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1. Renal effects of cyclooxygenase inhibitors in volume-depleted dogs

Author

David P. Brooks, Robert H. Palmer, Don E. Griswold, P. Dennis DePalma, Edward F. Webb, and Jerry M. Adams

Subjects
Pharmacology, biology, business.industry, Immunology, Renal function, Carrageenan, Nabumetone, chemistry.chemical_compound, Therapeutic index, chemistry, Renal blood flow, medicine, Celecoxib, biology.protein, Pharmacology (medical), Cyclooxygenase, business, Active metabolite, medicine.drug
Abstract

Objective: The objective of this study was to investigate the renal effects of celecoxib, a cyclooxygenase-2 (COX-2) specific nonsteroidal anti-inflammatory drug (NSAID). Subjects and treatment: Six volume-depleted, conscious, chronically instrumented dogs received four treatments using a cross-over design, with at least 13 days between treatments. An i.v. bolus dose (3, 10, and 30 μmol/kg) of vehicle, indomethacin, celecoxib, or 6-MNA, the active metabolite of nabumetone, were administered with an hour between doses. Methods: Renal function was assessed at baseline and 30 min after each dose. Results: Treatment with indomethacin or celecoxib resulted in a dose-dependent reduction in renal plasma flow (RPF), glomerular filtration rate (GFR), urine flow, sodium excretion, and fractional sodium excretion. GFR was reduced by 27% with 30 μmol/kg indomethacin (p < 0.05) and by 58% with 30 μmol/kg celecoxib (p < 0.5). Similarly, RPF was significantly (p < 0.05) reduced by 33% and 65% with 30 μmol/kg indomethacin and celecoxib, respectively. Reductions in renal function with celecoxib occurred at a therapeutic index (determined by comparison anti-edemic activities of the drugs in rat paw carrageenan assays) equal to or lower than indomethacin. In contrast, treatment with vehicle or 6-MNA resulted in no reductions in renal function. Conclusion: Administration of either celecoxib (specific COX-2 inhibitor) or indomethacin (selective COX-1 inhibitor) resulted in significant reductions in renal function. COX-2 specific inhibitors do not appear to lack the renal effects of NSAIDs.

Published
2000
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2. Contents, Vol. 72, 1996

