takahito Osawa, Jérôme Parisot, Laurie Pistre, Benjamin Quertier, Sean N. Raymond, Francis Rocard, Takeshi Sakanoi, Takao M. Sato, Eric Sawyer, Fériel Tache, Sylvain Trémolières, Fuminori Tsuchiya, Pierre Vernazza, and Didier Zeganadin
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MIRS ,MMX ,Imaging spectrometer ,Phobos ,Deimos ,Mars ,Geography. Anthropology. Recreation ,Geodesy ,QB275-343 ,Geology ,QE1-996.5 - Abstract
Abstract The MMX infrared spectrometer (MIRS) is an imaging spectrometer onboard MMX JAXA mission. MMX (Martian Moon eXploration) is scheduled to be launched in 2024 with sample return to Earth in 2029. MIRS is built at LESIA-Paris Observatory in collaboration with four other French laboratories, collaboration and financial support of CNES and close collaboration with JAXA and MELCO. The instrument is designed to fully accomplish MMX’s scientific and measurement objectives. MIRS will remotely provide near-infrared spectral maps of Phobos and Deimos containing compositional diagnostic spectral features that will be used to analyze the surface composition and to support the sampling site selection. MIRS will also study Mars atmosphere, in particular spatial and temporal changes such as clouds, dust and water vapor. Graphical Abstract
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- 2021
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15. SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes
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Camille Dupuy, Pierre Castelnau, Sylvie Mavel, Antoine Lefevre, Lydie Nadal-Desbarats, Sylvie Bodard, Julie Busson, Diane Dufour-Rainfray, Helene Blasco, Patrick Emond, and Laurent Galineau
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorder characterized by inattention, impulsivity, and hyperactivity. The neurobiological mechanisms underlying ADHD are still poorly understood, and its diagnosis remains difficult due to its heterogeneity. Metabolomics is a recent strategy for the holistic exploration of metabolism and is well suited for investigating the pathophysiology of diseases and finding molecular biomarkers. A few clinical metabolomic studies have been performed on peripheral samples from ADHD patients but are limited by their access to the brain. Here, we investigated the brain, blood, and urine metabolomes of SHR/NCrl vs WKY/NHsd rats to better understand the neurobiology and to find potential peripheral biomarkers underlying the ADHD-like phenotype of this animal model. We showed that SHR/NCrl rats can be differentiated from controls based on their brain, blood, and urine metabolomes. In the brain, SHR/NCrl rats displayed modifications in metabolic pathways related to energy metabolism and oxidative stress further supporting their importance in the pathophysiology of ADHD bringing news arguments in favor of the Neuroenergetic theory of ADHD. Besides, the peripheral metabolome of SHR/NCrl rats also shared more than half of these differences further supporting the importance of looking at multiple matrices to characterize a pathophysiological condition of an individual. This also stresses out the importance of investigating the peripheral energy and oxidative stress metabolic pathways in the search of biomarkers of ADHD.
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- 2021
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16. Design and performance of MIRS infrared imaging spectrometer onboard MMX mission
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Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Bernardi, P., Reess, J.-M., Castelnau, M., Chapron, F., Nguyen-Tuong, N., Gauffre, S., Quertier, B., Parisot, J., Bonafous, M., Zeganadin, D., Barucci, A., Fornasier, S., Merlin, F., Imbert, C., Piou, V., Sawyer, E., Theret, N., Le Du, M., Iwata, T., Nakagawa, H., and Nakamura, T.
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- 2024
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17. Multiscale modeling of the effective viscoplastic behavior of $\protect \mathrm{Mg}_2\protect \mathrm{SiO}_4$ wadsleyite: bridging atomic and polycrystal scales
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Castelnau, O., Derrien, K., Ritterbex, S., Carrez, P., Cordier, P., and Moulinec, H.
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Earth mantle ,Multiscale modelling ,Dislocations ,Polycrystal ,Viscoplasticity ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
The viscoplastic behavior of polycrystalline $\mathrm{Mg}_{2}\mathrm{SiO}_{4}$ wadsleyite aggregates, a major high pressure phase of the mantle transition zone of the Earth (depth range: 410–520 km), is obtained by properly bridging several scale transition models. At the very fine nanometric scale corresponding to the dislocation core structure, the behavior of thermally activated plastic slip is modeled for strain-rates relevant for laboratory experimental conditions, at high pressure and for a wide range of temperatures, based on the Peierls–Nabarro–Galerkin model. Corresponding single slip reference resolved shear stresses and associated constitutive equations are deduced from Orowan’s equation in order to describe the average viscoplastic behavior at the grain scale, for the easiest slip systems. These data have been implemented in two grain-polycrystal scale transition models, a mean-field one (the recent Fully-Optimized Second-Order Viscoplastic Self-Consistent scheme of [1]) allowing rapid evaluation of the effective viscosity of polycrystalline aggregates, and a full-field (FFT based [2, 3]) method allowing investigating stress and strain-rate localization in typical microstructures and heterogeneous activation of slip systems within grains. Calculations have been performed at pressure and temperatures relevant for in-situ conditions. Results are in very good agreement with available mechanical tests conducted at strain-rates typical for laboratory experiments.
