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4 results on '"PB nanocubes"'

1. Prussian blue nanocubes/carbon nanospheres heterostructure composite for biosensing of metformin

Author

Narang J, Malhotra N, Singhal C, Singh G, and Pundir CS

Subjects
Metformin, PB nanocubes, Carbon nanospheres, Sensor, FTO electrode, Medicine (General), R5-920
Abstract

Jagriti Narang,1 Nitesh Malhotra,2 Chaitali Singhal,1 Gajendra Singh,3 Chandra Shekhar Pundir4 1Amity Institute of Nanotechnology, 2Amity Institute of Physiotherapy, Amity University, Noida, Uttar Pradesh, 3Department of Pharmacy, University of Health Sciences, 4Department of Biochemistry, M. D. University, Rohtak, Haryana, India Abstract: This paper reports the fabrication of highly sensitive metformin sensor based on Prussian blue (PB) nanocubes/carbon nanosphere (CNS) heterostructures composed of a perfect cube and spherical composite on a fluorine-doped tin oxide surface. Due to the excellent biocompatibility of PB nanocubes the PB/CNS based Mf sensor exhibited a wide linear range of 0.001–10 mM with a response duration of less than 5 s and a detection limit (based on signal to noise ratio) of 0.1 µM. Keywords: metformin, PB nanocubes, carbon nanospheres, sensor, FTO electrode

Published
2018

2. Prussian blue nanocubes decorated three-dimensional silver nanowires network for high-performance electrochemical biosensing.

Author

Xu, Yaqi, Chu, Zhenyu, Shi, Lei, Peng, Jingmeng, and Jin, Wanqin

Subjects
*PRUSSIAN blue, *NANOSTRUCTURED materials, *SILVER nanoparticles, *NANOWIRES, *ELECTROCHEMICAL sensors, *BIOSENSORS, *GLUCOSE oxidase
Abstract

High sensitivity and selectivity play critical roles in practical applications of glucose biosensors. In this study, we reported a novel glucose biosensor based on three-dimensional (3D) structured biosensing film, which consisted of silver nanowires (AgNWs) network and Prussian blue nanocubes (PBNCs). 3D AgNWs network was successfully built on the electrode surface with assistance of self-assembled monolayers (SAMs), while PBNCs were in situ prepared on the network through aerosol deposition approach and glucose oxidase (GOx) was immobilized onto the surface of PBNCs/AgNWs film with glutaraldehyde cross-linking method. Owing to an enhanced surface area, high conductivity and synergistic electrocatalytic activity of fabricated PBNCs/AgNWs film, an ultrasensitive glucose biosensor with high selectivity was constructed. As a result, the as-prepared biosensor exhibited an ultrahigh sensitivity of 359.0 mA M −1 cm −2 with a linear range from 0.01 to 0.9 mM, an outstanding anti-interference ability at a low potential of −0.05 V, as well as excellent stability and reproducibility. It is believed that the proposed 3D sensing film would have widespread applications in biological sensing and quantitative biochemical analysis. [ABSTRACT FROM AUTHOR]

Published
2015
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3. Prussian blue nanocubes/carbon nanospheres heterostructure composite for biosensing of metformin

Author

Chandra Shekhar Pundir, Gajendra Singh, Chaitali Singhal, Jagriti Narang, and Nitesh Malhotra

Subjects
Materials science, Biocompatibility, Composite number, Short Report, Biophysics, Pharmaceutical Science, chemistry.chemical_element, Bioengineering, Nanotechnology, Biosensing Techniques, 030204 cardiovascular system & hematology, Biomaterials, carbon nanospheres, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, X-Ray Diffraction, International Journal of Nanomedicine, sensor, Limit of Detection, Drug Discovery, 030212 general & internal medicine, Electrodes, Detection limit, Prussian blue, Organic Chemistry, General Medicine, Tin oxide, Carbon, Metformin, PB nanocubes, chemistry, Linear range, Dielectric Spectroscopy, FTO electrode, Biosensor, Nanospheres, Ferrocyanides
Abstract