Author

Hiroshi Toma, L. Raffaele, V. Dalmastri, Filippo Salvati, Divyesh M. Bhatt, Hiroshi Ishida, Hikaru Sugimoto, Juan M. Gonzalez, Salih Hazar, J. Guiserix, Kyoko Kurose, V. Stefanović, Majed Odeh, Hiroshi Inuma, Kamberi Perparim, Nilwarangkur S, L. Perini, F. Locatelli, Peter Nilsson-Ehle, Shigeo Takebayashi, N. Seyrek, G. Paunović, Vivette D. D'Agati, J.C. Boulanger, Mohamed A. El-Shahawy, Smaragdi Antonopoulou, M. Dapporto, Hiroshi Mabuchi, Syuko Yamamoto, Hiroshi Kitamura, Yong Goo Kim, A.G. Brox, G. Erba, R. Margreiter, Hiroshi Osawa, Hiroyoshi Matsukura, M. Vedovato, Der-Cherng Tarng, Hiromichi Suzuki, Ching-Huai Huang, Constantinos A. Demopoulos, R.F. Gagnon, Yahya Sagliker, D Di Landro, M. Oh, Shuichi Hatakeyama, Panos Ziroyiannis, A. Michault, Masateru Kawabata, P. Finielz, I. Guarnori, R. Pérez-García, Satoru Tsunoda, Shinsuke Nomura, F. Malacarne, Zensuke Ota, Byung Kee Bang, G. Ricci, Per Kjellstrand, Sompong Ong-ajyooth, Y. Sagliker, Gengo Osawa, Mark W. Majesky, Tadashi Asami, Hideaki Yamabe, L.P.W.J. van den Heuvel, Young Ok Kim, F. Fabrizi, Satsuki Yamada, H.A. Jalil, Arie Oliven, Takao Kohsaka, Hans-Georg Classen, Arturo Borsatti, B. de Cagny, R. Mallmann, M. Lago, Christos Iatrou, Yoshiharu Hiratsuka, Tanekazu Harada, Luan D. Truong, Ank Nurol, Masaki Kobayashi, Watanachai Susaengrat, Yoshiko Fujita, G.F. Romagnoli, Saime Paydas, Rainer Nobiling, D. Oefner, J.P. Mallie, George Moustakas, Syunji Ishihara, Zhi-Hong Liu, Kogo Onodera, Sumalee Nimmannit, G. Devulder, Marian Klinger, J. Radivojević, Chairat Shayakul, P. Fievet, Susumu Inaba, Masaaki Nakayama, Akira Noguchi, B. Athmani, T. Dimitrov, Emine Kocabaş, Phannee Pidetcha, P. Fardelone, Fumihiko Hinoshita, Raja I. Zabaneh, Hiroshi Nihei, M. Hattori, C. Raimondi, Naoko Yusa, Todd S. Ing, Hirofumi Makino, Manuel Martinez-Maldonado, Kouichi Hirayama, Björn Holmquist, Jesús Montoliu, P. Gilli, Hirokazu Okada, Hisashi Ozasa, Mitsuaki Kaizuka, Stefan H. Jacobson, Ichiro Koni, C. Aichberger, Augusto Antonello, David J. Leehey, R. Makdassi, A.F. van Lieburg, Masami Matsumura, Osamu Sakai, I. Pejčić, Toshio Okada, Yoshiaki Fujimiya, Miwako Arai, Hans Thysell, Seunghun Lee, Yu-Li Cho, V. Djordjević, David P. Brooks, Chul Woo Yang, Huan-Sheng Chen, Makoto Katagiri, Julio Ramos, William J. Kimberling, Kosuke Ota, Jackson Joe Yium, Paritosh Tiwari, M. Andréjak, Gary E. Striker, G. Pontoriero, P. Vaillant, Tung-Po Huang, Roberto Barrios, A. Peco-Antić, H. Sonnenberg, Osamu Hotta, Kaoru Sakai, Prida Malasit, Chie Inoue, Liliane J. Striker, Kandemir Tolga, Lorenzo A. Calò, Scott O. Trerotola, Stephen V. Foster, PeterMaria Rob, Salvatore Cantaro, Yoshihiko Kanno, V. Stojanov, Ann M. Johnson, A. Fournier, F. Zhang, Kosaku Nitta, Alex W. Yu, Richard Skroeder, P. Dennis DePalma, Keitaro Yokoyama, W. Proesmans, G. Guerra, Koji Kawamura, Merit F. Gadallah, M. Gowrishankar, I. Cheong, Eiko Suzuki, Klaus Sack, Maria Golato, Silvana Favaro, Byung Kee Kim, S. Di Filippo, J. Gondry, Necmi Aksaray, Akira Yamada, D. Marcelli, Nobuo Watanabe, Adam Bahattin, Makoto Uchiyama, Michihiro Gotoh, E. Sestigiani, Naoto Yamaguchi, Patricia A. Gabow, Stawomir C. Zmonarski, C. Campieri, Kenichi Shikata, Kennichi Shiroto, Steven Foster, I. Constant, Katsuhiko Sudo, A. Giudicissi, Ulf Nilsson, L. Neri, Kunimasa Yan, Regina R. Verani, Shuichi Tomisawa, Je Hoon Lee, M. Avramović, Akpolat Tekin, Chih-Wei Yang, Stanistaw Miękisz, Mercè Borràs, Haruki Nagahana, A. Koenigsrainer, Jerzy W. Mozrzymas, S. Stefoni, M.L. Halperin, Margret Arnadottir, Sigeko Hara, Naoyuki Tamura, Tsutomu Takahashi, Ikuo Horigome, Hidehiko Kawato, M. Ramdane, Yoshio Taguma, Yukiyoshi Nakamura, Chege J. Mukuria, F. Anaya, Satoshi Iwabuchi, Jana Pindur, L.M. Ho, M. Zompatori, Tetsuo Shibata, Ettore Tresca, V.V.A.M. Knoers, Touru Nishihara, L.A.H. Monnens, Ichiro Kajiwara, Akio Koyama, M. Crepaldi, Yoshindo Kawaguchi, Youji Ogawa, M.S. Garcia de Vinuesa, J.M. Hoarau, Shigeru Horita, Scott J. Savader, Wadi N. Suki, Bedir Abdülkerim, E. Lobjoie, Yuki Sakai, Hiroaki Muramoto, Andrzej Teisseyre, Han-Nan Liu, Tun-Jun Tsai, G. Bacchini, Hitoshi Ebata, Yung-Ming Chen, E. De Paoli Vitali, D. Toncheva, M. Kostić, Maria José Panadés, E. David, F. Valderrábano, Monica Rizzolo, Mario Liani, Yosuke Ogura, G.K. Richards, Catherine I. Lai, Angela D'Angelo, Nobuhide Mimura, Takao Saruta, Masaru Nasu, V. Bonomini, Neslihan Seyrek, Yoshio Suzuki, Somkiat Vasuvattakul, V. Parezanović, Theodore P. Labus, Masaharu Naiki, Shaul G. Massry, Yasuo Magari, S. Paydas, and Ryokichi Yasumori

