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1. High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Brose, R., Brown, A., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Collins, T., Cotter, G., Mbarubucyeye, J. Damascene, Devin, J., Djuvsland, J., Dmytriiev, A., Egberts, K., Einecke, S., Ernenwein, J. -P., Fegan, S., Feijen, K., Fontaine, G., Funk, S., Gabici, S., Gallant, Y. A., Glicenstein, J. F., Glombitza, J., Grolleron, G., Heß, B., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynski, K., Kerszberg, D., Khatoon, R., Khelifi, B., Kluzniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Luashvili, A., Mackey, J., Malyshev, D., Marandon, V., Marinos, P., Marti-Devesa, G., Marx, R., Meyer, M., Mitchell, A., Moderski, R., Moghadam, M. O., Mohrmann, L., Montanari, A., Moulin, E., de Naurois, M., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, D., Pensec, U., Peron, G., Pühlhofer, G., Punch, M., Quirrenbach, A., Ravikularaman, S., Regeard, M., Reimer, A., Reimer, O., Reis, I., Ren, H., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Sharma, A., Sol, H., Spencer, S., Stawarz, L., Steinmassl, S., Steppa, C., Suzuki, H., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Tsirou, M., van Eldik, C., Vecchi, M., Venter, C., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zdziarski, A. A., Zech, A., and Zywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Owing to their rapid cooling rate and hence loss-limited propagation distance, cosmic-ray electrons and positrons (CRe) at very high energies probe local cosmic-ray accelerators and provide constraints on exotic production mechanisms such as annihilation of dark matter particles. We present a high-statistics measurement of the spectrum of CRe candidate events from 0.3 to 40 TeV with the High Energy Stereoscopic System (H.E.S.S.), covering two orders of magnitude in energy and reaching a proton rejection power of better than $10^{4}$. The measured spectrum is well described by a broken power law, with a break around 1 TeV, where the spectral index increases from $\Gamma_1 = 3.25$ $\pm$ 0.02 (stat) $\pm$ 0.2 (sys) to $\Gamma_2 = 4.49$ $\pm$ 0.04 (stat) $\pm$ 0.2 (sys). Apart from the break, the spectrum is featureless. The absence of distinct signatures at multi-TeV energies imposes constraints on the presence of nearby CRe accelerators and the local CRe propagation mechanisms., Comment: main paper: 8 pages, 4 figures, supplemental material: 12 pages, 14 figures, accepted for publication in Physical Review Letters https://journals.aps.org/prl/
Published: 2024
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2. On Using Certified Training towards Empirical Robustness

Author: De Palma, Alessandro, Durand, Serge, Chihani, Zakaria, Terrier, François, and Urban, Caterina
Subjects: Computer Science - Machine Learning, Computer Science - Cryptography and Security, Statistics - Machine Learning
Abstract: Adversarial training is arguably the most popular way to provide empirical robustness against specific adversarial examples. While variants based on multi-step attacks incur significant computational overhead, single-step variants are vulnerable to a failure mode known as catastrophic overfitting, which hinders their practical utility for large perturbations. A parallel line of work, certified training, has focused on producing networks amenable to formal guarantees of robustness against any possible attack. However, the wide gap between the best-performing empirical and certified defenses has severely limited the applicability of the latter. Inspired by recent developments in certified training, which rely on a combination of adversarial attacks with network over-approximations, and by the connections between local linearity and catastrophic overfitting, we present experimental evidence on the practical utility and limitations of using certified training towards empirical robustness. We show that, when tuned for the purpose, a recent certified training algorithm can prevent catastrophic overfitting on single-step attacks, and that it can bridge the gap to multi-step baselines under appropriate experimental settings. Finally, we present a novel regularizer for network over-approximations that can achieve similar effects while markedly reducing runtime.
Published: 2024

3. A Unified Multi-Wavelength Data Analysis Workflow with gammapy. Constraining the Broadband Emission of FSRQ OP 313

Author: Rosillo, M. Nievas, Acero, F., Otero-Santos, J., Acosta, M. Vazquez, Terrier, R., and Arbet-Engels, A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Flat Spectrum Radio Quasar OP~313 entered an enhanced activity phase in November 2023 and has undergone multiple flares since then which have motivated the organisation of several large multi-wavelength campaigns, including two deep observations from the hard X-ray telescope NuSTAR. The broadband emission from OP~313 during these two observations is investigated under a new unified analysis framework, with data spanning from optical to gamma rays. Traditional methods for analyzing blazar emissions often rely on proprietary software tailored to specific instruments, making it challenging to integrate and interpret data from multi-wavelength campaigns comprehensively. This study demonstrates the feasibility of utilizing gammapy, an open-source Python package, and common data formats originally developed for gamma-ray instrumentation, to perform a consistent multi-instrument analysis. This enables a forward folding approach that fully incorporates source observations, detector responses, and various instrumental and astrophysical backgrounds. The methodology is applied as an example to recent data collected from the distant quasar OP~313. We present a comprehensive data reconstruction and analysis for instruments including the Liverpool Telescope's IO:O detector, Swift-UVOT, Swift-XRT, NuSTAR, and Fermi-LAT. The resulting spectral analysis is validated against the native tools for each instrument. Additionally, a multi-wavelength phenomenological model of the source emission, encompassing optical to gamma-ray bands, is developed, incorporating absorption components across different energy regimes. We introduce and validate a new unified framework for multi-wavelength forward folding data analysis based on gammapy and open data formats, demonstrating its application to spectral data from the quasar OP~313., Comment: 20 pages, 10 figures github: https://github.com/mireianievas/gammapy_mwl_workflow zenodo: https://zenodo.org/records/13837637
Published: 2024

4. Very-high-energy $\gamma$-ray emission from young massive star clusters in the Large Magellanic Cloud

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Böttcher, M., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Brose, R., Brown, A., Brun, F., Bruno, B., Burger-Scheidlin, C., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Cristofari, P., Devin, J., Djannati-Ataï, A., Djuvsland, J., Dmytriiev, A., Egberts, K., Einecke, S., Feijen, K., Filipovic, M., Fontaine, G., Funk, S., Gabici, S., Gallant, Y. A., Glicenstein, J. F., Glombitza, J., Grolleron, G., Haerer, L., Heß, B., Hinton, J. A., Hofmann, W., Holch, T. L., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Mackey, J., Marandon, V., Martí-Devesa, G., Marx, R., Mehta, A., Mitchell, A., Moderski, R., Moghadam, M. O., Mohrmann, L., Montanari, A., Moulin, E., de Naurois, M., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Pensec, U., Peron, G., Pühlhofer, G., Quirrenbach, A., Ravikularaman, S., Regeard, M., Reimer, A., Reimer, O., Ren, H., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sabri, K., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Sol, H., Spencer, S., Stawarz, Ł., Steinmassl, S., Steppa, C., Streil, K., Sushch, I., Taylor, A. M., Terrier, R., Tsirou, M., Tsuji, N., van Eldik, C., Vecchi, M., Venter, C., Vink, J., Wagner, S. J., White, R., Wierzcholska, A., Zacharias, M., Zdziarski, A. A., Zech, A., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Tarantula Nebula in the Large Magellanic Cloud is known for its high star formation activity. At its center lies the young massive star cluster R136, providing a significant amount of the energy that makes the nebula shine so brightly at many wavelengths. Recently, young massive star clusters have been suggested to also efficiently produce high-energy cosmic rays, potentially beyond PeV energies. Here, we report the detection of very-high-energy $\gamma$-ray emission from the direction of R136 with the High Energy Stereoscopic System, achieved through a multicomponent, likelihood-based modeling of the data. This supports the hypothesis that R136 is indeed a very powerful cosmic-ray accelerator. Moreover, from the same analysis, we provide an updated measurement of the $\gamma$-ray emission from 30 Dor C, the only superbubble detected at TeV energies presently. The $\gamma$-ray luminosity above $0.5\,\mathrm{TeV}$ of both sources is $(2-3)\times 10^{35}\,\mathrm{erg}\,\mathrm{s}^{-1}$. This exceeds by more than a factor of 2 the luminosity of HESS J1646$-$458, which is associated with the most massive young star cluster in the Milky Way, Westerlund 1. Furthermore, the $\gamma$-ray emission from each source is extended with a significance of $>3\sigma$ and a Gaussian width of about $30\,\mathrm{pc}$. For 30 Dor C, a connection between the $\gamma$-ray emission and the nonthermal X-ray emission appears likely. Different interpretations of the $\gamma$-ray signal from R136 are discussed., Comment: 10+11 pages, 4+6 figures. Corresponding authors: L. Mohrmann, N. Komin
Published: 2024
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5. Extended gamma-ray emission from particle escape in pulsar wind nebulae -- Application to HESS J1809-193 and HESS J1825-137