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- 2021
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18. Analytical Parameterization of Self-Consistent Polycrystal Mechanics: Fast Calculation of Upper Mantle Anisotropy
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Goulding, Neil J., Ribe, Neil M., Castelnau, Olivier, Walker, Andrew M., and Wookey, James
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Physics - Geophysics - Abstract
Progressive deformation of upper mantle rocks via dislocation creep causes their constituent crystals to take on a non-random orientation distribution (crystallographic preferred orientation or CPO) whose observable signatures include shear-wave splitting and azimuthal dependence of surface wave speeds. Comparison of these signatures with mantle flow models thus allows mantle dynamics to be unraveled on global and regional scales. However, existing self-consistent models of CPO evolution are computationally expensive when used in 3-D and/or time-dependent convection models. Here we propose a new method, called ANPAR, which is based on an analytical parameterisation of the crystallographic spin predicted by the second-order (SO) self-consistent theory. Our parameterisation runs approximately 2-3 x 10^4 times faster than the SO model and fits its predictions for CPO and crystallographic spin with a variance reduction > 99%. We illustrate the ANPAR model predictions for three uniform deformations (uniaxial compression, pure shear, simple shear) and for a corner-flow model of a spreading ridge., Comment: Submitted to GJI December 2014
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- 2014
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19. MIRS: an imaging spectrometer for the MMX mission
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Barucci, Maria Antonietta, Reess, Jean-Michel, Bernardi, Pernelle, Doressoundiram, Alain, Fornasier, Sonia, Le Du, Michel, Iwata, Takahiro, Nakagawa, Hiromu, Nakamura, Tomoki, André, Yves, Aoki, Shohei, Arai, Takehiko, Baldit, Elisa, Beck, Pierre, Buey, Jean-Tristan, Canalias, Elisabet, Castelnau, Matthieu, Charnoz, Sebastien, Chaussidon, Marc, Chapron, Fréderic, Ciarletti, Valerie, Delbo, Marco, Dubois, Bruno, Gauffre, Stephane, Gautier, Thomas, Genda, Hidenori, Hassen-Khodja, Rafik, Hervet, Gilles, Hyodo, Ryuki, Imbert, Christian, Imamura, Takeshi, Jorda, Laurent, Kameda, Shingo, Kouach, Driss, Kouyama, Toru, Kuroda, Takeshi, Kurokawa, Hiroyuki, Lapaw, Laurent, Lasue, Jeremie, Le Deit, Laetitia, Ledot, Aurélien, Leyrat, Cedric, Le Ruyet, Bertrand, Matsuoka, Moe, Merlin, Frederic, Miyamoto, Hideaki, Moynier, Frederic, Nguyen Tuong, Napoleon, Ogohara, Kazunori, Osawa, Takahito, Parisot, Jérôme, Pistre, Laurie, Quertier, Benjamin, Raymond, Sean N., Rocard, Francis, Sakanoi, Takeshi, Sato, Takao M., Sawyer, Eric, Tache, Fériel, Trémolières, Sylvain, Tsuchiya, Fuminori, Vernazza, Pierre, and Zeganadin, Didier
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- 2021
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20. Caracterización clínico epidemiológica de los pacientes con infecciones por estafilococo dorado
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Junior Vega Jiménez and Adrian Ramiro Castelnau
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staphylococcus aureus ,estafilococo dorado ,antibióticos ,infecciones estafilocócicas ,farmacorresistencia microbiana ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: El estafilococo dorado es una causa importante de morbilidad y mortalidad en el mundo. En Cuba, es un germen a tener en cuenta como causa de infección intrahospitalaria. Objetivo: Caracterizar, clínica y epidemiológicamente, una muestra de pacientes con infecciones causadas por estafilococo dorado. Métodos: Se realizó un estudio observacional, descriptivo y transversal en el Hospital Militar "Dr. Mario Muñoz Monroy" de Matanzas, durante el período de enero a diciembre del año 2014. La población estuvo constituida por la totalidad de los pacientes hospitalizados con el diagnóstico de infección por estafilococo dorado (120 casos), identificados por el departamento de Microbiología; luego se revisaron las historias clínicas de las cuales se obtuvo la información. Resultados: Existió un predominio del sexo masculino (64,2 %), los mayores de 60 años fueron los más afectados (36,7 %). La diabetes mellitus fue la enfermedad asociada más frecuente (40,8 %) y la mayoría de las infecciones fueron de origen comunitario (67,5 %). Los aislamientos predominaron en las muestras tomadas de las lesiones en piel y los hemocultivos con un 50,8 % y 19,2 %, respectivamente. Se evidenció baja sensibilidad a la vancomicina (49,2 %) y al cotrimoxazol (38,3 %). Conclusiones: Las infecciones por estafilococo dorado fueron más frecuentes en pacientes masculinos geriátricos de su origen extrahospitalario. El germen presentó alta resistencia a los antibióticos y de estos, los aminoglucósidos mostraron la mayor sensibilidad antimicrobiana.
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- 2019
21. Foreword
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Diani, J., Castelnau, O., and Chinesta, F.
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Published
- 2021
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22. MMX Infrared Spectrometer's optical architecture
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Lépine, Thierry, Babington, James, Gross, Herbert, Castelnau, M., Bernardi, P., Bonafous, M., Imbert, C., Le Du, M., Reess, J.-M., and Théret, N.
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- 2024
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23. New advancements for laser-matter interaction applied to laser shock peening
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Phipps, Claude R., Gruzdev, Vitaly E., Rondepierre, A., Rouchausse, Y., Videau, L., Fabbro, R., Casagrande, O., Sano, Y., Castelnau, O., and Berthe, L.
