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417 results on '"PAPARO F."'

6. Concordance, disease progression, and heritability of coeliac disease in Italian twins

Author

Nistico, L., Fagnani, C., Coto, I., Percopo, S., Cotichini, R., Limongelli, M.G., Paparo, F., D'Alfonso, S., Giordano, M., Sferlazzas, C., Magazzu, G., Momigliano-Richiardi, P., Greco, L., and Stazi, M.A.

Subjects
Celiac disease -- Development and progression, Celiac disease -- Genetic aspects, Celiac disease -- Risk factors, Twins -- Health aspects, Twins -- Genetic aspects, Twins -- Research, Health
Published
2006

8. An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients. (Small Intestine)

Author

Mazzarella, G., Maglio, M., Paparo, F., Nardone, G., Stefanile, R., Greco, L., Wal, Y. van de, Kooy, Y., Koning, F., Auricchio, S., and Troncone, R.

Subjects
Celiac disease -- Research -- Health aspects, HLA class II antigens -- Health aspects -- Research, Health
Abstract

Background: Studies on intestinal T cell clones from the mucosa of patients with coeliac disease have led to the identification of immunogenic gliadin epitopes. One is HLA-DQ8 restricted, its recognition [...]

Published
2003

9. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. (Coeliac Disease)

Author

Esposito, C., Paparo, F., Caputo, I., Rossi, M., Maglio, M., Sblattero, D., Not, T., Porta, R., Auricchio, S., Marzari, R., and Troncone, R.

Subjects
Transglutaminases -- Physiological aspects, Celiac disease -- Physiological aspects, Viral antibodies -- Physiological aspects, Immunoglobulin A -- Physiological aspects, Immunoglobulin G -- Physiological aspects, Antibodies -- Physiological aspects, Health
Abstract

Background and aims: Coeliac disease (CD) is a multifactorial disarder which has an autoimmune camponent characterised by the occurrence of disease specific autoreactive antibodies against the enzyme tissue transglutaminase (tTG). [...]

Published
2002

10. The first large population based twin study of coeliac disease. (Small Intestine)

Author

Greco, L., Romino, R., Coto, I., Cosmo, N. Di, Percopo, S., Maglio, M., Paparo, F., Gasperi, V., Limongelli, M.G., Cotichini, R., D'Agate, C., Tinto, N., Sacchetti, L., Tosi, R., and Stazi, M.A.

Subjects
Celiac disease -- Genetic aspects -- Research, Familial diseases -- Research -- Genetic aspects, Twin studies -- Research, Twins -- Research -- Diseases -- Genetic aspects, Health, Diseases, Research, Genetic aspects
Abstract

Background and aims: The genetic load in coeliac disease has hitherto been inferred from case series or anecdotally referred twin pairs. We have evaluated the genetic component in coeliac disease [...]

Published
2002

21. Additional value of integrated 18F-choline PET/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile

Author

Piccardo, Arnoldo, primary, Trimboli, P., additional, Rutigliani, M., additional, Puntoni, M., additional, Foppiani, L., additional, Bacigalupo, L., additional, Crescenzi, Anna, additional, Bottoni, G., additional, Treglia, G., additional, Paparo, F., additional, Del Monte, P., additional, Lanata, M., additional, Paone, G., additional, Ferrarazzo, G., additional, Catrambone, U., additional, Arlandini, A., additional, Ceriani, L., additional, Cabria, M., additional, and Giovanella, L., additional

Published
2018
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22. Pigmented villonodular synovitis of the temporomandibular joint.

