Search

Your search keyword '"P. Romanski"' showing total 198 results
Start Over Author "P. Romanski"
198 results on '"P. Romanski"'

1. An Approach to Systematic Data Acquisition and Data-Driven Simulation for the Safety Testing of Automated Driving Functions

Author

Eisemann, Leon, Fehling-Kaschek, Mirjam, Gommel, Henrik, Hermann, David, Klemp, Marvin, Lauer, Martin, Lickert, Benjamin, Luettner, Florian, Moss, Robin, Neis, Nicole, Pohle, Maria, Romanski, Simon, Stadler, Daniel, Stolz, Alexander, Ziehn, Jens, and Zhou, Jingxing

Subjects
Computer Science - Robotics, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Human-Computer Interaction, Computer Science - Machine Learning
Abstract

With growing complexity and criticality of automated driving functions in road traffic and their operational design domains (ODD), there is increasing demand for covering significant proportions of development, validation, and verification in virtual environments and through simulation models. If, however, simulations are meant not only to augment real-world experiments, but to replace them, quantitative approaches are required that measure to what degree and under which preconditions simulation models adequately represent reality, and thus, using their results accordingly. Especially in R&D areas related to the safety impact of the "open world", there is a significant shortage of real-world data to parameterize and/or validate simulations - especially with respect to the behavior of human traffic participants, whom automated driving functions will meet in mixed traffic. We present an approach to systematically acquire data in public traffic by heterogeneous means, transform it into a unified representation, and use it to automatically parameterize traffic behavior models for use in data-driven virtual validation of automated driving functions., Comment: 8 pages, 5 figures

Published
2024
Full Text
View/download PDF

2. Improving Lidar-Based Semantic Segmentation of Top-View Grid Maps by Learning Features in Complementary Representations

Author

Bieder, Frank, Link, Maximilian, Romanski, Simon, Hu, Haohao, and Stiller, Christoph

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

In this paper we introduce a novel way to predict semantic information from sparse, single-shot LiDAR measurements in the context of autonomous driving. In particular, we fuse learned features from complementary representations. The approach is aimed specifically at improving the semantic segmentation of top-view grid maps. Towards this goal the 3D LiDAR point cloud is projected onto two orthogonal 2D representations. For each representation a tailored deep learning architecture is developed to effectively extract semantic information which are fused by a superordinate deep neural network. The contribution of this work is threefold: (1) We examine different stages within the segmentation network for fusion. (2) We quantify the impact of embedding different features. (3) We use the findings of this survey to design a tailored deep neural network architecture leveraging respective advantages of different representations. Our method is evaluated using the SemanticKITTI dataset which provides a point-wise semantic annotation of more than 23.000 LiDAR measurements.

Published
2022

8. The Dynamics of Fragment Formation

Author

Keane, D., Aichelin, J., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Gilkes, M.L., Gossiaux, P.-B., Hauger, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Kintner, J., Lisa, M.A., Matis, H.S., McMahan, M., McParland, C., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P.G., Weerasundara, D., Wieman, H.H., Wolf, K.L., and Elliott, J.B.

Published
2017

10. The pulsed effects of reintroducing wolves on the carnivore community of Isle Royale.

Author

Rodriguez Curras, Mauriel, Romanski, Mark C, and Pauli, Jonathan N

Subjects
RED fox, FOXES, SOCIAL dynamics, CARNIVOROUS animals, WOLVES, NATIONAL parks & reserves
Abstract

Large carnivores are being globally reintroduced with the goal of restoring ecological interactions. However, the extent that competitive interactions are restored within communities is often unclear. In a before–after study within Isle Royale National Park (in the US state of Michigan), we quantified the spatial, behavioral, trophic, and demographic effects of the reintroduction of a large carnivore (gray wolf; Canis lupus) on meso‐carnivores (red fox; Vulpes vulpes) and small carnivores (American marten; Martes americana). The wolf reintroduction produced a phase‐dependent pulse perturbation: wolves constrained the distribution of foxes, thereby benefiting martens, yet foxes altered their behavior, notably using human‐provided resource subsidies (campsites and food) more frequently, which buffered demographic consequences. Once wolf packs coalesced, all observed changes subsided, and competitive interactions returned to their pre‐wolf values. Our results show that some predicted—and often desired—consequences of large carnivore reintroductions may not be permanent due to the transitory dynamics of social carnivores and the presence of humans, even within a "pristine wilderness". [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Reigniting the Transformative Power of Puppets through Narrative Pedagogy, Contemporary Art, and Transdisciplinary Approaches in Art Education

Author

Romanski, Nicole M.

