46,303 results on '"P. Kent"'
Search Results
2. TravelAgent: Generative Agents in the Built Environment
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Noyman, Ariel, Hu, Kai, and Larson, Kent
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Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
Understanding human behavior in built environments is critical for designing functional, user centered urban spaces. Traditional approaches, such as manual observations, surveys, and simplified simulations, often fail to capture the complexity and dynamics of real world behavior. To address these limitations, we introduce TravelAgent, a novel simulation platform that models pedestrian navigation and activity patterns across diverse indoor and outdoor environments under varying contextual and environmental conditions. TravelAgent leverages generative agents integrated into 3D virtual environments, enabling agents to process multimodal sensory inputs and exhibit human-like decision-making, behavior, and adaptation. Through experiments, including navigation, wayfinding, and free exploration, we analyze data from 100 simulations comprising 1898 agent steps across diverse spatial layouts and agent archetypes, achieving an overall task completion rate of 76%. Using spatial, linguistic, and sentiment analyses, we show how agents perceive, adapt to, or struggle with their surroundings and assigned tasks. Our findings highlight the potential of TravelAgent as a tool for urban design, spatial cognition research, and agent-based modeling. We discuss key challenges and opportunities in deploying generative agents for the evaluation and refinement of spatial designs, proposing TravelAgent as a new paradigm for simulating and understanding human experiences in built environments., Comment: 21 pages 9 figs
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- 2024
3. New modeling for hybrid stars with an elastic quark core
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Dong, Zoey Zhiyuan, Lau, Shu Yan, and Yagi, Kent
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General Relativity and Quantum Cosmology - Abstract
Heavy neutron stars may contain solid quark cores as motivated by, e.g. the crystalline color superconducting phase, forming elastic hybrid stars (HSs). Many previous studies assumed an elastic core to be unsheared for the background, static and spherically symmetric configuration, and introduced shear deformation only at a perturbative level. This study relaxes this assumption and explores the influence of non-linear elasticity on the static, spherically symmetric structure of elastic HSs within a fully relativistic elasticity framework. Such a framework effectively introduces anisotropic pressure within the quark matter core due to elasticity. The quark core is modeled using a quasi-Hookean equation of state (EOS) with shear contributions, while the nuclear matter envelope is treated as a perfect fluid. We find that including elasticity increases the maximum mass of HSs by around 10%. This enhancement allows some soft EOSs to satisfy current observational constraints. However, since the effects of elasticity are primarily concentrated in the high-mass regime, the current observational constraints are insufficient to distinguish whether an elastic anisotropic quark core exists within these stars. Additionally, we show that the compactness of stable stars can exceed the critical value of 1/3 due to the inclusion of elasticity, making them potential candidates for black hole mimickers. Furthermore, we found that common phenomenological models fail to describe the anisotropy of the elastic core and propose a new parametrized anisotropy model that can accurately capture physically-motivated profiles with an error of 10% across a wide parameter space. This work not only bridges the gap between elastic EOSs and parametrized anisotropic models but also provides a foundation for applications such as studying nonradial perturbations, tidal deformability, and pulsation modes for elastic HSs., Comment: 16 pages, 13 figures, submitted to PRD
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- 2024
4. Measuring DNA Microswimmer Locomotion in Complex Flow Environments
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Imamura, Taryn, Kent, Teresa A., Taylor, Rebecca E., and Bergbreiter, Sarah
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Computer Science - Robotics - Abstract
Microswimmers are sub-millimeter swimming microrobots that show potential as a platform for controllable locomotion in applications including targeted cargo delivery and minimally invasive surgery. To be viable for these target applications, microswimmers will eventually need to be able to navigate in environments with dynamic fluid flows and forces. Experimental studies with microswimmers towards this goal are currently rare because of the difficulty isolating intentional microswimmer motion from environment-induced motion. In this work, we present a method for measuring microswimmer locomotion within a complex flow environment using fiducial microspheres. By tracking the particle motion of ferromagnetic and non-magnetic polystyrene fiducial microspheres, we capture the effect of fluid flow and field gradients on microswimmer trajectories. We then determine the field-driven translation of these microswimmers relative to fluid flow and demonstrate the effectiveness of this method by illustrating the motion of multiple microswimmers through different flows., Comment: 6 pages, 8 figures, preprint of ICRA conference submission
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- 2024
5. Elastic waves in bearing raceways: the forward and inverse problem
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Kent, Jessica J., Loures, Matheus de C., and Gower, Art L.
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Physics - Classical Physics ,74H10, 74J10 - Abstract
Turbines are crucial to our energy infrastructure, and ensuring their bearings function with minimal friction while often supporting heavy loads is vital. Vibrations within a bearing can signal the presence of defects, friction, or misalignment. However, current detection methods are neither robust nor easy to automate. We propose a more quantitative approach by modelling the elastic waves within bearing raceways. By approximating the raceway as a hollow cylinder, we derive straightforward 4x4 systems for its vibrational modes, enabling both forward and inverse problem-solving. We also demonstrate how to significantly reduce the number of required sensors by using a simple prior: the known number of rollers and their angular speed. We present numerical examples showcasing the full recovery of contact traction between bearings and the raceway, as well as the detection of elastic emissions.
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- 2024
6. Mixture equivalence principles and post-quantum theories of gravity
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Fedida, Samuel and Kent, Adrian
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General Relativity and Quantum Cosmology ,Quantum Physics - Abstract
We examine the mixture equivalence principle (MEP), which states that proper and improper mixed states with the same density matrix are always experimentally indistinguishable, and a weaker version, which states that this is sometimes true in gravity theories. We point out that Moller-Rosenfeld semiclassical gravity violates the weak MEP and that nonlinear extensions of quantum mechanics violate the MEP. We further demonstrate that modifications of the Born rule in quantum theory also typically violate the MEP. We analyse such violations in the context of thermal baths, where proper and improper thermal states induce different physical situations. This has significant implications in the context of black hole physics. We argue that Moller-Rosenfeld semiclassical gravity is not the semiclassical limit of quantum gravity in the context of black hole spacetimes, even in the presence of $N\gg1$ matter fields., Comment: 17 pages, 5 figures
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- 2024
7. NuSTAR broadband X-ray observation of EF Eri following its reawakening into a high accretion state
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Filor, Luke W., Mori, Kaya, Bridges, Gabriel, Hailey, Charles J., Buckley, David A. H., Ramsay, Gavin, Schwope, Axel D., Suleimanov, Valery F., Wolff, Michael T., and Wood, Kent S.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the first $\textit{NuSTAR}$ X-ray observation of EF Eri, a well-known polar system. The $\textit{NuSTAR}$ observation was conducted in conjunction with $\textit{NICER}$, shortly after EF Eri entered a high accretion state following an unprecedented period of low activity lasting 26 years since 1997. $\textit{NuSTAR}$ detected hard X-ray emission up to 50 keV with an X-ray flux of $1.2\times10^{-10}$ ergs s$^{-1}$ cm$^{-2}$ ($3\rm{-}50 keV$). Folded X-ray lightcurves exhibit a single peak with $\sim65\%$ spin modulation throughout the $3\rm{-}50$ keV band. We found no evidence of QPO signals at $\nu = 0.1\rm{-}100$ Hz with an upper limit on the QPO amplitude below $5\%$ ($90\%$ CL) at $\nu \sim 0.5$ Hz where the optical QPO was previously detected. Our 1-D accretion column model, called ${\tt MCVSPEC}$, was fitted to the $\textit{NuSTAR}$ spectral data, yielding an accurate WD mass measurement of $M = (0.55\rm{-}0.58) M_\odot$. $\texttt{MCVSPEC}$ accounts for radiative cooling by thermal bremsstrahlung and cyclotron emission, X-ray reflection off the WD surface, and a previously constrained range of the accretion column area. The derived WD mass range is in excellent agreement with the previous measurement of $M = (0.55\rm{-}0.60) M_\odot$ in the optical band. This demonstrates a combination of broadband X-ray spectral analysis and the ${\tt MCVSPEC}$ model that can be employed in our ongoing $\textit{NuSTAR}$ observation campaign of other polars to determine their WD masses accurately., Comment: 17 pages, 10 figures, 3 tables. Submitted to ApJ
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- 2024
8. Predicting Quality of Video Gaming Experience Using Global-Scale Telemetry Data and Federated Learning
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Zhang, Zhongyang, Wen, Jinhe, Chen, Zixi, Arbab, Dara, Sahani, Sruti, Lewis, William, Giard, Kent, Arbab, Bijan, Jin, Haojian, and Rahman, Tauhidur
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Information Retrieval - Abstract
Frames Per Second (FPS) significantly affects the gaming experience. Providing players with accurate FPS estimates prior to purchase benefits both players and game developers. However, we have a limited understanding of how to predict a game's FPS performance on a specific device. In this paper, we first conduct a comprehensive analysis of a wide range of factors that may affect game FPS on a global-scale dataset to identify the determinants of FPS. This includes player-side and game-side characteristics, as well as country-level socio-economic statistics. Furthermore, recognizing that accurate FPS predictions require extensive user data, which raises privacy concerns, we propose a federated learning-based model to ensure user privacy. Each player and game is assigned a unique learnable knowledge kernel that gradually extracts latent features for improved accuracy. We also introduce a novel training and prediction scheme that allows these kernels to be dynamically plug-and-play, effectively addressing cold start issues. To train this model with minimal bias, we collected a large telemetry dataset from 224 countries and regions, 100,000 users, and 835 games. Our model achieved a mean Wasserstein distance of 0.469 between predicted and ground truth FPS distributions, outperforming all baseline methods., Comment: 22 pages, 11 figures, 6 tables
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- 2024
9. True mass and atmospheric composition of the non-transiting hot Jupiter HD 143105 b
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Finnerty, Luke, Xin, Yinzi, Xuan, Jerry W., Inglis, Julie, Fitzgerald, Michael P, Agrawal, Shubh, Baker, Ashley, Blake, Geoffrey A., Calvin, Benjamin, Cetre, Sylvain, Delorme, Jacques-Robert, Doppman, Greg, Echeverri, Daniel, Horstman, Katelyn, Hsu, Chih-Chun, Jovanovic, Nemanja, Liberman, Joshua, López, Ronald A., Martin, Emily C., Mawet, Dimitri, Morris, Evan, Pezzato-Rovner, Jacklyn, Ruffio, Jean-Baptiste, Sappey, Ben, Schofield, Tobias, Skemer, Andrew, Venenciano, Taylor, Wallace, J. Kent, Wallack, Nicole L., Wang, Jason J., and Wang, Ji