Author: Martin, Pierrick, de Guillebon, Louis, Collard, Eliot, Mertz, Inès, Mohrmann, Lars, Principe, Giacomo, Lemoine-Goumard, Marianne, Marcowith, Alexandre, Terrier, Régis, and Filipović, Miroslav
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: There is growing evidence from gamma-ray observations at high and very high energies that particle escape is a key aspect shaping the morphological properties of pulsar wind nebulae (PWNe) at various evolutionary stages. We aim to provide a simple model for the gamma-ray emission from these objects including the transport of particles across the different components of the system. We applied it to sources HESS J1809-193 and HESS J1825-137. We developed a multi-zone framework applicable to dynamically young PWNe, taking into account the diffusive escape of relativistic electron-positron pairs out of the nebula into the parent supernova remnant (SNR) and their confinement downstream of the magnetic barrier of the forward shock until an eventual release into the surrounding interstellar medium (ISM). For a wide range of turbulence properties in the nebula, the GeV-TeV inverse-Compton radiation from pairs that escaped into the remnant can be a significant if not dominant contribution to the emission from the system. It may dominate the pion-decay radiation from cosmic rays accelerated at the forward shock and advected downstream of it. In the TeV-PeV range, the contribution from particles escaped into the ISM can exceed by far that of the SNR+PWN components. Applied to HESS J1809-193 and HESS J1825-137, we found that spatially extended GeV-TeV emission components can be accounted for mostly from particles escaped into the ISM, while morphologically more compact components above 50-100TeV are ascribed to the PWNe. In these two cases, the model suggests high turbulence in the nebula and a forward shock accelerating cosmic rays up to ~100TeV at most. The model provides the temporal and spectral properties of the flux of particles originally energized by the pulsar wind and ultimately released in the ISM. (Abridged)., Comment: 19 pages including 4 pages of appendix. Accepted for publication in A&A
Published: 2024

6. H.E.S.S. observations of the 2021 periastron passage of PSR B1259-63/LS 2883

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Brose, R., Brown, A., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Devin, J., Djuvsland, J., Dmytriiev, A., Egberts, K., Einecke, S., Ernenwein, J. -P., Fontaine, G., Funk, S., Gabici, S., Gallant, Y. A., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Haerer, L., Heß, B., Hofmann, W., Holch, T. L., Holler, M., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khangulyan, D., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Mackey, J., Malyshev, D., Martí-Devesa, G., Marx, R., Mehta, A., Meintjes, P. J., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., de Naurois, M., Niemiec, J., Ohm, S., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Pensec, U., Peron, G., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Regeard, M., Reimer, A., Reimer, O., Reis, I., Ren, H., Rieger, F., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Streil, K., Sushch, I., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Thorpe-Morgan, C., Tluczykont, M., Unbehaun, T., van Eldik, C., van Soelen, B., Vecchi, M., Venter, C., Vink, J., Wach, T., Wagner, S. J., Werner, F., Wierzcholska, A., Zacharias, M., Zdziarski, A. A., Zech, A., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: PSR B1259-63 is a gamma-ray binary system that hosts a pulsar in an eccentric orbit, with a 3.4 year period, around an O9.5Ve star. At orbital phases close to periastron passages, the system radiates bright and variable non-thermal emission. We report on an extensive VHE observation campaign conducted with the High Energy Stereoscopic System, comprised of ~100 hours of data taken from $t_p-24$ days to $t_p+127$ days around the system's 2021 periastron passage. We also present the timing and spectral analyses of the source. The VHE light curve in 2021 is consistent with the stacked light curve of all previous observations. Within the light curve, we report a VHE maximum at times coincident with the third X-ray peak first detected in the 2021 X-ray light curve. In the light curve -- although sparsely sampled in this time period -- we see no VHE enhancement during the second disc crossing. In addition, we see no correspondence to the 2021 GeV flare in the VHE light curve. The VHE spectrum obtained from the analysis of the 2021 dataset is best described by a power law of spectral index $\Gamma = 2.65 \pm 0.04_{\text{stat}}$ $\pm 0.04_{\text{sys}}$, a value consistent with the previous H.E.S.S. observations of the source. We report spectral variability with a difference of $\Delta \Gamma = 0.56 ~\pm~ 0.18_{\text{stat}}$ $~\pm~0.10_{\text{sys}}$ at 95% c.l., between sub-periods of the 2021 dataset. We also find a linear correlation between contemporaneous flux values of X-ray and TeV datasets, detected mainly after $t_p+25$ days, suggesting a change in the available energy for non-thermal radiation processes. We detect no significant correlation between GeV and TeV flux points, within the uncertainties of the measurements, from $\sim t_p-23$ days to $\sim t_p+126$ days. This suggests that the GeV and TeV emission originate from different electron populations., Comment: accepted to A&A
Published: 2024

7. In-vitro activity of newly-developed β-lactamase inhibitors avibactam, relebactam and vaborbactam in combination with anti-pseudomonal β-lactam antibiotics against AmpC-overproducing clinical Pseudomonas aeruginosa isolates

Author: Le Terrier, Christophe, Raro, Otávio Hallal Ferreira, Saad, Alaaeldin Mohamed, Nordmann, Patrice, and Poirel, Laurent
Published: 2024
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8. Förderung der manuellen Medizin in der Schweiz – die Schweizerische Ärztegesellschaft für Manuelle Medizin

Author: Gengenbacher, Michael and Terrier, Bernard
Published: 2024
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9. Unveiling extended gamma-ray emission around HESS J1813-178

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Martins, V. Barbosa, Barnard, J., Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chambery, P., Chand, T., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Dmytriiev, A., Doroshenko, V., Einecke, S., Ernenwein, J. -P., Feijen, K., Filipovic, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Ghafourizadeh, S., Giavitt, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Grondin, M. -H., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Katarzyński, K., Khatoon, R., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Mackey, J., Malyshev, D., Marandon, V., Marinos, P., Martí-Devesa, G., Marx, R., Mehta, A., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., de Naurois, M., Niemiec, J., Noel, A. Priyana, O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Regeard, M., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Renaud, M., Reville, B., Rieger, F., Roellinghoff, G., Rudak, B., Sahakian, V., Salzmann, H., Sasaki, M., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Specovius, A., Spencer, S., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Tluczykont, M., Tsuji, N., Unbehaun, T., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: HESS J1813$-$178 is a very-high-energy $\gamma$-ray source spatially coincident with the young and energetic pulsar PSR J1813$-$1749 and thought to be associated with its pulsar wind nebula (PWN). Recently, evidence for extended high-energy emission in the vicinity of the pulsar has been revealed in the Fermi Large Area Telescope (LAT) data. This motivates revisiting the HESS J1813$-$178 region, taking advantage of improved analysis methods and an extended data set. Using data taken by the High Energy Stereoscopic System (H.E.S.S.) experiment and the Fermi-LAT, we aim to describe the $\gamma$-ray emission in the region with a consistent model, to provide insights into its origin. We performed a likelihood-based analysis on 32 hours of H.E.S.S. data and 12 years of Fermi-LAT data and fit a spectro-morphological model to the combined datasets. These results allowed us to develop a physical model for the origin of the observed $\gamma$-ray emission in the region. In addition to the compact very-high-energy $\gamma$-ray emission centered on the pulsar, we find a significant yet previously undetected component along the Galactic plane. With Fermi-LAT data, we confirm extended high-energy emission consistent with the position and elongation of the extended emission observed with H.E.S.S. These results establish a consistent description of the emission in the region from GeV energies to several tens of TeV. This study suggests that HESS J1813$-$178 is associated with a $\gamma$-ray PWN powered by PSR J1813$-$1749. A possible origin of the extended emission component is inverse Compton emission from electrons and positrons that have escaped the confines of the pulsar and form a halo around the PWN., Comment: 13+5 pages, 13+11 figures. Accepted for publication in A&A. Corresponding authors: T.Wach, A.Mitchell, V.Joshi, P.Chamb\'ery
Published: 2024
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10. Spectrum and extension of the inverse-Compton emission of the Crab Nebula from a combined Fermi-LAT and H.E.S.S. analysis

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bradascio, F., Breuhaus, M., Brose, R., Brown, A., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chambery, P., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Cristofari, P., Devin, J., Djannati-Ataï, A., Djuvsland, J., Dmytriiev, A., Einecke, S., Ernenwein, J. -P., Fegan, S., Feijen, K., Filipović, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Glawion, D., Glicenstein, J. F., Glombitza, J., Goswami, P., Grolleron, G., Grondin, M. -H., Haerer, L., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Luashvili, A., Mackey, J., Malyshev, D., Marandon, V., Marinos, P., Martí-Devesa, G., Marx, R., Mehta, A., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., de Naurois, M., Niemiec, J., O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Regeard, M., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Renaud, M., Reville, B., Rieger, F., Roellinghoff, G., Rudak, B., Sahakian, V., Salzmann, H., Sasaki, M., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Streil, K., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Tluczykont, M., Tsuji, N., Unbehaun, T., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., Żywucka, N., and Harding, A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Crab Nebula is a unique laboratory for studying the acceleration of electrons and positrons through their non-thermal radiation. Observations of very-high-energy $\gamma$ rays from the Crab Nebula have provided important constraints for modelling its broadband emission. We present the first fully self-consistent analysis of the Crab Nebula's $\gamma$-ray emission between 1 GeV and $\sim$100 TeV, that is, over five orders of magnitude in energy. Using the open-source software package Gammapy, we combined 11.4 yr of data from the Fermi Large Area Telescope and 80 h of High Energy Stereoscopic System (H.E.S.S.) data at the event level and provide a measurement of the spatial extension of the nebula and its energy spectrum. We find evidence for a shrinking of the nebula with increasing $\gamma$-ray energy. Furthermore, we fitted several phenomenological models to the measured data, finding that none of them can fully describe the spatial extension and the spectral energy distribution at the same time. Especially the extension measured at TeV energies appears too large when compared to the X-ray emission. Our measurements probe the structure of the magnetic field between the pulsar wind termination shock and the dust torus, and we conclude that the magnetic field strength decreases with increasing distance from the pulsar. We complement our study with a careful assessment of systematic uncertainties., Comment: 18+6 pages, 15+2 figures. Accepted for publication in A&A. Corresponding authors: M. Meyer, L. Mohrmann, T. Unbehaun. v2: after A&A language editing
Published: 2024
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11. Curvature in the very-high energy gamma-ray spectrum of M87