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- 2024
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24. SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes
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Dupuy, Camille, Castelnau, Pierre, Mavel, Sylvie, Lefevre, Antoine, Nadal-Desbarats, Lydie, Bodard, Sylvie, Busson, Julie, Dufour-Rainfray, Diane, Blasco, Helene, Emond, Patrick, and Galineau, Laurent
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- 2021
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25. Monitoring Greenland ice sheet buoyancy-driven calving discharge using glacial earthquakes
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Amandine Sergeant, Anne Mangeney, Vladislav A. Yastrebov, Fabian Walter, Jean-Paul Montagner, Olivier Castelnau, Eléonore Stutzmann, Pauline Bonnet, Velotioana Jean-Luc Ralaiarisoa, Suzanne Bevan, and Adrian Luckman
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climate change ,glacier calving ,glacier discharge ,iceberg calving ,seismology ,Meteorology. Climatology ,QC851-999 - Abstract
Since the 2000s, Greenland ice sheet mass loss has been accelerating, followed by increasing numbers of glacial earthquakes (GEs) at near-grounded glaciers. GEs are caused by calving of km-scale icebergs which capsize against the terminus. Seismic record inversion allows a reconstruction of the history of GE sources which captures capsize dynamics through iceberg-to-terminus contact. When compared with a catalog of contact forces from an iceberg capsize model, seismic force history accurately computes calving volumes while the earthquake magnitude fails to uniquely characterize iceberg size, giving errors up to 1 km3. Calving determined from GEs recorded ateight glaciers in 1993–2013 accounts for up to 21% of the associated discharge and 6% of the Greenland mass loss. The proportion of discharge attributed to capsizing calving may be underestimated by at least 10% as numerous events could not be identified by standard seismic detections (Olsen and Nettles, 2018). While calving production tends to stabilize in East Greenland, Western glaciers have released more and larger icebergs since 2010 and have become major contributors to Greenland dynamic discharge. Production of GEs and calving behavior are controlled by glacier geometry with bigger icebergs being produced when the terminus advances in deepening water. We illustrate how GEs can help in partitioning and monitoring Greenland mass loss and characterizing capsize dynamics.
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- 2019
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26. Mortalidad en pacientes con enfermedad renal. Instituto de Nefrología. 2016 y 2017
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Irene Fiterre Lancis, Silvia Fernández-Vega García, Roberto Armando Rivas Sierra, Nancy Leydi Sabournin Castelnau, Bárbara Castillo Rodriguez, Francisco Gutiérrez García, and Laura López Marín
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mortalidad, enfermedad renal crónica, hemodiálisis, acceso vascular, infección. ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Introducción: La Enfermedad Renal Crónica es un problema de salud mundial.Objetivo: Determinar el comportamiento de la mortalidad en pacientes con enfermedad renal en el Instituto de Nefrología durante 2016 y 2017.Material y Métodos: Estudio observacional descriptivo transversal de pacientes fallecidos con necropsia realizada. Se registraron variables demográficas, de laboratorio, las relacionadas con la terapia de reemplazo de la función renal y con el diagnóstico anatomo-patológico. Para cada una de las variables se calcularon frecuencias absolutas y relativas. En el caso de la variable “presencia de sepsis” en las defunciones, fue empleada la prueba de chi-cuadrado para la bondad del ajuste, para probar la hipótesis nula H0: de igualdad de la distribución de las tres categorías de la variable.Resultados: Se estudiaron 48 fallecidos con necropsia, 48,9% del total de fallecidos en el periodo. La correspondencia clínico patológica fue 80,1%. Predominó el sexo masculino, el grupo de edad superior a 60 años y la hipertensión arterial como antecedente. El método de terapia de reemplazo renal más documentado fue la hemodiálisis, mediante catéter venoso central un 87,8%. El 61,8% de los fallecidos recibieron tratamiento hemodialítico por 3 meses o menos. La sepsis fue la segunda causa de muerte precedida por eventos cardio y cerebrovasculares; no obstante, en el análisis de la totalidad de necropsias, la infección asociada directa o indirecta a la muerte tuvo una frecuencia mayor.Conclusiones: La infección directa o indirectamente asociada a la muerte, la hipoalbuminemia y el acceso vascular mediante catéter se relacionan con la mortalidad en el periodo.Palabras clave: mortalidad, enfermedad renal crónica, hemodiálisis, acceso vascular, infección.
