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1. Scientific Communication and oncology – "The bridge between knowledge and patients"

Author

Galvano, Antonio, Gottardo, Andrea, Gristina, Valerio, Fanale, Daniele, Corsini, Lidia Rita, Pavone, Carlo, Bazan Russo, Tancredi Didier, Di Giovanni, Emilia, Iannì, Giuliana, Randazzo, Ugo, Iacono, Federica, Perez, Alessandro, Brando, Chiara, Bono, Marco, Bazan, Viviana, Incorvaia, Lorena, Badalamenti, Giuseppe, Cinieri, Saverio, Boldrini, Mauro, Berardi, Rossana, and Russo, Antonio

Published
2024
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3. Segmental Ureterectomy Versus Radical Nephroureterectomy in Older Patients Treated for Upper Tract Urothelial Carcinoma

Author

Abrate, Alberto, Sessa, Francesco, Sessa, Maurizio, Campi, Riccardo, Sebastianelli, Arcangelo, Varca, Virginia, Pavone, Carlo, Vella, Marco, Bartoletti, Riccardo, Ficarra, Vincenzo, Serni, Sergio, Brunocilla, Eugenio, Gregori, Andrea, Trombetta, Carlo, Lissiani, Andrea, Terrone, Carlo, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, and Simonato, Alchiede

Published
2022
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6. Segmental ureterectomy vs. radical nephroureterectomy for ureteral carcinoma in patients with a preoperative glomerular filtration rate less than 90 ml/min/1.73 m2: A multicenter study

Author

Abrate, Alberto, Sessa, Francesco, Campi, Riccardo, Preto, Mirko, Olivero, Alberto, Varca, Virginia, Benelli, Andrea, Sessa, Maurizio, Sebastianelli, Arcangelo, Pavone, Carlo, Serretta, Vincenzo, Vella, Marco, Brunocilla, Eugenio, Serni, Sergio, Trombetta, Carlo, Terrone, Carlo, Gregori, Andrea, Lissiani, Andrea, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, and Simonato, Alchiede

Published
2020
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9. Preliminary Results of ERAS Protocol in a Single Surgeon Prospective Case Series

Author

Tulone, Gabriele, primary, Pavan, Nicola, additional, Abrate, Alberto, additional, Dalmasso, Ettore, additional, Mannone, Piero, additional, Baiamonte, Davide, additional, Giannone, Sofia, additional, Giaimo, Rosa, additional, Vella, Marco, additional, Pavone, Carlo, additional, Bartoletti, Riccardo, additional, Ficarra, Vincenzo, additional, and Simonato, Alchiede, additional

Published
2022
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13. MP37-18 NO RELATIONSHIP BETWEEN HPV AND PROSTATE CANCER

Author

Minasola, Cristina, primary, Vella, Marco, additional, Tulone, Gabriele, additional, Pinelli, Mirko, additional, Abrate, Alberto, additional, Di Gregorio, Gianpaolo, additional, Agiato, Sonia Maria, additional, Giaimo, Rosellina, additional, Pavone, Carlo, additional, Capra, Giuseppina, additional, Mascarella, Chiara, additional, and Simonato, Alchiede, additional

Published
2022
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14. MP25-19 COMPARISON OF COMPLICATIONS, OPERATING TIME AND COSTS IN DOUBLE-LAYERED HAND-SEWN VS. MECHANICAL STAPLED ILEO-ILEAL ANASTOMOSIS DURING RADICAL CYSTECTOMY

Author

Tulone, Gabriele, primary, Pavan, Nicola, additional, Giannone, Sofia, additional, Alario, Giuseppe, additional, Abrate, Alberto, additional, Pinelli, Mirko, additional, Mannone, Piero, additional, Claps, Francesco, additional, Baiamonte, Davide, additional, Giaimo, Rosa, additional, Vella, Marco, additional, Pavone, Carlo, additional, Ficarra, Vincenzo, additional, and Simonato, Alchiede, additional

Published
2022
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16. Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy

Author

Giammanco, GiovanniM, primary, Pavone, Carlo, additional, Cascino, AndreaPio, additional, Baiamonte, Davide, additional, Pinelli, Mirko, additional, Cangelosi, Enrico, additional, Filizzolo, Chiara, additional, Sciortino, Giuseppa, additional, Grazia, SimonaDe, additional, and Bonura, Floriana, additional