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Bradascio, F., Brose, R., Brun, F., Bruno, B., Burger-Scheidlin, T. Bulik C., Bylund, T., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Collins, T., Cotter, G., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Djuvsland, J., Dmytriiev, A., Egberts, K., Einecke, S., Fegan, S., Fontaine, G., Funk, S., Gabici, S., Glicenstein, J. F., Glombitza, J., Grolleron, G., Haerer, L., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Lypova, I., Luashvili, A., Mackey, J., Malyshev, D., Martí-Devesa, G., Marx, R., Mehta, A., Meyer, M., Mitchell, A., Moderski, R., Moghadam, M. O., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., de Naurois, M., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Panny, S., Panter, M., Parsons, R. D., Pensec, U., Pita, S., Pühlhofer, G., Punch, M., Quirrenbach, A., Regeard, M., Reimer, A., Reimer, O., Ren, H., Reville, B., Rieger, F., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Sol, H., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Streil, K., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Tsirou, M., van Eldik, C., Venter, C., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zdziarski, A. A., Zech, A., Zilberman, P., and Zywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The radio galaxy M87 is a variable very-high energy (VHE) gamma-ray source, exhibiting three major flares reported in 2005, 2008, and 2010. Despite extensive studies, the origin of the VHE gamma-ray emission is yet to be understood. In this study, we investigate the VHE gamma-ray spectrum of M87 during states of high gamma-ray activity, utilizing 20.2$\,$ hours the H.E.S.S. observations. Our findings indicate a preference for a curved spectrum, characterized by a log-parabola model with extra-galactic background light (EBL) model above 0.3$\,$TeV at the 4$\sigma$ level, compared to a power-law spectrum with EBL. We investigate the degeneracy between the absorption feature and the EBL normalization and derive upper limits on EBL models mainly sensitive in the wavelength range 12.4$\,$$\mu$m - 40$\,$$\mu$m., Comment: 10 pages, 7 figures. Accepted for publication in A&A. Corresponding authors: Victor Barbosa Martins, Rahul Cecil, Iryna Lypova, Manuel Meyer, Perri Zilberman. Supplementary material: https://zenodo.org/records/10781524
Published: 2024
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12. Acceleration and transport of relativistic electrons in the jets of the microquasar SS 433

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaou, M., Breuhau, M., Brose, R., Brown, A. M., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Dai, S., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Dmytriiev, A., Doroshenko, V., Egberts, K., Einecke, S., Ernenwein, J. -P., Filipovic, M., Fontaine, G., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Grolleron, G., Haerer, L., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Martí-Devesa, G., Marx, R., Mehta, A., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V., Salzman, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schwanke, U., Shapopi, J. N. S., Sol, H., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Streil, K., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Tsirou, M., Tsuji, N., Unbehaun, T., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., Wach, T., Wagner, S. J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: SS 433 is a microquasar, a stellar binary system with collimated relativistic jets. We observed SS 433 in gamma rays using the High Energy Stereoscopic System (H.E.S.S.), finding an energy-dependent shift in the apparent position of the gamma-ray emission of the parsec-scale jets. These observations trace the energetic electron population and indicate the gamma rays are produced by inverse-Compton scattering. Modelling of the energy-dependent gamma-ray morphology constrains the location of particle acceleration and requires an abrupt deceleration of the jet flow. We infer the presence of shocks on either side of the binary system at distances of 25 to 30 parsecs and conclude that self-collimation of the precessing jets forms the shocks, which then efficiently accelerate electrons., Comment: Submitted 20th Apr. 2023, published 25th January 2024 (accepted version)
Published: 2024
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13. Erratum zu: Förderung der manuellen Medizin in der Schweiz – die Schweizerische Ärztegesellschaft für Manuelle Medizin

Author: Gengenbacher, Michael and Terrier, Bernard
Published: 2024
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14. Die Zukunft der manuellen Medizin in Europa – eine Analyse der aktuellen Entwicklungen und Herausforderungen

Author: Terrier, Bernard
Published: 2024
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15. Adverse myocardial and vascular side effects of immune checkpoint inhibitors: a prospective multimodal cardiovascular assessment

Author: Mirabel, Mariana, Eslami, Assié, Thibault, Constance, Oudard, Stéphane, Mousseaux, Elie, Wahbi, Karim, Fabre, Elizabeth, Terrier, Benjamin, Marijon, Eloi, Villefaillot, Aurélie, Fayol, Antoine, Dragon-Durey, Marie-Agnès, Le Louet, Agnès Lillo, Bruno, Rosa Maria, Soulat, Gilles, and Hulot, Jean Sébastien
Published: 2024
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16. Discovering High-Quality Process Models Despite Data Scarcity

Author: Adams, Jan Niklas, Peeperkorn, Jari, Brockhoff, Tobias, Terrier, Isabelle, Göhner, Heiko, Uysal, Merih Seran, Broucke, Seppe vanden, De Weerdt, Jochen, and van der Aalst, Wil M. P.
Subjects: Computer Science - Databases
Abstract: Process discovery algorithms learn process models from executed activity sequences, describing concurrency, causality, and conflict. Concurrent activities require observing multiple permutations, increasing data requirements, especially for processes with concurrent subprocesses such as hierarchical, composite, or distributed processes. While process discovery algorithms traditionally use sequences of activities as input, recently introduced object-centric process discovery algorithms can use graphs of activities as input, encoding partial orders between activities. As such, they contain the concurrency information of many sequences in a single graph. In this paper, we address the research question of reducing process discovery data requirements when using object-centric event logs for process discovery. We classify different real-life processes according to the control-flow complexity within and between subprocesses and introduce an evaluation framework to assess process discovery algorithm quality of traditional and object-centric process discovery based on the sample size. We complement this with a large-scale production process case study. Our results show reduced data requirements, enabling the discovery of large, concurrent processes such as manufacturing with little data, previously infeasible with traditional process discovery. Our findings suggest that object-centric process mining could revolutionize process discovery in various sectors, including manufacturing and supply chains.
Published: 2023

17. Discovery of a Radiation Component from the Vela Pulsar Reaching 20 Teraelectronvolts

Author: Collaboration, The H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bradascio, F., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Cangemi, F., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Dmytriiev, A., Egberts, K., Ernenwein, J. -P., Feijen, K., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Ghafourizadeh, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Grondin, M. -H., Haerer, L., Haupt, M., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Marinos, P., Martí-Devesa, G., Marx, R., Maurin, G., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Murach, T., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, OBrien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Renaud, M., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schüssler, F., Schwanke, U., Shapopi, J. N. S., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Tavernier, T., Terrier, R., Thorpe-Morgan, C., Tluczykont, M., Tsirou, M., Tsuji, N., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., Wagner, S. J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zouari, S., Żywucka, N., Zanin, R., Kerr, M., Johnston, S., Shannon, R. M., and Smith, D. A.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Gamma-ray observations have established energetic isolated pulsars as outstanding particle accelerators and antimatter factories in the Galaxy. There is, however, no consensus regarding the acceleration mechanisms and the radiative processes at play, nor the locations where these take place. The spectra of all observed gamma-ray pulsars to date show strong cutoffs or a break above energies of a few gigaelectronvolt (GeV). Using the H.E.S.S. array of Cherenkov telescopes, we discovered a novel radiation component emerging beyond this generic GeV cutoff in the Vela pulsar's broadband spectrum. The extension of gamma-ray pulsation energies up to at least 20 teraelectronvolts (TeV) shows that Vela pulsar can accelerate particles to Lorentz factors higher than $4\times10^7$. This is an order of magnitude larger than in the case of the Crab pulsar, the only other pulsar detected in the TeV energy range. Our results challenge the state-of-the-art models for high-energy emission of pulsars while providing a new probe, i.e. the energetic multi-TeV component, for constraining the acceleration and emission processes in their extreme energy limit., Comment: 38 pages, 6 figures. This preprint has not undergone peer review or any post-submission improvements or corrections. The Version of Record of this article is published in Nature Astronomy, Nat Astron (2023), and is available online at https://doi.org/10.1038/s41550-023-02052-3
Published: 2023
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18. Early reduction in gut microbiota diversity in critically ill patients is associated with mortality

Author: Wozniak, Hannah, Gaïa, Nadia, Lazarevic, Vladimir, Le Terrier, Christophe, Beckmann, Tal Sarah, Balzani, Eleonora, Urner, Martin, Pugin, Jérôme, Schrenzel, Jacques, and Heidegger, Claudia-Paula
Published: 2024
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19. Association between humoral serological markers levels and risk of SARS-CoV-2 infection after the primary COVID-19 vaccine course among ANRS0001S COV-POPART cohort participants

Author: Chalouni, Mathieu, Loubet, Paul, Lhomme, Edouard, Ninove, Laetitia, Barrou, Benoit, Blay, Jean-Yves, Hourmant, Maryvonne, de Seze, Jérome, Laville, Martine, Laviolle, Bruno, Lelièvre, Jean-Daniel, Morel, Jacques, Quoc, Stéphanie Nguyen, Spano, Jean-Philippe, Terrier, Benjamin, Thiebaut, Anne, Viallard, Jean-Francois, Vrtovsnik, François, Circosta, Sophie, Barquin, Aude, Gharib, Mariam, Tartour, Eric, Parfait, Béatrice, Thiébaut, Rodolphe, Meyer, Laurence, de Lamballerie, Xavier, Launay, Odile, and Wittkop, Linda
Published: 2024
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20. Correction to: Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19

