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278 results on '"PERKINS, SARAH E."'

9. Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer

Author

Weroha, S John, Becker, Marc A, Enderica-Gonzalez, Sergio, Harrington, Sean C, Oberg, Ann L, Maurer, Matthew J, Perkins, Sarah E, AlHilli, Mariam, Butler, Kristina A, McKinstry, Sarah, Fink, Stephanie, Jenkins, Robert B, Hou, Xiaonan, Kalli, Kimberly R, Goodman, Karin M, Sarkaria, Jann N, Karlan, Beth Y, Kumar, Amanika, Kaufmann, Scott H, Hartmann, Lynn C, and Haluska, Paul

Subjects
Rare Diseases, Ovarian Cancer, Orphan Drug, Cancer, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Animals, Biomarkers, Tumor, Chromosome Aberrations, Cluster Analysis, Comparative Genomic Hybridization, Disease Models, Animal, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Graft Survival, Heterografts, Humans, Mice, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Ovarian Neoplasms, Ultrasonography, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeOvarian cancer has a high recurrence and mortality rate. A barrier to improved outcomes includes a lack of accurate models for preclinical testing of novel therapeutics.Experimental designClinically relevant, patient-derived tumorgraft models were generated from sequential patients and the first 168 engrafted models are described. Fresh ovarian, primary peritoneal, and fallopian tube carcinomas were collected at the time of debulking surgery and injected intraperitoneally into severe combined immunodeficient mice.ResultsTumorgrafts demonstrated a 74% engraftment rate with microscopic fidelity of primary tumor characteristics. Low-passage tumorgrafts also showed comparable genomic aberrations with the corresponding primary tumor and exhibit gene set enrichment of multiple ovarian cancer molecular subtypes, similar to patient tumors. Importantly, each of these tumorgraft models is annotated with clinical data and for those that have been tested, response to platinum chemotherapy correlates with the source patient.ConclusionsPresented herein is the largest known living tumor bank of patient-derived, ovarian tumorgraft models that can be applied to the development of personalized cancer treatment.

Published
2014

17. Supplementary Figure Legend from Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer

Author

Weroha, S. John, primary, Becker, Marc A., primary, Enderica-Gonzalez, Sergio, primary, Harrington, Sean C., primary, Oberg, Ann L., primary, Maurer, Matthew J., primary, Perkins, Sarah E., primary, AlHilli, Mariam, primary, Butler, Kristina A., primary, McKinstry, Sarah, primary, Fink, Stephanie, primary, Jenkins, Robert B., primary, Hou, Xiaonan, primary, Kalli, Kimberly R., primary, Goodman, Karin M., primary, Sarkaria, Jann N., primary, Karlan, Beth Y., primary, Kumar, Amanika, primary, Kaufmann, Scott H., primary, Hartmann, Lynn C., primary, and Haluska, Paul, primary

Published
2023
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18. Supplementary Figures 1 - 4 from Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer

Author

Weroha, S. John, primary, Becker, Marc A., primary, Enderica-Gonzalez, Sergio, primary, Harrington, Sean C., primary, Oberg, Ann L., primary, Maurer, Matthew J., primary, Perkins, Sarah E., primary, AlHilli, Mariam, primary, Butler, Kristina A., primary, McKinstry, Sarah, primary, Fink, Stephanie, primary, Jenkins, Robert B., primary, Hou, Xiaonan, primary, Kalli, Kimberly R., primary, Goodman, Karin M., primary, Sarkaria, Jann N., primary, Karlan, Beth Y., primary, Kumar, Amanika, primary, Kaufmann, Scott H., primary, Hartmann, Lynn C., primary, and Haluska, Paul, primary

Published
2023
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21. The presence of territorial damselfish predicts choosy client species richness at cleaning stations

Author

Dunkley, Katie, Whittey, Kathryn E, Ellison, Amy, Perkins, Sarah E, Cable, Jo, Herbert-Read, James E, Dunkley, Katie [0000-0002-6032-6577], Whittey, Kathryn E [0000-0002-1557-757X], Ellison, Amy [0000-0003-3885-6077], Perkins, Sarah E [0000-0002-7457-2699], Cable, Jo [0000-0002-8510-7055], Herbert-Read, James E [0000-0003-0243-4518], and Apollo - University of Cambridge Repository

Subjects
cleaner fish, mutualism, biological market theory, Elacatinus evelynae, partner choice, Animal Science and Zoology, ecological networks, Ecology, Evolution, Behavior and Systematics
Abstract

Mutualisms are driven by partners deciding to interact with one another to gain specific services or rewards. As predicted by biological market theory, partners should be selected based on the likelihood, quality, reward level, and or services each partner can offer. Third-party species that are not directly involved in the interaction, however, may indirectly affect the occurrence and or quality of the services provided, thereby affecting which partners are selected or avoided. We investigated how different clients of the sharknose goby (Elacatinus evelynae) cleaner fish were distributed across cleaning stations, and asked what characteristics, relating to biological market theory, affected this distribution. Through quantifying the visitation and cleaning patterns of client fish that can choose which cleaning station(s) to visit, we found that the relative species richness of visiting clients at stations was negatively associated with the presence of disruptive territorial damselfish at the station. Our study highlights, therefore, the need to consider the indirect effects of third-party species and their interactions (e.g., agonistic interactions) when attempting to understand mutualistic interactions between species. Moreover, we highlight how cooperative interactions may be indirectly governed by external partners.

