79 results on '"PETRELLA V."'
Search Results
2. Aedes albopictus bionomics in Procida Island, a promising Mediterranean site for the assessment of innovative and community-based integrated pest management methods
- Author
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Caputo, B., primary, Langella, G., additional, Petrella, V., additional, Virgillito, C., additional, Manica, M., additional, Filipponi, F., additional, Varone, M., additional, Primo, P., additional, Puggioli, A., additional, Bellini, R., additional, D’Antonio, C., additional, Iesu, L., additional, Tullo, L., additional, Rizzo, C., additional, Longobardi, A., additional, Sollazzo, G., additional, Perrotta, M. M., additional, Fabozzi, M., additional, Palmieri, F., additional, Saccone, G, additional, Rosà, R., additional, della Torre, A., additional, and Salvemini, M., additional
- Published
- 2021
- Full Text
- View/download PDF
3. Cortisol, Testosterone and Soccer; Modulation of Adrenal and Testis Function during a Competititve Season.
- Author
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Petrella, V, primary, Bucci, I, additional, Giuliani, C, additional, Di Blasio, A, additional, Vitale, R, additional, Monaco, F, additional, and Napolitano, G, additional
- Published
- 2010
- Full Text
- View/download PDF
4. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
- Author
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Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., Agrusta M., Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., and Agrusta M.
- Abstract
Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50–75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2–3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15–45 mg) or a sulfonylurea (5–15 mg glibenclamide, 2–6 mg glimepiride, or 30–120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57·3 months. The primary outcome occurred in 105 patients (1·5 per 100 person-years) who were given pioglitazone and 108 (1·5 p
- Published
- 2017
5. La tutela del terzo nella esecuzione per consegna o rilascio su titiolo esecutivo notarile
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ACONE, M, ANDOLINA, IA, AULETTA, F, BALENA, G, BASILICO, G, CAVALLINI, C, CAVALLONE, B, CHIZZINI, A, COMOGLIO, LP, CORSINI, F, DI CARLO, G, DITTRICH, L, GIORGETTI, M, GIOVANNUCCI ORLANDI, C, GIUSSANI, A, GUARNIERI, G, IMPAGNATIELLO, G, LA CHINA, S, LANFRANCHI, L, MENCHINI, S, PETRELLA, V, PICARDI, N, RUFFINI, G, SANDULLI, P, SOTGIU, N, TRISORIO LIUZZI, G, VALENTINI, S, CAPPONI, B, GRAZIOSI, A, IANNICELLI, L, MACCARRONE, R, NERI, A, PROTO PISANI, A, CORDOPATRI, F, LAZZARA, G, TESORIERE, G, VACCARELLA, R, VELLANI, M, CHIARLONI, S, COSTANTINO, G, DI FABIO, M, PAGNI, I, SASSANI, B, SCALA, A, BERNARDINI, P, BERTOLDI, V, BOCCAGNA, S, BORGHESI, D, BOVE, M, CANALE, G, CARPI, F, CONSOLO, C, DANOVI, F, FAZZALARI, E, GROSSI, D, LUBRANO, F, MARINELLI, M, MARINUCCI, E, NELA, PL, PICOZZA, E, RAVIDÀ, F, RICCI, EF, RICCI, GF, RIGHETTI, E, SEATZU, F, TAMPONI, M, TAVORMINA, V, VERDE, Giuseppe, VIGORITI, V, ZUCCONI GALLI FONSECA, E, BRIGUGLIO, A, CARRATTA, A, DALFINO, D, GRADI, M, MARTINO, R, OLIVIERI, G, PICCININNI, L, POLI, R, RASCIO, N, RINALDI, S, RUGGERI, E, TROIANO, R, VITRÒ, V, CIPRIANI, F, D’ALESSIO, A, DALMOTTO, E, DELLA PIETRA G, LUISO, FP, NARDO, GN, PROSPERETTI, G, QUERZOLA, L, TOMMASEO, F, VULLO, E, BONGIORNO, G, CORRADO, C, DE SANTIS, F, FABIANI, M, FINOCCHIARO, G, FARINA, P, LIGUORI, G, MANCUSO, C, MONTANARI, M, NICÒTINA, G, ORIANI ,R, RECCHIONI, S, SALETTI, A, DE ROBERTO, A, FANTOZZI, A, ODORISIO, E, SCOCA, F. G, VIOLANTE, V, LIBERTINI, M, MURRA, R, RENZETTI, F, RESTA, D, SCIASCIA, T, BONNET, P. A, LLOBELL, J, PUNZI NICOLÒ, AM, CICERO, C, CUFFARO, V, FERRI, G. B, GIACOBBE, G, GRANATA, R, MAZZAMUTO, S, RESCIGNO, P, SCARSELLI, G, SCOZZAFAVA, OT, TULLIO, L, VITUCCI, P, ANGELICI, C, FERRI, Gjr, GATTI, S, GUERRA, P, SANTONASTASO, F, SCOGNAMIGLIO, G, TERRANOVA, G, CAPONI, R, MARENGO, R, MONTERO AROCA, J, RAMOS MÉNDEZ, F, STÜRNER, R, TROCKER, N, VELLANI, C, WALTER, G, WOPERA, Z, CARDIA, C, DALLA TORRE ,G, PICOZZA, P, APICE, U, CASTAGNOLA, A, COLESANTI, V, D’ALESSANDRO, F, FERRI, C, FRASCAROLI SANTI, E, LASCARO, P, MELUCCO, A, NORELLI, E, SCALERA, I, VONA, G, PESSI, R, RAMACCI, F, FERCIA, R, SCHIPANI, S, BERLINGUER, A, BIAVATI, P, GHIA, L, LUPOI, MA, PROTO, V, CAPRIOLI, S, CARCATERRA, G, D’ADDIO, M, DE SANCTIS, FM, IRTI, N, NASI, A, PACE, A, PUNZI, A, ROMANO, B., MONTELEONE, Girolamo, ZIINO, Salvatore, Fazzalari, E (presidente comitato promotore), Bongiorno, G (coordinatore), Monteleone, G (coordinatore), Ruffini, G(coordinatore), ACONE, M, ANDOLINA, IA, AULETTA, F, BALENA, G, BASILICO, G, CAVALLINI, C, CAVALLONE, B, CHIZZINI, A, COMOGLIO, LP, CORSINI, F, DI CARLO, G, DITTRICH, L, GIORGETTI, M, GIOVANNUCCI ORLANDI, C, GIUSSANI, A, GUARNIERI, G, IMPAGNATIELLO, G, LA CHINA, S, LANFRANCHI, L, MENCHINI, S, MONTELEONE, G, PETRELLA, V, PICARDI, N, RUFFINI, G, SANDULLI, P, SOTGIU, N, TRISORIO LIUZZI, G, VALENTINI, S, CAPPONI, B, GRAZIOSI, A, IANNICELLI, L, MACCARRONE, R, NERI, A, PROTO PISANI, A, CORDOPATRI, F, LAZZARA, G, TESORIERE, G, VACCARELLA, R, VELLANI, M, CHIARLONI, S, COSTANTINO, G, DI FABIO, M, PAGNI, I, SASSANI, B, SCALA, A, BERNARDINI, P, BERTOLDI, V, BOCCAGNA, S, BORGHESI, D, BOVE, M, CANALE, G, CARPI, F, CONSOLO, C, DANOVI, F, FAZZALARI, E, GROSSI, D, LUBRANO, F, MARINELLI, M, MARINUCCI, E, NELA, PL, PICOZZA, E, RAVIDÀ, F, RICCI, EF, RICCI, GF, RIGHETTI, E, SEATZU, F, TAMPONI, M, TAVORMINA, V, VERDE, G, VIGORITI, V, ZUCCONI GALLI FONSECA, E, BRIGUGLIO, A, CARRATTA, A, DALFINO, D, GRADI, M, MARTINO, R, OLIVIERI, G, PICCININNI, L, POLI, R, RASCIO, N, RINALDI, S, RUGGERI, E, TROIANO, R, VITRÒ, V, CIPRIANI, F, D’ALESSIO, A, DALMOTTO, E, DELLA PIETRA G, LUISO, FP, NARDO, GN, PROSPERETTI, G, QUERZOLA, L, TOMMASEO, F, VULLO, E, BONGIORNO, G, CORRADO, C, DE SANTIS, F, FABIANI, M, FINOCCHIARO, G, FARINA, P, LIGUORI, G, MANCUSO, C, MONTANARI, M, NICÒTINA, G, ORIANI ,R, RECCHIONI, S, SALETTI, A, ZIINO, S, DE ROBERTO, A, FANTOZZI, A, ODORISIO, E, SCOCA, F G, VIOLANTE, V, LIBERTINI, M, MURRA, R, RENZETTI, F, RESTA, D, SCIASCIA, T, BONNET, P A, LLOBELL, J, PUNZI NICOLÒ, AM, CICERO, C, CUFFARO, V, FERRI, G B, GIACOBBE, G, GRANATA, R, MAZZAMUTO, S, RESCIGNO, P, SCARSELLI, G, SCOZZAFAVA, OT, TULLIO, L, VITUCCI, P, ANGELICI, C, FERRI, Gjr, GATTI, S, GUERRA, P, SANTONASTASO, F, SCOGNAMIGLIO, G, TERRANOVA, G, CAPONI, R, MARENGO, R, MONTERO AROCA, J, RAMOS MÉNDEZ, F, STÜRNER, R, TROCKER, N, VELLANI, C, WALTER, G, WOPERA, Z, CARDIA, C, DALLA TORRE ,G, PICOZZA, P, APICE, U, CASTAGNOLA, A, COLESANTI, V, D’ALESSANDRO, F, FERRI, C, FRASCAROLI SANTI, E, LASCARO, P, MELUCCO, A, NORELLI, E, SCALERA, I, VONA, G, PESSI, R, RAMACCI, F, FERCIA, R, SCHIPANI, S, BERLINGUER, A, BIAVATI, P, GHIA, L, LUPOI, MA, PROTO, V, CAPRIOLI, S, CARCATERRA, G, D’ADDIO, M, DE SANCTIS, FM, IRTI, N, NASI, A, PACE, A, PUNZI, A, and ROMANO, B