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- 2019
27. Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders (TAND): New Findings on Age, Sex, and Genotype in Relation to Intellectual Phenotype
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Petrus J. de Vries, Elena Belousova, Mirjana P. Benedik, Tom Carter, Vincent Cottin, Paolo Curatolo, Maria Dahlin, Lisa D'Amato, Guillaume Beaure d'Augères, José C. Ferreira, Martha Feucht, Carla Fladrowski, Christoph Hertzberg, Sergiusz Jozwiak, John A. Lawson, Alfons Macaya, Ruben Marques, Rima Nabbout, Finbar O'Callaghan, Jiong Qin, Valentin Sander, Matthias Sauter, Seema Shah, Yukitoshi Takahashi, Renaud Touraine, Sotiris Youroukos, Bernard Zonnenberg, John C. Kingswood, Anna C. Jansen, Nobuo Shinohara, Shigeo Horie, Masaya Kubota, Jun Tohyama, Katsumi Imai, Mari Kaneda, Hideo Kaneko, Yasushi Uchida, Tomoko Kirino, Shoichi Endo, Yoshikazu Inoue, Katsuhisa Uruno, Ayse Serdaroglu, Zuhal Yapici, Banu Anlar, Sakir Altunbasak, Olga Lvova, Oleg Valeryevich Belyaev, Oleg Agranovich, Elena Vladislavovna Levitina, Yulia Vladimirovna Maksimova, Antonina Karas, Yuwu Jiang, Liping Zou, Kaifeng Xu, Yushi Zhang, Guoming Luan, Yuqin Zhang, Yi Wang, Meiling Jin, Dingwei Ye, Weiping Liao, Liemin Zhou, Jie Liu, Jianxiang Liao, Bo Yan, Yanchun Deng, Li Jiang, Zhisheng Liu, Shaoping Huang, Hua Li, Kijoong Kim, Pei-Lung Chen, Hsiu-Fen Lee, Jeng-Dau Tsai, Ching-Shiang Chi, Chao-Ching Huang, Kate Riney, Deborah Yates, Patrick Kwan, Surachai Likasitwattanakul, Charcrin Nabangchang, Lunliya Thampratankul Krisnachai Chomtho, Kamornwan Katanyuwong, Somjit Sriudomkajorn, Jo Wilmshurst, Reeval Segel, Tal Gilboa, Michal Tzadok, Aviva Fattal-Valevski, Panagiotis Papathanasopoulos, Antigone Syrigou Papavasiliou, Stylianos Giannakodimos, Stylianos Gatzonis, Evangelos Pavlou, Meropi Tzoufi, A. M. H. Vergeer, Marc Dhooghe, Hélène Verhelst, Filip Roelens, Marie Cecile Nassogne, Pierre Defresne, Liesbeth De Waele, Patricia Leroy, Nathalie Demonceau, Benjamin Legros, Patrick Van Bogaert, Berten Ceulemans, Lina Dom, Pierre Castelnau, Anne De Saint Martin, Audrey Riquet, Mathieu Milh, Claude Cances, Jean-Michel Pedespan, Dorothee Ville, Agathe Roubertie, Stéphane Auvin, Patrick Berquin, Christian Richelme, Catherine Allaire, Sophie Gueden, Sylvie Nguyen The Tich, Bertrand Godet, Maria Luz Ruiz Falco Rojas, Jaume Campistol Planas, Antonio Martinez Bermejo, Patricia Smeyers Dura, Susana Roldan Aparicio, Maria Jesus Martinez Gonzalez, Javier Lopez Pison, Manuel Oscar Blanco Barca, Eduardo Lopez Laso, Olga Alonso Luengo, Francisco Javier Aguirre Rodriguez, Ignacio Malaga Dieguez, Ana Camacho Salas, Itxaso Marti Carrera, Eduardo Martinez Salcedo, Maria Eugenia Yoldi Petri, Ramon Cancho Candela, Ines da Conceicao Carrilho, Jose Pedro Vieira, José Paulo da Silva Oliveira Monteiro, Miguel Jorge Santos de Oliveira Ferreira Leao, Catarina Sofia Marceano Ribeiro Luis, Carla Pires Mendonca, Milda Endziniene, Jurgis Strautmanis, Inga Talvik, Maria Paola Canevini, Antonio Gambardella, Dario Pruna, Salvatore Buono, Elena Fontana, Bernardo Dalla Bernardina, Carmen Burloiu, Iuliu Stefan Bacos Cosma, Mihaela Adela Vintan, Laura Popescu, Karel Zitterbart, Jaroslava Payerova, Ladislav Bratsky, Zuzana Zilinska, Ursula Gruber-Sedlmayr, Matthias Baumann, Edda Haberlandt, Kevin Rostasy, Ekaterina Pataraia, Frances Elmslie, Clare Ann Johnston, Pamela Crawford, Peter Uldall, Paul Uvebrant, Olof Rask, Marit Bjoernvold, Eylert Brodtkorb, Andreas Sloerdahl, Ragnar Solhoff, Martine Sofie Gilje Jaatun, Marek Mandera, Elzbieta Janina Radzikowska, Mariusz Wysocki, Michael Fischereder, Gerhard Kurlemann, Bernd Wilken, Adelheid Wiemer-Kruel, Klemens Budde, Klaus Marquard, Markus Knuf, Andreas Hahn, Hans Hartmann, Andreas Merkenschlager, and Regina Trollmann
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intelligence quotient ,tuberous sclerosis complex ,TSC-associated neuropsychiatric disorders ,TOSCA ,TAND profile ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Knowledge is increasing about TSC-Associated Neuropsychiatric Disorders (TAND), but little is known about the potentially confounding effects of intellectual ability (IA) on the rates of TAND across age, sex, and genotype. We evaluated TAND in (a) children vs. adults, (b) males vs. females, and (c) TSC1 vs. TSC2 mutations, after stratification for levels of IA, in a large, international cohort.Methods: Individuals of any age with a documented visit for TSC in the 12 months prior to enrolment were included. Frequency and percentages of baseline TAND manifestations were presented by categories of IA (no intellectual disability [ID, intelligence quotient (IQ)>70]; mild ID [IQ 50–70]; moderate-to-profound ID [IQ
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- 2020
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28. Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype?