Abstract

It is vital for the art education field to continue defining and redefining its multimodal versatility and malleability in the education of children in this ever-changing organic culture. Marshall (2014) called for art integration to be framed as a transdisciplinary paradigm to meet the current needs of education. This article provides a framework of employing contemporary puppetry as a powerful narrative and transdisciplinary tool in K-12 and adult educational settings. The hybrid nature of puppetry provides many opportunities for the merging of various disciplines, learning styles, and technologies to create contemporary comprehensive learning experiences. In addition, puppetry is a natural bridge to play, imagination, experimentation, storytelling, and collaboration. Puppetry provides multifaceted pedagogical/learning opportunities for (1) narrative pedagogy (Romanski, 2015; Rolling, 2010, 2012; Zander, 2007), (2) transdisciplinary and substantive arts integration (Marshall, 2006, 2014), and (3) a conceptual approach with contemporary art and curriculum built on enduring ideas (Stewart & Walker, 2005). In this article, the author describes a course in which shadow puppetry is investigated and its potential for transformative curriculum approaches is considered, specifically in elementary settings.

Published
2019
Full Text
View/download PDF

20. Lambda Hyperons in 2 A*GeV Ni + Cu Collisions

Author

EOS Collaboration, Justice, M., Albergo, S., Bieser, F., Brady, F. P., Caccia, Z., Cebra, D. A., Chacon, A. D., Chance, J. L., Choi, Y., Costa, S., Elliott, J. B., Gilkes, M. L., Hauger, J. A., Hirsch, A. S., Hjort, E. L., Insolia, A., Keane, D., Kintner, J. C., Lisa, M. A., Liu, H., Matis, H. S., McGrath, R., McMahan, M., McParland, C., Olson, D. L., Partlan, M. D., Porile, N. T., Potenza, R., Rai, G., Rasmussen, J. O., Ritter, H. G., Romanski, J., Romero, J. L., Russo, G. V., Scharenberg, R. P., Scott, A., Shao, Y., Srivastava, B. K., Symons, T. J. M., Tincknell, M., Tuve, C., Wang, S., Warren, P. G., Weerasundara, D., Wieman, H. H., Wienold, T., and Wolf, K.

Subjects
Nuclear Experiment
Abstract

A sample of Lambda's produced in 2 A*GeV Ni + Cu collisions has been obtained with the EOS Time Projection Chamber at the Bevalac. Low background in the invariant mass distribution allows for the unambiguous demonstration of Lambda directed flow. The transverse mass spectrum at mid-rapidity has the characteristic shoulder-arm shape of particles undergoing radial transverse expansion. A linear dependence of Lambda multiplicity on impact parameter is observed, from which a total Lambda + Sigma^0 production cross section of $112 +/- 24 mb is deduced. Detailed comparisons with the ARC and RVUU models are made., Comment: Revised version accepted for publication in Phys. Lett. B

Published
1997
Full Text
View/download PDF

21. The Evolution of Nuclear Multifragmentation in the Temperature-Density Plane

Author

Warren, P. G., Albergo, S., Alexander, J. M., Bieser, F., Brady, F. P., Caccia, Z., Cebra, D. A., Chacon, A. D., Chance, J. L., Choi, Y., Costa, S., Elliott, J. B., Gilkes, M. L., Hauger, J. A., Hirsch, A. S., Hjort, E. L., Insolia, A., Justice, M., Keane, D., Kitner, J. C., Lacey, R., Lauret, J., Lindenstruth, V., Lisa, M. A., Matis, H. S., McGrath, R. L., McMahan, M., McParlan, C., Mueller, W. F. J., Olson, D. L., Partlan, M. D., Porile, N. T., Potenza, R., Rai, G., Rasmussen, J., Ritter, H. G., Romanski, J., Romero, J. L., Russo, G. V., Sann, H., Scharenberg, R. P., Scott, A., Shao, Y., Srivastava, B. K., Symons, T. J. M., Tincknell, M. L., Tuve, C., Wang, S., Wieman, H. H., Wienold, T., and Wolf, K.