Published
2022
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17. Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy

Author

Pavone, Carlo, Giammanco, Giovanni, Cascino, Andrea Pio, Baiamonte, Davide, Pinelli, Mirko, Cangelosi, Enrico, Filizzolo, Chiara, Sciortino, Giuseppa, Grazia, Simona De, Bonura, Floriana, Pavone, Carlo, Giammanco, Giovanni, Cascino, Andrea Pio, Baiamonte, Davide, Pinelli, Mirko, Cangelosi, Enrico, Filizzolo, Chiara, Sciortino, Giuseppa, Grazia, Simona De, and Bonura, Floriana

Subjects
coronaviru, Male, Italy, SARS-CoV-2, Semen, Urology, COVID-19, Humans, RNA, Viral, General Medicine, Pandemics, sexual transmission
Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), has been identified in the human testis, but the risk of transmission of SARS-CoV-2 through sexual intercourse still needs to be defined. The goal of our study was to determine if SARS-CoV-2 is detectable in the semen of patients suffering or recovering from coronavirus disease-19 (COVID-19), still testing positive at nasopharyngeal swabs but showing mild or no symptoms at the time of sampling. Detection of SARS-CoV-2 RNA in semen was performed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and nested PCR targeting open reading frame (ORF) 1ab. Medical history of the enrolled patients was taken, including COVID-19-correlated symptoms, both at the time of diagnosis and at the time of interview. Results of real-time RT-PCR and nested PCR in semen showed no evidence of SARS-CoV-2 RNA in the 36 patients suffering or recovering from COVID-19 but still positive in a nasopharyngeal swab, from over 116 patients enrolled in the study. SARS-CoV-2 detection and persistence in semen would have an impact on both clinical practice and public health strategies, but our results would suggest that SARS-CoV-2 is not present in the semen of men recovering from COVID-19.

Published
2022
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19. MP43-14 COMPARISON BETWEEN QUINOLONES AND OTHER ANTIBIOTICS IN PREVENTING INFECTIVE COMPLICATIONS IN TRANSRECTAL PROSTATE BIOPSY

Author

Tulone, Gabriele, primary, Serretta, Vincenzo, additional, Dalmasso, Ettore, additional, Vella, Marco, additional, Dispensa, Nino, additional, Pavone, Carlo, additional, Baiamonte, Davide, additional, Mannone, Piero, additional, Abrate, Alberto, additional, Aimar, Roberta, additional, Ficarra, Vincenzo, additional, Bartoletti, Riccardo, additional, and Simonato, Alchiede, additional

Published
2021
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22. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis

Author

Serretta, Vincenzo, primary, Berardinis, Ettore De, additional, Simonato, Alchiede, additional, Guarneri, Alessio, additional, Dispensa, Nino, additional, Pavone, Carlo, additional, Busetto, Gian Maria, additional, Del Giudice, Francesco, additional, and Sanfilippo, Chiara, additional

Published
2021
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23. How Can the COVID-19 Pandemic Lead to Positive Changes in Urology Residency?