Author

Cascone P, Filiaci F, Paparo F, and Mustazza MC

Abstract

Pigmented villonodular synovitis (PVNS) is a relatively rare disease affecting synovium-lined joints. PVNS was first fully described in 1941 by Jaffe et al, who considered it a benign inflammatory state of the synovium of uncertain etiology. Reports of this disease in the temporomandibular joint (TMJ) are extremely rare. This report describes a case of a 78-year-old man affected by PVNS of the right TMJ. Clinical examination revealed the presence of a right-sided preauricular mass; a magnetic resonance imaging scan showed a mass located lateral to the right mandibular condyle, close to the TMJ capsule. The clinical and pathologic features of the case are described. [ABSTRACT FROM AUTHOR]

Published
2008

24. Additional value of integrated 18F-choline PET/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile.

Author

Piccardo, Arnoldo, Trimboli, P., Rutigliani, M., Puntoni, M., Foppiani, L., Bacigalupo, L., Crescenzi, Anna, Bottoni, G., Treglia, G., Paparo, F., Del Monte, P., Lanata, M., Paone, G., Ferrarazzo, G., Catrambone, U., Arlandini, A., Ceriani, L., Cabria, M., and Giovanella, L.

Subjects
PARATHYROID glands, POSITRON emission tomography, CHOLINE, DIAGNOSTIC imaging, BIOGENIC amines
Abstract

Purpose: The localization of hyperfunctioning parathyroid gland(s) (HPTG) in patients with primary hyperparathyroidism (PHPT) with negative or inconclusive first-line imaging is a significant challenge. This study aimed to evaluate the role of integrated 18F-choline PET/4D contrast-enhanced computed tomography (4DCeCT) in these patients, compare its detection rate and sensitivity with those of 18F-choline PET/CT and (4DCeCT), and analyse the association between choline metabolism and morphological, biochemical and molecular parameters of HPTG.Methods: We prospectively enrolled 44 PHPT patients with negative or inconclusive first-line imaging. 18F-Choline PET/CT and 4DCeCT were performed at the same time, and integrated 18F-choline PET/4DCeCT images were obtained after coregistration. Experienced physicians examined the images. The SUVratio and degree of contrast enhancement were recorded for each positive finding. Histopathology, laboratory and multidisciplinary follow-up were used as the standard of reference. Both the detection rates and sensitivities of the three imaging modalities were calculated retrospectively. Immunohistochemistry was performed to evaluate the molecular profile of HPTGs.Results: 18F-Choline PET/4DCeCT was positive in 32 of 44 patients with PHPT (detection rate 72.7%), and 31 of 31 surgically treated patients (sensitivity 100%). These results were significantly (p < 0.05) better than those of 18F-choline PET/CT (56.8% and 80%, respectively) and those of 4DCeCT (54.5 and 74%, respectively). A significant correlation between SUV and calcium level was found. In a multivariate analysis, only calcium level was significantly associated with 18F-choline PET/4DCeCT findings. SUVratio and Ki67 expression were significantly correlated.Conclusion: Integrated 18F-choline PET/4DCeCT should be considered as an effective tool to detect PHPT in patients with negative or inconclusive first-line imaging. Choline metabolism is correlated with both calcium level and Ki67 expression in HPTG. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Serum immunoglobulins A and G, and Monoclonal antibodies anti tissue transglutaminase from coeliac patients inhibit the catalytic activity both in vitro and in situ

Author

ESPOSITO C., PAPARO F., CAPUTO I., ROSSI M., MAGLIO M., SBLATTERO D., NOT T., PORTA R., MARZARI R., TRONCONE, RICCARDO, AURICCHIO, SALVATORE, MAKI M, TOSSAVAINEN M., Esposito, C, Paparo, F, Caputo, I, Rossi, M, Maglio, M, Sblattero, D, Not, T, Porta, Raffaele, Auricchio, S, Marzari, R, Troncone, Riccardo, Esposito, C., Paparo, F., Caputo, I., Rossi, M., Maglio, M., Sblattero, D., Not, T., Porta, R., Auricchio, Salvatore, and Marzari, R.