Published
2022
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24. A hierarchical approach to defining marine heatwaves

Author

Hobday, Alistair J., Alexander, Lisa V., Perkins, Sarah E., Smale, Dan A., Straub, Sandra C., Oliver, Eric C.J., Benthuysen, Jessica A., Burrows, Michael T., Donat, Markus G., Feng, Ming, Holbrook, Neil J., Moore, Pippa J., Scannell, Hillary A., Sen Gupta, Alex, and Wernberg, Thomas

Published
2016
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27. Which is a better predictor of plant traits: temperature or precipitation?

Author

Moles, Angela T., Perkins, Sarah E., Laffan, Shawn W., Flores-Moreno, Habacuc, Awasthy, Monica, Tindall, Marianne L., Sack, Lawren, Pitman, Andy, Kattge, Jens, Aarssen, Lonnie W., Anand, Madhur, Bahn, Michael, Blonder, Benjamin, Cavender-Bares, Jeannine, Cornelissen, J. Hans C., Cornwell, Will K., Díaz, Sandra, Dickie, John B., Freschet, Grégoire T., Griffiths, Joshua G., Gutierrez, Alvaro G., Hemmings, Frank A., Hickler, Thomas, Hitchcock, Timothy D., Keighery, Matthew, Kleyer, Michael, Kurokawa, Hiroko, Leishman, Michelle R., Liu, Kenwin, Niinemets, Ülo, Onipchenko, Vladimir, Onoda, Yusuke, Penuelas, Josep, Pillar, Valério D., Reich, Peter B., Shiodera, Satomi, Siefert, Andrew, Sosinski, Enio E., Soudzilovskaia, Nadejda A., Swaine, Emily K., Swenson, Nathan G., van Bodegom, Peter M., Warman, Laura, Weiher, Evan, Wright, Ian J., Zhang, Hongxiang, Zobel, Martin, and Bonser, Stephen P.

Published
2014
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32. Do invasive species perform better in their new ranges?

Author

Parker, John D., Torchin, Mark E., Hufbauer, Ruth A., Lemoine, Nathan P., Alba, Christina, Blumenthal, Dana M., Bossdorf, Oliver, Byers, James E., Dunn, Alison M., Heckman, Robert W., Hejda, Martin, Jarošík, Vojtěch, Kanarek, Andrew R., Martin, Lynn B., Perkins, Sarah E., Pyšek, Petr, Schierenbeck, Kristina, Schlöder, Carmen, van Klinken, Rieks, Vaughn, Kurt J., Williams, Wyatt, and Wolfe, Lorne M.

Published
2013

34. Indirect effects of parasites in invasions

Author

Dunn, Alison M., Torchin, Mark E., Hatcher, Melanie J., Kotanen, Peter M., Blumenthal, Dana M., Byers, James E., Coon, Courtney A.C., Frankel, Victor M., Holt, Robert D., Hufbauer, Ruth A., Kanarek, Andrew R., Schierenbeck, Kristina A., Wolfe, Lorne M., and Perkins, Sarah E.

Published
2012
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48. Parasites of an Arctic scavenger; the wolverine (Gulo gulo)

Author

Watson, Sophie E., primary, Hailer, Frank, additional, Lecomte, Nicolas, additional, Kafle, Pratap, additional, Sharma, Rajnish, additional, Jenkins, Emily J., additional, Awan, Malik, additional, L’Hérault, Vincent, additional, and Perkins, Sarah E., additional

Published
2020
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49. Sacred cows and sympathetic squirrels: the importance of biological diversity to human health

Author

Dobson, Andy, Cattadori, Isabella, Holt, Robert D., Ostfeld, Richard S., Keesing, Felicia, Krichbaum, Kristle, Rohr, Jason R., Perkins, Sarah E., and Hudson, Peter J.

Subjects
Biological diversity, Cows, Health, Human-animal relationships, Holy, The, Squirrels
Abstract

Why are cows sacred? Travel anywhere in India and they have the right of way. Travel anywhere in the eastern United States and you'll see squirrels, more than likely, as [...]

Published
2006

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