1. Leukemia and cysts in mice of the AFB line
- Author
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Parnes Va
- Subjects
Pathology ,medicine.medical_specialty ,Strain (chemistry) ,Culture fluid ,General Medicine ,Biology ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Leukemia ,Serous fluid ,Monkey kidney ,medicine ,Tumor growth ,Lymph - Abstract
Culture fluid from the 7th successive passage of human leukemic material through monkey kidney culture was injected into 6 mice of the high-leukemic strain Afb during the first day after birth. All the mice died between the 80th and 148th days after injection with systemic enlargement of the lymph glands. Serous and hemorrhagyc cysts were observed in 2 mice. Material from one of these mice sacrificed on the 125th day after birth was serially passaged through mice of the same strain. All of them developed leukemia. The leukemic line isolated, which was called Gamaleya No. 1, is hemocytoblastic in type. It is characterized by the absence of local tumor growth and by transplantability to mice of the low leukemic strain C3HA. The possible role of various factors in the development of early leukemia and casts in Afb mice is discussed.
- Published
- 1963
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