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present Keck/KPIC phase II $K$-band observations of the non-transiting hot Jupiter HD 143105 b. Using a cross-correlation approach, we make the first detection of the planetary atmosphere at $K_p = 185^{+11}_{-13}\rm km\ s^{-1}$ and an inferior conjunction time 2.5 hours before the previously-published ephemeris. The retrieved $K_p$ value, in combination with orbital period, mass of the host star, and lack of transit detection, gives an orbital inclination of $78^{\circ+2}_{-12}$ and a true planet mass of 1.23$\pm0.10\rm\ M_J$. While the equilibrium temperature of HD 143105 b is in the transition regime between non-inverted and inverted atmospheres, our analysis strongly prefers a non-inverted atmosphere. Retrieval analysis indicates the atmosphere of HD 143105 b is cloud-free to approximately 1 bar and dominated by H$_2$O absorption ($\log \rm H_2O_{MMR} = -3.9^{+0.8}_{-0.5}$), placing only an upper limit on the CO abundance ($\log \rm CO_{MMR} < -3.7$ at 95% confidence). We place no constraints on the abundances of Fe, Mg, or $^{13}$CO. From these abundances, we place an upper limit on the carbon-to-oxygen ratio for HD 143105 b, $\rm C/O < 0.2$ at 95% confidence, and find the atmospheric metallicity is approximately $0.1\times$ solar. The low metallicity may be responsible for the lack of a thermal inversion, which at the temperature of HD 143105 b would likely require significant opacity from TiO and/or VO. With these results, HD 143105 b joins the small number of non-transiting hot Jupiters with detected atmospheres., Comment: 19 pages, 7 figures, 2 tables. Accepted in AJ
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- 2024
10. History and Habitability of the LP 890-9 Planetary System
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Barnes, Rory, Amaral, Laura N. R. do, Birky, Jessica, Carone, Ludmila, Driscoll, Peter, Livesey, Joseph R., Graham, David, Becker, Juliette, Cui, Kaiming, Schlecker, Martin, Garcia, Rodolfo, Gialluca, Megan, Adams, Arthur, Ahmed, MD Redyan, Bonney, Paul, Broussard, Wynter, Chawla, Chetan, Damasso, Mario, Danchi, William C., Deitrick, Russell, Ducrot, Elsa, Fromont, Emeline F., Gaches, Brandt A. L., Gupta, Sakshi, Hill, Michelle L., Jackman, James A. G., Janin, Estelle M., Karawacki, Mikolaj, Koren, Matheus Daniel, La Greca, Roberto, Leung, Michaela, Miranda-Rosete, Arturo, Olohoy, Michael Kent A., Ngo, Cecelia, Paul, Daria, Sahu, Chandan Kumar, Sarkar, Debajyoti Basu, Shadab, Mohammad Afzal, Schwieterman, Edward W., Sedler, Melissa, Texeira, Katie, Vazan, Allona, Vega, Karen N. Delgado, Vijayakumar, Rohit, and Wojack, Jonathan T.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present numerous aspects of the evolution of the LP 890-9 (SPECULOOS-2/TOI-4306) planetary system, focusing on the likelihood that planet c can support life. We find that the host star reaches the main sequence in 1 Gyr and that planet c lies close to the inner boundary of the habitable zone. We find the magma ocean stage can last up to 50 Myr, remove 8 Earth-oceans of water, and leave up to 2000 bars of oxygen in the atmosphere. However, if the planet forms with a hydrogen envelope as small as 0.1 Earth-masses, no water will be lost during the star's pre-main sequence phase from thermal escape processes. We find that the planets are unlikely to be in a 3:1 mean motion resonance and that both planets tidally circularize within 0.5 Gyr when tidal dissipation is held constant. However, if tidal dissipation is a function of mantle temperature and rheology, then we find that planet c's orbit may require more than 7 Gyr to circularize, during which time tidal heating may reach hundreds of terawatts. We thus conclude that the habitability of planet c depends most strongly on the initial volatile content and internal properties, but no data yet preclude the viability of an active biosphere on the planet., Comment: 16 pages, 9 figures, accepted to PSJ
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- 2024
11. On the Hidden Transient Interphase in Metal Anodes: Dynamic Precipitation Controls Electrochemical Interfaces in Batteries
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Fuller, Stephen T. and Zheng, J. -X. Kent
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
The Solid-Electrolyte Interphase, SEI, formed on a battery electrode has been a central area of research for decades. This thin, complex layer profoundly impacts the electrochemical deposition morphology and stability of the metal in battery anodes. Departing from conventional approaches, we investigate metal dissolution, the reverse reaction of deposition, in battery environments using a state-of-the-art electroanalytical system combining a rotating-disk electrode and in-operando visualization. Our key finding is the presence of a Transient Solid-Electrolyte Interphase, T-SEI, that forms during fast discharging at high dissolution rates. We attribute T-SEI formation to transient local supersaturation and resultant electrolyte salt deposition. The T-SEI fundamentally alters the dissolution kinetics at the electrochemical interface, leading to a self-limiting morphological evolution and eventually yielding a flat, clean surface. Unlike a classical SEI formed due to electrolyte decomposition, the T-SEI is fully relaxable upon removal of the enforced dissolution current. The formation of T-SEI, surprisingly, plays a critical role in the subsequent electrodeposition. When the metal is redeposited on a fully relaxed T-SEI surface, the morphology is remarkably different from that deposited on pristine or low-rate discharged metal electrodes. Electron backscatter diffraction analysis suggests a homoepitaxial relationship with the original grains in the electrode. This is in stark contrast to the isolated, particulate nuclei seen on standard metal electrodes without T-SEI formation. Our findings provide important insights into the electrochemical kinetics at the metal-electrolyte interface, particularly in concentrated or water-in-salt electrolytes that are close to the salt saturation limit. The results suggest a new dimension for electrochemical engineering in batteries.
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- 2024
12. PDS 70b Shows Stellar-like Carbon-to-oxygen Ratio
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Hsu, Chih-Chun, Wang, Jason J., Blake, Geoffrey A., Xuan, Jerry W., Zhang, Yapeng, Ruffio, Jean-Baptiste, Horstman, Katelyn, Cronin, Julianne, Sappey, Ben, Xin, Yinzi, Finnerty, Luke, Echeverri, Daniel, Mawet, Dimitri, Jovanovic, Nemanja, Ó, Clarissa R. Do, Baker, Ashley, Bartos, Randall, Calvin, Benjamin, Cetre, Sylvain, Delorme, Jacques-Robert, Doppmann, Gregory W., Fitzgerald, Michael P., Liberman, Joshua, López, Ronald A., Morris, Evan, Pezzato-Rovner, Jacklyn, Schofield, Tobias, Skemer, Andrew, Wallace, J. Kent, and Wang, Ji
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The $\sim$5 Myr PDS 70 is the only known system with protoplanets residing in the cavity of the circumstellar disk from which they formed, ideal for studying exoplanet formation and evolution within its natal environment. Here we report the first spin constraint and C/O measurement of PDS 70b from Keck/KPIC high-resolution spectroscopy. We detected CO (3.8 $\sigma$) and H$_2$O (3.5 $\sigma$) molecules in the PDS 70b atmosphere via cross-correlation, with a combined CO and H$_2$O template detection significance of 4.2 $\sigma$. Our forward model fits, using BT-Settl model grids, provide an upper limit for the spin-rate of PDS 70b ($<$29 km s$^{-1}$). The atmospheric retrievals constrain the PDS 70b C/O ratio to ${0.28}^{+0.20}_{-0.12}$ ($<$0.63 under 95$\%$ confidence level) and a metallicity [C/H] of ${-0.2}^{+0.8}_{-0.5}$ dex, consistent with that of its host star. The following scenarios can explain our measured C/O of PDS 70b in contrast with that of the gas-rich outer disk (for which C/O $\gtrsim$ 1). First, the bulk composition of PDS 70b might be dominated by dust+ice aggregates rather than disk gas. Another possible explanation is that the disk became carbon-enriched $\textit{after}$ PDS 70b was formed, as predicted in models of disk chemical evolution and as observed in both very low mass star and older disk systems with $\textit{JWST}$/MIRI. Because PDS 70b continues to accrete and its chemical evolution is not yet complete, more sophisticated modeling of the planet and the disk, and higher quality observations of PDS 70b (and possibly PDS 70c), are necessary to validate these scenarios., Comment: Accepted to ApJ Letters; 13 pages, 3 figures
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- 2024
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13. DINO-X: A Unified Vision Model for Open-World Object Detection and Understanding
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Ren, Tianhe, Chen, Yihao, Jiang, Qing, Zeng, Zhaoyang, Xiong, Yuda, Liu, Wenlong, Ma, Zhengyu, Shen, Junyi, Gao, Yuan, Jiang, Xiaoke, Chen, Xingyu, Song, Zhuheng, Zhang, Yuhong, Huang, Hongjie, Gao, Han, Liu, Shilong, Zhang, Hao, Li, Feng, Yu, Kent, and Zhang, Lei
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In this paper, we introduce DINO-X, which is a unified object-centric vision model developed by IDEA Research with the best open-world object detection performance to date. DINO-X employs the same Transformer-based encoder-decoder architecture as Grounding DINO 1.5 to pursue an object-level representation for open-world object understanding. To make long-tailed object detection easy, DINO-X extends its input options to support text prompt, visual prompt, and customized prompt. With such flexible prompt options, we develop a universal object prompt to support prompt-free open-world detection, making it possible to detect anything in an image without requiring users to provide any prompt. To enhance the model's core grounding capability, we have constructed a large-scale dataset with over 100 million high-quality grounding samples, referred to as Grounding-100M, for advancing the model's open-vocabulary detection performance. Pre-training on such a large-scale grounding dataset leads to a foundational object-level representation, which enables DINO-X to integrate multiple perception heads to simultaneously support multiple object perception and understanding tasks, including detection, segmentation, pose estimation, object captioning, object-based QA, etc. Experimental results demonstrate the superior performance of DINO-X. Specifically, the DINO-X Pro model achieves 56.0 AP, 59.8 AP, and 52.4 AP on the COCO, LVIS-minival, and LVIS-val zero-shot object detection benchmarks, respectively. Notably, it scores 63.3 AP and 56.5 AP on the rare classes of LVIS-minival and LVIS-val benchmarks, improving the previous SOTA performance by 5.8 AP and 5.0 AP. Such a result underscores its significantly improved capacity for recognizing long-tailed objects., Comment: Technical Report
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- 2024
14. Robotic transcatheter tricuspid valve replacement with hybrid enhanced intelligence: a new paradigm and first-in-vivo study
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Wang, Shuangyi, Lin, Haichuan, Xie, Yiping, Wang, Ziqi, Chen, Dong, Tan, Longyue, Hou, Xilong, Chen, Chen, Zhou, Xiao-Hu, Lin, Shengtao, Pan, Fei, So, Kent Chak-Yu, and Hou, Zeng-Guang
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Computer Science - Robotics ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Transcatheter tricuspid valve replacement (TTVR) is the latest treatment for tricuspid regurgitation and is in the early stages of clinical adoption. Intelligent robotic approaches are expected to overcome the challenges of surgical manipulation and widespread dissemination, but systems and protocols with high clinical utility have not yet been reported. In this study, we propose a complete solution that includes a passive stabilizer, robotic drive, detachable delivery catheter and valve manipulation mechanism. Working towards autonomy, a hybrid augmented intelligence approach based on reinforcement learning, Monte Carlo probabilistic maps and human-robot co-piloted control was introduced. Systematic tests in phantom and first-in-vivo animal experiments were performed to verify that the system design met the clinical requirement. Furthermore, the experimental results confirmed the advantages of co-piloted control over conventional master-slave control in terms of time efficiency, control efficiency, autonomy and stability of operation. In conclusion, this study provides a comprehensive pathway for robotic TTVR and, to our knowledge, completes the first animal study that not only successfully demonstrates the application of hybrid enhanced intelligence in interventional robotics, but also provides a solution with high application value for a cutting-edge procedure.