Author

Busetto, Gian Maria, Del Giudice, Francesco, Mari, Andrea, Sperduti, Isabella, Longo, Nicola, Antonelli, Alessandro, Cerruto, Maria Angela, Costantini, Elisabetta, Carini, Marco, Minervini, Andrea, Rocco, Bernardo, Artibani, Walter, Porreca, Angelo, Porpiglia, Francesco, Damiano, Rocco, De Sio, Marco, Arcaniolo, Davide, Cimino, Sebastiano, Russo, Giorgio Ivan, Lucarelli, Giuseppe, Di Tonno, Pasquale, Gontero, Paolo, Soria, Francesco, Trombetta, Carlo, Liguori, Giovanni, Scarpa, Roberto Mario, Papalia, Rocco, Terrone, Carlo, Borghesi, Marco, Verze, Paolo, Madonia, Massimo, De Lisa, Antonello, Bove, Pierluigi, Guazzoni, Giorgio, Lughezzani, Giovanni, Racioppi, Marco, Di Gianfrancesco, Luca, Brunocilla, Eugenio, Schiavina, Riccardo, Simeone, Claudio, Veccia, Alessandro, Montorsi, Francesco, Briganti, Alberto, Dal Moro, Fabrizio, Pavone, Carlo, Serretta, Vincenzo, Di Stasi, Savino Mauro, Galosi, Andrea Benedetto, Schips, Luigi, Marchioni, Michele, Montanari, Emanuele, Carrieri, Giuseppe, Cormio, Luigi, Greco, Francesco, Musi, Gennaro, Maggi, Martina, Conti, Simon L, Tubaro, Andrea, De Berardinis, Ettore, Sciarra, Alessandro, Gallucci, Michele, Mirone, Vincenzo, de Cobelli, Ottavio, Ferro, Matteo, Racioppi, Marco (ORCID:0000-0001-9129-8479), Busetto, Gian Maria, Del Giudice, Francesco, Mari, Andrea, Sperduti, Isabella, Longo, Nicola, Antonelli, Alessandro, Cerruto, Maria Angela, Costantini, Elisabetta, Carini, Marco, Minervini, Andrea, Rocco, Bernardo, Artibani, Walter, Porreca, Angelo, Porpiglia, Francesco, Damiano, Rocco, De Sio, Marco, Arcaniolo, Davide, Cimino, Sebastiano, Russo, Giorgio Ivan, Lucarelli, Giuseppe, Di Tonno, Pasquale, Gontero, Paolo, Soria, Francesco, Trombetta, Carlo, Liguori, Giovanni, Scarpa, Roberto Mario, Papalia, Rocco, Terrone, Carlo, Borghesi, Marco, Verze, Paolo, Madonia, Massimo, De Lisa, Antonello, Bove, Pierluigi, Guazzoni, Giorgio, Lughezzani, Giovanni, Racioppi, Marco, Di Gianfrancesco, Luca, Brunocilla, Eugenio, Schiavina, Riccardo, Simeone, Claudio, Veccia, Alessandro, Montorsi, Francesco, Briganti, Alberto, Dal Moro, Fabrizio, Pavone, Carlo, Serretta, Vincenzo, Di Stasi, Savino Mauro, Galosi, Andrea Benedetto, Schips, Luigi, Marchioni, Michele, Montanari, Emanuele, Carrieri, Giuseppe, Cormio, Luigi, Greco, Francesco, Musi, Gennaro, Maggi, Martina, Conti, Simon L, Tubaro, Andrea, De Berardinis, Ettore, Sciarra, Alessandro, Gallucci, Michele, Mirone, Vincenzo, de Cobelli, Ottavio, Ferro, Matteo, and Racioppi, Marco (ORCID:0000-0001-9129-8479)

Abstract

The COVID-19 outbreak, in a few weeks, overloaded Italian hospitals, and the majority of medical procedures were postponed. During the pandemic, with hospital reorganization, clinical and learning activities performed by residents suffered a forced remodulation. The objective of this study is to investigate how urology training in Italy has been affected during the COVID-19 era. In this multi-academic study, we compared residents' training during the highest outbreak level with their previous activity. Overall 387 (67.1%) of the 577 Italian Urology residents participated in a 72-h anonymous online survey with 36 items sent via email. The main outcomes were clinical/surgical activities, social distancing, distance learning, and telemedicine. Clinical and learning activity was significantly reduced for the overall group, and after categorizing residents as those working only in COVID hospitals, both "junior" and "senior" residents, and those working in any of three geographical areas created (Italian regions were clustered in three major zones according to the prevalence of COVID-19). A significant decrease in outpatient activity, invasive diagnostic procedures, and endoscopic and major surgeries was reported. Through multivariate analysis, the specific year of residency has been found to be an independent predictor for all response modification. Being in zone 3 and zone 2 and having "senior" resident status were independent predictors associated with a lower reduction of the clinical and learning activity. Working in a COVID hospital and having "senior" resident status were independent predictors associated with higher reduction of the outpatient activity. Working in zone 3 and having "senior" resident status were independent predictors of lower and higher outpatient surgical activity, respectively. Working in a COVID hospital was an independent predictor associated with robotic surgical activity. The majority of residents reported that distance teaching and multidis

Published
2020

24. Segmental ureterectomy vs. radical nephroureterectomy for ureteral carcinoma in patients with a preoperative glomerular filtration rate less than 90 ml/min/1.73 m2:A multicenter study