Published
2001

28. Magnetic resonance imaging of the hand in psoriatic arthritis

Author

Cimmino MA, Parodi M, Zampogna G, Paparo F, Silvestri E, Garlaschi G, SCARPA, RAFFAELE, Scarpa R, Olivieri I, Salvarano C, Ayala F, Moll JHM, Cimmino, Ma, Parodi, M, Zampogna, G, Paparo, F, Silvestri, E, Garlaschi, G, and Scarpa, Raffaele

Published
2009

30. Dynamic contrast-enhanced, extremity-dedicated MRI identifies synovitis changes in the follow-up of rheumatoid arthritis patients treated with rituximab

Author

Parodi, M, Zampogna, G, Boesen, M, Kubassova, O, Barbieri, Francesca, Paparo, F, and Cutolo, M.

Subjects
Adult, Murine-Derived, Male, Wrist Joint, Synovitis, Time Factors, Arthritis, Synovial Membrane, Contrast Media, Middle Aged, Severity of Illness Index, Magnetic Resonance Imaging, Antibodies, Treatment Outcome, Predictive Value of Tests, Antirheumatic Agents, Rheumatoid, Monoclonal, Humans, Aged, Antibodies, Monoclonal, Murine-Derived, Arthritis, Rheumatoid, Female, Prospective Studies
Published
2014

31. Growth-factor like activity of gliadin, an alimentary protein: implications for celiac disease

Author

BARONE MV, GIMIGLIANO A, CASTORIA G, MAURANO F, PAPARO F, MAGLIO M, MINEO A, NANAYAKKARA M, TRONCONE R, AURICCHIO S., PAOLELLA, GIOVANNI, MIELE, ERASMO, Barone, Mv, Gimigliano, A, Castoria, G, Paolella, Giovanni, Maurano, F, Paparo, F, Maglio, M, Mineo, A, Miele, Erasmo, Nanayakkara, M, Troncone, R, and Auricchio, S.

Abstract

Background: Gliadins, a family of wheat proteins, are central to the pathogenesis of celiac disease (CD). In addition to 'immunogenic' effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate 'toxic' peptide, such as A-gliadin p31-43 (P31-43). Aims: Understanding the molecular mechanisms underlying direct non T-cell mediated effects of gliadin peptides, and assessing their potential role in promoting CD. Method: Gliadin effects were tested on a number of cell lines and on cultured mucosa samples by evaluating cytoskeleton rearrangements, endocytosis, proliferation and apoptosis. Standard biochemical methods were used to assess prolonged epidermal growth factor receptor (EGFR) activation. Results: Crude gliadin peptic-tryptic peptides [PTG], or P31-43 alone, fully reproduce the effects of epidermal growth factor [EGF] on actin cytosketon, cell cycle and cell proliferation of various cell lines. Inhibitor studies demonstrate the role of EGFR in the early response to gliadin exposure, pointing to activation of the EGFR pathway. Peptide P31-43 is not similar to any EGFR ligand, but can delay inactivation of the EGFR interfering with its endocytosis. Gliadin-induced delay of EGFR endocytosis in cultured intestinal biopsies, together with S-phase entry of epithelial intestinal cells, confirm a role for EGFR activation in CD. Conclusion: The ability of gliadin peptides to delay EGFR inactivation through interference with the endocytic pathway suggests a model where gliadin fragments amplify the effects of trace amounts of EGF, and possibly of other growth factors, by prolonging receptor activation. The results, using cultures of coeliac intestinal biopsies, highlight the role of the EGF pathway in establishing and maintaining the typical atrophic and proliferative alterations of the small intestine in CD.

Published
2007

32. Thyroid nodules with indeterminate cytology: prospective comparison between 18F-FDG-PET/CT, multiparametric neck ultrasonography, 99mTc-MIBI scintigraphy and histology

Author

Piccardo, A, primary, Puntoni, M, additional, Treglia, G, additional, Foppiani, L, additional, Bertagna, F, additional, Paparo, F, additional, Massollo, M, additional, Dib, B, additional, Paone, G, additional, Arlandini, A, additional, Catrambone, U, additional, Casazza, S, additional, Pastorino, A, additional, Cabria, M, additional, and Giovanella, L, additional

Published
2016
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33. Diagnostic Value of fecal calprotectin in pediatric clinical practice