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natura giuridica del titolo esecutivo ,Settore IUS/15 - Diritto Processuale Civile ,esecuzione diretta ,opposizione - Published
- 2008
6. Stochastic Design Improvement of a Vehicle Substructure in Impact Conditions
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LAMANNA, Giuseppe, CAPUTO, Francesco, MONACELLI G, PETRELLA V, SOPRANO, Alessandro, Lamanna, Giuseppe, Caputo, Francesco, Monacelli, G, Petrella, V, and Soprano, Alessandro
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- 2005
7. De novo assembly and sex-specific transcriptome profiling in the sand fly Phlebotomus perniciosus (Diptera, Phlebotominae), a major Old World vector of Leishmania infantum
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Petrella, V, Aceto, S, Musacchia, F, Colonna, V, Robinson, Mark D; https://orcid.org/0000-0002-3048-5518, Benes, V, Cicotti, G, Bongiorno, G, Gradoni, L, Volf, P, Salvemini, M, Petrella, V, Aceto, S, Musacchia, F, Colonna, V, Robinson, Mark D; https://orcid.org/0000-0002-3048-5518, Benes, V, Cicotti, G, Bongiorno, G, Gradoni, L, Volf, P, and Salvemini, M
- Abstract
Background The phlebotomine sand fly Phlebotomus perniciosus (Diptera: Psychodidae, Phlebotominae) is a major Old World vector of the protozoan Leishmania infantum, the etiological agent of visceral and cutaneous leishmaniases in humans and dogs, a worldwide re-emerging diseases of great public health concern, affecting 101 countries. Despite the growing interest in the study of this sand fly species in the last years, the development of genomic resources has been limited so far. To increase the available sequence data for P. perniciosus and to start studying the molecular basis of the sexual differentiation in sand flies, we performed whole transcriptome Illumina RNA sequencing (RNA-seq) of adult males and females and de novo transcriptome assembly. Results We assembled 55,393 high quality transcripts, of which 29,292 were unique, starting from adult whole body male and female pools. 11,736 transcripts had at least one functional annotation, including full-length low abundance salivary transcripts, 981 transcripts were classified as putative long non-coding RNAs and 244 transcripts encoded for putative novel proteins specific of the Phlebotominae sub-family. Differential expression analysis identified 8590 transcripts significantly biased between sexes. Among them, some show relaxation of selective constraints when compared to their orthologs of the New World sand fly species Lutzomyia longipalpis. Conclusions In this paper, we present a comprehensive transcriptome resource for the sand fly species P. perniciosus built from short-read RNA-seq and we provide insights into sex-specific gene expression at adult stage. Our analysis represents a first step towards the identification of sex-specific genes and pathways and a foundation for forthcoming investigations into this important vector species, including the study of the evolution of sex-biased genes and of the sexual differentiation in phlebotomine sand flies.
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- 2015
8. PROGETTAZIONE DELLE TOLLERANZE PER IL MIGLIORAMENTO DELLASSEMBLABILITÀ DI SOTTOSISTEMI AUTOMOBILISTICI
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LANZOTTI, ANTONIO, MONACELLI G., PETRELLA V., GERBINO S., Lanzotti, Antonio, Monacelli, G., Petrella, V., and Gerbino, S.
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- 2003
9. IMPIEGO DI MODELLI VIRTUALI NELLA PROGETTAZIONE AUTOMOBILISTICA
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LANZOTTI, ANTONIO, MONACELLI G., PETRELLA V., Lanzotti, Antonio, Monacelli, G., and Petrella, V.
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- 2003
10. Integrazione FEM/Multibody nella Simulazione degli Urti ad Alta Velocità
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MONACELLI G, PETRELLA V, MATTERA M, ZINNO A, ESPOSITO R, SOPRANO, Alessandro, Monacelli, G, Petrella, V, Mattera, M, Zinno, A, Esposito, R, and Soprano, Alessandro
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- 2003
11. Role of the Y chromosome in the Ceratitis capitata sex determination and reproduction. Symposium 504: Development and evaluation of improved strains of insect pests for sterile insect technique
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Saccone, G., Salvemini, M., D'Amato, R., Tomar, A., Petrella, V., Ciolfi, Silvia, Dallai, R., Marchini, Daniela, Franz, G., Nagaraju, J., and Polito, Cl
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reproduction ,transcriptomics ,sex determination ,Y chromosome ,Sterile Insect Technique - Published
- 2012
12. Flies and mosquitoes: The Y chromosome role in the Ceratitis capitata sex determination/reproduction and the Drosophila fruitless orthologue characterization in Aedes aegypti
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Saccone, G., Salvemini, M., D'Amato, R., Tomar, A., Petrella, V., Romanelli, A., Ciolfi, Silvia, Dallai, R., Marchini, Daniela, Franz, G., Caceres, C., Rempoulakis, P, Vreysen, M., Nagaraju, J., and Polito, L. C.