Subjects
Nuclear Experiment
Abstract

The mean transverse kinetic energies of the fragments formed in the interaction of 1 A GeV Au+C have been determined. An energy balance argument indicates the presence of a collective energy which increases in magnitude with increasing multiplicity and accounts for nearly half of the measured mean transverse kinetic energy. The radial flow velocity associated with the collective energy yields estimates for the time required to expand to the freeze-out volume. Isentropic trajectories in the temperature-density plane are shown for the expansion and indicate that the system goes through the critical region at the same multiplicities as deduced from a statistical analysis. Here, the expansion time is approximately 70 fm/c.

Published
1996

22. Radial Flow in Au+Au Collisions at E=0.25-1.15 A GeV

Author

Lisa, M. A., Albergo, S., Bieser, F., Brady, F. P., Caccia, Z., Cebra, D. A., Chacon, A. D., Chance, J. L., Choi, Y., Costa, S., Elliott, J. B., Gilkes, M. L., Hauger, J. A., Hirsch, A. S., Hjort, E. L., Insolia, A., Justice, M., Keane, D., Kintner, J., Matis, H. S., McMahan, M., McParland, C., Olson, D. L., Partlan, M. D., Porile, N. T., Potenza, R., Rai, G., Rasmussen, J., Ritter, H. G., Romanski, J., Romero, J. L., Russo, G. V., Scharenberg, R., Scott, A., Shao, Y., Srivastava, B. K., Symons, T. J. M., Tincknell, M., Tuve, C., Wang, S., Warren, P., Westfall, G. D., Wieman, H. H., and Wolf, K.

Subjects
Nuclear Experiment
Abstract

A systematic study of energy spectra for light particles emitted at midrapidity from Au+Au collisions at E=0.25-1.15 A GeV reveals a significant non-thermal component consistent with a collective radial flow. This component is evaluated as a function of bombarding energy and event centrality. Comparisons to Quantum Molecular Dynamics (QMD) and Boltzmann-Uehling-Uhlenbeck (BUU) models are made for different equations of state., Comment: 10 pages of text and 4 figures (all ps files in a uuencoded package).

Published
1995
Full Text
View/download PDF

24. Constructing the phase diagram of finite neutral nuclear matter

Author

Elliott, J.B., Moretto, L.G., Phair, L., Wozniak, G.L., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Gilkes, M.L., Hauger, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Kintner, J.C., Lindenstruth, V., Lisa, M.A., Matis, H.S., McMahan, M., McParland, C., Muller, W.F.J., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J., Ritter, H.G., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M., Tuve, C., Wang, S., Warren, P., Wieman, H.H., Wienold, T., and Wolf, K.

Published
2002

25. The coexistence curve of finite charged nuclear matter

Author

Elliott, J.B., Moretto, L.G., Phair, L., Wozniak, G.J., Beaulieu, L., Breuer, H., Korteling, R.G., Kwiatkowski, K., Lefort, T., Pienkowski, L., Ruangma, A., Viola, V.E., Yennello, S.J., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Gilkes, M.L., Hauger, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Kintner, J.C., Lindenstruth, V., Lisa, M.A., Matis, H.S., McMahan, M., McParland, C., Muller, W.F.J., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J., Ritter, H.G., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M., Tuve, C., Wang, S., Warren, P., Wieman, H.H., Wienold, T., and Wolf, K.