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Maëlle Biotteau, Sébastien Déjean, Sandrine Lelong, Stéphanie Iannuzzi, Nathalie Faure-Marie, Pierre Castelnau, François Rivier, Valérie Lauwers-Cancès, Eloïse Baudou, and Yves Chaix
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NF1 ,child ,cognitive profile ,sporadic ,familial ,hereditary ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Cognitive impairment is the most common neurological manifestation in NF1 and occurs in 30–70% of NF1 cases. The onset and severity of each specific cognitive deficit varies greatly from child to child, with no apparent external causes. The wide variability of phenotype is the most complex aspect in terms of management and care. Despite multiple research, the mechanism underlying the high heterogeneity in NF1 has not yet been elucidated. While many studies have focused on the effects of specific and precise genetic mutations on the NF1 phenotype, little has been done on the impact of NF1 transmission (sporadic vs. familial cases). We used a complete neuropsychological evaluation designed to assess five large cognitive areas: general cognitive functions (WISC-IV and EVIP); reading skills (“L'Alouette,” ODEDYS-2 and Lobrot French reading tests); phonological process (ODEDYS-2 test); visual perceptual skills (JLO, Thurstone and Corsi block tests) and attention (CPT-II), as well as psychosocial adjustments (CBCL) to explore the impact of NF1 transmission on cognitive disease manifestation in 96 children affected by NF1 [55 sporadic cases (29♀, 26♂); 41 familial cases (24♀, 17♂)].Results: Familial and Sporadic form of NF1 only differ in IQ expression. The families' socioeconomic status (SES) impacts IQ performance but not differently between sporadic and familial variants. However, SES is lower in familial variants than in the sporadic variant of NF1. No other cognitive differences emerge between sporadic and familial NF1.Conclusions: Inheritance in NF1 failed to explain the phenotype variability in its entirety. IQ differences between groups seems in part linked to the environment where the child grows up. Children with NF1, and especially those that have early diagnoses (most often in inherited cases), must obtain careful monitoring from their early childhood, at home to strengthen investment in education and in school to early detect emerging academic problems and to quickly place them into care.Trial Registration: IDRCB, IDRCB2008-A01444-51. Registered 19 January 2009.
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- 2020
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29. Efficacy and safety of sofosbuvir-based therapies in patients with advanced liver disease in a real-life cohort
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Kutala BK, Mouri F, Castelnau C, Bouton V, Giuily N, Boyer N, Asselah T, and Marcellin P
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Sofosbuvir ,hepatitis C virus ,interferon-free therapies ,cirrhosis ,advanced fibrosis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Blaise K Kutala,1,2 Feryel Mouri,1 Corinne Castelnau,1 Valerie Bouton,1 Nathalie Giuily,1 Nathalie Boyer,1 Tarik Asselah,1,2 Patrick Marcellin1,2 1Service d’hépatologie, Hopital Beaujon-APHP, 2INSERM – University of Paris Diderot, Paris, France Background: The combination of sofosbuvir (SOF) with ribavirin (RBV) or daclatasvir (DCV) or simeprevir (SIM) for the treatment of patients infected by chronic hepatitis C (CHC) have led to significantly increased rates of sustained virological response (SVR). However, there is only limited data regarding factors associated with treatment failure in a “real-life” cohort. Patients and methods: Consecutive treatment-naive and treatment-experienced patients F3–F4 were treated with SOF-based interferon-free therapy in our hospital from November 2013 to July 2015. The primary endpoint was the proportion of patients with sustained virological response 12 weeks after cessation of therapy (SVR12). Results: A total of 167 treatment-naive and 207 treatment-experienced patients were treated and followed up for 2 years (n=383). Overall, 71% were men; among them, 54% had cirrhosis and the median age was 53 years. SVR12 was achieved by 82% of the patients receiving SOF+RBV, 92% receiving SOF+DCV, and 79% receiving SOF+SIM. Metavir F4 and albumin serum were found as independent risk factors associated with treatment failure in groups receiving SOF+RBV (p=0.008 and p=0.001), SOF+DCV (p=0.038 and p=0.043), and SOF+SIM±RBV (p=0.014 and p=0.017), respectively. The most common adverse events were fatigue, nausea, headache, and anemia. Three patients discontinued the treatment due to an adverse event. Conclusion: These findings suggest that 12-week SOF-based regimen plus RBV or DCV or SIM is an efficacious and well-tolerated treatment in CHC patients with fibrosis stage F3–F4. Patients, who display risk factors for cirrhosis, should be referred to an experienced viral hepatitis center. Keywords: sofosbuvir, hepatitis C virus, interferon-free therapies, cirrhosis, advanced fibrosis
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- 2017
30. Analysis of As-Built Microstructures and Recrystallization Phenomena on Inconel 625 Alloy Obtained via Laser Powder Bed Fusion (L-PBF)
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Thibaut De Terris, Olivier Castelnau, Zehoua Hadjem-Hamouche, Halim Haddadi, Vincent Michel, and Patrice Peyre
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laser-powder bed fusion ,Inconel 625 ,electron backscatter diffraction (EBSD) ,X-ray diffraction (XRD) ,recrystallization ,dislocation density ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The microstructures induced by the laser-powder bed fusion (L-PBF) process have been widely investigated over the last decade, especially on austenitic stainless steels (AISI 316L) and nickel-based superalloys (Inconel 718, Inconel 625). However, the conditions required to initiate recrystallization of L-PBF samples at high temperatures require further investigation, especially regarding the physical origins of substructures (dislocation densities) induced by the L-PBF process. Indeed, the recrystallization widely depends on the specimen substructure, and in the case of the L-PBF process, the substructure is obtained during rapid solidification. In this paper, a comparison is presented between Inconel 625 specimens obtained with different laser-powder bed fusion (L-PBF) conditions. The effects of the energy density (VED) values on as-built and heat-under microstructures are also investigated. It is first shown that L-PBF specimens created with high-energy conditions recrystallize earlier due to a larger density of geometrically necessary dislocations. Moreover, it is shown that lower energy densities offers better tensile properties for as-built specimens. However, an appropriate heat treatment makes it possible to homogenize the tensile properties.
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- 2021
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31. Relatorio da viagem de Cuiabá ao Forte d’Olimpo e volta a Villa Maria, pelo Sr. Conde de Castelnau, 1845
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Conde de Castelnau
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relatório de viagem ,cuiabá ,século xix ,Anthropology ,GN1-890 ,Social sciences (General) ,H1-99 - Abstract
Documento histórico, século XIX.