Author: Terrier, Christophe Le, Walter, Thaïs, Lebbah, Said, Hajage, David, Sigaud, Florian, Guérin, Claude, Desmedt, Luc, Primmaz, Steve, Joussellin, Vincent, Badia, Chiara Della, Ricard, Jean Damien, Pugin, Jérôme, and Terzi, Nicolas
Published: 2024
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21. Perceptions, expectations, and recommendations of trans adults on gender-affirming care in France: a qualitative study

Author: Veilleux, Michelle, Terrier, Jean-Etienne, Bécu, Maxence, Lafon, Marina, Bourmaud, Aurélie, and Martin, Philippe
Published: 2024
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22. Author Correction: Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice

Author: Ogonczyk-Makowska, Daniela, Brun, Pauline, Vacher, Clémence, Chupin, Caroline, Droillard, Clément, Carbonneau, Julie, Laurent, Emilie, Dulière, Victoria, Traversier, Aurélien, Terrier, Olivier, Julien, Thomas, Galloux, Marie, Paul, Stéphane, Eléouët, Jean-François, Fouret, Julien, Hamelin, Marie-Eve, Pizzorno, Andrés, Boivin, Guy, Rosa-Calatrava, Manuel, and Dubois, Julia
Published: 2024
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23. Effects of metronome walking on long-term attractor divergence and correlation structure of gait: a validation study in older people

Author: Piergiovanni, Sophia and Terrier, Philippe
Published: 2024
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24. Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19

Author: Le Terrier, Christophe, Walter, Thaïs, Lebbah, Said, Hajage, David, Sigaud, Florian, Guérin, Claude, Desmedt, Luc, Primmaz, Steve, Joussellin, Vincent, Della Badia, Chiara, Ricard, Jean-Damien, Pugin, Jérôme, and Terzi, Nicolas
Published: 2024
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25. Flow dynamics

Author: Schmutz, Thomas, Le Terrier, Christophe, and Ribordy, Vincent
Published: 2024
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26. Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice

Author: Ogonczyk-Makowska, Daniela, Brun, Pauline, Vacher, Clémence, Chupin, Caroline, Droillard, Clément, Carbonneau, Julie, Laurent, Emilie, Dulière, Victoria, Traversier, Aurélien, Terrier, Olivier, Julien, Thomas, Galloux, Marie, Paul, Stéphane, Eléouët, Jean-François, Fouret, Julien, Hamelin, Marie-Eve, Pizzorno, Andrés, Boivin, Guy, Rosa-Calatrava, Manuel, and Dubois, Julia
Published: 2024
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27. Evolution of therapeutic management of patients with ANCA associated vasculitis in France after licensing Rituximab use

Author: Durel, Cécile-Audrey, Thervet, Eric Simon, Chauveau, Dominique, Schmidt, Aurélie, Terrier, Benjamin, and Bataille, Pierre M
Published: 2024
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28. Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study

Author: Clot, Pierre-Francois, Farenc, Christine, Suratt, Benjamin T., Krahnke, Tillmann, Tardat, Agnes, Florian, Peter, Pomponio, Robert, Patel, Naimish, Wiekowski, Maria, Lin, Yong, Terrier, Benjamin, and Staudinger, Heribert
Published: 2024
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29. Transcriptomic analysis of developing sorghum grains to detect genes related to cell wall biosynthesis and remodelling

Author: Costes, Camille, Navarro Sanz, Sergi, Calatayud, Caroline, Soriano, Alexandre, Mameri, Hamza, Terrier, Nancy, and Francin-Allami, Mathilde
Published: 2024
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30. VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation

Author: Kosmider, Olivier, Possémé, Céline, Templé, Marie, Corneau, Aurélien, Carbone, Francesco, Duroyon, Eugénie, Breillat, Paul, Chirayath, Twinu-Wilson, Oules, Bénédicte, Sohier, Pierre, Luka, Marine, Gobeaux, Camille, Lazaro, Estibaliz, Outh, Roderau, Le Guenno, Guillaume, Lifermann, François, Berleur, Marie, Le Mene, Melchior, Friedrich, Chloé, Lenormand, Cédric, Weitten, Thierry, Guillotin, Vivien, Burroni, Barbara, Boussier, Jeremy, Willems, Lise, Aractingi, Selim, Dionet, Léa, Tharaux, Pierre-Louis, Vergier, Béatrice, Raynaud, Pierre, Ea, Hang-Korng, Ménager, Mickael, Duffy, Darragh, and Terrier, Benjamin
Published: 2024
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31. Exploring the effects of dietary inulin in rainbow trout fed a high-starch, 100% plant-based diet

Author: Defaix, Raphaël, Lokesh, Jep, Frohn, Laura, Le Bechec, Mickael, Pigot, Thierry, Véron, Vincent, Surget, Anne, Biasutti, Sandra, Terrier, Frédéric, Skiba-Cassy, Sandrine, Roy, Jérôme, Panserat, Stéphane, and Ricaud, Karine
Published: 2024
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32. Early reduction in gut microbiota diversity in critically ill patients is associated with mortality

Author: Hannah Wozniak, Nadia Gaïa, Vladimir Lazarevic, Christophe Le Terrier, Tal Sarah Beckmann, Eleonora Balzani, Martin Urner, Jérôme Pugin, Jacques Schrenzel, Claudia-Paula Heidegger, and Gut Microbiota working group
Subjects: Critical care, Gut microbiota, Patients’ outcome, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Critical illness is associated with an altered gut microbiota, yet its association with poor outcomes remains unclear. This study evaluates the early gut microbiota diversity changes in intensive care unit patients and its association with mortality. Additionally, it explores fecal pH as a potential biomarker for these changes. Methods In this prospective observational cohort study, fecal samples were collected at two time points: S1, the first stool passed upon intensive care unit admission, and S2, the first stool passed at least 24 h after S1. Full-length 16S rRNA gene sequencing was performed for gut microbiota analysis, with α-diversity measured using the Shannon index. Bayesian joint models were used to estimate the association between time-varying changes in gut microbiota diversity and 60-day mortality, as well as the association between daily changes in stool pH and in diversity. Results Twenty-four of 96 patients overall died during follow-up. Daily Shannon index decreased on average by −0.1 points [95% Credible Intervals (CrI) −0.20 to −0.10]. Every point decrease in Shannon index was associated with a 1.99-fold increase in the hazard of death (95% CrI, 1.04 to 4.51). Time-varying fecal pH levels were not associated with changes in Shannon index. Conclusions Gut microbiota diversity decreased over time, associated with increased mortality. Fecal pH is an unreliable marker of gut microbiota change. Future studies on gut microbiota and related biomarkers should focus on the initial days in the intensive care unit to detect and mitigate a decline in gut microbiota diversity.
Published: 2024
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33. Working Together and Being Physically Active Are Not Enough to Advise Uniformly and Adequately Low Back Pain Patients: A Cross-Sectional Study

Author: C. Praz, J. Ducki, M. L. Connaissa, P. Terrier, P. Vuistiner, B. Léger, and F. Luthi
Subjects: Medicine (General), R5-920
Abstract: The profession of the health-care providers (HCPs) influences their recommendations to the patients. Conversely, interdisciplinarity seeks to challenge such differences, so that the patient receives one single and consistent therapeutic message. Some studies also suggest associations between HCPs life habits and recommendations. Our hypotheses were (1) that despite interdisciplinary work, the profession remains a predictor of recommendations and (2) that HCPs who are more physically active recommend more activity. Three clinical vignettes were presented to a group of experts of low back pain (LBP) (guidelines), and 20 physicians, 22 physiotherapists, and 23 nurses to assess how they evaluate the symptoms and pathologies of LBP patients and how much work and physical activity they recommend. Physical activity was assessed with accelerometers and questionnaires. Some interprofessional differences remained present within an interdisciplinary team. The nurses were more restrictive and further away from the guidelines. The physicians were the most in line with them. The physiotherapists recommend as much physical activity, but less work activity than the physicians. The level of physical activity of the HCPs is not associated with their recommendations. To ensure a clear and unique message, educational actions may be undertaken to promote the biopsychosocial model and clarify the guidelines.
Published: 2018
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34. No Trust without regulation!