Author

BERNI CANANI, ROBERTO, RAPACCIUOLO L, ROMANO MT, TANTURRI DE HORATIO L, TERRIN G, MANGUSO F, CIRILLO P, PAPARO F, TRONCONE, RICCARDO, BERNI CANANI, Roberto, Rapacciuolo, L, Romano, Mt, TANTURRI DE HORATIO, L, Terrin, G, Manguso, F, Cirillo, P, Paparo, F, and Troncone, Riccardo

Published
2004

35. AN IMMUNODOMINANT DQ8 RESTRICTED GLIADIN PEPTIDE ACTIVATES SMALL INTESTINAL IMMUNE RESPONSE IN 'IN VITRO' CULTURED MUCOSA FROM HLA-DQ8 POSITIVE BUT NOT HLA-DQ8 NEGATIVE CELIAC PATIENTS

Author

MAZZARELLA G., MAGLIO M., PAPARO F., NARDONE, GERARDO ANTONIO PIO, STEFANILE R., GRECO, LUIGI, VAN DE WAL Y., KOOY Y., TRONCONE R., AURICCHIO, SALVATORE, Mazzarella, G., Maglio, M., Paparo, F., Nardone, GERARDO ANTONIO PIO, Stefanile, R., Greco, Luigi, VAN DE WAL, Y., Kooy, Y., Auricchio, Salvatore, and Troncone, R.

Published
2003

36. AN IMMUNODOMINANT DQ8-RESTRICTED GLIADIN PEPTIDE ACTIVATES SMALL INTESTINAL IMMUNE RESPONSE IN 'IN VITRO' CULTURED MUCOSA FROM HLA-DQ8, BUT NOT HLA-DQ2 POSITIVE COELIAC PATIENTS

Author

MAZZARELLA G., MAGLIO M., PAPARO F., STEFANILE R., GRECO, LUIGI, VAN DE WAL Y., KOOY Y., KONING F., AURICCHIO S., NARDONE, GERARDO ANTONIO PIO, TRONCONE, RICCARDO, Mazzarella, G., Maglio, M., Paparo, F., Nardone, GERARDO ANTONIO PIO, Stefanile, R., Greco, Luigi, VAN DE WAL, Y., Kooy, Y., Koning, F., Auricchio, S., and Troncone, Riccardo

Published
2003

39. Serum immunoglobulin A and G, and monoclonal antibodies anti-tissue transglutaminase from coeliac patients inhibit the catalytic activity both in vitro and in situ

Author

ESPOSITO C, PAPARO F, CAPUTO I, ROSSI M, MAGLIO D, SBLATTERO D, NOT, TARCISIO, PORTA S, TRONCONE R., MARZARI, ROBERTO, Esposito, C, Paparo, F, Caputo, I, Rossi, M, Maglio, D, Sblattero, D, Not, Tarcisio, Porta, S, Marzari, Roberto, and Troncone, R.

Subjects
Celiac disease Transglutaminase Cloned antibodies Phage display
Published
2002

46. Coeliac disease and unfavorable outcome of pregnancy

Author

MARTINELLI, PASQUALE, NARDONE, GERARDO ANTONIO PIO, GRECO, LUIGI, TRONCONE, RICCARDO, PAPARO F., TORRE P., TRAPANESE E., FASANO C., LAMBERTI A., BUDILLON G., Martinelli, Pasquale, Troncone, Riccardo, Paparo, F., Torre, P., Trapanese, E., Fasano, C., Lamberti, A., Budillon, G., Nardone, GERARDO ANTONIO PIO, and Greco, Luigi

Published
2000

48. The spectrum of gluten sensitivity

Author

TRONCONE, RICCARDO, PAPARO F, MAZZARELLA G, MAGLIO M, IOVINE G, MAYER M, GRECO, LUIGI, AURICCHIO S., AURICCHIO S, GRECO L, MAIURI L, TRONCONE R., Troncone, Riccardo, Paparo, F, Mazzarella, G, Maglio, M, Iovine, G, Mayer, M, Greco, Luigi, and Auricchio, S.

Published
2000

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