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- 2017
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32. Infecciones asociadas a la Asistencia Sanitaria en un Hospital especializado en el paciente nefro-urológico
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Irene Fiterre Lancis, Nancy L. Sabournín Castelnau, Osladis Bandera Sánchez, Rosa Lidia Sarduy Chapis, Bárbara Castillo Rodríguez, and Vivian S. Fernández Salazar
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Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Introducción: Las Infecciones asociadas a la Asistencia Sanitaria constituyen un evento negativo para el paciente al determinar aumento de la morbilidad y mortalidad y gastos hospitalarios, comportándose como indicador de la calidad asistencial. Objetivo: Describir las infecciones asociadas a la asistencia sanitaria que ocurrieron durante 2013 y 2014 en un hospital especializado en la atención del paciente nefrológico. Material y Métodos: Los datos se recolectaron mediante pesquisa activa, revisión de historias clínicas y registro de infecciones asociadas a la asistencia sanitaria en cada servicio del hospital. En el análisis estadístico se utilizaron distribuciones de frecuencias, y como medidas de resumen, las tasas y porcentajes. Resultados: La frecuencia de infección asociada a la asistencia sanitaria fue 8 y 7,5% en cada año de estudio, con predominio de infecciones relacionadas con el acceso vascular en pacientes en hemodiálisis, y la infección del tracto urinario en pacientes instrumentados y cirugía endo-urológica. Los microorganismos más reportados fueron Estafilococcco aureus, Estafilococo aureus meticilino resistente y Escherichia coli. La mortalidad asociada a la IAAS fue de 5,1%, en los 2 años de estudio. Conclusiones: Las infecciones asociadas a la asistencia sanitaria son las esperadas por la complejidad de los procesos que se realizan en el centro, donde se destacan las infecciones asociadas al acceso vascular y el reporte de microorganismos Gram positivos. Palabras claves: Infecciones, asistencia sanitaria, acceso vascular, paciente nefrológico, microorganismos, Gram positivo, Gram negativo.
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- 2017
33. Logothérapie, groupe de paroles et analyse existentielle en cours de radiothérapie : expérience pilote d’un centre parisien de radiothérapie
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Sarfati, G.-E., Delattre, I., Castelnau-Marchand, P., and Toledano, A.
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- 2017
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34. Microstructure and Property Modifications of Cold Rolled IF Steel by Local Laser Annealing
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Hallberg, Håkan, Adamski, Frédéric, Baïz, Sarah, and Castelnau, Olivier
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- 2017
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35. Stress partitioning in a near-β Titanium alloy induced by elastic and plastic phase anisotropies: experimental and modeling
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PURUSHOTTAM RAJ PUROHIT Ravi raj purohit, LHADI Safaa, GEY Nathalie, CASTELNAU Olivier, RICHETON Thiebaud, GERMAIN Lionel, and BERBENNI Stephane
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The load transfer induced by the elastic and plastic phase anisotropies of a Ti–10V–2Fe–3Al titanium alloy is studied. The microstructure consists in α nodules embedded in elongated β grains. EBSD performed on the alloy shows no crystallographic texture neither for α nor β phase. Tensile tests along the elongation direction, at a strain rate of 2 x 10-3 s-1 give a yield stress of 830 MPa with 13% ductility. Simulations based on an advanced two-phase polycrystalline elasto-viscoplastic self-consistent (EVPSC) model predict that the β phase first plastifies with a sequential onset of plasticity starting from oriented β grains, then and finally oriented β grains. This leads to a strong load transfer from the β grains to the α nodules whose average behavior remains elastic up to high stresses (~940 MPa). However, additional simulations considering exclusively β grains of specific orientation show that the behavior of α nodules is strongly dependent on the β texture in which they are embedded. Especially, in β grains, which plastify the latest, the model predicts the onset of plasticity in favorably orientated α nodules. Moreover, the orientation spread within the β grains can modify the average plastic behavior of α phase. In future, these results will be compared to data obtained from in-situ High Energy XRD and SEM/EBSD experiments.
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- 2020
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36. Respiratory chain inhibition: one more feature to propose MPTP intoxication as a Leigh syndrome model
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Da Costa, Barbara, Dumon, Elodie, Le Moigno, Laurence, Bodard, Sylvie, Castelnau, Pierre, Letellier, Thierry, and Rocher, Christophe
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- 2016
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37. Carcinoma de células renales: hipernefroma. Presentación de un caso
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José Jesús Miranda Folch, Dalia García Cuervo, Junior Vega Jiménez, Bárbara Alemán Marichal, Adianez Jiménez Álvarez, and Adrián Ramiro Castelnau Sánchez
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carcinoma renal ,metástasis cerebral ,anemia ,síndrome de Stauffer ,Medicine - Abstract
Se presentó el caso clínico de una mujer de 51 años de edad, fumadora inveterada, con antecedentes de anemia de varios años de evolución y trastornos de la personalidad, tratados en ocasiones con fenotiacinas, que comienza a referir desde hace un mes episodios recurrentes, caracterizados por trastornos del estado de ánimo con elementos melancólicos. Estos problemas fueron percibidos por sus compañeros de trabajo, pero sin darle la debida importancia hasta que, en una mañana, la paciente despierta con una hemiparesia izquierda. Se constató por tomografía axial computarizada una imagen de tumoración cerebral valorada por Neurocirugía, y se sometió a tratamiento conservador por parte de dicha especialidad con radiaciones. Mejorado el cuadro, la paciente fue dada de alta con seguimiento ambulatorio hasta que regresa al hospital dos meses después con fiebre de doce días de duración, vómitos en proyectil, cefalea y estado confusional agudo, decidiéndose su reingreso en el hospital militar de Matanzas. La paciente falleció y en la autopsia se constató un adenocarcinoma renal derecho, pobremente diferenciado con metástasis cerebrales múltiples.