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- 2024
15. DESI 2024 VII: Cosmological Constraints from the Full-Shape Modeling of Clustering Measurements
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Prieto, C. Allende, Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Bonici, M., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chebat, D., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elbers, W., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Joyce, R., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lahav, O., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Matthewson, W., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Valogiannis, G., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yi, L., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological results from the measurement of clustering of galaxy, quasar and Lyman-$\alpha$ forest tracers from the first year of observations with the Dark Energy Spectroscopic Instrument (DESI Data Release 1). We adopt the full-shape (FS) modeling of the power spectrum, including the effects of redshift-space distortions, in an analysis which has been validated in a series of supporting papers. In the flat $\Lambda$CDM cosmological model, DESI (FS+BAO), combined with a baryon density prior from Big Bang Nucleosynthesis and a weak prior on the scalar spectral index, determines matter density to $\Omega_\mathrm{m}=0.2962\pm 0.0095$, and the amplitude of mass fluctuations to $\sigma_8=0.842\pm 0.034$. The addition of the cosmic microwave background (CMB) data tightens these constraints to $\Omega_\mathrm{m}=0.3056\pm 0.0049$ and $\sigma_8=0.8121\pm 0.0053$, while further addition of the the joint clustering and lensing analysis from the Dark Energy Survey Year-3 (DESY3) data leads to a 0.4% determination of the Hubble constant, $H_0 = (68.40\pm 0.27)\,{\rm km\,s^{-1}\,Mpc^{-1}}$. In models with a time-varying dark energy equation of state, combinations of DESI (FS+BAO) with CMB and type Ia supernovae continue to show the preference, previously found in the DESI DR1 BAO analysis, for $w_0>-1$ and $w_a<0$ with similar levels of significance. DESI data, in combination with the CMB, impose the upper limits on the sum of the neutrino masses of $\sum m_\nu < 0.071\,{\rm eV}$ at 95% confidence. DESI data alone measure the modified-gravity parameter that controls the clustering of massive particles, $\mu_0=0.11^{+0.45}_{-0.54}$, while the combination of DESI with the CMB and the clustering and lensing analysis from DESY3 constrains both modified-gravity parameters, giving $\mu_0 = 0.04\pm 0.22$ and $\Sigma_0 = 0.044\pm 0.047$, in agreement with general relativity. [Abridged.], Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/). 55 pages, 10 figures
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- 2024
16. DESI 2024 II: Sample Definitions, Characteristics, and Two-point Clustering Statistics
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Brown, Z., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Demina, R., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Hou, J., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kitaura, F. -S., Kong, H., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Scholte, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the samples of galaxies and quasars used for DESI 2024 cosmological analyses, drawn from the DESI Data Release 1 (DR1). We describe the construction of large-scale structure (LSS) catalogs from these samples, which include matched sets of synthetic reference `randoms' and weights that account for variations in the observed density of the samples due to experimental design and varying instrument performance. We detail how we correct for variations in observational completeness, the input `target' densities due to imaging systematics, and the ability to confidently measure redshifts from DESI spectra. We then summarize how remaining uncertainties in the corrections can be translated to systematic uncertainties for particular analyses. We describe the weights added to maximize the signal-to-noise of DESI DR1 2-point clustering measurements. We detail measurement pipelines applied to the LSS catalogs that obtain 2-point clustering measurements in configuration and Fourier space. The resulting 2-point measurements depend on window functions and normalization constraints particular to each sample, and we present the corrections required to match models to the data. We compare the configuration- and Fourier-space 2-point clustering of the data samples to that recovered from simulations of DESI DR1 and find they are, generally, in statistical agreement to within 2\% in the inferred real-space over-density field. The LSS catalogs, 2-point measurements, and their covariance matrices will be released publicly with DESI DR1., Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/)
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- 2024
17. DESI 2024 V: Full-Shape Galaxy Clustering from Galaxies and Quasars
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Rodríguez-Martínez, F., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the measurements and cosmological implications of the galaxy two-point clustering using over 4.7 million unique galaxy and quasar redshifts in the range $0.1
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- 2024
18. Mining for Protoclusters at $z\sim4$ from Photometric Datasets with Deep Learning
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Takeda, Yoshihiro, Kashikawa, Nobunari, Ito, Kei, Toshikawa, Jun, Momose, Rieko, Fujiwara, Kent, Liang, Yongming, Ishimoto, Rikako, Yoshioka, Takehiro, Arita, Junya, Kubo, Mariko, and Uchiyama, Hisakazu
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Protoclusters are high-$z$ overdense regions that will evolve into clusters of galaxies by $z=0$, making them ideal for studying galaxy evolution expected to be accelerated by environmental effects. However, it has been challenging to identify protoclusters beyond $z=3$ only by photometry due to large redshift uncertainties, hindering statistical study. To tackle the issue, we develop a new deep-learning-based protocluster detection model, PCFNet, which considers a protocluster as a point cloud. To detect protoclusters at $z\sim4$ using only optical broad-band photometry, we train and evaluate PCFNet with mock $g$-dropout galaxies based on the N-body simulation with the semi-analytic model. We use the sky distribution, $i$-band magnitude, $(g-i)$ color, and the redshift probability density function surrounding a target galaxy on the sky. PCFNet achieves to detect five times more protocluster member candidates while maintaining high purity (recall $=7.5\pm0.2$%, precision $=44\pm1$%) than conventional methods. Moreover, PCFNet is able to detect more progenitors ($M_\mathrm{halo}^{z=0}=10^{14-14.5}\,M_\odot$) that are less massive than supermassive clusters like the Coma cluster. We apply PCFNet to the observational photometric dataset of the HSC-SSP Deep/UltraDeep layer ($\sim17\mathrm{\,deg^2}$) and detect $121$ protocluster candidates at $z\sim4$. We find the rest-UV luminosities of our protocluster member candidates are brighter than those of field galaxies, which is consistent with previous studies. Additionally, the quenching of satellite galaxies depends on both the core galaxy's halo mass at $z\sim4$ and accumulated mass until $z=0$ in the simulation. PCFNet is very flexible and can find protoclusters at other redshifts or in future extensive surveys by Euclid, LSST, and Roman., Comment: 22 pages, 16 figures, 5 tables, Accepted in ApJ
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- 2024
19. A Monocular SLAM-based Multi-User Positioning System with Image Occlusion in Augmented Reality
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Lien, Wei-Hsiang, Chandra, Benedictus Kent, Fischer, Robin, Tang, Ya-Hui, Wang, Shiann-Jang, Hsu, Wei-En, and Fu, Li-Chen
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Computer Science - Human-Computer Interaction ,Computer Science - Computer Vision and Pattern Recognition - Abstract
In recent years, with the rapid development of augmented reality (AR) technology, there is an increasing demand for multi-user collaborative experiences. Unlike for single-user experiences, ensuring the spatial localization of every user and maintaining synchronization and consistency of positioning and orientation across multiple users is a significant challenge. In this paper, we propose a multi-user localization system based on ORB-SLAM2 using monocular RGB images as a development platform based on the Unity 3D game engine. This system not only performs user localization but also places a common virtual object on a planar surface (such as table) in the environment so that every user holds a proper perspective view of the object. These generated virtual objects serve as reference points for multi-user position synchronization. The positioning information is passed among every user's AR devices via a central server, based on which the relative position and movement of other users in the space of a specific user are presented via virtual avatars all with respect to these virtual objects. In addition, we use deep learning techniques to estimate the depth map of an image from a single RGB image to solve occlusion problems in AR applications, making virtual objects appear more natural in AR scenes.
