1. CMTM4 和 PD-L1蛋白在胰腺癌组织中的表达及其与临床病理特征的关系.
- Author
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杨珍芳, 刘 慧, 郭志娟, 吉 茹, and 靳君华
- Subjects
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TUMOR classification , *TISSUE differentiation , *LYMPHATIC metastasis , *PANCREATIC cancer , *PROGRAMMED death-ligand 1 - Abstract
Objective: To explore the expression status of CMTM 4 and PD-L1 protein in pancreatic cancer tissues and analyzed the relationship between the clinician and clinicopathological features. Methods: From January 2016 to 2020.1, our Hospital of Inner Mongolia Medical University collected 40 cases as the experimental group, and selected adjacent tissues as the control group, to detect the expression of CMTM 4 and PD-L1 protein by immunohistochemistry Envision, the expression of CMTM 4 and PD-L1 protein in cancer tissues and adjacent tissues, and the relationship between the two and clinical pathological features. Results: CMTM 4 is mainly distributed in tumor cell membrane and cytoplasm, both brown or brown particles; PD-L1 is mainly distributed in tumor stromal immune cells, cell membrane and cytoplasm, brown or light yellow. The levels of CMTM 4 and PD-L1 in pancreatic cancer were higher than those in adjacent cancer (P<0.05). Compared with adjacent tissues, pancreatic cancer tissues had high expression of CMTM 4 protein and PD-L1 protein, and low expression of CMTM 4 protein and PD-L1 protein was lower than adjacent tissues(P<0.05). The incidence of nerve invasion with high PD-L1 expression and lymph node metastasis was higher than that of CMTM 4 and PD-L1 expression (P<0.05); however, gender, age, tumor site, tumor diameter, tissue differentiation, TNM stage, high CMTM 4 expression and high PD-L1 protein expression and low CMTM 4 protein and low PD-L1 expression (P>0.05). CMTM 4 protein and PD-L1 protein expression were not correlated with the degree of tissue differentiation or TNM stage of pancreatic cancer(P>0.05). Conclusion: CMTM4 and PD-L1 proteins are highly expressed in pancreatic cancer tissues, which are related to nerve invasion and lymph node metastasis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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