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- 2015
38. « En raison des conquêtes, de la religion et du commerce »
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Charlotte de Castelnau L’Estoile
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Brazil ,colonisation ,Indians ,Jesuits ,16th century ,tongue ,History of Spain ,DP1-402 ,Latin America. Spanish America ,F1201-3799 ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
The linguistic situation in 16th-century Brazil was divergent, with a dominant indigenous tongue on the coast and multiple tongues among the tribes of the interior. This article analyses the different stages whereby the dominant indigenous language of the coast became the lingua franca of Brazil: acquisition by the Portuguese, production of a written form, grammaticalisation and publication. The publication of Anchieta’s Grammar in 1595 can be understood in the context of rivalries between settlers and Jesuits regarding the Indian populations. The high death rate among the coastal tribes prompted a new policy whereby peoples from the interior were encouraged to move to the coastal areas, a process that was instrumental in the dissemination of a lingua franca. The debates about grammar and the capacity of the Indians’ tongue to express Christian faith and law should be seen in the context of the bitter struggle between Jesuit missionaries and settlers for control of the Indian populations.
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- 2015
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39. Sinonasal squamous cell carcinoma without clinical lymph node involvement: Which neck management is best?
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Castelnau-Marchand, Pauline, Levy, Antonin, Moya-Plana, Antoine, Mirghani, Haïtham, Nguyen, France, Del Campo, Eleonor Rivin, Janot, François, Kolb, Frédéric, Ferrand, François-Régis, Temam, Stéphane, Blanchard, Pierre, and Tao, Yungan
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- 2016
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40. Interferometric imaging as an alternative to telescopes
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Minoglou, Kyriaki, Karafolas, Nikos, Cugny, Bruno, Debary, Hiyam, Michau, Vincent, Mugnier, Laurent, Cassaing, Frédéric, Castelnau, Matthieu, and Lopez, Sébastien
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- 2023
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41. Active optics for the DICOS project
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Minoglou, Kyriaki, Karafolas, Nikos, Cugny, Bruno, Le Duigou, J.M., Bernard, L., Castelnau, M., Cucchetti, E., Latry, C., Soulier, M., and Salih Alj, A.
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- 2023
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42. Textures in deforming forsterite aggregates up to 8 GPa and 1673 K
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Bollinger, Caroline, Raterron, Paul, Castelnau, Olivier, Detrez, Fabrice, and Merkel, Sébastien
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- 2016
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43. On the Accuracy of Elastic Strain Field Measurements by Laue Microdiffraction and High-Resolution EBSD: a Cross-Validation Experiment
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Plancher, E., Petit, J., Maurice, C., Favier, V., Saintoyant, L., Loisnard, D., Rupin, N., Marijon, J.-B., Ulrich, O., Bornert, M., Micha, J.-S., Robach, O., and Castelnau, O.
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- 2016
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44. Personal Involvement of Young People in HIV Prevention Campaign Messages: The Role of Message Format, Culture, and Gender
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Geary, Cynthia Waszak, Burke, Holly M., Johnson, Laura, Liku, Jennifer, Castelnau, Laure, Neupane, Shailes, and Niang, Cheikh
- Abstract
To examine young people's reactions to and understanding of HIV prevention messages developed for MTV's global HIV prevention campaign Staying Alive, videotaped campaign materials were shown to focus group discussion (FGD) participants living in urban areas of Brazil, Kenya, Nepal, and Senegal. Responses related to "personal involvement" with the message were identified in the data from these FGDs and were examined in relationship to the emerging message themes, the message format (public service announcements [PSAs] vs. documentary), cultural context (site), and participant gender. Across groups, greater personal involvement (measured by personal connections, emotional reactions, and lessons learned) was found in responses about the documentary format compared to the PSA format. Exceptions were found for specific PSAs that were considered more relevant within specific gender or cultural contexts. Implications of findings for global campaigns were considered. (Contains 2 tables and 4 notes.)
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- 2008
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45. Exposure to MTV's Global HIV Prevention Campaign in Kathmandu, Nepal; Sao Paulo, Brazil; and Dakar, Senegal
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Geary, Cynthia Waszak, Burke, Holly McClain, Castelnau, Laure, Neupane, Shailes, Sall, Yacine Ba, and Wong, Emily
- Abstract
In 2002 MTV aired a global media campaign, "Staying Alive," to promote HIV prevention among 16- to 25-year-olds. Skeptics believed that a global MTV campaign would reach only a small group of elite young people. MTV increased access to its campaign, however, by making all materials "rights free" to third-party (non-MTV) broadcasters. Over 789 million households in over 166 countries had access to some or all of the campaign. To understand the level of actual exposure and the types of young people exposed, data were analyzed from population-based household surveys in three diverse urban areas where a campaign evaluation was conducted: Kathmandu, Nepal; Sao Paulo, Brazil and Dakar, Senegal. Exposure rates ranged from 12% in Kathmandu, 23% in Sao Paulo, and 82% in Dakar, reaching an estimated 32,000, 400,000, 220,000 16- to 25-year-olds in each city, respectively. A number of personal, social and economic characteristics found to predict campaign exposure were identified in each site; in general, these were related to economic status and use of "new" media technologies. Though this skew toward more exposure by those with greater resources existed, we found that the campaign audience was in no way composed only of "elite" young people. (For example, although more of those exposed to the campaign had used the Internet compared with those not exposed, this was not the majority of those exposed in most countries.) The possibility of reaching millions of young people through global networks with minimal marginal costs after production, creates a new paradigm for reaching an important segment of young people.