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- 2024
20. Nuclear Dependence of Beam Normal Single Spin Asymmetry in Elastic Scattering from Nuclei
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Gal, Ciprian, Ghosh, Chandan, Park, Sanghwa, Adhikari, Devi, Armstrong, David, Beminiwattha, Rakitha, Camsonne, Alexandre, Chandrasena, Shashini, Dalton, Mark, Deshpande, Abhay, Gaskell, Dave, Higinbotham, Douglas, Horowitz, Charles J., King, Paul, Kumar, Krishna, Kutz, Tyler, Mammei, Juliette, McNulty, Dustin, Michaels, Robert, Palatchi, Caryn, Panta, Anil, Paschke, Kent, Pitt, Mark, Sen, Arindam, Simicevic, Neven, Weliyanga, Lasitha, and Wells, Steven P.
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Nuclear Experiment - Abstract
We propose to measure the beam normal single spin asymmetry in elastic scattering of transversely polarized electron from target nuclei with 12 $\leq Z \leq$ 90 at Q$^2$ = 0.0092 GeV$^2$ to study its nuclear dependence. While the theoretical calculations based on two-photon exchange suggest no nuclear dependence at this kinematics, the results of 208Pb from Jefferson Lab show a striking disagreement from both theoretical predictions and light nuclei measurements. The proposed measurements will provide new data for intermediate to heavy nuclei where no data exists for $Z \geq$ 20 in the kinematics of previous high-energy experiments. It will allow one to investigate the missing contributions that are not accounted in the current theoretical models., Comment: Submitted to Jefferson Lab PAC52
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- 2024
21. Background ambiguity and the G\'odel double copy
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Kent, Brian, Manton, Tucker, and Shashi, Sanjit
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
In this work, we investigate the assumptions regarding spacetime backgrounds underlying the classical double copy. We argue (contrary to the norm) that single-copy fields naturally constructed on the original curved background metric are only interpretable on a flat metric when such a well-defined limit exists, for which Kerr--Schild coordinates offer a natural choice. As an explicit example where such a distinction matters, we initiate an exploration of single-copies for the G\"odel universe. This metric lacks a (geodesic) Kerr--Schild representation yet is Petrov type-D, meaning the technology of the ``Weyl double copy" may be utilized. The Weyl derived single copy has many desirable features, including matching the defining properties of the spacetime, and being sourced by the mixed Ricci tensor just as Kerr--Schild single copies are. To compare, we propose a sourced flat-space single-copy interpretation for the G\"odel metric by leveraging its symmetries, and find that this proposal lacks the defining properties of the spacetime, and is not consistent with the flat limit of our curved-space single copy. Notably, this inconsistency does not occur in Kerr--Schild metrics. Our curved-space single copy also lead to the same electromagnetic analogue of the G\"odel universe found separately through tidal force analogies, opening a new avenue of exploration between the double copy and gravitoelectromagnetism programs., Comment: 29 pages, 2 figures
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- 2024
22. Usefulness of LLMs as an Author Checklist Assistant for Scientific Papers: NeurIPS'24 Experiment
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Goldberg, Alexander, Ullah, Ihsan, Khuong, Thanh Gia Hieu, Rachmat, Benedictus Kent, Xu, Zhen, Guyon, Isabelle, and Shah, Nihar B.
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Computer Science - Computation and Language ,Computer Science - Digital Libraries ,Computer Science - Human-Computer Interaction - Abstract
Large language models (LLMs) represent a promising, but controversial, tool in aiding scientific peer review. This study evaluates the usefulness of LLMs in a conference setting as a tool for vetting paper submissions against submission standards. We conduct an experiment at the 2024 Neural Information Processing Systems (NeurIPS) conference, where 234 papers were voluntarily submitted to an "LLM-based Checklist Assistant." This assistant validates whether papers adhere to the author checklist used by NeurIPS, which includes questions to ensure compliance with research and manuscript preparation standards. Evaluation of the assistant by NeurIPS paper authors suggests that the LLM-based assistant was generally helpful in verifying checklist completion. In post-usage surveys, over 70% of authors found the assistant useful, and 70% indicate that they would revise their papers or checklist responses based on its feedback. While causal attribution to the assistant is not definitive, qualitative evidence suggests that the LLM contributed to improving some submissions. Survey responses and analysis of re-submissions indicate that authors made substantive revisions to their submissions in response to specific feedback from the LLM. The experiment also highlights common issues with LLMs: inaccuracy (20/52) and excessive strictness (14/52) were the most frequent issues flagged by authors. We also conduct experiments to understand potential gaming of the system, which reveal that the assistant could be manipulated to enhance scores through fabricated justifications, highlighting potential vulnerabilities of automated review tools.
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- 2024
23. Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems
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McGrath, Jake, Kent, Brian, Johnson, Colin, and Alvarado, José
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Physics - Biological Physics - Abstract
Myosin motors are fundamental biological actuators, powering diverse mechanical tasks in eukaryotic cells via ATP hydrolysis. Recent work revealed that myosin's velocity-dependent detachment rate can bridge actomyosin dynamics to macroscale Hill muscle predictions. However, the influence of this microscale unbinding, which we characterize by a dimensionless parameter $\alpha$, on macroscale energetic flows-such as power consumption, output and efficiency-remains elusive. Here we develop an analytical model of myosin dynamics that relates unbinding rates $\alpha$ to energetics. Our model agrees with published in-vivo muscle data and, furthermore, uncovers a performance-efficiency tradeoff governed by $\alpha$. To experimentally validate the tradeoff, we build HillBot, a robophysical model of Hill's muscle that mimics nonlinearity. Through HillBot, we decouple $\alpha$'s concurrent effect on performance and efficiency, demonstrating that nonlinearity drives efficiency. We compile 136 published measurements of $\alpha$ in muscle and myoblasts to reveal a distribution centered at $\alpha^* = 3.85 \pm 2.32$. Synthesizing data from our model and HillBot, we quantitatively show that $\alpha^*$ corresponds to a class of generalist actuators that are both relatively powerful and efficient, suggesting that the performance-efficiency tradeoff underpins the prevalence of $\alpha^*$ in nature. We leverage these insights and propose a nonlinear variable-impedance protocol to shift along a performance-efficiency axis in robotic applications., Comment: 23 pages, 6 figures. PDF of supplemental information available in zip download
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- 2024
24. Multiwavelength study of 1eRASS J085039.9-421151 with eROSITA NuSTAR and X-shooter
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Zainab, Aafia, Avakyan, Artur, Doroshenko, Victor, Thalhammer, Philipp, Sokolova-Lapa, Ekaterina, Ballhausen, Ralf, Zalot, Nicolas, Stierhof, Jakob, Haemmerich, Steven, Diez, Camille M., Weber, Philipp, Dauser, Thomas, Berger, Katrin, Kretschmar, Peter, Pottschmidt, Katja, Pradhan, Pragati, Islam, Nazma, Maitra, Chandreyee, Coley, Joel B., Blay, Pere, Corbet, Robin H. D., Rothschild, Richard E., Wood, Kent, Santangelo, Andrea, Heber, Ulrich, and Wilms, Joern
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The eROSITA instrument on board Spectrum-Roentgen-Gamma has completed four scans of the X-ray sky, leading to the detection of almost one million X-ray sources in eRASS1 only, including multiple new X-ray binary candidates. We report on analysis of the X-ray binary 1eRASS J085039.9-421151, using a ~55\,ks long NuSTAR observation, following its detection in each eROSITA scan. Analysis of the eROSITA and NuSTAR X-ray spectra in combination with X-shooter data of the optical counterpart provide evidence of an X-ray binary with a red supergiant (RSG) companion, confirming previous results, although we determine a cooler spectral type of M2-3, owing to the presence of TiO bands in the optical and near infrared spectra. The X-ray spectrum is well-described by an absorbed power law with a high energy cutoff typically applied for accreting high mass X-ray binaries. In addition, we detect a strong fluorescent neutral iron line with an equivalent width of ~700\,eV and an absorption edge, the latter indicating strong absorption by a partial covering component. It is unclear if the partial absorber is ionised. There is no significant evidence of a cyclotron resonant scattering feature. We do not detect any pulsations in the NuSTAR lightcurves, possibly on account of a large spin period that goes undetected due to insufficient statistics at low frequencies or potentially large absorption that causes pulsations to be smeared out. Even so, the low persistent luminosity, the spectral parameters observed (photon index, $\Gamma<1.0$), and the minuscule likelihood of detection of RSG-black hole systems, suggest that the compact object is a neutron star., Comment: 17 pages, 11 figures, accepted by A&A
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- 2024
25. Number of musculoskeletal pain sites leads to increased long-term healthcare contacts and healthcare related costs – a Danish population-based cohort study
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S. Mose, P. Kent, A. Smith, J. H. Andersen, and D. H. Christiansen
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Number of pain sites ,Health anxiety ,Healthcare utilization ,Musculoskeletal pain ,Cohort study ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background People with musculoskeletal pain seek more healthcare than the general population, however little is known about the long-term effect on healthcare use. The aim of this study was to examine the consequences of number of musculoskeletal pain sites on long-term care-seeking and healthcare-related costs and explore how health anxiety influences this relationship. Methods We conducted a Danish population-based longitudinal cohort study of 4883 participants combining self-reported survey data from 2008 with ten-year follow-up data from national health registers. Using a causal inference framework, we examined associations between number of pain sites (range 0–7)/level of health anxiety (high/low level) and face-to-face healthcare contacts/healthcare-related costs. Data were analyzed using negative binomial regression with generalized estimating equations. Regression models were adjusted for sex, age, duration of pain, level of education, comorbidity, personality traits, risk of depression, marital status, physical job exposure, and previous healthcare utilization. Results For each additional pain site general healthcare contacts (Incidence Rate Ratio (IRR): 1.04 (95% CI: 1.03–1.05)), healthcare-related costs (IRR: 1.06 (95% CI: 1.03–1.08) and musculoskeletal healthcare contacts (IRR: 1.11 (95% CI:1.09–1.14) increased. Those with high levels of health anxiety at baseline had a slightly higher number of general healthcare contacts (IRR 1.06 (1.01–1.11), independent of number of pain sites. However, level of anxiety did not influence the effect of number of pain sites on any healthcare use or cost outcomes. Conclusions We found evidence for a causal association between increasing number of pain sites and greater healthcare use and cost, and high levels of health anxiety did not increase the strength of this association. This suggests that number of pain sites could be a potential target for biopsychosocial interventions in order to reduce the need for future care-seeking.