Author

Abrate, Alberto, Sessa, Francesco, Campi, Riccardo, Preto, Mirko, Olivero, Alberto, Varca, Virginia, Benelli, Andrea, Sessa, Maurizio, Sebastianelli, Arcangelo, Pavone, Carlo, Serretta, Vincenzo, Vella, Marco, Brunocilla, Eugenio, Serni, Sergio, Trombetta, Carlo, Terrone, Carlo, Gregori, Andrea, Lissiani, Andrea, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, Simonato, Alchiede, Abrate, Alberto, Sessa, Francesco, Campi, Riccardo, Preto, Mirko, Olivero, Alberto, Varca, Virginia, Benelli, Andrea, Sessa, Maurizio, Sebastianelli, Arcangelo, Pavone, Carlo, Serretta, Vincenzo, Vella, Marco, Brunocilla, Eugenio, Serni, Sergio, Trombetta, Carlo, Terrone, Carlo, Gregori, Andrea, Lissiani, Andrea, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, and Simonato, Alchiede

Abstract

Objectives: To compare segmental ureterectomy (SU) and radical nephroureterectomy (RNU) in terms of overall survival (OS) and impact on postoperative renal function in patients treated for upper tract urothelial carcinoma (UTUC) of the ureter with preoperatively reduced estimated glomerular filtration rate (eGFR). Materials and methods: We retrospectively collected the data of consecutive patients treated for UTUC, in 6 Italian tertiary referral centers, from 2003 to 2013, and analyzed those treated with RNU or SU for ureteral cancer and with a preoperative eGFR <90 ml/min/1.73m2. The primary outcome was to compare the postoperative eGFR variation and the OS according to the surgical technique chosen. Results: Out of 521 patients with UTUC, 228 patients had preoperative reduced eGFR. Out of these patients, 93 had ureteral cancer and were included in the primary analyses – 67 (72.0%) treated with RNU and 26 (28.0%) with SU. Preoperative characteristics were similar in the 2 groups. The overall median follow-up period was 26.5 months. A nonsignificant postoperative eGFR decrease of 3.0 ml/min/1.73m2 was found overall (P = 0.094), with nonsignificant difference between the 2 groups (P = 0.735). A comparable 5-year OS was calculated for RNU and SU patients (P = 0.99). Conclusions: The type of surgery (SU vs. RNU) has a low impact on postoperative renal function and OS in patients with ureteral cancer and preoperative eGFR <90 ml/min/1.73m2. The indications for kidney sparing surgery for UTUC should be based on the surgical and oncological risks in these patients.

Published
2020

25. Prevalence, Incidence Estimation, Risk Factors and Characterization of Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Urological Hospital Outpatients in Italy: Results of a Multicenter Case-Control Observational Study

Author

Bartoletti, Riccardo, Cai, Tommaso, Mondaini, Nicola, Dinelli, Nicola, Pinzi, Novello, Pavone, Carlo, Gontero, Paolo, Gavazzi, Andrea, Giubilei, Gianluca, Prezioso, Domenico, Mazzoli, Sandra, Boddi, Vieri, and Naber, Kurt G.

Published
2007
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30. How Can the COVID-19 Pandemic Lead to Positive Changes in Urology Residency?

Author

Busetto, Gian Maria, primary, Del Giudice, Francesco, additional, Mari, Andrea, additional, Sperduti, Isabella, additional, Longo, Nicola, additional, Antonelli, Alessandro, additional, Cerruto, Maria Angela, additional, Costantini, Elisabetta, additional, Carini, Marco, additional, Minervini, Andrea, additional, Rocco, Bernardo, additional, Artibani, Walter, additional, Porreca, Angelo, additional, Porpiglia, Francesco, additional, Damiano, Rocco, additional, De Sio, Marco, additional, Arcaniolo, Davide, additional, Cimino, Sebastiano, additional, Russo, Giorgio Ivan, additional, Lucarelli, Giuseppe, additional, Di Tonno, Pasquale, additional, Gontero, Paolo, additional, Soria, Francesco, additional, Trombetta, Carlo, additional, Liguori, Giovanni, additional, Scarpa, Roberto Mario, additional, Papalia, Rocco, additional, Terrone, Carlo, additional, Borghesi, Marco, additional, Verze, Paolo, additional, Madonia, Massimo, additional, De Lisa, Antonello, additional, Bove, Pierluigi, additional, Guazzoni, Giorgio, additional, Lughezzani, Giovanni, additional, Racioppi, Marco, additional, Di Gianfrancesco, Luca, additional, Brunocilla, Eugenio, additional, Schiavina, Riccardo, additional, Simeone, Claudio, additional, Veccia, Alessandro, additional, Montorsi, Francesco, additional, Briganti, Alberto, additional, Dal Moro, Fabrizio, additional, Pavone, Carlo, additional, Serretta, Vincenzo, additional, Di Stasi, Savino Mauro, additional, Galosi, Andrea Benedetto, additional, Schips, Luigi, additional, Marchioni, Michele, additional, Montanari, Emanuele, additional, Carrieri, Giuseppe, additional, Cormio, Luigi, additional, Greco, Francesco, additional, Musi, Gennaro, additional, Maggi, Martina, additional, Conti, Simon L., additional, Tubaro, Andrea, additional, De Berardinis, Ettore, additional, Sciarra, Alessandro, additional, Gallucci, Michele, additional, Mirone, Vincenzo, additional, de Cobelli, Ottavio, additional, and Ferro, Matteo, additional