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- 2012
13. VALIDAZIONE SPERIMENTALE DI MODELLI VIRTUALI PER LA GESTIONE DELLE TOLLERANZE DI SOTTOSISTEMI COMPLESSI DELL'AUTOVEICOLO
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LANZOTTI, ANTONIO, MONACELLI G., PETRELLA V., SALERNO A., AA.VV., Lanzotti, Antonio, Monacelli, G., Petrella, V., and Salerno, A.
- Published
- 2000
14. Progettazione delle tolleranze per il miglioramento dell’assemblabilità di sottosistemi automobilistici
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Monacelli, G., Petrella, V., Gerbino, Salvatore, Lanzotti, A., Monacelli G., Petrella E., Gerbino S., LanzottiA., Monacelli, G., Petrella, V., Gerbino, S, Lanzotti, A., F. CAPUTO, G. MONACELLI A CURA DI, Gerbino, S., and Lanzotti, Antonio
- Abstract
Nella progettazione di sottosistemi complessi dell'autoveicolo è necessaria un'attenta valutazione delle tolleranze dimensionali e geometriche per garantire il montaggio e la funzionalità; la disponibilità dei sistemi CAT (Computer Aided Tolerancing) che assistono nelle progettazione e verifica delle tolleranze favorisce il miglioramento dell’assemblabilità sin dalla fase d'impostazione del progetto. Le potenzialità di tali strumenti sono illustrate con un caso applicativo: la progettazione delle asole per l'assemblaggio del gruppo motopropulsore su scocca, sviluppato presso Elasis, Sistema Ricerca Fiat nel Mezzogiorno.
- Published
- 1999
15. De novo assembly and sex-specific transcriptome profiling in the sand fly Phlebotomus perniciosus (Diptera, Phlebotominae), a major Old World vector of Leishmania infantum
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Petrella, V., primary, Aceto, S., additional, Musacchia, F., additional, Colonna, V., additional, Robinson, M., additional, Benes, V., additional, Cicotti, G., additional, Bongiorno, G., additional, Gradoni, L., additional, Volf, P., additional, and Salvemini, M., additional
- Published
- 2015
- Full Text
- View/download PDF
16. Improving design of engine bonnet by simultaneous engineering
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CAPUTO, FRANCESCO, LANZOTTI, ANTONIO, PETRELLA V., SELLITTO V., Caputo, Francesco, Lanzotti, Antonio, Petrella, V., and Sellitto, V.
- Abstract
Firenze, Italy
- Published
- 1997
17. A study on structural behaviour of a car-bonnet during child-head impact, using parametric-variational cad/cae modelling techniques and numeric computation by explicit codes
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Monacelli, G., Petrella, V., Alessandro Naddeo, Donnarumma, A., and Nicola Cappetti
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- 2002
18. Strain-rate effects on the energy absorption capability of crash boxes with different geometry
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Peroni, L., Avalle, Massimiliano, Petrella, V, and Monacelli, G.
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- 2002
19. New Methodologies to study in a Virtual Reality Centre the automotive behaviour during different Crash Tests
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Monacelli, G., Petrella, V., and Alessandro Naddeo
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- 2002
20. A New Palliative Prognostic Score: A First Step for the Staging of Terminally Ill Cancer Patients
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Pirovano, M., Maltoni, M., Nanni, O., Marinari, M., Indelli, M., Zaninetta, G., Petrella, V., Barni, S., Zecca, E., and Scarpi, E.
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- 1999
- Full Text
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21. Lower leg impactor’s knee joint modellation for pedestrian test simulation using explicit codes
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Alessandro Naddeo, Monacelli, G., and Petrella, V.
22. Properties of cholera toxin- and NaF-stimulated adenylate cyclase from mouse thymocytes☆
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PETRELLA, V, primary and ZENSER, T, additional
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- 1976
- Full Text
- View/download PDF
23. Spin-labeled stearates as probes for microenvironment of murine thymocyte adenylate cyclase-cyclic adenosine 3':5'-monophosphate system.
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Zenser, T V, primary, Petrella, V J, additional, and Hughes, F, additional
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- 1976
- Full Text
- View/download PDF
24. Dell’espropriazione presso terzi. Commento agli artt. 543-554
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Salvatore Ziino, Carratta, A, Cossignani, F, Fradeani, F, Adorno, M, Bonato, G, Carbone, D, Carrea, L, Cartoni, C, Cerrato, A, Del Zozzo, E, Desiato, O, Di Cola, L, Emili, L, Farina, P, Fava, R, Fuina, M, Gianfelice, A, Giordano, A, Mantovani, M L, Marozzi, S, Martorano, D, Minafra, Parisi, G, Petrella, V, Picozzi, E, Pofi, E, Quero, P, Romanelli, S, Savi, G, Ventura, N, Ziino, S, and Salvatore Ziino
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Responsabilità patrimoniale, crediti del debitore e beni del debitore nella disponibilità di terzi, espropriazione presso terzi ,Settore IUS/15 - Diritto Processuale Civile ,Civil obligations, seizure of goods, garnishment - Abstract
Commento alle disposizioni del codice di procedura civile in materia di espropriazione presso terzi Commentary on the articles of Italian civil procedure code ruling garnishment
- Published
- 2022
25. Citizen Science and Asian Tiger Mosquito: A Pilot Study on Procida Island, A Possible Mediterranean Site for Mosquito Integrated Vector Management Trials
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Marco Salvemini, Giuseppe Saccone, Federico Filipponi, A. Della Torre, Beniamino Caputo, Mattia Manica, Giuliano Langella, Valeria Petrella, AA.VV., Hendrichs, Jorge, Petrella, V., Saccone, G., Langella, G., Caputo, B., Manica, M., Filipponi, F., Della Torre, A., and Salvemini, M.
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Mediterranean climate ,Baseline data ,Aedes albopictus ,Culex laticinctus ,Fishery ,SIT ,Geography ,IVM SIT sterile insect technique ,Mosquito surveillance ,IVM ,Italy ,Culex pipiens ,Tiger mosquito ,baseline data ,mosquito surveillance ,aedes albopictus ,culex pipiens ,culex laticinctus ,italy ,Citizen science ,Sterile insect technique ,Vector management ,Settore VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI - Abstract
During the past twenty years, the number of research projects involving people not trained as scientists, the so-called citizen science, has increased consistently, including mosquito monitoring and control projects. The involvement of citizens in mosquito monitoring programmes not only helps scientists during the data collection phase, but also raises public awareness on mosquito-transmitted diseases and educates citizens about virtuous behaviours that can help in reducing mosquito populations and their spread. The Asian tiger mosquito Aedes albopictus (Skuse) is an invasive species that became established in Europe starting in 1979, with Italy representing currently one of the most infested countries. Procida, a small Mediterranean island in the Naples gulf (Campania region, southern Italy) has unique and very interesting features facilitating the field testing of mosquito integrated vector management (IVM) approaches and control methods, including the Sterile Insect Technique (SIT). With the help of the local municipal administration, the Procida citizens are actively involved as volunteers in monitoring the seasonal and spatial distribution of the Asian tiger mosquito. The collected baseline data will be useful to implement a future island-wide integrated suppression trial of Ae. albopictus, including the release of sterile males, to be carried out in collaboration with the local municipal administration and with the technical support of the Joint FAO/IAEA Division in Vienna.