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- 2021
- Full Text
- View/download PDF
26. Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies
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Zhang, Daiwei, Gao, Boran, Feng, Qidi, Manichaikul, Ani, Peloso, Gina M, Tracy, Russell P, Durda, Peter, Taylor, Kent D, Liu, Yongmei, Johnson, W Craig, Gabriel, Stacey, Gupta, Namrata, Smith, Joshua D, Aguet, Francois, Ardlie, Kristin G, Blackwell, Thomas W, Gerszten, Robert E, Rich, Stephen S, Rotter, Jerome I, Scott, Laura J, Zhou, Xiang, and Lee, Seunggeun
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Biological Sciences ,Genetics ,Biotechnology ,Human Genome ,Atherosclerosis ,Prevention ,Heart Disease ,Cardiovascular ,2.1 Biological and endogenous factors ,Generic health relevance ,Good Health and Well Being ,Multi-omics ,blood lipids ,proteome-wide association studies ,transcriptome-wide association studies - Abstract
Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most of the causal mechanisms of lipids remain unknown. To better understand the biological processes underlying lipid metabolism, we investigated the associations of plasma protein levels with total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol in blood. We trained protein prediction models based on samples in the Multi-Ethnic Study of Atherosclerosis (MESA) and applied them to conduct proteome-wide association studies (PWASs) for lipids using the Global Lipids Genetics Consortium (GLGC) data. Of the 749 proteins tested, 42 were significantly associated with at least one lipid trait. Furthermore, we performed transcriptome-wide association studies (TWASs) for lipids using 9,714 gene expression prediction models trained on samples from peripheral blood mononuclear cells (PBMCs) in MESA and 49 tissues in the Genotype-Tissue Expression (GTEx) project. We found that although PWASs and TWASs can show different directions of associations in an individual gene, 40 out of 49 tissues showed a positive correlation between PWAS and TWAS signed p values across all the genes, which suggests high-level consistency between proteome-lipid associations and transcriptome-lipid associations.
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- 2025
27. Muscle satellite cells and fibro‐adipogenic progenitors from muscle contractures of children with cerebral palsy have impaired regenerative capacity
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Loomis, Taryn, Kulkarni, Vedant A, Villalba, Marie, Davids, Jon R, Leach, J Kent, and Smith, Lucas R
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Health Sciences ,Sports Science and Exercise ,Cerebral Palsy ,Stem Cell Research ,Pediatric ,Rehabilitation ,Brain Disorders ,Stem Cell Research - Nonembryonic - Non-Human ,Perinatal Period - Conditions Originating in Perinatal Period ,Musculoskeletal ,Humans ,Satellite Cells ,Skeletal Muscle ,Child ,Male ,Contracture ,Female ,Cell Differentiation ,Regeneration ,Muscle ,Skeletal ,Adolescent ,Child ,Preschool ,Stem Cells ,Medical and Health Sciences ,Pediatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
AimTo evaluate the mechanosensitivity of muscle satellite cells (MuSCs) and fibro-adipogenic progenitors (FAPs) in cerebral palsy (CP) and the efficacy of the drug verteporfin in restoring cells' regenerative capacity.MethodMuscle biopsies were collected from six children with CP and six typically developing children. MuSCs and FAPs were isolated and plated on collagen-coated polyacrylamide gels at stiffnesses of 0.2 kPa, 8 kPa, and 25 kPa. Cells were treated with verteporfin to block mechanosensing or with dimethyl sulfoxide as a negative control. MuSC differentiation and FAP activation into myofibroblasts were measured using immunofluorescence staining.ResultsSurprisingly, MuSC differentiation was not affected by stiffness; however, stiff substrates resulted in large myonuclear clustering. Across all stiffnesses, MuSCs from children with CP had less differentiation than those of their typically developing counterparts. FAP activation into myofibroblasts was significantly higher in children with CP than their typically developing peers, but was not affected by stiffness. Verteporfin did not affect differentiation or activation in either cell population, but slightly decreased myonuclear clustering on stiff substrates.InterpretationCells from children with CP were less regenerative and more fibrotic compared to those of their typically developing counterparts, with MuSCs being sensitive to increases in stiffness. Therefore, the mechanosensitivity of MuSCs and FAPs may represent a new target to improve differentiation and activation in CP muscle.
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- 2025
28. Toward decolonized fiscal relationships between universities and community organizations: lessons learned from the California community engagement alliance against COVID-19
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Burke, Nancy J, Espinosa, Patricia Rodriguez, Corchado, Claudia C, Vázquez, Evelyn, Rosas, Lisa G, Wooe, Kent J, LeSarre, Monique, Gallegos-Castillo, Angela, Cheney, Ann, Lo, David D, Hintz, Rachel, Vassar, Stefanie D, and Brown, Arleen F
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Health Services and Systems ,Health Sciences ,Good Health and Well Being ,Community-based participatory research ,community engaged research ,COVID-19 ,fiscal relationships ,equity ,Public Health and Health Services ,Sociology ,Public Health ,Public health ,Anthropology - Published
- 2024
29. The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system
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Agca, Yuksel, Amos-Landgraf, James, Araiza, Renee, Brennan, Jennifer, Carlson, Charisse, Ciavatta, Dominic, Clary, Dave, Franklin, Craig, Korf, Ian, Lutz, Cathleen, Magnuson, Terry, de Villena, Fernando Pardo-Manuel, Mirochnitchenko, Oleg, Patel, Samit, Port, Dan, Reinholdt, Laura, and Lloyd, KC Kent
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Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,2.6 Resources and infrastructure (aetiology) ,Good Health and Well Being ,Animals ,Mice ,United States ,Cryopreservation ,Humans ,Mice ,Mutant Strains ,Disease Models ,Animal ,Biomedical Research ,National Institutes of Health (U.S.) ,Mouse ,Repository ,Phenotyping ,Disease model ,Genetics & Heredity - Abstract
Now in its 25th year, the Mutant Mouse Resource and Research Center (MMRRC) consortium continues to serve the United States and international biomedical scientific community as a public repository and distribution archive of laboratory mouse models of human disease for research. Supported by the National Institutes of Health (NIH), the MMRRC consists of 4 regionally distributed and dedicated vivaria, offices, and specialized laboratory facilities and an Informatics Coordination and Service Center (ICSC). The overarching purpose of the MMRRC is to facilitate groundbreaking biomedical research by offering an extensive repertoire of mutant mice that are essential for advancing the understanding of human physiology and disease. The function of the MMRRC is to identify, acquire, evaluate, characterize, cryopreserve, and distribute mutant mouse strains to qualified biomedical investigators around the nation and the globe. Mouse strains accepted from the research community are held to the highest scientific standards to optimize reproducibility and enhance scientific rigor and transparency. All submitted strains are thoroughly reviewed, documented, and validated using extensive scientific quality control measures. In addition, the MMRRC conducts resource-related research on cryopreservation, mouse genetics, environmental conditions, and other topics that enhance operations of the MMRRC. Today, the MMRRC maintains an archive of mice, cryopreserved embryos and sperm, embryonic stem (ES) cell lines, and murine hybridomas for nearly 65,000 alleles. Since its inception, the MMRRC has fulfilled more than 20,000 orders from 13,651 scientists at 8441 institutions worldwide. The MMRRC also provides numerous services to assist researchers, including scientific consultation, technical assistance, genetic assays, microbiome analysis, analytical phenotyping, pathology, cryorecovery, husbandry, breeding and colony management, infectious disease surveillance, and disease modeling. The ICSC coordinates MMRRC operations, interacts with researchers, and manages the website (mmrrc.org) and online catalogue. Researchers benefit from an expansive list of well-defined mouse models of disease that meet the highest scientific standards while submitting investigators benefit by having their mouse strains cryopreserved, protected, and distributed in compliance with NIH policies.
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- 2024
30. Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome
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Lloyd, KC Kent
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Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Rare Diseases ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Generic health relevance ,Good Health and Well Being ,Animals ,Mice ,Phenotype ,Genome ,Humans ,Mice ,Knockout ,Molecular Sequence Annotation ,Mammals ,Genetics & Heredity - Abstract
The International Mouse Phenotyping Consortium (IMPC) is a worldwide effort producing and phenotyping knockout mouse lines to expose the pathophysiological roles of all genes in human diseases and make mice and data available and accessible to the global research community. It has created new knowledge on the function of thousands of genes for which little to anything was known. This new knowledge has informed the genetic basis of rare diseases, posited gene product influences on common diseases, influenced research on targeted therapies, revealed functional pleiotropy, essentiality, and sexual dimorphism, and many more insights into the role of genes in health and disease. Its scientific contributions have been many and widespread, however there remain thousands of "dark" genes yet to be illuminated. Nearing the end of its current funding cycle, IMPC is at a crossroads. The vision forward is clear, the path to proceed less so.