Subjects
Nuclear physics and radiation physics
Published
2001

26. Strange Particle Measurements Strange Particle Measurements from the EOS TPC

Author

Justice, M., Alberto, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D., Chacon, A.D., Chance, J., Choi, Y., Costa, S., Elliott, J., Gilkes, M., Hauger, J., Hirsch, A., Hjort, E., Insolia, A., Keane, D., Kintner, J., Lisa, M., Liu, H., Matis, H.S., McGrath, R., McMahan, M., McParland, C., Olson, D., Partlan, M., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Weerasundara, D., Wieman, H.H., and Wolf, K.

Published
1995

27. Fragment Flow in Au + Au Collisions

Author

Partlan, M.D., Alberto, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D., Chacon, A.D., Chance, J., Choi, Y., Costa, S., Elliott, J.B., Gilkes, M.L., Hauger, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Kintner, J., Lisa, M.A., Matis, H.S., McMahan, M., McParland, C., Olson, D.L., Peilert, G., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Scharenberg, R.P., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P.G., Wieman, H.H., and Wolf, K.

Published
1994

28. Is There Evidence for a Liquid-Gas Phase Transition in Nuclear Matter?

Author

Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Elliott, J.B., Gilkes, M.L., Hauger, J.A., Hjort, E.L., Isolia, A., Justice, M., Keane, D., Kintner, J.C., Lindenstruth, V., Lisa, M.A., Lynen, U., Matis, H.S., McMahan, M., McParland, C., Muller, W.F.J., Olson, D.L., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Wieman, H.H., and Wolf, K.

Published
1994

29. Radial Flow in Au+Au Collisions at E=0.25-1.15 A GeV

Author

Lisa, M.A., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Elliott, J.B., Gilkes, M.L., Huager, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Kintner, J., Matis, H.S., McMahan, M., McParland, C., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Westfall, G.D., Wieman, H.H., and Wolf, K.

Published
1994

30. Flow and Multifragmentation in Nuclear Collisions at Intermediate Energies

Author

Ritter, Hans G., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Elliott, J.B., Gilkes, M.L., Hauger, J.A., Hirsch, A.S., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Kintner, J., Lindenstruth, V., Lisa, M.A., Lynen, U., Matis, H.S., McMahan, M., McParland, C., Mueller, W.F.J., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P.G., Wieman, H.H., and Wolf, K.L.

Published
1994

31. Collective Flow in Au+Au Collisions

Author

Ritter, Hans G., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Elliott, J., Gilkes, M., Hauger, J.A., Hirsch, A., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Lindenstruth, V., Matis, H.S., McMahan, M., McParland, C., Mueller, W.F.J., Oldon, D.L., Partlan, M., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Weerasundara, D., Wieman, H.H., and Wolf, K.L.

Published
1994

32. Heavy Ion Reaction Measurements with EOS TPC (Looking for Central Collisions with Missing Energy)

Author

Wieman, H.H., Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D.A., Chacon, A.D., Chance, J.L., Choi, Y., Costa, S., Elliott, J., Gilkes, M., Hauger, J.A., Hirsch, A., Hjort, E.L., Insolia, A., Justice, M., Keane, D., Lindenstruth, V., Matis, H.S., McMahan, M., McParland, C., Mueller, W.F.J., Olson, D.L., Partlan, M., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Weerasundara, D., and Wolf, K.L.

Published
1994

36. Collective Flow and Azimuthal Correlations in Nucleus-Nucleus Collisions at the Bevalac

Author

Albergo, S., Bieser, F., Brady, F.P., Caccia, Z., Cebra, D., Chacon, A.D., Chance, J., Choi, Y., Costa, S., Elliott, J., Gilkes, M., Hauger, A., Hirsch, A., Hjort, E., Insolia, A., Justice, M., Keane, D., Lindenstruth, V., Matis, H.S., McMahan, M., McParland, C., Muller, W.F.J., Olson, D.L., Partlan, M.D., Porile, N.T., Potenza, R., Rai, G., Rasmussen, J.O., Ritter, Hans G., Romanski, J., Romero, J.L., Russo, G.V., Sann, H., Scharenberg, R.P., Scott, A., Shao, Y., Srivastava, B.K., Symons, T.J.M., Tincknell, M.L., Tuve, C., Wang, S., Warren, P., Wieman, H.H., and Wolf, K.