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1996
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3. Subject Index Vol. 72, 1996

Author

P. Fardelone, Naoko Yusa, Hirokazu Okada, J. Gondry, N. Seyrek, Hiroshi Mabuchi, D Di Landro, Michihiro Gotoh, Patricia A. Gabow, Per Kjellstrand, Ichiro Koni, Osamu Hotta, Naoyuki Tamura, Hiroshi Toma, Stephen V. Foster, Julio Ramos, V. Bonomini, M. Andréjak, Nilwarangkur S, Stawomir C. Zmonarski, Somkiat Vasuvattakul, Ikuo Horigome, Hidehiko Kawato, L. Raffaele, Toshio Okada, Satoshi Iwabuchi, Keitaro Yokoyama, Neslihan Seyrek, Masateru Kawabata, Yahya Sagliker, Seunghun Lee, Yung-Ming Chen, D. Toncheva, P. Finielz, Kennichi Shiroto, M. Zompatori, Yong Goo Kim, Masaaki Nakayama, M. Crepaldi, Yoshindo Kawaguchi, Yoshiharu Hiratsuka, L. Neri, I. Cheong, Eiko Suzuki, A. Michault, V. Dalmastri, R. Margreiter, Shinsuke Nomura, R. Makdassi, Maria Golato, Kosuke Ota, Scott J. Savader, R. Mallmann, Maria José Panadés, M.S. Garcia de Vinuesa, Hiroshi Osawa, Wadi N. Suki, Yoshiaki Fujimiya, M. Vedovato, T. Dimitrov, Sigeko Hara, Emine Kocabaş, Akpolat Tekin, M. Avramović, Der-Cherng Tarng, A. Giudicissi, Fumihiko Hinoshita, Chih-Wei Yang, Yoshio Suzuki, Regina R. Verani, H. Sonnenberg, Takao Kohsaka, Watanachai Susaengrat, Hiromichi Suzuki, F. Malacarne, Tsutomu Takahashi, Prida Malasit, Chie Inoue, Kandemir Tolga, Lorenzo A. Calò, F. Locatelli, Tun-Jun Tsai, Han-Nan Liu, Augusto Antonello, David J. Leehey, A. Fournier, Mercè Borràs, PeterMaria Rob, F. Zhang, F. Fabrizi, E. De Paoli Vitali, Masami Matsumura, Juan M. Gonzalez, Salih Hazar, J. Guiserix, Raja I. Zabaneh, M. Kostić, George Moustakas, Syunji Ishihara, Chul Woo Yang, B. Athmani, Salvatore Cantaro, Rainer Nobiling, D. Oefner, P. Gilli, Kogo Onodera, Chege J. Mukuria, Y. Sagliker, Vivette D. D'Agati, Shigeo Takebayashi, Hans-Georg Classen, Phannee Pidetcha, M. Hattori, G. Paunović, G.K. Richards, P. Dennis DePalma, Todd S. Ing, Catherine I. Lai, Angela D'Angelo, Hiroshi Kitamura, Zhi-Hong Liu, F. Anaya, Hisashi Ozasa, Mitsuaki Kaizuka, Byung Kee Bang, Christos Iatrou, V. Parezanović, Yoshiko Fujita, G.F. Romagnoli, Mario Liani, Makoto Katagiri, Theodore P. Labus, David P. Brooks, Majed Odeh, Masaru Nasu, Koji Kawamura, A. Peco-Antić, Tanekazu Harada, Kosaku Nitta, Nobuhide Mimura, Liliane J. Striker, I. Guarnori, Syuko Yamamoto, Gengo Osawa, Arturo Borsatti, Ann M. Johnson, Zensuke Ota, Filippo Salvati, Alex W. Yu, Hirofumi Makino, Takao Saruta, Richard Skroeder, Divyesh M. Bhatt, G. Ricci, Masaki Kobayashi, C. Raimondi, L.P.W.J. van den Heuvel, Akira Yamada, C. Aichberger, Young Ok Kim, Kamberi Perparim, Youji Ogawa, Chairat Shayakul, P. Fievet, Hikaru Sugimoto, Necmi Aksaray, D. Marcelli, Osamu Sakai, Ulf Nilsson, Huan-Sheng Chen, Shigeru Horita, Björn Holmquist, Naoto Yamaguchi, E. Lobjoie, Steven Foster, L. Perini, G. Guerra, M. Gowrishankar, Masaharu Naiki, Luan D. Truong, Ank Nurol, Haruki Nagahana, A.F. van Lieburg, Mohamed A. El-Shahawy, Merit F. Gadallah, Hiroshi Inuma, Kaoru Sakai, Kenichi Shikata, Shuichi Tomisawa, Je Hoon Lee, Ching-Huai Huang, Miwako Arai, S. Di Filippo, Stanistaw Miękisz, Constantinos A. Demopoulos, Kouichi Hirayama, R.F. Gagnon, Nobuo Watanabe, G. Pontoriero, Adam Bahattin, Roberto Barrios, P. Vaillant, Makoto Uchiyama, Hiroshi Ishida, Mark W. Majesky, A.G. Brox, G. Erba, Tung-Po Huang, E. Sestigiani, Tadashi Asami, Kunimasa Yan, R. Pérez-García, M. Ramdane, Yoshio Taguma, Yukiyoshi Nakamura, C. Campieri, Shaul G. Massry, Scott O. Trerotola, Satsuki Yamada, Yasuo Magari, Yoshihiko Kanno, S. Paydas, Jana Pindur, L.M. Ho, Peter Nilsson-Ehle, Smaragdi Antonopoulou, W. Proesmans, J. Radivojević, H.A. Jalil, Yu-Li Cho, Ettore Tresca, V.V.A.M. Knoers, Ryokichi Yasumori, J.P. Mallie, Jackson Joe Yium, Byung Kee Kim, Paritosh Tiwari, Kyoko Kurose, V. Stojanov, Hiroyoshi Matsukura, J.M. Hoarau, Silvana Favaro, Bedir Abdülkerim, Hitoshi Ebata, Yuki Sakai, Hiroaki Muramoto, Andrzej Teisseyre, G. Bacchini, Klaus Sack, E. David, I. Constant, F. Valderrábano, Monica Rizzolo, Katsuhiko Sudo, Yosuke Ogura, A. Koenigsrainer, Jerzy W. Mozrzymas, S. Stefoni, M.L. Halperin, Margret Arnadottir, M. Dapporto, Satoru Tsunoda, Arie Oliven, V. Djordjević, I. Pejčić, William J. Kimberling, Gary E. Striker, M. Oh, Shuichi Hatakeyama, Hideaki Yamabe, M. Lago, Akira Noguchi, Tetsuo Shibata, Saime Paydas, Hiroshi Nihei, Sumalee Nimmannit, G. Devulder, Marian Klinger, Susumu Inaba, Touru Nishihara, L.A.H. Monnens, Hans Thysell, V. Stefanović, J.C. Boulanger, Ichiro Kajiwara, Akio Koyama, Jesús Montoliu, Panos Ziroyiannis, Stefan H. Jacobson, Sompong Ong-ajyooth, Manuel Martinez-Maldonado, and B. de Cagny