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- 2024
31. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity
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Laughlin, Maren, McIndoe, Richard, Adams, Sean H, Araiza, Renee, Ayala, Julio E, Kennedy, Lucy, Lanoue, Louise, Lantier, Louise, Macy, James, Malabanan, Eann, McGuinness, Owen P, Perry, Rachel, Port, Daniel, Qi, Nathan, Elias, Carol F, Shulman, Gerald I, Wasserman, David H, and Lloyd, KC Kent
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Biological Sciences ,Genetics ,Diabetes ,Obesity ,Nutrition ,Behavioral and Social Science ,Metabolic and endocrine ,Good Health and Well Being ,Animals ,Mice ,United States ,Disease Models ,Animal ,Phenotype ,National Institutes of Health (U.S.) ,Diabetes Mellitus ,National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) ,Metabolism ,Mouse ,Phenotyping ,In vivo ,Resource ,Service ,Tests ,Genetics & Heredity - Abstract
The Mouse Metabolic Phenotyping Center (MMPC)Live Program was established in 2023 by the National Institute for Diabetes, Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high quality phenotyping services for mouse models of diabetes and obesity. Emerging as the next iteration of the MMPC Program which served the biomedical research community for 20 years (2001-2021), MMPCLive is designed as an outwardly-facing consortium of service cores that collaborate to provide reduced-cost consultation and metabolic, physiologic, and behavioral phenotyping tests on live mice for U.S. biomedical researchers. Four MMPCLive Centers located at universities around the country perform complex and often unique procedures in vivo on a fee for service basis, typically on mice shipped from the client or directly from a repository or vendor. Current areas of expertise include energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics. Additionally, an opportunity arose to reduce barriers to access and expand the diversity of the biomedical research workforce by establishing the VIBRANT Program. Directed at researchers historically underrepresented in the biomedical sciences, VIBRANT-eligible investigators have access to testing services, travel and career development awards, expert advice and experimental design consultation, and short internships to learn test technologies. Data derived from experiments run by the Centers belongs to the researchers submitting mice for testing which can be made publicly available and accessible from the MMPCLive database following publication. In addition to services, MMPCLive staff provide expertise and advice to researchers, develop and refine test protocols, engage in outreach activities, publish scientific and technical papers, and conduct educational workshops and training sessions to aid researchers in unraveling the heterogeneity of diabetes and obesity.
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- 2024
32. Roadmap on methods and software for electronic structure based simulations in chemistry and materials
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Blum, Volker, Asahi, Ryoji, Autschbach, Jochen, Bannwarth, Christoph, Bihlmayer, Gustav, Blügel, Stefan, Burns, Lori A, Crawford, T Daniel, Dawson, William, de Jong, Wibe Albert, Draxl, Claudia, Filippi, Claudia, Genovese, Luigi, Giannozzi, Paolo, Govind, Niranjan, Hammes-Schiffer, Sharon, Hammond, Jeff R, Hourahine, Benjamin, Jain, Anubhav, Kanai, Yosuke, Kent, Paul RC, Larsen, Ask Hjorth, Lehtola, Susi, Li, Xiaosong, Lindh, Roland, Maeda, Satoshi, Makri, Nancy, Moussa, Jonathan, Nakajima, Takahito, Nash, Jessica A, Oliveira, Micael JT, Patel, Pansy D, Pizzi, Giovanni, Pourtois, Geoffrey, Pritchard, Benjamin P, Rabani, Eran, Reiher, Markus, Reining, Lucia, Ren, Xinguo, Rossi, Mariana, Schlegel, H Bernhard, Seriani, Nicola, Slipchenko, Lyudmila V, Thom, Alexander, Valeev, Edward F, Van Troeye, Benoit, Visscher, Lucas, Vlček, Vojtěch, Werner, Hans-Joachim, Williams-Young, David B, and Windus, Theresa L
- Subjects
Information and Computing Sciences ,Software Engineering - Abstract
This Roadmap article provides a succinct, comprehensive overview of the state of electronic structure (ES) methods and software for molecular and materials simulations. Seventeen distinct sections collect insights by 51 leading scientists in the field. Each contribution addresses the status of a particular area, as well as current challenges and anticipated future advances, with a particular eye towards software related aspects and providing key references for further reading. Foundational sections cover density functional theory and its implementation in real-world simulation frameworks, Green’s function based many-body perturbation theory, wave-function based and stochastic ES approaches, relativistic effects and semiempirical ES theory approaches. Subsequent sections cover nuclear quantum effects, real-time propagation of the ES, challenges for computational spectroscopy simulations, and exploration of complex potential energy surfaces. The final sections summarize practical aspects, including computational workflows for complex simulation tasks, the impact of current and future high-performance computing architectures, software engineering practices, education and training to maintain and broaden the community, as well as the status of and needs for ES based modeling from the vantage point of industry environments. Overall, the field of ES software and method development continues to unlock immense opportunities for future scientific discovery, based on the growing ability of computations to reveal complex phenomena, processes and properties that are determined by the make-up of matter at the atomic scale, with high precision.
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- 2024
33. A modular platform for bioluminescent RNA tracking.
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Halbers, Lila, Cole, Kyle, Ng, Kevin, Fuller, Erin, Chan, Christelle, Callicoatte, Chelsea, Metcalfe, Mariajose, Chen, Claire, Barhoosh, Ahfnan, Reid-McLaughlin, Edison, Kent, Alexandra, Torrey, Zachary, Steward, Oswald, Lupták, Andrej, and Prescher, Jennifer
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Animals ,Humans ,RNA ,Luminescent Measurements ,Luciferases ,Mice - Abstract
A complete understanding of RNA biology requires methods for tracking transcripts in vivo. Common strategies rely on fluorogenic probes that are limited in sensitivity, dynamic range, and depth of interrogation, owing to their need for excitation light and tissue autofluorescence. To overcome these challenges, we report a bioluminescent platform for serial imaging of RNAs. The RNA tags are engineered to recruit light-emitting luciferase fragments (termed RNA lanterns) upon transcription. Robust photon production is observed for RNA targets both in cells and in live animals. Importantly, only a single copy of the tag is necessary for sensitive detection, in sharp contrast to fluorescent platforms requiring multiple repeats. Overall, this work provides a foundational platform for visualizing RNA dynamics from the micro to the macro scale.
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- 2024
34. FAP20 is required for flagellum assembly in Trypanosoma brucei.
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Shimogawa, Michelle, Jonnalagadda, Keya, and Hill, Kent
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Trypanosoma brucei brucei ,Flagella ,Protozoan Proteins ,Axoneme ,Microtubules - Abstract
Trypanosoma brucei is a human and animal pathogen that depends on flagellar motility for transmission and infection. The trypanosome flagellum is built around a canonical 9+2 axoneme, containing nine doublet microtubules (DMTs) surrounding two singlet microtubules. Each DMT contains a 13-protofilament A-tubule and a 10-protofilament B-tubule, connected to the A-tubule by a conserved, non-tubulin inner junction (IJ) filament made up of alternating PACRG and FAP20 subunits. Here we investigate FAP20 in procyclic form T. brucei. A FAP20-NeonGreen fusion protein localized to the axoneme as expected. Surprisingly, FAP20 knockdown led to a catastrophic failure in flagellum assembly and concomitant lethality. This differs from other organisms, where FAP20 is required for normal flagellum motility, but generally dispensable for flagellum assembly and viability. Transmission electron microscopy demonstrates failed flagellum assembly in FAP20 mutants is associated with a range of DMT defects and defective assembly of the paraflagellar rod, a lineage-specific flagellum filament that attaches to DMT 4-7 in trypanosomes. Our studies reveal a lineage-specific requirement for FAP20 in trypanosomes, offering insight into adaptations for flagellum stability and motility in these parasites and highlighting pathogen versus host differences that might be considered for therapeutic intervention in trypanosome diseases.
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- 2024
35. Optical Lens Attack on Monocular Depth Estimation for Autonomous Driving
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Zhou, Ce, Yan, Qiben, Kent, Daniel, Wang, Guangjing, Ding, Weikang, Zhang, Ziqi, and Radha, Hayder
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Cryptography and Security - Abstract
Monocular Depth Estimation (MDE) is a pivotal component of vision-based Autonomous Driving (AD) systems, enabling vehicles to estimate the depth of surrounding objects using a single camera image. This estimation guides essential driving decisions, such as braking before an obstacle or changing lanes to avoid collisions. In this paper, we explore vulnerabilities of MDE algorithms in AD systems, presenting LensAttack, a novel physical attack that strategically places optical lenses on the camera of an autonomous vehicle to manipulate the perceived object depths. LensAttack encompasses two attack formats: concave lens attack and convex lens attack, each utilizing different optical lenses to induce false depth perception. We first develop a mathematical model that outlines the parameters of the attack, followed by simulations and real-world evaluations to assess its efficacy on state-of-the-art MDE models. Additionally, we adopt an attack optimization method to further enhance the attack success rate by optimizing the attack focal length. To better evaluate the implications of LensAttack on AD, we conduct comprehensive end-to-end system simulations using the CARLA platform. The results reveal that LensAttack can significantly disrupt the depth estimation processes in AD systems, posing a serious threat to their reliability and safety. Finally, we discuss some potential defense methods to mitigate the effects of the proposed attack., Comment: 28 pages. arXiv admin note: substantial text overlap with arXiv:2409.17376
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- 2024
36. A Toffoli Gadget for Magnetic Tunnel Junctions Boltzmann Machines
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Chen, Dairong, Wyporek, Augustin Couton, Chailloleau, Pierre, Valli, Ahmed Sidi El, Morone, Flaviano, Mangin, Stephane, Sun, Jonathan Z., Sels, Dries, and Kent, Andrew D.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Applied Physics - Abstract
Magnetic Tunnel Junctions (MTJs) are of great interest for non-conventional computing applications. The Toffoli gate is a universal reversible logic gate, enabling the construction of arbitrary boolean circuits. Here, we present a proof-of-concept construction of a gadget which encodes the Toffoli gate's truth table into the ground state of coupled uniaxial nanomagnets that could form the free layers of perpendicularly magnetized MTJs. This construction has three input bits, three output bits, and one ancilla bit. We numerically simulate the seven macrospins evolving under the stochastic Landau-Lifshitz-Gilbert (s-LLG) equation. We investigate the effect of the anisotropy-to-exchange-coupling strength ratio $H_A/H_\text{ex}$ on the working of the gadget. We find that for $H_A/H_\text{ex} \lesssim 0.93$, the spins evolve to the Toffoli gate truth table configurations under LLG dynamics alone, while higher $H_A/H_\text{ex}$ ratios require thermal annealing due to suboptimal metastable states. Under our chosen annealing procedure, the s-LLG simulation with thermal annealing achieves a 100% success rate up to $H_A/H_\text{ex}\simeq3.0$. The feasibility of constructing MTJ-free-layer-based Toffoli gates highlights their potential in designing new types of MTJ-based circuits.