Published
1993

39. P-588 Evaluation of anti-Müllerian hormone levels as a predictor of pregnancy outcome following intrauterine insemination in infertile women

Author

P Romanski, P Bortoletto, J Malmsten, and S Spandorfer

Subjects
Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Abstract

Study question Is a low anti-Müllerian hormone (AMH) level ( Summary answer Clinical pregnancy, spontaneous abortion, and ongoing pregnancy rates are comparable between patients with AMH levels What is known already Before ovarian stimulation for IVF treatment is recommended, many patients will first be treated with ovulation induction and IUI. Compared to IVF, intrauterine insemination has acceptable success rates, fewer risks, and is less expensive. However, in patients with diminished ovarian reserve, clinicians may be inclined to recommend that a patient proceed straight to IVF due to a concern that IUI cycles may yield unacceptable pregnancy and live birth rates, and that these cycles may waste valuable time for the patient. Study design, size, duration This was a retrospective cohort study of infertile patients at an academic center. The first ovulation induction/IUI cycle with oral medication (clomiphene or letrozole) between 2015-2019 was included. Patients that did not have an AMH level within 12 months of the treatment cycle were excluded. Spontaneous abortion was defined as the spontaneous demise of an intrauterine fetus before 8 weeks’ gestation. Ongoing pregnancy was defined as a viable intrauterine fetus at 8 weeks’ gestation. Participants/materials, setting, methods The primary outcome was ongoing pregnancy. Patients were stratified into two groups based on their AMH level: Group 1 (AMH 40 years). Modified Poisson regression model with robust error variance adjusted a priori for patient age was used to estimate the RR (95% CI). Main results and the role of chance The mean age of patients with an AMH 40 years (3.3% versus 4.5%; RR 0.89 (0.32-2.45). Limitations, reasons for caution As this was a retrospective study, selection bias is possible given that treatment decisions could not be prospectively controlled. However, we attempted to control for this in the study design by restricting our analysis to the first initiated cycle per patient and by excluding natural cycle and gonadotropin treatment cycles. Wider implications of the findings Our observations provide reassurance that a low AMH level is not associated with the chance of success or failure in an ovulation induction/IUI. Ovulation induction/IUI is, therefore, a reasonable option to consider before proceeding to IVF in patients with an AMH level Trial registration number not applicable

Published
2022
Full Text
View/download PDF

41. O-001 Delay in IVF treatment up to 180 days does not affect pregnancy outcomes in women with diminished ovarian reserve

Author

P Romanski, P Bortoletto, Z Rosenwaks, and G Schattman

Subjects
Reproductive Medicine, Keynote Session, Rehabilitation, Oral Presentations, Obstetrics and Gynecology, AcademicSubjects/MED00905
Abstract