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- 2021
26. Aedes albopictus bionomics data collection by citizen participation on Procida Island, a promising Mediterranean site for the assessment of innovative and community-based integrated pest management methods
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Ciro Rizzo, Liliana Tullo, Marco Salvemini, Valeria Petrella, Romeo Bellini, Germano Sollazzo, Luca Iesu, Costantino D’Antonio, Pasquale Primo, Federico Filipponi, Annalisa Longobardi, Maryanna Martina Perrotta, Beniamino Caputo, Marianna Varone, Roberto Rosà, Chiara Virgillito, Miriana Fabozzi, Giuliano Langella, Giuseppe Saccone, Alessandra della Torre, Mattia Manica, Fabiana Palmieri, Arianna Puggioli, Caputo, B., Langella, G., Petrella, V., Virgillito, C., Manica, M., Filipponi, F., Varone, M., Primo, P., Puggioli, A., Bellini, R., D'Antonio, C., Iesu, L., Tullo, L., Rizzo, C., Longobardi, A., Sollazzo, G., Perrotta, M. M., Fabozzi, M., Palmieri, F., Saccone, G., Rosa, R., Torre, A. D., and Salvemini, M.
- Subjects
Male ,Integrated pest management ,Topography ,Mosquito Control ,Physiology ,Eggs ,Oviposition ,community based integrated mosquito management ,RC955-962 ,Disease Vectors ,Ovitrap ,Mosquitoes ,Geographical locations ,Sterile insect technique ,Medical Conditions ,Aedes ,Residence Characteristics ,Reproductive Physiology ,invasive mosquito ,aedes albopictus ,bionomics, dispersal, sit ,management ,Arctic medicine. Tropical medicine ,Geoinformatics ,Medicine and Health Sciences ,Islands ,education.field_of_study ,Ecology ,Geography ,biology ,Population size ,Eukaryota ,Insects ,Europe ,Mosquito control ,Infectious Diseases ,Italy ,bionomics ,Female ,Seasons ,Public aspects of medicine ,RA1-1270 ,Aede ,Human ,Research Article ,Cartography ,Computer and Information Sciences ,Aedes albopictus ,Arthropoda ,Population Size ,Population ,Environment ,Island ,sit ,Population Metrics ,Animals ,Humans ,European Union ,education ,Settore VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI ,dispersal ,Population Density ,Landforms ,Spatial Analysis ,Population Biology ,Animal ,Organisms ,Public Health, Environmental and Occupational Health ,Biology and Life Sciences ,Geomorphology ,biology.organism_classification ,Invertebrates ,Insect Vectors ,Species Interactions ,Residence Characteristic ,Earth Sciences ,Biological dispersal ,People and places ,Animal Distribution ,Zoology ,Entomology - Abstract
In the last decades, the colonization of Mediterranean Europe and of other temperate regions by Aedes albopictus created an unprecedented nuisance problem in highly infested areas and new public health threats due to the vector competence of the species. The Sterile Insect Technique (SIT) and the Incompatible Insect Technique (IIT) are insecticide-free mosquito-control methods, relying on mass release of irradiated/manipulated males, able to complement existing and only partially effective control tools. The validation of these approaches in the field requires appropriate experimental settings, possibly isolated to avoid mosquito immigration from other infested areas, and preliminary ecological and entomological data. We carried out a 4-year study in the island of Procida (Gulf of Naples, Italy) in strict collaboration with local administrators and citizens to estimate the temporal dynamics, spatial distribution, and population size of Ae. albopictus and the dispersal and survival of irradiated males. We applied ovitrap monitoring, geo-spatial analyses, mark-release-recapture technique, and a citizen-science approach. Results allow to predict the seasonal (from April to October, with peaks of 928–9,757 males/ha) and spatial distribution of the species, highlighting the capacity of Ae. albopictus population of Procida to colonize and maintain high frequencies in urban as well as in sylvatic inhabited environments. Irradiated males shown limited ability to disperse (mean daily distance travelled, Author summary Mosquitoes represent a nuisance as well as public health risk due to their ability to transmit pathogens to humans. The Asian tiger mosquito Aedes albopictus is an invasive species nowadays established in all Mediterranean countries, reaching highest abundance in Italy. Innovative control approaches have been proposed to complement conventional ones and to increase the success of the fight against this aggressive day-biting species, but still need to be validated in the field. Small islands are ideal places for these validation experiments as they are naturally protected by the spill over of mosquitoes from neighbouring untreated areas. The island of Procida, in the gulf of Naples (Italy), has the right ecological characteristics (e.g., homogeneous landscape and high densities of human and Ae. albopictus populations) to represent an ideal experimental site. In collaboration with the Municipality and the residents we obtained relevant data on the mosquito distribution and seasonality on the island and performed preliminary experiments, creating an instrumental baseline information which will facilitate the effective testing of novel control schemes.
- Published
- 2021
27. Codice di procedura civile ragionato. Commenti agli artt. 543 - 566
- Author
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salvatore ziino, Carratta, A, Cossignani, F, Fradeani, F, Adorno, M, Bonato, G, Carbone, D, Carrea, L, Cartoni, C, Cerrato, A, Del Zozzo, E, Desiato, O, Di Cola, L, Emili, L, Farina, P, Fava, R, Fuina, M, Gianfelice, A, Giordano, A, Mantovani, M L, Marozzi, S, Martorano, D, Minafra, Parisi, G, Petrella, V, Picozzi, E, Pofi, E, Quero, P, Romanelli, S, Savi, G, Ventura, N, Ziino, S, and salvatore ziino
- Subjects
Settore IUS/15 - Diritto Processuale Civile ,seizure in the hands of a third person, seizure of immoble assets of the debtor ,espropriazione forzata , espropriazione presso terzi, espropriazione immobiliare - Abstract
Commento agli articoli del codice di procedura civile che regolano la espropriazione presso terzi e la espropriazione immobiliare Commentary of civil procedure code articles ruling a) seizure in the hands of a third person; b) seizure of immoble assets of the debtor
- Published
- 2021
28. Zanzamapp: A scalable citizen science tool to monitor perception of mosquito abundance and nuisance in italy and beyond
- Author
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Luca Iesu, Cesare Bianchi, Valeria Petrella, Luca Delucchi, Beniamino Caputo, Marta Blangiardo, Carlo De Marco, Federico Filipponi, Alessandra della Torre, Marco Salvemini, Paola Morano, Pietro Cobre, Mattia Manica, Caputo, B., Manica, M., Filipponi, F., Blangiardo, M., Cobre, P., Delucchi, L., De Marco, C. M., Iesu, L., Morano, P., Petrella, V., Salvemini, M., Bianchi, C., and della Torre, A.