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- 2024
37. Time Slicing of Neutrino Fluxes in Oscillation Experiments at Fermilab
- Author
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Ganguly, Sudeshna, Yonehara, Katsuya, Bhat, Chandrashekhara M, Triplett, A. Kent, Ainsworth, Robert, Hinds, Clara, and Abdelhamid, Maan
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Physics - Accelerator Physics - Abstract
Long and short baseline neutrino oscillation experiments, such as DUNE, ANNIE, SBND, demand high precision in reducing systematic errors, particularly those related to neutrino-nucleus interaction cross-sections. The stroboscopic approach offers a method to capture distinct neutrino energy spectra, aiding in the separation of flux and cross-section uncertainties. This report outlines the creation of short proton bunch lengths and the transport of a narrow beam down the Booster Neutrino Beamline, essential steps for the successful implementation of the stroboscopic approach.
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- 2024
38. Coronagraph-based wavefront sensors for the high Strehl regime
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Chambouleyron, Vincent, Wallace, J. Kent, Jensen-Clem, Rebecca, and Macintosh, Bruce
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
A crucial component of the high-contrast instrumental chain in astronomy is the wavefront sensor (WFS). A key property of this component is its sensitivities, which reflect its ability to efficiently use incoming photons to encode the phase aberrations. This paper introduces a new class of highly sensitive wavefront sensors that approach the fundamental sensitivity limits dictated by physics. Assuming a high Strehl regime, we define what linear operator is describing the ideal WFS that would achieve maximum sensitivity. We then show that there is a substantial similarity between this ideal WFS and the second-order ideal coronagraph. Leveraging the exhibited link between ideal wavefront sensing and coronagraphy, we propose a novel WFS concept based on high-performance coronagraphic architecture : the bivortex WFS. This sensor employs charge-2 vortex masks. Simulations for an ideal system demonstrate that this sensor achieves unprecedented sensitivity, even surpassing the highly sensitive Zernike WFS class (especially for low spatial frequencies), while paving the way for new high-contrast architectures integrating simultaneous sensing and coronagraphy.
- Published
- 2024
39. Subversive Characters and Stereotyping Readers: Characterizing Queer Relationalities with Dialogue-Based Relation Extraction
- Author
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Chang, Kent K., Ho, Anna, and Bamman, David
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Computer Science - Computation and Language - Abstract
Television is often seen as a site for subcultural identification and subversive fantasy, including in queer cultures. How might we measure subversion, or the degree to which the depiction of social relationship between a dyad (e.g. two characters who are colleagues) deviates from its typical representation on TV? To explore this question, we introduce the task of stereotypic relationship extraction. Built on cognitive stylistics, linguistic anthropology, and dialogue relation extraction, in this paper, we attempt to model the cognitive process of stereotyping TV characters in dialogic interactions. Given a dyad, we want to predict: what social relationship do the speakers exhibit through their words? Subversion is then characterized by the discrepancy between the distribution of the model's predictions and the ground truth labels. To demonstrate the usefulness of this task and gesture at a methodological intervention, we enclose four case studies to characterize the representation of queer relationalities in the Big Bang Theory, Frasier, and Gilmore Girls, as we explore the suspicious and reparative modes of reading with our computational methods., Comment: CHR 2024: Computational Humanities Research Conference
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- 2024
40. On Classification with Large Language Models in Cultural Analytics
- Author
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Bamman, David, Chang, Kent K., Lucy, Li, and Zhou, Naitian
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Computer Science - Computation and Language ,Computer Science - Computers and Society - Abstract
In this work, we survey the way in which classification is used as a sensemaking practice in cultural analytics, and assess where large language models can fit into this landscape. We identify ten tasks supported by publicly available datasets on which we empirically assess the performance of LLMs compared to traditional supervised methods, and explore the ways in which LLMs can be employed for sensemaking goals beyond mere accuracy. We find that prompt-based LLMs are competitive with traditional supervised models for established tasks, but perform less well on de novo tasks. In addition, LLMs can assist sensemaking by acting as an intermediary input to formal theory testing.
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- 2024
41. Some Artin-Schelter Regular Algebras From Dual Reflection Groups and their Geometry
- Author
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Goetz, Peter, Kirkman, Ellen E., Moore, W. Frank, and Vashaw, Kent B.
- Subjects
Mathematics - Rings and Algebras ,Mathematics - Quantum Algebra ,16S38, 16W22, 16T05, 16E65, 16S37, 16W50 - Abstract
Let $G$ be a group coacting on an Artin-Schelter regular algebra $A$ homogeneously and inner-faithfully. When the identity component $A_e$ is also Artin-Schelter regular, providing a generalization of the Shephard-Todd-Chevalley Theorem, we say that $G$ is a dual reflection group for $A$. We give two examples of dual reflection groups of order 16, and study algebraic and geometric properties of three associated Artin-Schelter regular algebras of dimension four., Comment: Comments welcome
- Published
- 2024
42. Improved Analytic Love-C Relations for Neutron Stars
- Author
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Lowrey, Tristen, Yagi, Kent, and Yunes, Nicolás
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Precise measurements of neutron star observables (such as mass and radius) allow one to constrain the equations of state for supranuclear matter and develop a stronger understanding of nuclear physics. The Neutron star Interior Composition ExploreR (NICER) tracks X-ray hotspots on rotating NSs and is able to infer precise information about the compactness of the star. Gravitational waves carry information about the tidal deformability (related to the tidal Love number) of neutron stars, which has been measured by the LIGO/Virgo/KAGRA collaboration. These two observables enjoy an approximately universal property between each other that is insensitive to the equations of state (the "universal Love-C relation"). In this paper, we focus on deriving two analytic expressions for the Love-C relations that are ready-to-use and improve upon previous analytic expressions. The first model is inspired by a Newtonian polytrope, whose perturbation to the gravitational potential can be found analytically. We extend this Newtonian model to the relativistic regime by providing a quadratic fit to the gravitational potential perturbation against stellar compactness. The second model makes use of the Tolman VII model and adopts a spectral expansion with Chebyshev polynomials, which converges faster than the Taylor expansions used in previous work. We find that the first model provides a more accurate description of the Love-C relation for realistic neutron stars than the second model, and it provides the best expression among all other analytic relations studied here in terms of describing the averaged numerical Love-C relation. These new models are not only useful in practice, but they also show the power and importance of analytic modeling of neutron stars., Comment: 11 pages, 9 figures
- Published
- 2024
43. U-net based prediction of cerebrospinal fluid distribution and ventricular reflux grading
- Author
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Rieff, Melanie, Holzberger, Fabian, Lapina, Oksana, Ringstad, Geir, Valnes, Lars Magnus, Warsza, Bogna, Mardal, Kent-Andre, Eide, Per Kristian, and Wohlmuth, Barbara
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Previous work shows evidence that cerebrospinal fluid (CSF) plays a crucial role in brain waste clearance processes, and that altered flow patterns are associated with various diseases of the central nervous system. In this study, we investigate the potential of deep learning to predict the distribution in human brain of a gadolinium-based CSF contrast agent (tracer) administered intrathecal. For this, T1-weighted magnetic resonance imaging (MRI) scans taken at multiple time points before and after intrathecal injection were utilized. We propose a U-net-based supervised learning model to predict pixel-wise signal increases at their peak after 24 hours. Its performance is evaluated based on different tracer distribution stages provided during training, including predictions from baseline scans taken before injection. Our findings indicate that using imaging data from just the first two hours post-injection for training yields tracer flow predictions comparable to those trained with additional later-stage scans. The model was further validated by comparing ventricular reflux gradings provided by neuroradiologists, and inter-rater grading among medical experts and the model showed excellent agreement. Our results demonstrate the potential of deep learning-based methods for CSF flow prediction, suggesting that fewer MRI scans could be sufficient for clinical analysis, which might significantly improve clinical efficiency, patient well-being, and lower healthcare costs., Comment: 13 pages, 7 figures
- Published
- 2024
44. The Last Loophole in Bell's Theorem? A prima facie problem with superdeterminism
- Author
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Peacock, Kent A.
- Subjects
Physics - General Physics - Abstract
Hance and Hossenfelder recently claim that the extensive experimental confirmations of Bell's Theorem do not in fact demonstrate that nature is nonlocal, but merely that nature can be local only if the distant detector settings in a Bell-EPR setup are not statistically independent. They suggest that such interdependence could take a local-deterministic form. There is no question that in general quantum mechanics not only allows but demands that the distant detectors be entangled and thus correlated, even though it is possible to do experiments in which such correlations can be ignored. The real question is whether entanglement itself could have a deterministic explanation. We review why any such attempted deterministic underpinning for quantum statistics would run into immediate conflict with quantum indeterminacy and the noncommutativity upon which the latter is based. Some cosmological implications are briefly explored.