Author: Terrier, François
Subjects: Computer Science - Computers and Society, Computer Science - Artificial Intelligence
Abstract: The explosion in the performance of Machine Learning (ML) and the potential of its applications are strongly encouraging us to consider its use in industrial systems, including for critical functions such as decision-making in autonomous systems. While the AI community is well aware of the need to ensure the trustworthiness of AI-based applications, it is still leaving too much to one side the issue of safety and its corollary, regulation and standards, without which it is not possible to certify any level of safety, whether the systems are slightly or very critical.The process of developing and qualifying safety-critical software and systems in regulated industries such as aerospace, nuclear power stations, railways or automotive industry has long been well rationalized and mastered. They use well-defined standards, regulatory frameworks and processes, as well as formal techniques to assess and demonstrate the quality and safety of the systems and software they develop. However, the low level of formalization of specifications and the uncertainties and opacity of machine learning-based components make it difficult to validate and verify them using most traditional critical systems engineering methods. This raises the question of qualification standards, and therefore of regulations adapted to AI. With the AI Act, the European Commission has laid the foundations for moving forward and building solid approaches to the integration of AI-based applications that are safe, trustworthy and respect European ethical values. The question then becomes "How can we rise to the challenge of certification and propose methods and tools for trusted artificial intelligence?"
Published: 2023

35. Prospects for $\gamma$-ray observations of the Perseus galaxy cluster with the Cherenkov Telescope Array

Author: Consortium, The Cherenkov Telescope Array, Abe, K., Abe, S., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Angüner, E. O., Antonelli, L. A., Aramo, C., Araya, M., Arcaro, C., Arrabito, L., Asano, K., Ascasíbar, Y., Aschersleben, J., Ashkar, H., Stuani, L. Augusto, Baack, D., Backes, M., Baktash, A., Balazs, C., Balbo, M., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batista, P. I., Batkovic, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Tjus, J. Becker, Benbow, W., Medrano, J. Bernete, Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Bhattacharjee, P., Bhattacharyya, S., Bi, B., Biederbeck, N., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bolmont, J., Bordas, P., Bosnjak, Z., Bottacini, E., Bradascio, F., Braiding, C., Bronzini, E., Brose, R., Brown, A. M., Brun, F., Brunetti, G., Bucciantini, N., Bulgarelli, A., Burelli, I., Burmistrov, L., Burton, M., Bylund, T., Calisse, P. G., Campoy-Ordaz, A., Cantlay, B. K., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Carquin, E., Carrasco, M. -S., Cascone, E., Cassol, F., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cifuentes, A., Araujo, C. H. Coimbra, Conforti, V., Conte, F., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dalchenko, M., Dazzi, F., de Lavergne, M. de Bony, De Caprio, V., Laadim, F. De Frondat, Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., De Martino, D., de Menezes, R., de Naurois, M., De Simone, N., de Souza, V., del Valle, M. V., Delagnes, E., Giler, A. G. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Diebold, S., Djannati-Ataï, A., Djuvsland, J., Dominik, R. M., Donini, A., Dorner, D., Dörner, J., Doro, M., Anjos, R. D. C. dos, Dournaux, J. -L., Duangchan, C., Dubos, C., Dumora, D., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Evoli, C., Falceta-Goncalves, D., Ramazani, V. Fallah, Fattorini, A., Faure, A., Fedorova, E., Fegan, S., Feijen, K., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Gaug, M., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giesbrecht, J., Giglietto, N., Giordano, F., Glicenstein, J. -F., Göksu, H., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Granot, J., Grau, R., Gréaux, L., Green, D., Green, J. G., Grenier, I., Grolleron, G., Grube, J., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hie, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoang, J., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hrupec122, D., Hütten, M., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jankowsky, F., Jarnot, C., Jean, P., Martínez, I. Jiménez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kantzas, D., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kerszberg, D., Khélifi, B., Kissmann, R., Kleiner, T., Kluge, G., Kluźniak, W., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Leitgeb, F., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Linhoff, M., Liodakis, I., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Luque-Escamilla, P. L., Macias, O., Mackey, J., Majumdar, P., Malyshev, D., Mandat, D., Manganaro, M., Manicò, G., Mariotti, M., Markoff, S., Márquez, I., Marquez, P., Marsella, G., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Maurin, G., Mazin, D., Melkumyan, D., Mello, A. J. T. S., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Morcuende, D., Morik, K., Morlino, G., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nagataki, S., Nakamori, T., Nemmen, R., Neyroud, N., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., O'Brien, P., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Olmi, B., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Ostrowski, M., Oya, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paoletti, R., Paredes, J. M., Parmiggiani, N., Patel, S. R., Patricelli, B., Pavlović, D., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Peron, G., Persic, M., Petrucci, P. -O., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pintore, F., Pirola, G., Pita, S., Plard, C., Podobnik, F., Pohl, M., Polo, M., Pons, E., Ponti, G., Prandini, E., Prast, J., Principe, G., Priyadarshi, C., Produit, N., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Regeard, M., Reichherzer, P., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Righi, C., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rulten, C. B., Russo, F., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Šarić, T., Sarkar, A., Sarkar, S., Satalecka, K., Saturni, F. G., Savchenko, V., Scherer, A., Schipani, P., Schleicher, B., Schubert, J. L., Schussler, F., Schwanke, U., Schwefer, G., Arroyo, M. Seglar, Seiji, S., Semikoz, D., Sergijenko, O., Servillat, M., Sguera, V., Shang, R. Y., Sharma, P., Siejkowski, H., Sinha, A., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Stolarczyk, T., Strišković, J., Suda, Y., Suomijärvi, T., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tanaka, S. J., Tavernier, T., Tejedor, L. A., Terauchi, K., Terrier, R., Teshima, M., Tian, W. W., Tibaldo, L., Tibolla, O., Torradeflot, F., Torres, D. F., Torresi, E., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Touzard, V., Tramacere, A., Travnicek, P., Tripodo, G., Truzzi, S., Tsiahina, A., Tutone, A., Vacula, M., Vallage, B., Vallania, P., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vigorito, C. F., Vitale, V., Vodeb, V., Voisin, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Wechakama, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yamazaki, R., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhdanov, V. I., Živec, M., Zuriaga-Puig, J., and Luque, P. De la Torre
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract: Galaxy clusters are expected to be dark matter (DM) reservoirs and storage rooms for the cosmic-ray protons (CRp) that accumulate along the cluster's formation history. Accordingly, they are excellent targets to search for signals of DM annihilation and decay at gamma-ray energies and are predicted to be sources of large-scale gamma-ray emission due to hadronic interactions in the intracluster medium. We estimate the sensitivity of the Cherenkov Telescope Array (CTA) to detect diffuse gamma-ray emission from the Perseus galaxy cluster. We perform a detailed spatial and spectral modelling of the expected signal for the DM and the CRp components. For each, we compute the expected CTA sensitivity. The observing strategy of Perseus is also discussed. In the absence of a diffuse signal (non-detection), CTA should constrain the CRp to thermal energy ratio within the radius $R_{500}$ down to about $X_{500}<3\times 10^{-3}$, for a spatial CRp distribution that follows the thermal gas and a CRp spectral index $\alpha_{\rm CRp}=2.3$. Under the optimistic assumption of a pure hadronic origin of the Perseus radio mini-halo and depending on the assumed magnetic field profile, CTA should measure $\alpha_{\rm CRp}$ down to about $\Delta\alpha_{\rm CRp}\simeq 0.1$ and the CRp spatial distribution with 10% precision. Regarding DM, CTA should improve the current ground-based gamma-ray DM limits from clusters observations on the velocity-averaged annihilation cross-section by a factor of up to $\sim 5$, depending on the modelling of DM halo substructure. In the case of decay of DM particles, CTA will explore a new region of the parameter space, reaching models with $\tau_{\chi}>10^{27}$s for DM masses above 1 TeV. These constraints will provide unprecedented sensitivity to the physics of both CRp acceleration and transport at cluster scale and to TeV DM particle models, especially in the decay scenario., Comment: 93 pages (including author list, appendix and references), 143 figures. Submitted to JCAP
Published: 2023
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36. Gammapy: A Python package for gamma-ray astronomy

Author: Donath, Axel, Terrier, Régis, Remy, Quentin, Sinha, Atreyee, Nigro, Cosimo, Pintore, Fabio, Khélifi, Bruno, Olivera-Nieto, Laura, Ruiz, Jose Enrique, Brügge, Kai, Linhoff, Maximilian, Contreras, Jose Luis, Acero, Fabio, Aguasca-Cabot, Arnau, Berge, David, Bhattacharjee, Pooja, Buchner, Johannes, Boisson, Catherine, Fidalgo, David Carreto, Chen, Andrew, de Lavergne, Mathieu de Bony, Cardoso, José Vinícius de Miranda, Deil, Christoph, Füßling, Matthias, Funk, Stefan, Giunti, Luca, Hinton, Jim, Jouvin, Léa, King, Johannes, Lefaucheur, Julien, Lemoine-Goumard, Marianne, Lenain, Jean-Philippe, López-Coto, Rubén, Mohrmann, Lars, Morcuende, Daniel, Panny, Sebastian, Regeard, Maxime, Saha, Lab, Siejkowski, Hubert, Siemiginowska, Aneta, Sipőcz, Brigitta M., Unbehaun, Tim, van Eldik, Christopher, Vuillaume, Thomas, and Zanin, Roberta
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: In this article, we present Gammapy, an open-source Python package for the analysis of astronomical $\gamma$-ray data, and illustrate the functionalities of its first long-term-support release, version 1.0. Built on the modern Python scientific ecosystem, Gammapy provides a uniform platform for reducing and modeling data from different $\gamma$-ray instruments for many analysis scenarios. Gammapy complies with several well-established data conventions in high-energy astrophysics, providing serialized data products that are interoperable with other software packages. Starting from event lists and instrument response functions, Gammapy provides functionalities to reduce these data by binning them in energy and sky coordinates. Several techniques for background estimation are implemented in the package to handle the residual hadronic background affecting $\gamma$-ray instruments. After the data are binned, the flux and morphology of one or more $\gamma$-ray sources can be estimated using Poisson maximum likelihood fitting and assuming a variety of spectral, temporal, and spatial models. Estimation of flux points, likelihood profiles, and light curves is also supported. After describing the structure of the package, we show, using publicly available $\gamma$-ray data, the capabilities of Gammapy in multiple traditional and novel $\gamma$-ray analysis scenarios, such as spectral and spectro-morphological modeling and estimations of a spectral energy distribution and a light curve. Its flexibility and power are displayed in a final multi-instrument example, where datasets from different instruments, at different stages of data reduction, are simultaneously fitted with an astrophysical flux model., Comment: 26 pages, 16 figures
Published: 2023
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37. Gammapy: present status and future roadmap