- Subjects
Mosquito Control ,business.product_category ,OUTBREAK ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,Toxicology ,medicine.disease_cause ,CHIKUNGUNYA ,0302 clinical medicine ,Mosquito ,Aedes ,Citizen science ,Aedes albopictus ,Chikungunya ,Public, Environmental & Occupational Health ,media_common ,0303 health sciences ,Environmental resource management ,Mobile Applications ,Authentication (law) ,Europe ,Biting activity ,Italy ,Female ,Smartphone ,Life Sciences & Biomedicine ,Nuisance ,media_common.quotation_subject ,030231 tropical medicine ,Environmental Sciences & Ecology ,Mosquito Vectors ,Biology ,Article ,03 medical and health sciences ,aedes albopictus ,biting activity ,citizen science ,mosquito ,nuisance ,tiger mosquito ,animals ,europe ,female ,humans ,italy ,mosquito control ,smartphone ,spatial analysis ,aedes ,mobile applications ,mosquito vectors ,Perception ,Tiger mosquito ,parasitic diseases ,Internet access ,medicine ,Animals ,Humans ,Settore VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI ,030304 developmental biology ,Spatial Analysis ,Science & Technology ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Public institution ,AEDES-ALBOPICTUS ,biology.organism_classification ,MODEL ,Aedes albopictu ,business ,Environmental Sciences - Abstract
Mosquitoes represent a considerable nuisance and are actual/potential vectors of human diseases in Europe. Costly and labour-intensive entomological monitoring is needed to correct planning of interventions aimed at reducing nuisance and the risk of pathogen transmission. The widespread availability of mobile phones and of massive Internet connections opens the way to the contribution of citizen in complementing entomological monitoring. ZanzaMapp is the first mobile &ldquo, mosquito&rdquo, application for smartphones specifically designed to assess citizens&rsquo, perception of mosquito abundance and nuisance in Italy. Differently from other applications targeting mosquitoes, ZanzaMapp prioritizes the number of records over their scientific authentication by requesting users to answer four simple questions on perceived mosquito presence/abundance/nuisance and geo-localizing the records. The paper analyses 36,867 ZanzaMapp records sent by 13,669 devices from 2016 to 2018 and discusses the results with reference to either citizens&rsquo, exploitation and appreciation of the app and to the consistency of the results obtained with the known biology of main mosquito species in Italy. In addition, we provide a first small-scale validation of ZanzaMapp data as predictors of Aedes albopictus biting females and examples of spatial analyses and maps which could be exploited by public institutions and administrations involved in mosquito and mosquito-borne pathogen monitoring and control.
- Published
- 2020
29. Codice di procedura civile ragionato. Commento agli articoli da 543 a 566
- Author
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Ziino, Carratta, A, Cossignani, F, Fradeani, F, Adorno, M, Bonato, G, Carbone, D, Carrea, L, Cartoni, C, Cerrato, A, Del Zozzo, E, Desiato, O, Di Cola, L, Emili, L, Farina, P, Fava, R, Fuina, M, Gianfelice, A, Giordano, A, Mantovani, M L, Marozzi, S, Martorano, D, Minafra, N, Petrella, V, Picozzi, E, Pofi, E, Quero, P, Romanelli, S, Savi, G, Ventura, N, Ziino, S, and Ziino
- Subjects
Settore IUS/15 - Diritto Processuale Civile ,espropriazione forzata- espropriazione presso terzi - espropriazione immobiliare ,seizure in the hands of a third person - seizure of immoble assets of the debtor - Abstract
Commento agli articoli del codice di procedura civile che regolano la espropriazione presso terzi e la espropriazione immobiliare Commentary of civil procedure code articles ruling a) seizure in the hands of a third person; b) seizure of immoble assets of the debtor
- Published
- 2020
30. Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
- Author
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Brantley Hall, Zhijian Tu, Stephan Schmeing, Michela Anna Gucciardino, Valeria Petrella, Angela Meccariello, Kostas Bourtzis, Andrea Gravina, Marco Salvemini, Ennio Giordano, Simona Maria Monti, Maryanna Martina Perrotta, Alessia Ruggiero, Javaregowda Nagaraju, Panagiota Koskinioti, Federica Forlenza, František Marec, Pasquale Primo, Maria Eleni Gregoriou, Giuseppe Saccone, Francesca Scolari, Philippos Aris Papathanos, Martina Dalíková, Kostas D. Mathiopoulos, Domenica Ippolito, Mark D. Robinson, Jiannis Ragoussis, Luigi Vitagliano, Kallare P. Arunkumar, Nikolai Windbichler, Konstantina T. Tsoumani, University of Zurich, Papathanos, Philippos Aris, Meccariello, A., Salvemini, M., Primo, P., Hall, B., Koskinioti, P., Dalikova, M., Gravina, A., Gucciardino, M. A., Forlenza, F., Gregoriou, M. -E., Ippolito, D., Monti, S. M., Petrella, V., Perrotta, M. M., Schmeing, S., Ruggiero, A., Scolari, F., Giordano, E., Tsoumani, K. T., Marec, F., Windbichler, N., Arunkumar, K. P., Bourtzis, K., Mathiopoulos, K. D., Ragoussis, J., Vitagliano, L., Tu, Z., Papathanos, P. A., Robinson, M. D., and Saccone, G.
- Subjects
CERATITIS-CAPITATA ,EXPRESSION ,PROVIDES ,Feminization (biology) ,media_common.quotation_subject ,Male sex determination ,Insect ,Biology ,Y chromosome ,Genome ,Bactrocera dorsalis ,UFSP13-7 Evolution in Action: From Genomes to Ecosystems ,03 medical and health sciences ,0302 clinical medicine ,Tephritidae ,Gene ,media_common ,030304 developmental biology ,Genetics ,0303 health sciences ,1000 Multidisciplinary ,Multidisciplinary ,Sexual differentiation ,genetics of development ,business.industry ,Novel protein ,fungi ,Ceratitis capitata ,biology.organism_classification ,GENE ,10124 Institute of Molecular Life Sciences ,GENOME ,Agriculture ,M factor ,570 Life sciences ,biology ,insect sex determination ,business ,030217 neurology & neurosurgery - Abstract
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module producing sex-specific proteins that direct sex determination and sexual differentiation1-4. In the agricultural pestCeratitis capitata(medfly), a Y-linked maleness factor (M) is thought to repress the autoregulatory splicing oftransformer(Cctra), which is required in XX individuals to establish and maintain female sex determination5,6. Despite previous attempts of isolating Y-linked genes using the medfly whole genome, theMfactor has remained elusive7. Here, we report the identification of a Y-linked gene,Maleness-on the-Y(MoY), and show that it encodes a small novel protein which is both necessary and sufficient for medfly male sex determination. Transient silencing ofMoYin XY individuals leads to the development of fertile females while transient expression ofMoYin XX individuals results in fertile males. Notably, a cross between these sex reverted individuals gives rise to both fertile males and females indicating that a functionalMoYcan be maternally transmitted. In contrast to the diversity ofMfactors found in dipteran species8-11, we discoveredMoYorthologues in seven other Tephritid species spanning ∼111 millions of years of evolution (Mya). We confirmed their male determining function in the olive fly (Bactrocera oleae) and the oriental fruit fly (Bactrocera dorsalis). This unexpected conservation of the primaryMoYsignal in a large number of important agricultural pests12will facilitate the development of transferable genetic control strategies in these species, for example sterile male releases or sex-ratio-distorting gene drives.