- Published
- 2024
45. Tidal response beyond vacuum General Relativity with a canonical definition
- Author
-
Katagiri, Takuya, Cardoso, Vitor, Ikeda, Tact, and Yagi, Kent
- Subjects
General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
Tidal effects on compact objects provide profound theoretical insights into the structure of the field equations, and are wonderful probes of the equation of state of matter, the nature of black holes and of the underlying theory of gravity. The natural framework for understanding tides is a perturbative scheme. Here, we point out ambiguities in determining tidal response functions within such a framework, which may lead to bias in constraining physical parameters with gravitational-wave observations if the computed quantities are not properly linked to observables. We propose a Canonical Tidal Response Function (CTRF) definition to compare values of tides in theories beyond vacuum General Relativity in a unified manner. As an example, we provide black hole tidal response functions, including both conservative and dissipative pieces, in various theories of gravity. Tidal dissipation Love numbers for black holes are derived here for the first time in most of the non-Einsteinian theories considered in this paper., Comment: 24 pages
- Published
- 2024
46. Formal extension of noncommutative tensor-triangular support varieties
- Author
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Cai, Merrick and Vashaw, Kent B.
- Subjects
Mathematics - Category Theory ,Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,Mathematics - Representation Theory ,18G65, 18G80, 18M05 - Abstract
Given a support variety theory defined on the compact part of a monoidal triangulated category, we define an extension to the non-compact part following the blueprint of Benson--Carlson--Rickard, Benson--Iyengar--Krause, Balmer--Favi, and Stevenson. We generalize important aspects of the theory of extended support varieties to the noncommutative case, and give characterizations of when an extended support theory detects the zero object, under certain assumptions. In particular, we show that when the original support variety theory is based on a Noetherian topological space, detects the zero object, satisfies a generalized tensor product property, and comes equipped with a comparison map, then the extended support variety also detects the zero object. In the case of stable categories of finite tensor categories, this gives conditions under which the central cohomological support admits an extension that detects the zero object, confirming part of a recent conjecture made by the second author together with Nakano and Yakimov., Comment: 27 pages
- Published
- 2024
47. On relativistic dynamical tides: subtleties and calibration
- Author
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Katagiri, Takuya, Yagi, Kent, and Cardoso, Vitor
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The response of astrophysical compact objects to external tidal fields carries valuable information on the nature of these objects, on the equation of state of matter, and on the underlying gravitational theory. In this work, we highlight subtleties in describing relativistic dynamical tidal responses that arise from ambiguities in the decomposition of a perturbed metric into external tidal and induced response pieces. Observables are unambiguous. However in practice, differences arising from implicit assumptions in the definition of tidal deformabilities may lead to a bias in constraining nuclear physics or gravitational theories, if not properly tied to observational data. We propose calibration of a tidal response function for any compact objects in vacuum General Relativity. Within this framework, the dynamical tidal Love numbers of a Schwarzschild black hole in both even and odd sectors vanish at any multipole order. The calibration allows one to define dynamical tidal deformabilities of relativistic stars, such as neutron stars, as the difference from the BH values (zero) under the unified definition in a simple manner. As a straightforward extension of our framework, we compute the next-to-leading dissipative tidal response of Schwarzschild black holes for the first time., Comment: 22 pages
- Published
- 2024
48. Astrophysical systematics on testing general relativity with gravitational waves from galactic double white dwarfs
- Author
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Lau, Shu Yan, Yagi, Kent, and Arras, Phil
- Subjects
General Relativity and Quantum Cosmology - Abstract
Gravitational waves have been shown to provide new constraints on gravitational theories beyond general relativity (GR), especially in the strong field regime. Gravitational wave signals from galactic double white dwarfs, expected to be detected by the Laser Interferometer Space Antenna (LISA), also have the potential to place stringent bounds on certain theories that give rise to relatively large deviations from GR in less compact binaries, such as through scalar radiation. Nevertheless, the orbital evolution of close double white dwarf systems is also affected by various astrophysical effects, such as stellar rotation, tidal interactions, and magnetic interactions, which add complexity to the gravity tests. In this work, we employ the parametrized post-Einsteinian model to capture the leading beyond-GR effect on the signal and estimate the measurement uncertainties using the Fisher information matrix. We then study the systematic error caused by ignoring each astrophysical effect mentioned above on the parameter estimation. Our numerical results show that, to place bounds on the non-GR effects comparable to existing bounds from pulsar observations, tight priors on the mass of the binary and long observation time are required. At this level of sensitivity, we found that systematic errors from the astrophysical effects dominate statistical errors. The most significant effects investigated here are torques from tidal synchronization and magnetic unipolar induction for sufficiently large magnetic fields ($>10^7$G). Meanwhile, even the weaker astrophysical effects from quadrupolar deformations are of a similar order of magnitude as the statistical uncertainty, and hence cannot be ignored in the waveform model. We conclude that the astrophysical effects must be carefully accounted for in the parameter estimation to test gravity with galactic double white dwarfs detected by LISA., Comment: 14 pages, 8 figures, submitted to PRD
- Published
- 2024
49. Optical Lens Attack on Deep Learning Based Monocular Depth Estimation
- Author
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Zhou, Ce, Yan, Qiben, Kent, Daniel, Wang, Guangjing, Zhang, Ziqi, and Radha, Hayder
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Monocular Depth Estimation (MDE) plays a crucial role in vision-based Autonomous Driving (AD) systems. It utilizes a single-camera image to determine the depth of objects, facilitating driving decisions such as braking a few meters in front of a detected obstacle or changing lanes to avoid collision. In this paper, we investigate the security risks associated with monocular vision-based depth estimation algorithms utilized by AD systems. By exploiting the vulnerabilities of MDE and the principles of optical lenses, we introduce LensAttack, a physical attack that involves strategically placing optical lenses on the camera of an autonomous vehicle to manipulate the perceived object depths. LensAttack encompasses two attack formats: concave lens attack and convex lens attack, each utilizing different optical lenses to induce false depth perception. We begin by constructing a mathematical model of our attack, incorporating various attack parameters. Subsequently, we simulate the attack and evaluate its real-world performance in driving scenarios to demonstrate its effect on state-of-the-art MDE models. The results highlight the significant impact of LensAttack on the accuracy of depth estimation in AD systems., Comment: 26 pages, 13 figures, SecureComm 2024
- Published
- 2024
50. Calibration Measurements of the BICEP3 and BICEP Array CMB Polarimeters from 2017 to 2024
- Author
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Giannakopoulos, Christos, Vergès, Clara, Ade, P. A. R., Ahmed, Zeeshan, Amiri, Mandana, Barkats, Denis, Thakur, Ritoban Basu, Bischoff, Colin A., Beck, Dominic, Bock, James J., Boenish, Hans, Buza, Victor, Cheshire IV, James R., Connors, Jake, Cornelison, James, Crumrine, Michael, Cukierman, Ari Jozef, Denison, Edward, Dierickx, Marion, Duband, Lionel, Eiben, Miranda, Elwood, Brodi D., Fatigoni, Sofia, Filippini, Jeff P., Fortes, Antonio, Gao, Min, Goeckner-Wald, Neil, Goldfinger, David C., Grayson, James A., Grimes, Paul K., Hall, Grantland, Halal, George, Halpern, Mark, Hand, Emma, Harrison, Sam A., Henderson, Shawn, Hubmayr, Johannes, Hui, Howard, Irwin, Kent D., Kang, Jae Hwan, Karkare, Kirit S., Kefeli, Sinan, Kovac, J. M., Kuo, Chao-Lin, Lau, King, Lautzenhiser, Margaret, Lennox, Amber, Liu, Tongtian, Megerian, Koko G., Miller, Oliver, Minutolo, Lorenzo, Moncelsi, Lorenzo, Nakato, Yuka, Nguyen, H. T., O'brient, Roger, Patel, Anika, Petroff, Matthew A., Polish, Anna R., Precup, Nathan, Prouve, Thomas, Pryke, Clement, Reintsema, Carl D., Romand, Thibault, Salatino, Maria, Schillaci, Alessandro, Schmitt, Benjamin, Singari, Baibhav, Soliman, Ahmed, Germaine, Tyler St, Steiger, Aaron, Steinbach, Bryan, Sudiwala, Rashmi, Thompson, Keith L., Tsai, Calvin, Tucker, Carole, Turner, Anthony D., Vieregg, Abigail G., Wandui, Albert, Weber, Alexis C., Willmert, Justin, Wu, Wai Ling K., Yang, Hung-I, Yu, Cyndia, Zeng, Lingzhen, Zhang, Cheng, and Zhang, Silvia
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The BICEP3 and BICEP Array polarimeters are small-aperture refracting telescopes located at the South Pole designed to measure primordial gravitational wave signatures in the Cosmic Microwave Background (CMB) polarization, predicted by inflation. Constraining the inflationary signal requires not only excellent sensitivity, but also careful control of instrumental systematics. Both instruments use antenna-coupled orthogonally polarized detector pairs, and the polarized sky signal is reconstructed by taking the difference in each detector pair. As a result, the differential response between detectors within a pair becomes an important systematic effect we must control. Additionally, mapping the intensity and polarization response in regions away from the main beam can inform how sidelobe levels affect CMB measurements. Extensive calibration measurements are taken in situ every austral summer for control of instrumental systematics and instrument characterisation. In this work, we detail the set of beam calibration measurements that we conduct on the BICEP receivers, from deep measurements of main beam response to polarized beam response and sidelobe mapping. We discuss the impact of these measurements for instrumental systematics studies and design choices for future CMB receivers., Comment: 13 pages, 7 figures, 1 table, Proceedings paper SPIE 2024
- Published
- 2024
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