Author: Khélifi, B., Terrier, R., Donath, A., Sinha, A., Remy, Q., and Pintore, F.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Since its start in 2014, the lightweight open source Python library Gammapy has come a long way to become a popular data analysis package for high-energy astrophysics. Selected as the official CTAO Science Analysis tool, it is also an approved analysis software within the H.E.S.S. and MAGIC collaborations. The first long-term version, Gammapy v1.0 was released on late 2022. It is compliant with several well-established data conventions in high-energy astrophysics, and provides serialised data products that are interoperable with other software. Event lists and instrument response functions curated within the same format from various instruments can be reduced to data binned in energy, time or spatial coordinates. Thereafter, the flux and morphology of one or more gamma-ray sources can be estimated using Poisson maximum likelihood fitting and assuming a variety of spectral, temporal and spatial models. Flux points, likelihood profiles and light curves extractions are supported. Complex user defined likelihoods and models can also be implemented. In this contribution, we will highlight the main features of Gammapy v1.0, including data reduction and analysis examples from different space and ground-based instruments, applications of various background rejection techniques, and a simultaneous fitting across multiple instruments with astrophysical models. We will also present our plans for the future, showcasing new features such as the support of different event types, unbinned likelihood analysis, spectral unfolding and transient source detections. In addition to an improved API with distributed computing for scalable analysis, enhanced support for all-sky instruments like Fermi-LAT and HAWC is foreseen., Comment: Proceedings paper presented at the 38th International Cosmic Ray Conference (ICRC2023), held 26 July - 3 August, 2023, in Nagoya, Japan
Published: 2023

38. The vanishing of the primary emission region in PKS 1510-089

Author: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Barnard, J., Batzofin, R., Becherini, Y., Berge, D., Bernloehr, K., Bi, B., de Lavergne, M. de Bony, Boettcher, M., Boisson, C., Bolmont, J., Borowska, J., Bouyahiaoui, M., Bradascio, F., Breuhaus, M., Brose, R., Brown, A. M., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Davids, I. D., Djannati-Atai, A., Dmytriiev, A., Doroshenko, V., Egberts, K., Einecke, S., Ernenwein, J. -P., Fegan, S., Fontaine, G., Fuessling, M., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Haerer, L., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyski, K., Khatoon, R., Khelifi, B., Klu/'zniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemiere, A., Lenain, J. -P., Leuschner, F., Luashvili, A., Mackey, J., Marandon, V., Marchegiani, P., Marti-Devesa, G., Marx, R., Mehta, A., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., de Naurois, M., Niemiec, J., Noel, A. Priyana, O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Peron, G., Prokhorov, D. A., Puehlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Rieger, F., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schuessler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Sol, H., Specovius, A., Spencer, S., Stawarz, L., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Tsuji, N., van Eldik, C., van Soelen, B., Vecchi, M., Veh, J., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., Zywucka, N., Buckley, D. A. H., Cooper, J., and Groenewald, D.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: In July 2021, PKS 1510-089 exhibited a significant flux drop in the high-energy gamma-ray (by a factor 10) and optical (by a factor 5) bands and remained in this low state throughout 2022. Similarly, the optical polarization in the source vanished, resulting in the optical spectrum being fully explained through the steady flux of the accretion disk and the broad-line region. Unlike the aforementioned bands, the very-high-energy gamma-ray and X-ray fluxes did not exhibit a significant flux drop from year to year. This suggests that the steady-state very-high-energy gamma-ray and X-ray fluxes originate from a different emission region than the vanished parts of the high-energy gamma-ray and optical jet fluxes. The latter component has disappeared through either a swing of the jet away from the line-of-sight or a significant drop in the photon production efficiency of the jet close to the black hole. Either change could become visible in high-resolution radio images., Comment: 18 pages, 4 figures, 6 tables; accepted for publication in ApJ Letters; corresponding authors: Joleen Barnard, Markus Boettcher, Hester Schutte, Michael Zacharias
Published: 2023
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39. Gut physiology of rainbow trout (Oncorhynchus mykiss) is influenced more by short-term fasting followed by refeeding than by feeding fishmeal-free diets

Author: Frohn, Laura, Peixoto, Diogo, Terrier, Frédéric, Costas, Benjamin, Bugeon, Jérôme, Cartier, Christel, Richard, Nadège, Pinel, Karine, and Skiba-Cassy, Sandrine
Published: 2024
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40. Shared and distinct mechanisms of UBA1 inactivation across different diseases

Author: Collins, Jason C, Magaziner, Samuel J, English, Maya, Hassan, Bakar, Chen, Xiang, Balanda, Nicholas, Anderson, Meghan, Lam, Athena, Fernandez-Pol, Sebastian, Kwong, Bernice, Greenberg, Peter L, Terrier, Benjamin, Likhite, Mary E, Kosmider, Olivier, Wang, Yan, Samara, Nadine L, Walters, Kylie J, Beck, David B, and Werner, Achim
Published: 2024
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41. Multiwavelength Observations of the Blazar PKS 0735+178 in Spatial and Temporal Coincidence with an Astrophysical Neutrino Candidate IceCube-211208A

Author: Acharyya, A., Adams, C. B., Archer, A., Bangale, P., Bartkoske, J. T., Batista, P., Benbow, W., Brill, A., Buckley, J. H., Christiansen, J. L., Chromey, A. J., Errando, M., Falcone, A., Feng, Q., Foote, G. M., Fortson, L., Furniss, A., Gallagher, G., Hanlon, W., Hanna, D., Hervet, O., Hinrichs, C. E., Hoang, J., Holder, J., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kherlakian, M., Kieda, D., Kleiner, T. K., Korzoun, N., Kumar, S., Lang, M. J., Lundy, M., Maier, G., McGrath, C. E, Millard, M. J., Millis, J., Mooney, C. L., Moriarty, P., Mukherjee, R., O'Brien, S., Ong, R. A., Pohl, M., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Roache, E., Sadeh, I., Sadun, A. C., Saha, L., Santander, M., Sembroski, G. H., Shang, R., Splettstoesser, M., Talluri, A. Kaushik, Tucci, J. V., Vassiliev, V. V., Weinstein, A., Williams, D. A., Wong, S. L., Woo, J., Aharonian, F., Aschersleben, J., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Bradascio, F., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Dai, S., Mbarubucyeye, J. Damascene, Djannati-Atai, A., Dmytriiev, A., Doroshenko, V., Einecke, S., Ernenwein, J. -P., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Fussling, M., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Haerer, L., Hinton, J. A., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynski, K., Khatoon, R., Khelifi, B., Klepser, S., Kluzniak, W., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Lemiere, A., Lenain, J. P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Marti-Devesa, G., Marx, R., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., Nakashima, K., Niemiec, J., Noel, A. Priyana, O'Brien, P., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Peron, G., Prokhorov, D. A., Puhlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Renaud, M., Rieger, F., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Santangelo, A., Sasaki, M., Schafer, J., Schussler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Specovius, A., Spencer, S., Stawarz, L., Steenkamp, R., Steinmassl, S., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., Zywucka, N., and Mori, K.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on multiwavelength target-of-opportunity observations of the blazar PKS 0735+178, located 2.2$^\circ$ away from the best-fit position of the IceCube neutrino event IceCube-211208A detected on December 8, 2021. The source was in a high-flux state in the optical, ultraviolet, X-ray, and GeV gamma-ray bands around the time of the neutrino event, exhibiting daily variability in the soft X-ray flux. The X-ray data from Swift-XRT and NuSTAR characterize the transition between the low-energy and high-energy components of the broadband spectral energy distribution (SED), and the gamma-ray data from Fermi -LAT, VERITAS, and H.E.S.S. require a spectral cut-off near 100 GeV. Both X-ray and gamma-ray measurements provide strong constraints on the leptonic and hadronic models. We analytically explore a synchrotron self-Compton model, an external Compton model, and a lepto-hadronic model. Models that are entirely based on internal photon fields face serious difficulties in matching the observed SED. The existence of an external photon field in the source would instead explain the observed gamma-ray spectral cut-off in both leptonic and lepto-hadronic models and allow a proton jet power that marginally agrees with the Eddington limit in the lepto-hadronic model. We show a numerical lepto-hadronic model with external target photons that reproduces the observed SED and is reasonably consistent with the neutrino event despite requiring a high jet power., Comment: 21 pages, 3 figures, accepted by ApJ
Published: 2023