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1996
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4. Effect of fenoldopam in dogs with spontaneous renal insufficiency

Author

Kristen Karpinski, P. Dennis DePalma, Robin Goldstein, marty Hyneck, David P. Brooks, Martin DiCristo, and Paul F. Koster

Subjects
Male, medicine.medical_specialty, Kidney Cortex, Fenoldopam, Renal cortex, Dopamine Agents, Urology, Extraction ratio, Administration, Oral, PAH clearance, In Vitro Techniques, urologic and male genital diseases, Dopamine agonist, Dogs, Oral administration, Internal medicine, medicine, Animals, Humans, Pharmacology, business.industry, medicine.anatomical_structure, Endocrinology, Renal blood flow, Creatinine, Injections, Intravenous, Organic anion transport, Kidney Failure, Chronic, Female, p-Aminohippuric Acid, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, business, medicine.drug
Abstract

Fenoldopam administration orally or i.v. resulted in significant increases in paraaminohippuric acid (PAH) clearance in both four control dogs and four dogs with chronic renal failure. Oral fenoldopam resulted in significant plasma levels of fenoldopam sulfate metabolites. One metabolite, fenoldopam-8-sulfate, a potential inhibitor of organic anion transport, did not depress renal cortical slice accumulation of PAH. The data therefore indicate that in dogs with chronic renal failure, PAH clearance after fenoldopam administration is a reliable measure of renal plasma flow, and fenoldopam can result in an increase in renal plasma flow.

Published
1990

5. The effects of dopamine on mean arterial blood pressure in the spontaneously hypertensive rat

Author

P. Dennis DePalma and Dennis M. Ackerman

Subjects
Pharmacology, Male, medicine.medical_specialty, Phenoxybenzamine, business.industry, Dopamine, Pharmaceutical Science, Blood Pressure, Rats, Blood pressure, Spontaneously hypertensive rat, Internal medicine, Hypertension, medicine, Cardiology, Animals, Drug Interactions, business, Antihypertensive Agents, medicine.drug
Published
1983

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