text In clinical practice, infertility treatment delays can occur due to medical, logistical, or financial reasons. Concerns over treatment delays were brought to the forefront in March 2020 when the SARS-CoV-2 pandemic prompted both the ESHRE and ASRM to recommend the suspension of new infertility treatment cycles. At the time, little was known about the risk of viral transmission on reproductive health and necessary medical resources urgently needed to be reallocated to the front lines of the pandemic. These society recommendations were met with resistance from some clinicians and patients that raised valid concerns about whether delaying IVF treatment for a few months could negatively affect pregnancy outcomes. To help answer this question, we designed a retrospective cohort study to assess whether a delay up to 180 days in initiating IVF treatment affects pregnancy outcomes in infertile women with diminished ovarian reserve. This population was selected because their treatment outcomes were the most likely to affected by treatment delays due to the continuous decline in ovarian reserve over time. Infertile women treated at our IVF center were included if they had diminished ovarian reserve and started an ovarian stimulation cycle within 180 days of their initial consultation that resulted in an oocyte retrieval with planned fresh embryo transfer between 1 January 2012 and 31 December 2018. Diminished ovarian reserve was defined as an anti-Mŭllerian hormone (AMH) < 1.1 ng/mL. In total, 1,790 patients met inclusion criteria (1,115 immediate and 675 delayed treatment). Each patient had one included cycle and no subsequent data from additional frozen embryo transfer cycles were included. Since all cycle outcomes evaluated were from fresh embryo transfers, no genetically tested embryos were included. Patients were grouped by whether their cycle started 1-90 days after presentation (immediate) or 91-180 days (delayed). The primary outcome was live birth (≥24 weeks of gestation). A subgroup analysis of more severe forms of diminished ovarian reserve was performed to evaluate outcomes for patients with an AMH < 0.5 and for patients >40 years old with an AMH < 1.1 ng/mL (Bologna criteria for diminished ovarian reserve). Logistic regression analysis, adjusted a priori for patient age, was used to estimate the odds ratio (OR) with a 95% CI. All pregnancy outcomes were additionally adjusted for the number of embryos transferred. The mean ± SD number of days from presentation to IVF start was 50.5 ± 21.9 (immediate) and 128.8 ± 25.9 (delayed). After embryo transfer, the live birth rate was similar between groups (immediate: 23.9%; delayed: 25.6%; OR 1.08, 95% CI 0.85-1.38). Additionally, a similar live birth rate was observed in a subgroup analysis of patients with an AMH < 0.5 ng/mL (immediate: 18.8%; delayed: 19.1%; OR 0.99, 95% CI 0.65-1.51) and in patients >40 years old with an AMH < 1.1 ng/mL (immediate: 12.3%; delayed: 14.7%; OR 1.21, 95% CI 0.77-1.91). Overall, we observed that a delay in initiating IVF treatment up to 180 days does not affect the live birth rate for women with diminished ovarian reserve when compared to women who initiate IVF treatment within 90 days of presentation. This observation persisted for patients who in the highest-risk categories for poor response to ovarian stimulation. Providers and patients should be reassured that when a short-term treatment delay is deemed necessary for medical, logistical, or financial reasons, treatment outcomes will not be negatively affected.

Published
2021

45. PO-1785 Non-target dose reduction at phantom study for prostate radiotherapy using TrueBeam and CyberKnife

Author

Katarzyna Kulcenty, P. Romanski, A. Ryczkowski, Wiktoria Maria Suchorska, N. Matuszak, I. Piotrowski, A. Skrobala, Julian Malicki, and Marta Kruszyna-Mochalska

Subjects
Non target, Oncology, Cyberknife, business.industry, Truebeam, Prostate radiotherapy, Medicine, Radiology, Nuclear Medicine and imaging, Dose reduction, Hematology, business, Nuclear medicine, Imaging phantom
Published
2021
Full Text
View/download PDF

49. Vinylogous Winstein Rearrangement: Unexpected Isomerization of an Azide-Substituted Cyclohexadiene–Fe(CO)3Complex

Author

Schlundt née Göderz, Anna, Hemmersbach, Lars, Romanski, Steffen, Neudörfl, Jörg-Martin, and Schmalz, Hans-Günther

Abstract

In the course of our research into enzyme-triggered CO-releasing molecules (ET-CORMs), we were interested in using 2-acetoxy-5-azido-1,3-cyclohexadiene–Fe(CO)3(rac-2) as a building block for further structural modification by means of Cu-catalyzed azide–alkyne cycloaddition (CuAAC click chemistry). Treatment of [2-acetoxy-cyclohexadienyl–Fe(CO)3]+[PF6]−with Zn(N3)2, TMS-N3, or NaN3surprisingly afforded 2-acetoxy-1-azido-2,4-cyclohexadiene–Fe(CO)3(rac-9) as the main product. We could show that rac-2is primarily formed under kinetic control but undergoes a rapid isomerization to rac-9(as the thermodynamic product) in a formal vinylogous Winstein rearrangement under concomitant migration of the Fe(CO)3moiety. This unprecedented reaction displays a 1st order kinetics and appears to proceed via an ionic (rather than a concerted intramolecular) mechanism as supported by crossover experiments using deuterated compounds. The CuAAC reaction of rac-9with propargylic alcohol afforded triazole rac-13, which was demonstrated (by headspace-gas chromatography (GC)) to act as an ET-CORM in the presence of porcine liver esterase.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results