Jagriti Narang,1 Nitesh Malhotra,2 Chaitali Singhal,1 Gajendra Singh,3 Chandra Shekhar Pundir4 1Amity Institute of Nanotechnology, 2Amity Institute of Physiotherapy, Amity University, Noida, Uttar Pradesh, 3Department of Pharmacy, University of Health Sciences, 4Department of Biochemistry, M. D. University, Rohtak, Haryana, India Abstract: This paper reports the fabrication of highly sensitive metformin sensor based on Prussian blue (PB) nanocubes/carbon nanosphere (CNS) heterostructures composed of a perfect cube and spherical composite on a fluorine-doped tin oxide surface. Due to the excellent biocompatibility of PB nanocubes the PB/CNS based Mf sensor exhibited a wide linear range of 0.001–10mM with a response duration of less than 5s and a detection limit (based on signal to noise ratio) of 0.1µM. Keywords: metformin, PB nanocubes, carbon nanospheres, sensor, FTO electrode

Published
2018
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4. Enhanced bone regeneration using an insulin-loaded nano-hydroxyapatite/collagen/PLGA composite scaffold

Author

Xuguang Lu, Jing Zhao, Bin Zhao, Xing Wang, Guilan Zhang, Lu Wang, Yongfeng Cheng, and Feng Qi

Subjects
0301 basic medicine, Male, Scaffold, Bone Regeneration, Composite number, Pharmaceutical Science, 02 engineering and technology, Bone remodeling, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, Osteogenesis, sensor, International Journal of Nanomedicine, Drug Discovery, Glucose homeostasis, Insulin, Tissue Scaffolds, Chemistry, Cell Differentiation, General Medicine, Adhesion, Middle Aged, 021001 nanoscience & nanotechnology, PB nanocubes, PLGA, Female, Collagen, Rabbits, 0210 nano-technology, FTO electrode, Porosity, Adult, Biophysics, Short Report, Bioengineering, Biomaterials, 03 medical and health sciences, carbon nanospheres, In vivo, Animals, Humans, Lactic Acid, Bone regeneration, Osteoblasts, Organic Chemistry, Mesenchymal Stem Cells, Nanostructures, 030104 developmental biology, Durapatite, metformin, Polyglycolic Acid
Abstract

Xing Wang,1,* Guilan Zhang,2,* Feng Qi,3 Yongfeng Cheng,1 Xuguang Lu,1 Lu Wang,1 Jing Zhao,1 Bin Zhao1 1Shanxi Medical University Stomatological Hospital, Taiyuan, 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China; 3Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO, USA *These authors contributed equally to this work Abstract: Insulin is widely considered as a classical hormone and drug in maintaining energy and glucose homeostasis. Recently, insulin has been increasingly recognized as an indispensable factor for osteogenesis and bone turnover, but its applications in bone regeneration have been restricted because of the short periods of activity and uncontrolled release. In this study, we incorporated insulin-loaded poly lactic-co-glycolic-acid (PLGA) nanospheres into nano-hydroxyapatite/collagen (nHAC) scaffolds and investigated the bioactivity of the composite scaffolds in vitro and in vivo. Bioactive insulin was successfully released from the nanospheres within the scaffold, and the release kinetics of insulin could be efficiently controlled by uniform-sized nanospheres. The physical characterizations of the composite scaffolds demonstrated that incorporation of nanospheres in nHAC scaffolds using this method did not significantly change the porosity, pore diameters, and compressive strengths of nHAC. In vitro, the insulin-loaded nHAC/PLGA composite scaffolds possessed favorable biological function for bone marrow mesenchymal stem cells adhesion and proliferation, as well as the differentiation into osteoblasts. In vivo, the optimized bone regenerative capability of this composite scaffold was confirmed in rabbit mandible critical size defects. These results demonstrated successful development of a functional insulin–PLGA–nHAC composite scaffold that enhances the bone regeneration capability of nHAC. Keywords: insulin, composite scaffold, drug delivery system, bone tissue engineering&nbsp

Published
2017

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