Published
2020
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35. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis.

Author

Serretta, Vincenzo, Berardinis, Ettore De, Simonato, Alchiede, Guarneri, Alessio, Dispensa, Nino, Pavone, Carlo, Busetto, Gian Maria, Del Giudice, Francesco, and Sanfilippo, Chiara

Subjects
INTRAVESICAL administration, ELLAGIC acid, CANCER invasiveness, BLADDER cancer, ANNONA, LONGITUDINAL method, UROTHELIUM
Abstract

Introduction: BCG and MMC shortage and Covid-19 pandemic, more recently, limit accessibility to maintenance regimen in intravesical prophylaxis against recurrence of non-muscle invasive bladder cancer (NMIBC). Ellagic acid (EA) and Annona muricata (AM) exert antitumor activity against different human tumours. An observational prospective study on the prophylactic effect of oral administration of EA+AM in patients avoiding maintenance regimen is presented. Materials and methods: Patients affected by NMIBC and not undergoing maintenance after a 6-week course of intravesical prophylaxis with MMC or BCG were entered. Tis and very high-risk tumours were excluded. After informed consent, the patients were subdivided in relation to the oral assumption or not of EA (100 mg) plus AM (100 mg), daily for 6 months. All patients were submitted to 3-month cytology and cystoscopy. Results: 162 (90%) of 180 entered patients are evaluable, 90 and 72 receiving or not EA+AM. No difference emerged in patients' characteristics between the two groups. BCG was given in 86 (54%) and chemotherapy in 74 (46%) patients. The recurrence free rate at 3, 6 and 12 months in patients assuming or not EA was 96.5% versus 84.6% (p = 0.003), 85.4% versus 64.8% (p = 0.005) and 74.2% versus 60.6% (p = 0.246), respectively. The recurrence free survival at 12 months in patients assuming or not EA was 63.0% versus 34.5% (p < 0.0001). Discussion and conclusions: Our study suffers several limits: not randomized trial although prospective, limited number of patients and short follow-up, nevertheless it shows the prophylactic effect of oral EA+AM in absence of maintenance after intravesical chemotherapy or immunotherapy induction. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma:results of a multicentre study

Author

Abrate, Alberto, Sessa, Francesco, Sebastianelli, Arcangelo, Preto, Mirko, Olivero, Alberto, Varca, Virginia, Benelli, Andrea, Campi, Riccardo, Sessa, Maurizio, Pavone, Carlo, Serretta, Vincenzo, Vella, Marco, Brunocilla, Eugenio, Serni, Sergio, Trombetta, Carlo, Terrone, Carlo, Gregori, Andrea, Lissiani, Andrea, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, Simonato, Alchiede, Abrate, Alberto, Sessa, Francesco, Sebastianelli, Arcangelo, Preto, Mirko, Olivero, Alberto, Varca, Virginia, Benelli, Andrea, Campi, Riccardo, Sessa, Maurizio, Pavone, Carlo, Serretta, Vincenzo, Vella, Marco, Brunocilla, Eugenio, Serni, Sergio, Trombetta, Carlo, Terrone, Carlo, Gregori, Andrea, Lissiani, Andrea, Gontero, Paolo, Schiavina, Riccardo, Gacci, Mauro, and Simonato, Alchiede