- Published
- 2007
- Full Text
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46. MTV's 'Staying Alive' Global Campaign Promoted Interpersonal Communication about HIV and Positive Beliefs about HIV Prevention
- Author
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Geary, Cynthia Waszak, Burke, Holly McClain, Castelnau, Laure, Neupane, Shailes, Sall, Yacine Ba, Wong, Emily, and Tucker, Heidi Toms
- Abstract
In 2002 MTV launched a global multicomponent HIV prevention campaign, "Staying Alive," reaching over 166 countries worldwide. An evaluation of this campaign focused on three diverse sites: Kathmandu, Nepal; Sao Paulo, Brazil; and Dakar, Senegal. Data were collected before and after campaign implementation through population-based household surveys. Using linear regression techniques, our evaluation examined the effects of campaign exposure on interpersonal communication about HIV and the effects of campaign exposure and interpersonal communication on beliefs about HIV prevention. We found a consistent positive effect of exposure on interpersonal communication across all sites, though there were differences among sites with regard to whom the respondent talked about HIV. We also found a consistent positive effect of exposure on HIV prevention beliefs across sites when interpersonal communication was simultaneously entered into the model. Finally, in two sites we found a relationship between interpersonal communication and HIV prevention beliefs, controlling for exposure, though again, the effects differed by the type of person the communication was with. These similar findings in three diverse sites provide ecological validity of the findings that "Staying Alive" promoted interpersonal communication and influenced young people's beliefs about HIV prevention in a positive way, evidence for the potential of a global media campaign to have an impact on social norms.
- Published
- 2007
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47. Gestión didáctica para la enseñanza de lenguas extranjeras: retos y proyecciones en la educación superior
- Author
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Pura de la Caridad Rey Rivas, Yaritza Tardo Fernández, Rubén Maymir Pacheco, and Yolaisy Méndez Castelnau
- Subjects
lenguas extranjeras, proceso de enseñanza-aprendizaje, gestión de la enseñanza, educación superior, pregrado, marco común de referencia europeo para las lenguas. ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
En este artículo se propone una estrategia de gestión didáctica cuyo objetivo es disminuir el insuficiente tratamiento al proceso de enseñanza-aprendizaje de las lenguas extranjeras en la educación superior, con énfasis en el pregrado, sobre la base de lo establecido en el Marco Común de Referencia Europeo para las Lenguas, y a partir de la inserción de enfoques novedosos y alejados de métodos tradicionales, en correspondencia con los requerimientos teórico-prácticos y las competencias socio-profesionales y comunicativas exigidas actualmente por dicho Marco de referencia. Para su elaboración se adopta un enfoque de jerarquía-subordinación desde el método sistémico-estructural-funcional. La implementación de esta estrategia ha permitido el fortalecimiento de una dinámica docente más centrada en los estudiantes y el logro de una participación más protagónica y comprometida, a partir de los descriptores del citado Marco, como primer acercamiento a un proceso que requiere aún un perfeccionamiento constante y permanente en su praxis formativa.
- Published
- 2016
48. Novel Human Reovirus Isolated from Children with Acute Necrotizing Encephalopathy
- Author
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Louise A. Ouattara, Francis Barin, Marie Anne Barthez, Bertrand Bonnaud, Philippe Roingeard, Alain Goudeau, Pierre Castelnau, Guy Vernet, Gláucia Paranhos-Baccalà, and Florence Komurian-Pradel
- Subjects
encephalitis ,mammalian orthoreovirus 2 ,reassortant viruses ,viruses ,research ,France ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
For many encephalitis cases, the cause remains unidentified. After 2 children (from the same family) received a diagnosis of acute necrotizing encephalopathy at Centre Hospitalier Universitaire (Tours, France), we attempted to identify the etiologic agent. Because clinical samples from the 2 patients were negative for all pathogens tested, urine and throat swab specimens were added to epithelial cells, and virus isolates detected were characterized by molecular analysis and electron microscopy. We identified a novel reovirus strain (serotype 2), MRV2Tou05, which seems to be closely related to porcine and human strains. A specific antibody response directed against this new reovirus strain was observed in convalescent-phase serum specimens from the patients, whereas no response was observed in 38 serum specimens from 38 healthy adults. This novel reovirus is a new etiologic agent of encephalitis.
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- 2011
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49. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly
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Poirier, Karine, Lebrun, Nicolas, Broix, Loic, Tian, Guoling, Saillour, Yoann, Boscheron, Cécile, Parrini, Elena, Valence, Stephanie, Pierre, Benjamin Saint, Oger, Madison, Lacombe, Didier, Geneviève, David, Fontana, Elena, Darra, Franscesca, Cances, Claude, Barth, Magalie, Bonneau, Dominique, Bernadina, Bernardo Dalla, N'Guyen, Sylvie, Gitiaux, Cyril, Parent, Philippe, des Portes, Vincent, Pedespan, Jean Michel, Legrez, Victoire, Castelnau-Ptakine, Laetitia, Nitschke, Patrick, Hieu, Thierry, Masson, Cecile, Zelenika, Diana, Andrieux, Annie, Francis, Fiona, Guerrini, Renzo, Cowan, Nicholas J, Bahi-Buisson, Nadia, and Chelly, Jamel
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- 2013
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50. Proton MR spectroscopic imaging of basal ganglia and thalamus in neurofibromatosis type 1: correlation with T2 hyperintensities
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Barbier, Charlotte, Chabernaud, Camille, Barantin, Laurent, Bertrand, Philippe, Sembely, Catherine, Sirinelli, Dominique, Castelnau, Pierre, and Cottier, Jean-Philippe
- Published
- 2011
- Full Text
- View/download PDF
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