- Published
- 2019
31. Positive selection in Europeans and East-Asians at the ABCA12 gene
- Author
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Dario Antonini, Roberto Sirica, Ombretta Guardiola, Lucia Sticco, Giovanni D'Angelo, Heerman Kumar, Caterina Missero, Chris Tyler-Smith, Qasim Ayub, Yali Xue, Valeria Petrella, Gennaro Andolfi, Marco Salvemini, Donatella Tramontano, Vincenza Colonna, Marianna Buonaiuto, Sirica, R., Buonaiuto, M., Petrella, V., Sticco, L., Tramontano, D., Antonini, D., Missero, C., Guardiola, O., Andolfi, G., Kumar, H., Ayub, Q., Xue, Y., Tyler-Smith, C., Salvemini, M., D'Angelo, G., and Colonna, V.
- Subjects
0301 basic medicine ,lcsh:Medicine ,Gene Expression ,Genomics ,Biology ,Polymorphism, Single Nucleotide ,DNA sequencing ,Article ,White People ,ABCA12 gene ,03 medical and health sciences ,Exon ,0302 clinical medicine ,Asian People ,Gene Frequency ,Transcription (biology) ,Gene expression ,Humans ,Allele ,Selection, Genetic ,lcsh:Science ,Gene ,Alleles ,030304 developmental biology ,Genetics ,0303 health sciences ,Multidisciplinary ,Natural selection ,lcsh:R ,Intron ,030104 developmental biology ,Haplotypes ,lcsh:Q ,ATP-Binding Cassette Transporters ,030217 neurology & neurosurgery - Abstract
Natural selection acts on genetic variants by increasing the frequency of alleles responsible for a cellular function that is favorable in a certain environment. In a previous genome-wide scan for positive selection in contemporary humans, we identified a signal of positive selection in European and Asians at the genetic variant rs10180970. The variant is located in the second intron of the ABCA12 gene, which is implicated in the lipid barrier formation and down-regulated by UVB radiation. We studied the signal of selection in the genomic region surrounding rs10180970 in a larger dataset that includes DNA sequences from ancient samples. We also investigated the functional consequences of gene expression of the alleles of rs10180970 and another genetic variant in its proximity in healthy volunteers exposed to similar UV radiation.We confirmed the selection signal and refine its location that extends over 35 kb and includes the first intron, the first two exons and the transcription starting site of ABCA12. We found no obvious effect of rs10180970 alleles on ABCA12 gene expression. We reconstructed the trajectory of the T allele over the last 80,000 years to discover that it was specific to H. sapiens and frequent among non-Africans already 45,000 years ago.
- Published
- 2019
32. A predictive model identifies patients less likely to have adenomas after a colon cancer
- Author
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L. Frazzoni, M. Scagliarini, L. Laterza, C. Trovato, A. Mussetto, M. De Bellis, S. Paggi, C. Spada, L. Petrella, V. Smania, F. Bazzoli, L. Ricciardiello, F. Radaelli, C. Hassan, L. Fuccio, and L. Frazzoni, M. Scagliarini, L. Laterza, C.Trovato, A. Mussetto, M. De Bellis, S. Paggi, C. Spada, L. Petrella, V. Smania, F. Bazzoli, L. Ricciardiello, F. Radaelli, C. Hassan, L. Fuccio
- Subjects
Surveillance ,Predictive model ,Risk Factor ,Colonoscopy ,Colon cancer - Abstract
Background. Patients with prior colorectal cancer (CRC) are at slightly increased risk of metachronous colorectal neoplasms, therefore endoscopic surveillance is indicated. Current recommendations of repeating examinations at 1, 3 and 5 years after surgery, are not tailored according to risk stratification. Our aim was to find predictive factors of colorectal neoplasms to build a predictive model, to spare colonoscopies for lowrisk patients. Methods. Multicenter retrospective study including patients with colon carcinoma surgically resected from 2001 to 2008 (training cohort) and from 2009 to 2013 (validation cohort). A predictive model for neoplasms occurrence at second surveillance colonoscopy was developed and externally validated. Results. 396 and 131 patients were included in training and validation cohort respectively. Patients with >=1 adenoma at the 2nd surveillance colonoscopy were 113/396 (28.5%) and 21/131 (16.5%) in the two groups. In the validation cohort, 3 cancers were found. Four variables were associated with higher risk of metachronous colorectal adenomas at 2nd surveillance colonoscopy on multivariate analysis: age >65 years old, left colectomy, >=1 advanced adenoma at basal colonoscopy and >=1 adenoma at first surveillance colonoscopy (table 1). The predictive model showed fair discrimination, with an area under the ROC curve of 0.69 and 0.64, in training and validation cohort respectively. In validation group, If patients with a low-risk profile (i.e. none of the risk factors) skip the 2nd surveillance colonoscopy, 25/131 (19.1%) exams would be saved while missing 2/ 21 (9.5%) patients with 1 adenoma; no cancer would be missed. Conclusions We provided a risk-stratification tool for adenoma occurrence after colon surgery, which could prove cost-effective to select patients who could skip the second surveillance colonoscopy.
- Published
- 2019
33. A predictive model identifies patients less likely to have adenomas after a colon cancer
- Author
-
Liboria Laterza, Silvia Paggi, Luigi Ricciardiello, Cesare Hassan, N. De Bortoli, Laura Petrella, Franco Bazzoli, Veronica Smania, Lorenzo Fuccio, Cristina Trovato, Michele Scagliarini, Alessandro Mussetto, Cristiano Spada, M. De Bellis, Leonardo Frazzoni, Franco Radaelli, and L. Frazzoni, M. Scagliarini, L. Laterza, C. Trovato, A. Mussetto, M. De Bellis, S. Paggi, C. Spada, L. Petrella, V. Smania, N. De Bortoli, F. Bazzoli, L. Ricciardiello, F. Radaelli, C. Hassan, L. Fuccio
- Subjects
Oncology ,medicine.medical_specialty ,Surveillance ,medicine.diagnostic_test ,business.industry ,Colorectal cancer ,Risk Factor ,Colonoscopy ,medicine.disease ,Colon cancer ,Predictive model ,Internal medicine ,medicine ,business - Abstract
Aims. Patients with prior colorectal cancer (CRC) are at slightly increased risk of metachronous colorectal neoplasms, therefore endoscopic surveillance is indicated. Current recommendations of repeating examinations at 1, 3 and 5 years after surgery, are not tailored according to risk stratification. Our aim was to find predictive factors of colorectal neoplasms to build a predictive model, to spare colonoscopies for low-risk patients. Methods. Multicenter retrospective study including patients with colon carcinoma surgically resected from 2001 to 2008 (training cohort) and from 2009 to 2013 (validation cohort). A predictive model for neoplasms occurrence at second surveillance colonoscopy was developed and externally validated. Results 396 and 131 patients were included in training and validation cohort, respectively. Patients with ≥1 adenoma at 2nd surveillance colonoscopy were 113/396 (28.5%) and 21/131 (16.5%) in the two groups. In validation cohort, 3 cancers were found. Four variables identified the low-risk patient's profile of developing metachronous colorectal adenomas: age ≤65 years old, right colectomy, no advanced adenoma at basal colonoscopy and no adenoma at first surveillance colonoscopy. The predictive model showed fair discrimination, with an area under the ROC curve of 0.69 and 0.64, in training and validation cohort. In validation group, If patients with a low-risk profile skip the 2nd surveillance colonoscopy, 25/131 (19.1%) exams would be saved while missing 2/21 (9.5%) patients with ≥1 adenoma; no advanced adenoma nor cancer would be missed. Conclusions We provided a risk-stratification tool for adenoma occurrence after colon surgery, which could prove cost-effective to select patients who could skip the second surveillance colonoscopy.