Abstract

Objectives: To compare overall (OS), cancer-specific (CSS), recurrence-free survival (RFS) and postoperative renal function amongst patients with upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteric re-implantation (RR). Patients and methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome, we compared the postoperative creatinine values as an index of renal function in the two groups. Results: Of 521 patients with UTUC, 65 (77.4%) and 19 (22.6%) patients underwent RR and TT, respectively. Pre- and postoperative characteristics were not statistically different between the two groups. The median follow-up period was 22.7 months. Patients treated with TT and those treated with RR did not have significantly different 5-year OS, CSS or RFS (73.7% vs 92.3%, P = 0.052; 94.7% vs 95.4%, P = 0.970: and 63.2% vs 53.9%, P = 0.489, respectively). No difference in postoperative creatinine variation emerged in association with the surgical technique (P = 0.411). Conclusion: Patients treated with TT or RR for UTUC showed comparable OS, CSS, RFS and postoperative renal function. Our data suggest that bladder cuff removal is not imperative in the treatment of distal ureteric UTUC, and TT can be a safe solution in selected cases.

Published
2019

38. MP60-08 INCIDENCE OF PATHOLOGICAL HIGH GRADE AND STAGE CANCERS IN PATIENTS DIAGNOSED WITH MICROFOCAL ADENOCARCINOMA OF THE PROSTATE AT BIOPSY: A MULTICENTER STUDY

Author

Abrate*, Alberto, primary, Romagnoli, Daniele, additional, Bianchi, Federico Mineo, additional, Pavan, Nicola, additional, Mantica, Guglielmo, additional, Romagnoli, Andrea, additional, Terrone, Carlo, additional, Pavone, Carlo, additional, Serretta, Vincenzo, additional, Vella, Marco, additional, Brunocilla, Eugenio, additional, Gregori, Andrea, additional, Varca, Virginia, additional, Milanese, Garbagnate, additional, Diminutto, Alberto, additional, Siracusano, Salvatore, additional, Lissiani, Andrea, additional, Porreca, Angelo, additional, Terme, Abano, additional, Schiavina, Riccardo, additional, and Simonato, Alchiede, additional

Published
2019
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39. Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma: results of a multicentre study

Author

Abrate, Alberto, primary, Sessa, Francesco, additional, Sebastianelli, Arcangelo, additional, Preto, Mirko, additional, Olivero, Alberto, additional, Varca, Virginia, additional, Benelli, Andrea, additional, Campi, Riccardo, additional, Sessa, Maurizio, additional, Pavone, Carlo, additional, Serretta, Vincenzo, additional, Vella, Marco, additional, Brunocilla, Eugenio, additional, Serni, Sergio, additional, Trombetta, Carlo, additional, Terrone, Carlo, additional, Gregori, Andrea, additional, Lissiani, Andrea, additional, Gontero, Paolo, additional, Schiavina, Riccardo, additional, Gacci, Mauro, additional, and Simonato, Alchiede, additional

Published
2019
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40. ENDOUROLOGY ON CD-ROM

Author

Pavone-Macaluso, Michele, Paoletti, Pier Paolo, De Angelis, Michele, Torchiana, Bernardo, Benelli, Roberto, Gavazzi, Marco, Tariffi, Falvio, and Pavone, Carlo

Published
1997

43. MP18-18 SURVIVAL AFTER SEGMENTAL RESECTION OF DISTAL URETER AND TERMINO-TERMINAL URETERAL ANASTOMOSIS VS. BLADDER CUFF REMOVAL AND URETERAL REIMPLANTATION FOR UROTHELIAL CARCINOMA OF THE URETER: RESULTS OF A MULTICENTER STUDY

Author

Abrate, Alberto, primary, Sessa, Francesco, additional, Sebastianelli, Arcangelo, additional, Scalici Gesolfo, Cristina, additional, Preto, Mirko, additional, Olivero, Alberto, additional, Varca, Virginia, additional, Benelli, Andrea, additional, Pavone, Carlo, additional, Serretta, Vincenzo, additional, Vella, Marco, additional, Brunocilla, Eugenio, additional, Serni, Sergio, additional, Trombetta, Carlo, additional, Terrone, Carlo, additional, Gregori, Andrea, additional, Lissiani, Andrea, additional, Gontero, Paolo, additional, Schiavina, Riccardo, additional, Gacci, Mauro, additional, and Simonato, Alchiede, additional

Published
2018
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45. The relationship between endothlial ABD erectile dysfunction, levels of testosterone and cardiovascular events in the follow-up