42. Constraints on the intergalactic magnetic field using Fermi-LAT and H.E.S.S. blazar observations

Author: S., H. E. S., Collaborations, Fermi-LAT, Aharonian, F., Aschersleben, J., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bi, B., Bouyahiaoui, M., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., de Bony, M., Egberts, K., Ernenwein, J. -P., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grondin, M. -H., Haerer, L., Holch, T. L., Holler, M., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Martí-Devesa, G., Marx, R., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Murach, T., Nakashima, K., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sanchez, D. A., Sasaki, M., Schüussler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Sol, H., Spencer, S., Steinmassl, S., Suzuki, H., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Thorpe-Morgan, C., Tsirou, M., Tsuji, N., Uchiyama, Y., van Eldik, C., Veh, J., Venter, C., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zouari, S., and Zywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Magnetic fields in galaxies and galaxy clusters are believed to be the result of the amplification of intergalactic seed fields during the formation of large-scale structures in the universe. However, the origin, strength, and morphology of this intergalactic magnetic field (IGMF) remain unknown. Lower limits on (or indirect detection of) the IGMF can be obtained from observations of high-energy gamma rays from distant blazars. Gamma rays interact with the extragalactic background light to produce electron-positron pairs, which can subsequently initiate electromagnetic cascades. The $\gamma$-ray signature of the cascade depends on the IGMF since it deflects the pairs. Here we report on a new search for this cascade emission using a combined data set from the Fermi Large Area Telescope and the High Energy Stereoscopic System. Using state-of-the-art Monte Carlo predictions for the cascade signal, our results place a lower limit on the IGMF of $B > 7.1\times10^{-16}$ G for a coherence length of 1 Mpc even when blazar duty cycles as short as 10 yr are assumed. This improves on previous lower limits by a factor of 2. For longer duty cycles of $10^4$ ($10^7$) yr, IGMF strengths below $1.8\times10^{-14}$ G ($3.9\times10^{-14}$ G) are excluded, which rules out specific models for IGMF generation in the early universe., Comment: 20 pages, 7 figures, 4 tables. Accepted for publication in ApJ Letters. Auxiliary data is provided in electronic format at https://zenodo.org/record/8014311
Published: 2023
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43. Constraining the cosmic-ray pressure in the inner Virgo Cluster using H.E.S.S. observations of M 87

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Arcaro, C., Aschersleben, J., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Borowska, J., Bradascio, F., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Caroff, S., Casanova, S., Cecil, R., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Egberts, K., Ernenwein, J. -P., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Grondin, M. -H., Haerer, L., Haupt, M., Hermann, G., Hinton, J. A., Holch, T. L., Horns, D., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Marinos, P., Martí-Devesa, G., Marx, R., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Renaud, M., Rieger, F., Rowell, G., Rudak, B., Velasco, E. Ruiz, Sahakian, V., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schwanke, U., Shapopi, J. N. S., Sol, H., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Tsirou, M., Tsuji, N., Uchiyama, Y., van Eldik, C., van Soelen, B., Vecchi, M., Veh, J., Venter, C., Vink, J., Wach, T., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: The origin of the gamma-ray emission from M87 is currently a matter of debate. This work aims to localize the VHE (100 GeV-100 TeV) gamma-ray emission from M87 and probe a potential extended hadronic emission component in the inner Virgo Cluster. The search for a steady and extended gamma-ray signal around M87 can constrain the cosmic-ray energy density and the pressure exerted by the cosmic rays onto the intra-cluster medium, and allow us to investigate the role of the cosmic rays in the active galactic nucleus feedback as a heating mechanism in the Virgo Cluster. H.E.S.S. telescopes are sensitive to VHE gamma rays and have been utilized to observe M87 since 2004. We utilized a Bayesian block analysis to identify M87 emission states with H.E.S.S. observations from 2004 until 2021, dividing them into low, intermediate, and high states. Because of the causality argument, an extended ($\gtrsim$kpc) signal is allowed only in steady emission states. Hence, we fitted the morphology of the 120h low state data and found no significant gamma-ray extension. Therefore, we derived for the low state an upper limit of 58"(corresponding to $\approx$4.6kpc) in the extension of a single-component morphological model described by a rotationally symmetric 2D Gaussian model at 99.7% confidence level. Our results exclude the radio lobes ($\approx$30 kpc) as the principal component of the VHE gamma-ray emission from the low state of M87. The gamma-ray emission is compatible with a single emission region at the radio core of M87. These results, with the help of two multiple-component models, constrain the maximum cosmic-ray to thermal pressure ratio $X_{{CR,max.}}$$\lesssim$$0.32$ and the total energy in cosmic-ray protons (CRp) to $U_{CR}$$\lesssim$5$\times10^{58}$ erg in the inner 20kpc of the Virgo Cluster for an assumed CRp power-law distribution in momentum with spectral index $\alpha_{p}$=2.1., Comment: 15 pages, 7 figures. Accepted for publication in A&A. Corresponding authors: Victor Barbosa Martins, Stefan Ohm, Cornelia Arcaro, Natalia \.Zywucka, Mathieu de Naurois
Published: 2023
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44. Dynamic sizing of required balancing capacities: the operational approach in France

Author: Dumas, Jonathan, Terrier, Viktor, Bienvenu, Frédéric, Finet, Sébastien, and Grisey, Nathalie
Subjects: Electrical Engineering and Systems Science - Systems and Control
Abstract: System operators employ operating reserves to deal with unexpected variations of demand and generation and guarantee the security of supply. However, they face new challenges to ensure this mission with the increasing share of renewable generation. This article focuses on the operational approach adopted by the French transmission system operator RTE for dynamically sizing the required margins in the dynamic margin monitoring strategy context. It relies on continuous forecasts of the main drivers of the uncertainties of the system imbalance. Four types of forecast errors, assumed to be independent, are considered in this approach: the errors in the wind and photovoltaic power generation, production of conventional power units, and electricity consumption. Then, the required margin is the result of comparing the global forecast error, computed as the convolution of these independent errors, with a security of supply criterion. This study presents the results of this method implemented at RTE and used in real-time operation., Comment: Preprint version of the paper accepted for EEM 23 conference
Published: 2023
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45. Detection of extended gamma-ray emission around the Geminga pulsar with H.E.S.S

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Borowska, J., Bouyahiaoui, M., Bradascio, F., Brose, R., Brun, F., Bruno, B., Bulik, T., Scheidlin, C. Burger, Cangemi, F., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chambery, P., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Mbarubucyeye, J. Damascene, Devin, J., Djannati-Ataï, A., Dmytriiev, A., Egberts, K., Einecke, S., Ernenwein, J. P., Feijen, K., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Füssling, M., Funk, S., Gabici, S., Gallant, Y. A., Ghafourizadeh, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Grondin, M. -H., Haerer, L., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Marinos, P., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Pühlhofer, G., Quirrenbach, A., Reimer, A., Reimer, O., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schüssler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Sinha, A., Sol, H., Specovius, A., Spencer, S., Stawarz, Ł., Steinmassl, S., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thorpe-Morgan, C., Tsirou, M., Tsuji, N., Vecchi, M., Venter, C., Vink, J., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Geminga is an enigmatic radio-quiet gamma-ray pulsar located at a mere 250 pc distance from Earth. Extended very-high-energy gamma-ray emission around the pulsar was discovered by Milagro and later confirmed by HAWC, which are both water Cherenkov detector-based experiments. However, evidence for the Geminga pulsar wind nebula in gamma rays has long evaded detection by imaging atmospheric Cherenkov telescopes (IACTs) despite targeted observations. The detection of gamma-ray emission on angular scales > 2 deg poses a considerable challenge for the background estimation in IACT data analysis. With recent developments in understanding the complementary background estimation techniques of water Cherenkov and atmospheric Cherenkov instruments, the H.E.S.S. IACT array can now confirm the detection of highly extended gamma-ray emission around the Geminga pulsar with a radius of at least 3 deg in the energy range 0.5-40 TeV. We find no indications for statistically significant asymmetries or energy-dependent morphology. A flux normalisation of $(2.8\pm0.7)\times10^{-12}$ cm$^{-2}$s$^{-1}$TeV$^{-1}$ at 1 TeV is obtained within a 1 deg radius region around the pulsar. To investigate the particle transport within the halo of energetic leptons around the pulsar, we fitted an electron diffusion model to the data. The normalisation of the diffusion coefficient obtained of $D_0 = 7.6^{+1.5}_{-1.2} \times 10^{27}$ cm$^2$s$^{-1}$, at an electron energy of 100 TeV, is compatible with values previously reported for the pulsar halo around Geminga, which is considerably below the Galactic average., Comment: 16 pages, 15 figures, 7 tables. Accepted for publication in Astronomy & Astrophysics
Published: 2023
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46. Association between humoral serological markers levels and risk of SARS-CoV-2 infection after the primary COVID-19 vaccine course among ANRS0001S COV-POPART cohort participants

Author: Mathieu Chalouni, Paul Loubet, Edouard Lhomme, Laetitia Ninove, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Jérome de Seze, Martine Laville, Bruno Laviolle, Jean-Daniel Lelièvre, Jacques Morel, Stéphanie Nguyen Quoc, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, François Vrtovsnik, Sophie Circosta, Aude Barquin, Mariam Gharib, Eric Tartour, Béatrice Parfait, Rodolphe Thiébaut, Laurence Meyer, Xavier de Lamballerie, Odile Launay, Linda Wittkop, and for the ANRS0001S COV-POPART study group
Subjects: Specific populations, SARS-CoV-2, Vaccine, Prediction, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background We assessed the prognostic value of serological humoral markers measured one month after the last dose of the primary COVID-19 vaccine course for predicting the risk of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection over the following six months in specific populations. Methods ANRS0001SCOV-POPART is a French nationwide multicenter prospective observational cohort study assessing the immune response to Covid-19 vaccines routinely administered to 11 subgroups of patients with chronic disease and a control group. Participants from the ANRS0001S COV-POPART were included if they received at least two doses of Covid-19 vaccine for the primary vaccine course, had measurements of anti-Spike, anti-receptor binding domain (RBD) IgG-specific or neutralizing antibodies one month after the end of the primary vaccine course, without being infected by SARS-CoV-2 before the measurement. SARS-CoV-2 infections defined by a positive PCR/antigenic test or seroconversion to detectable anti nucleocapsid antibodies were evaluated until the first COVID-19 booster injection. Cox proportional hazards models taking into account interval-censored data were implemented to estimate the association between each antibody level and the risk of SARS-CoV-2 infection. Predictive performances were evaluated by the area under the receiving operating characteristic curve (AUROC). Results Two thousand five hundred seventy adults from a specific population and 1,123 from the control group were included. The cumulative probabilities of SARS-CoV-2 infections at five months after serological measurement were 6.0% 95% confidence interval: [5.0; 7.9] and 10.1% 95% confidence interval: [8.3; 11.9], respectively. Higher levels of anti-Spike IgG antibody were associated with a lower risk of SARS-CoV-2 infections in the control group, but not in the specific populations. Among the specific populations, AUROC were 74.5%, 74.9%, and 72.4% for anti-Spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. AUROC were superior in the specific populations, 82.0%, 81.2%, and 81.4% for anti-Spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Conclusions Vaccine-induced antibody response after the primary course of Covid-19 infection only moderately discriminated between participants developing a SARS-CoV-2 infection during the Omicron wave. Trial registration NCT04824651 (first posted: 2021-04-01).
Published: 2024
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47. Perceptions, expectations, and recommendations of trans adults on gender-affirming care in France: a qualitative study