- Published
- 2019
34. Le novità in materia di ricerca dei beni da pignorare e le disposizioni sulla espropriazione degli autoveicoli
- Author
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ZIINO, Salvatore, Punzi, C, Ruffini G, Punzi, A, Sandulli, P, Basilico, G, Cordoppatri, F, Gradi, M, Manzo, E, Perin, A, Poli, R, Bongiorno, G, Capri, F, D'Alessio, A, Iannelli, L, Neri, A, Petrella, V, Polinari, J, Recchioni, S, Trinchi, A, Corrado, C, Farina, P, Lovise, C, Odorisio, E, Picozza, E, Porcelli, F, Rizza, C, Ziino, S, and ZIINO, S
- Subjects
Settore IUS/15 - Diritto Processuale Civile ,Espropriazione forzata - effettività della tutela esecutiva - ricerca dei beni del debitore - Abstract
Lo scritto esamina le nuove forme di ricerca dei beni del debitore. La ricerca dei beni, che viene eseguita dall'ufficiale giudiziario, è diretta a garantire la effettività della tutela esecutiva, ma comporta ingenti costi, che potranno ostacolare l'accesso alla tutela esecutiva. Altro argomento trattato riguarda le nuove disposizioni sul pignoramento di autoveicoli.
- Published
- 2015
35. Efficacy and safety of vaginal formulations with tyndallized ferments in subjects with nonspecific vulvovaginitis: A randomized study in Italy.
- Author
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Forleo F, Pelosi FM, Bianco L, and Petrella V
- Subjects
- Female, Humans, Vagina, Italy, Papillomavirus Infections, Vulvovaginitis drug therapy, Vulvar Diseases
- Abstract
Aim: In this study, we tested the efficacy, safety, and tolerability of vaginal ovules and a vaginal douche containing tyndallized ferments in women affected by nonspecific vulvovaginitis, with or without the human papillomavirus (HPV)., Methods: The study included 91 female patients and had a randomized, controlled sequential design, with parallel groups. Ovules and douche were tested and compared to a control group treated with sterile physiological solution. Total symptom score (TSS), individual signs and symptoms, therapeutic success were evaluated, as well as safety and tolerability., Results: The tyndallized ferments formulations (ovules and douche) had a safe and tolerable profile, and resulted in a significant decrease in TSS in patients affected by nonspecific vulvovaginitis, both at 5 and 10 days of treatment, when compared to a control group. The treatment was more effective than the control in reducing symptoms such as vulvar erythema, vulvar edema, itching, and burning. Patients affected by vulvovaginitis and HPV-positive received a 30 days treatment either with ovules or ovules + douche, and we observed an improvement at Day 30 compared to Day 0, for both regimens., Conclusions: Our study suggests that topical treatment with tyndallized ferments is a safe and effective strategy to reduce symptoms of nonspecific vulvovaginitis., (© 2024 Japan Society of Obstetrics and Gynecology.)
- Published
- 2024
- Full Text
- View/download PDF
36. Aedes albopictus bionomics data collection by citizen participation on Procida Island, a promising Mediterranean site for the assessment of innovative and community-based integrated pest management methods.
- Author
-
Caputo B, Langella G, Petrella V, Virgillito C, Manica M, Filipponi F, Varone M, Primo P, Puggioli A, Bellini R, D'Antonio C, Iesu L, Tullo L, Rizzo C, Longobardi A, Sollazzo G, Perrotta MM, Fabozzi M, Palmieri F, Saccone G, Rosà R, Della Torre A, and Salvemini M
- Subjects
- Aedes growth & development, Animal Distribution, Animals, Ecology, Environment, Female, Humans, Islands, Italy, Male, Population Density, Residence Characteristics, Seasons, Aedes physiology, Mosquito Control methods
- Abstract
In the last decades, the colonization of Mediterranean Europe and of other temperate regions by Aedes albopictus created an unprecedented nuisance problem in highly infested areas and new public health threats due to the vector competence of the species. The Sterile Insect Technique (SIT) and the Incompatible Insect Technique (IIT) are insecticide-free mosquito-control methods, relying on mass release of irradiated/manipulated males, able to complement existing and only partially effective control tools. The validation of these approaches in the field requires appropriate experimental settings, possibly isolated to avoid mosquito immigration from other infested areas, and preliminary ecological and entomological data. We carried out a 4-year study in the island of Procida (Gulf of Naples, Italy) in strict collaboration with local administrators and citizens to estimate the temporal dynamics, spatial distribution, and population size of Ae. albopictus and the dispersal and survival of irradiated males. We applied ovitrap monitoring, geo-spatial analyses, mark-release-recapture technique, and a citizen-science approach. Results allow to predict the seasonal (from April to October, with peaks of 928-9,757 males/ha) and spatial distribution of the species, highlighting the capacity of Ae. albopictus population of Procida to colonize and maintain high frequencies in urban as well as in sylvatic inhabited environments. Irradiated males shown limited ability to disperse (mean daily distance travelled <60m) and daily survival estimates ranging between 0.80 and 0.95. Overall, the ecological characteristics of the island, the acquired knowledge on Ae. albopictus spatial and temporal distribution, the high human and Ae. albopictus densities and the positive attitude of the resident population in being active parts in innovative mosquito control projects provide the ground for evidence-based planning of the interventions and for the assessment of their effectiveness. In addition, the results highlight the value of creating synergies between research groups, local administrators, and citizens for affordable monitoring (and, in the future, control) of mosquito populations., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
- Full Text
- View/download PDF
37. ZanzaMapp: A Scalable Citizen Science Tool to Monitor Perception of Mosquito Abundance and Nuisance in Italy and Beyond.