Author

NOVO, Salvatore, Bonomo, V, Iacona, R, Evola, V, CORRADO, Egle, Di Piazza, M, NOVO, Giuseppina, PAVONE, Carlo, Novo, S, Bonomo, V, Iacona, R, Evola, V, Corrado, E, Di Piazza, M, Novo, G, and Pavone, C

Subjects
testosterone levels, endothelial function, erectile dysfunction, cardiovascular risk, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Settore MED/24 - Urologia
Abstract

Background: Clinical and experimental evidence suggest that testosterone levels play a role in cardiac and vascular pathology. A long history of observational studies investigating serum testosterone level and cardiovascular risks, specifically mortality, reveals important associations between low testosterone and mortality, while higher serum testosterone level appear to be predictive in the majority of studies. On the other hand, it is well documented and accepted that endothelial dysfunction is expression of preclinical atherosclerosis and it is associated with an increased amount of CV events in the follow-up. Erectile dysfunction is also an early manifestation of arteriosclerosis associated with endothelial damage/dysfunction. Endothelial function plays a very important role in the process of erection. Moreover, erectile dysfunction and coronary artery disease (CAD) overlap in risk factors, etiology and clinical outcomes. Endothelial dysfunction is considered to be their shared etiological factor. There is growing evidence that patients presenting with erectile dysfunction should be investigated for CAD, even if with no symptoms of the problem. Earlier diagnosis of erectile dysfunction can facilitate prompt intervention, reduce long-term complications, especially the risk of CAD, and provide effective treatment for erectile dysfunction. Objectives: We aimed to assess whether baseline testosterone levels may be predictors of future CV events in a cohort of patients at intermediate cardiovascular risk. Methods: Our cohort included 802 adult subjects, males from 40 to 80 years (mean age of the whole population was 57.52±13.85 years old). Thy were at intermediate cardiovascular risk, according to the Framingham risk score and all referred between 2009 and 2014. Patients were excluded if they had a past history of peripheral artery disease, coronary revascularization, angina pectoris, myocardial infarction, carotid surgery or cerebrovascular event. The study of the endothelial function was performed by using the method of flow mediated vasodilation. Moreover, it was administered a standard questionnaire for the evaluation of the erectile function and the dosage of the plasma testosterone was carried out. The median follow-up time for major CV events was 5.1 years. Results: Patients with lower serum testosterone levels (n=332) had a higher prevalence of traditional CV risk factors, such as hypertension (p=0.009), diabetes (p=0.03), dyslipidemia (p

Published
2016

46. Long-term consequences of bilateral cavernous crush injury in normal and diabetic rats: a functional study

Author

Castiglione, Fabio, Albersen, Maarten, Fiorenzo, Salvatore, Hedlund, Petter, Cakir, Omer Onur, Pavone, Carlo, Alnajjar, Hussain M, Joniau, Steven, and Muneer, Asif

Abstract

A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 diabetic (DM) rats 30-male/12-week-old rats were divided into four groups: Sham, BNCI, DM, and BNCI + DM. Sham group underwent an intraperitoneal injection (IP) of saline solution and after 1 month underwent a sham laparotomy. BNCI underwent an IP of saline solution and after 1 month to BNCI. DM underwent an IP of 60 mg/kg-1-streptozotocin (STZ) and after 1 month to a sham laparotomy. BNCI + DM underwent an IP of 60 mg/kg-1-STZ and after 1 month to BNCI. After 5 months from the induction of diabetes, all rats underwent measurement of intracorporeal pressure (ICP) and mean arterial pressure (MAP) during CN-electrostimulation. Multiple groups were compared using Kruskal–Wallis one-way analysis of variance followed by Mann–Whitney Utest for post hoc comparisons. Blood glucose-level was higher (p< 0.05) in the groups with DM and BNCI + DM. After 5-months, DM and BNCI + DM also showed a lower weight compared to other groups (p< 0.05). No differences were noted in ICP/MAP between the sham and BNCI. BNCI + DM showed lower ICP/MAP compared to all the groups (p< 0.05). DM Showed lower ICP/MAP compared to Sham and BNCI (p< 0.05). BNCI in rats without comorbidities did not induce long-term erectile dysfunction (ED) suggesting a spontaneous EF recovery. BNCI in DM induced long-term ED. The results of previous short-term studies can only provide evidence on the time to recovery of spontaneous EF as to the actual EF recovery rate.

Published
2021
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