Author: Michelle Veilleux, Jean-Etienne Terrier, Maxence Bécu, Marina Lafon, Aurélie Bourmaud, and Philippe Martin
Subjects: Trans health, Gender-affirming care, Healthcare in france, Health experience, Patient expectations, Public aspects of medicine, RA1-1270
Abstract: Abstract Trans people have diverse life experiences which may include gender-affirming care (GAC). GAC positively impacts the quality of life of trans adults. However, they are often met with barriers to care and are particularly vulnerable within the healthcare system. The needs and expectations surrounding GAC may vary between individual patients. This article aims to analyze trans adults’ perceptions, expectations, and recommendations on GAC. Twenty-seven semi-structured interviews were conducted by a team of academic and peer researchers; transcribed interviews were then analyzed using a codebook and thematic analysis. Three main themes were identified; the liberating experience of GAC; the uneven distribution of knowledge and power between patients and providers; and the recommended practices in GAC. Additional training and research are necessary to facilitate high-quality care for trans adults accessing GAC.
Published: 2024
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48. Effects of metronome walking on long-term attractor divergence and correlation structure of gait: a validation study in older people

Author: Sophia Piergiovanni and Philippe Terrier
Subjects: Gait analysis, Aging, Nonlinear dynamics, Metronome walking, Medicine, Science
Abstract: Abstract This study investigates the effects of metronome walking on gait dynamics in older adults, focusing on long-range correlation structures and long-range attractor divergence (assessed by maximum Lyapunov exponents). Sixty older adults participated in indoor walking tests with and without metronome cues. Gait parameters were recorded using two triaxial accelerometers attached to the lumbar region and to the foot. We analyzed logarithmic divergence of lumbar acceleration using Rosenstein’s algorithm and scaling exponents for stride intervals from foot accelerometers using detrended fluctuation analysis (DFA). Results indicated a concomitant reduction in long-term divergence exponents and scaling exponents during metronome walking, while short-term divergence remained largely unchanged. Furthermore, long-term divergence exponents and scaling exponents were significantly correlated. Reliability analysis revealed moderate intrasession consistency for long-term divergence exponents, but poor reliability for scaling exponents. Our results suggest that long-term divergence exponents could effectively replace scaling exponents for unsupervised gait quality assessment in older adults. This approach may improve the assessment of attentional involvement in gait control and enhance fall risk assessment.
Published: 2024
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49. H.E.S.S. follow-up observations of GRB221009A

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Bradascio, F., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Cotter, G., Dai, S., Mbarubucyeye, J. Damascene, Devin, J., Djannati-Ataï, A., Dmytriiev, A., Doroshenko, V., Egberts, K., Einecke, S., Ernenwein, J. -P., Fegan, S., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Ghafourizadeh, S., Giavitto, G., Glawion, D., Glicenstein, J. F., Goswami, P., Grolleron, G., Hinton, M. -H. Grondin J. A., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khatoon, R., Khélifi, B., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. P., Leuschner, F., Lohse, T., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Martí-Devesa, G., Marx, R., Meyer, M., Mitchell, A., Mohrmann, L., Montanari, A., Moulin, E., Murach, T., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, O'Brien, P., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Ren, H., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Steppa, C., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Tsuji, N., Uchiyama, Y., Vecchi, M., Venter, C., Vink, J., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: GRB221009A is the brightest gamma-ray burst ever detected. To probe the very-high-energy (VHE, $>$\!100 GeV) emission, the High Energy Stereoscopic System (H.E.S.S.) began observations 53 hours after the triggering event, when the brightness of the moonlight no longer precluded observations. We derive differential and integral upper limits using H.E.S.S. data from the third, fourth, and ninth nights after the initial GRB detection, after applying atmospheric corrections. The combined observations yield an integral energy flux upper limit of $\Phi_\mathrm{UL}^{95\%} = 9.7 \times 10^{-12}~\mathrm{erg\,cm^{-2}\,s^{-1}}$ above $E_\mathrm{thr} = 650$ GeV. The constraints derived from the H.E.S.S. observations complement the available multiwavelength data. The radio to X-ray data are consistent with synchrotron emission from a single electron population, with the peak in the SED occurring above the X-ray band. Compared to the VHE-bright GRB190829A, the upper limits for GRB221009A imply a smaller gamma-ray to X-ray flux ratio in the afterglow. Even in the absence of a detection, the H.E.S.S. upper limits thus contribute to the multiwavelength picture of GRB221009A, effectively ruling out an IC dominated scenario., Comment: 10 pages, 4 figures. Accepted for publication in APJL. Corresponding authors: J. Damascene Mbarubucyeye, H. Ashkar, S. J. Zhu, B. Reville, F. Sch\"ussler
Published: 2023
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50. HESS J1809$-$193: a halo of escaped electrons around a pulsar wind nebula?

Author: Collaboration, H. E. S. S., Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Böttcher, M., Boisson, C., Bolmont, J., Borowska, J., Bouyahiaoui, M., Bradascio, F., Breuhaus, M., Brose, R., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Caroff, S., Casanova, S., Celic, J., Cerruti, M., Chambery, P., Chand, T., Chen, A., Chibueze, J., Chibueze, O., Mbarubucyeye, J. Damascene, Djannati-Ataï, A., Dmytriiev, A., Einecke, S., Ernenwein, J. -P., Feijen, K., Filipovic, M., Fontaine, G., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Ghafourizadeh, S., Giavitto, G., Giunti, L., Glawion, D., Goswami, P., Grolleron, G., Grondin, M. -H., Haerer, L., Hinton, J. A., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Khélifi, B., Kluźniak, W., Komin, Nu., Kosack, K., Kostunin, D., Lang, R. G., Stum, S. Le, Leitl, F., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Marinos, P., Martí-Devesa, G., Marx, R., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moulin, E., Muller, J., Nakashima, K., de Naurois, M., Niemiec, J., Noel, A. Priyana, Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Prokhorov, D. A., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Renaud, M., Reville, B., Rieger, F., Rowell, G., Rudak, B., Sahakian, V., Santangelo, A., Sasaki, M., Schutte, H. M., Schwanke, U., Shapopi, J. N. S., Sol, H., Specovius, A., Spencer, S., Stawarz, Ł., Steenkamp, R., Steinmassl, S., Sushch, I., Suzuki, H., Takahashi, T., Tanaka, T., Terrier, R., Thorpe-Morgan, C., Tsirou, M., Tsuji, N., Uchiyama, Y., van Eldik, C., Vecchi, M., Veh, J., Venter, C., Vink, J., Wach, T., Wagner, S. J., White, R., Wierzcholska, A., Wong, Yu Wun, Zacharias, M., Zargaryan, D., Zdziarski, A. A., Zech, A., Zouari, S., and Żywucka, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Context. HESS J1809$-$193 is an unassociated very-high-energy $\gamma$-ray source located on the Galactic plane. While it has been connected to the nebula of the energetic pulsar PSR J1809$-$1917, supernova remnants and molecular clouds present in the vicinity also constitute possible associations. Recently, the detection of $\gamma$-ray emission up to energies of $\sim$100 TeV with the HAWC observatory has led to renewed interest in HESS J1809$-$193. Aims. We aim to understand the origin of the $\gamma$-ray emission of HESS J1809$-$193. Methods. We analysed 93.2 h of data taken on HESS J1809$-$193 above 0.27 TeV with the High Energy Stereoscopic System (H.E.S.S.), using a multi-component, three-dimensional likelihood analysis. In addition, we provide a new analysis of 12.5 yr of Fermi-LAT data above 1 GeV within the region of HESS J1809$-$193. The obtained results are interpreted in a time-dependent modelling framework. Results. For the first time, we were able to resolve the emission detected with H.E.S.S. into two components: an extended component that exhibits a spectral cut-off at $\sim$13 TeV, and a compact component that is located close to PSR J1809$-$1917 and shows no clear spectral cut-off. The Fermi-LAT analysis also revealed extended $\gamma$-ray emission, on scales similar to that of the extended H.E.S.S. component. Conclusions. Our modelling indicates that based on its spectrum and spatial extent, the extended H.E.S.S. component is likely caused by inverse Compton emission from old electrons that form a halo around the pulsar wind nebula. The compact component could be connected to either the pulsar wind nebula or the supernova remnant and molecular clouds. Due to its comparatively steep spectrum, modelling the Fermi-LAT emission together with the H.E.S.S. components is not straightforward. (abridged), Comment: 14 pages, 10 figures. Accepted for publication in A&A. Corresponding authors: Vikas Joshi, Lars Mohrmann
Published: 2023
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