- Author
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Caputo B, Manica M, Filipponi F, Blangiardo M, Cobre P, Delucchi L, De Marco CM, Iesu L, Morano P, Petrella V, Salvemini M, Bianchi C, and Della Torre A
- Subjects
- Animals, Europe, Female, Humans, Italy, Mosquito Control, Smartphone, Spatial Analysis, Aedes, Citizen Science, Mobile Applications, Mosquito Vectors
- Abstract
Mosquitoes represent a considerable nuisance and are actual/potential vectors of human diseases in Europe. Costly and labour-intensive entomological monitoring is needed to correct planning of interventions aimed at reducing nuisance and the risk of pathogen transmission. The widespread availability of mobile phones and of massive Internet connections opens the way to the contribution of citizen in complementing entomological monitoring. ZanzaMapp is the first mobile "mosquito" application for smartphones specifically designed to assess citizens' perception of mosquito abundance and nuisance in Italy. Differently from other applications targeting mosquitoes, ZanzaMapp prioritizes the number of records over their scientific authentication by requesting users to answer four simple questions on perceived mosquito presence/abundance/nuisance and geo-localizing the records. The paper analyses 36,867 ZanzaMapp records sent by 13,669 devices from 2016 to 2018 and discusses the results with reference to either citizens' exploitation and appreciation of the app and to the consistency of the results obtained with the known biology of main mosquito species in Italy. In addition, we provide a first small-scale validation of ZanzaMapp data as predictors of Aedes albopictus biting females and examples of spatial analyses and maps which could be exploited by public institutions and administrations involved in mosquito and mosquito-borne pathogen monitoring and control.
- Published
- 2020
- Full Text
- View/download PDF
38. Maleness-on-the-Y ( MoY ) orchestrates male sex determination in major agricultural fruit fly pests.
- Author
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Meccariello A, Salvemini M, Primo P, Hall B, Koskinioti P, Dalíková M, Gravina A, Gucciardino MA, Forlenza F, Gregoriou ME, Ippolito D, Monti SM, Petrella V, Perrotta MM, Schmeing S, Ruggiero A, Scolari F, Giordano E, Tsoumani KT, Marec F, Windbichler N, Arunkumar KP, Bourtzis K, Mathiopoulos KD, Ragoussis J, Vitagliano L, Tu Z, Papathanos PA, Robinson MD, and Saccone G
- Subjects
- Animals, Conserved Sequence, Embryo, Nonmammalian, Female, Genes, Insect, Male, RNA Interference, Ceratitis capitata genetics, Genes, Y-Linked, Sex Determination Processes, Y Chromosome genetics
- Abstract
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y ( MoY ), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Published
- 2019
- Full Text
- View/download PDF
39. Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).
- Author
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Petrella V, Aceto S, Colonna V, Saccone G, Sanges R, Polanska N, Volf P, Gradoni L, Bongiorno G, and Salvemini M
- Subjects
- Alternative Splicing, Amino Acid Sequence, Animals, Data Mining, Female, Gene Expression Profiling, Gene Expression Regulation, Developmental, Genomics, Insect Proteins chemistry, Insect Proteins genetics, Male, Phylogeny, RNA, Messenger genetics, Selection, Genetic, Evolution, Molecular, Psychodidae genetics, Sex Determination Processes genetics
- Abstract
Background: Phlebotomine sand flies (Diptera, Nematocera) are important vectors of several pathogens, including Leishmania parasites, causing serious diseases of humans and dogs. Despite their importance as disease vectors, most aspects of sand fly biology remain unknown including the molecular basis of their reproduction and sex determination, aspects also relevant for the development of novel vector control strategies., Results: Using comparative genomics/transcriptomics data mining and transcriptional profiling, we identified the sex determining genes in phlebotomine sand flies and proposed the first model for the sex determination cascade of these insects. For all the genes identified, we produced manually curated gene models, developmental gene expression profile and performed evolutionary molecular analysis. We identified and characterized, for the first time in a Nematocera species, the transformer (tra) homolog which exhibits both conserved and novel features. The analysis of the tra locus in sand flies and its expression pattern suggest that this gene is able to autoregulate its own splicing, as observed in the fruit fly Ceratitis capitata and several other insect species., Conclusions: Our results permit to fill the gap about sex determination in sand flies, contribute to a better understanding of this developmental pathway in Nematocera and open the way for the identification of sex determining orthologs in other species of this important Diptera sub-order. Furthermore, the sex determination genes identified in our work also provide the opportunity of future biotechnological applications to control natural population of sand flies, reducing their impact on public health.
- Published
- 2019
- Full Text
- View/download PDF
40. Positive selection in Europeans and East-Asians at the ABCA12 gene.
- Author
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Sirica R, Buonaiuto M, Petrella V, Sticco L, Tramontano D, Antonini D, Missero C, Guardiola O, Andolfi G, Kumar H, Ayub Q, Xue Y, Tyler-Smith C, Salvemini M, D'Angelo G, and Colonna V
- Subjects
- Alleles, Gene Expression genetics, Gene Frequency genetics, Haplotypes genetics, Humans, ATP-Binding Cassette Transporters genetics, Asian People genetics, Polymorphism, Single Nucleotide genetics, Selection, Genetic genetics, White People genetics
- Abstract
Natural selection acts on genetic variants by increasing the frequency of alleles responsible for a cellular function that is favorable in a certain environment. In a previous genome-wide scan for positive selection in contemporary humans, we identified a signal of positive selection in European and Asians at the genetic variant rs10180970. The variant is located in the second intron of the ABCA12 gene, which is implicated in the lipid barrier formation and down-regulated by UVB radiation. We studied the signal of selection in the genomic region surrounding rs10180970 in a larger dataset that includes DNA sequences from ancient samples. We also investigated the functional consequences of gene expression of the alleles of rs10180970 and another genetic variant in its proximity in healthy volunteers exposed to similar UV radiation. We confirmed the selection signal and refine its location that extends over 35 kb and includes the first intron, the first two exons and the transcription starting site of ABCA12. We found no obvious effect of rs10180970 alleles on ABCA12 gene expression. We reconstructed the trajectory of the T allele over the last 80,000 years to discover that it was specific to H. sapiens and present in non-Africans 45,000 years ago.
- Published
- 2019
- Full Text
- View/download PDF
41. De novo assembly and transcriptome analysis of the Mediterranean fruit fly Ceratitis capitata early embryos.
- Author
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Salvemini M, Arunkumar KP, Nagaraju J, Sanges R, Petrella V, Tomar A, Zhang H, Zheng W, and Saccone G
- Subjects
- Animals, Ceratitis capitata physiology, Chromosomes, Insect genetics, Computer Simulation, Databases, Genetic, Female, Genes, Insect genetics, Male, Sequence Analysis, Sex Characteristics, Sex Determination Processes genetics, Y Chromosome genetics, Ceratitis capitata embryology, Ceratitis capitata genetics, Embryo, Nonmammalian metabolism, Gene Expression Profiling
- Abstract
The agricultural pest Ceratitis capitata, also known as the Mediterranean fruit fly or Medfly, belongs to the Tephritidae family, which includes a large number of other damaging pest species. The Medfly has been the first non-drosophilid fly species which has been genetically transformed paving the way for designing genetic-based pest control strategies. Furthermore, it is an experimentally tractable model, in which transient and transgene-mediated RNAi have been successfully used. We applied Illumina sequencing to total RNA preparations of 8-10 hours old embryos of C. capitata, This developmental window corresponds to the blastoderm cellularization stage. In summary, we assembled 42,614 transcripts which cluster in 26,319 unique transcripts of which 11,045 correspond to protein coding genes; we identified several hundreds of long ncRNAs; we found an enrichment of transcripts encoding RNA binding proteins among the highly expressed transcripts, such as CcTRA-2, known to be necessary to establish and, most likely, to maintain female sex of C. capitata. Our study is the first de novo assembly performed for Ceratitis capitata based on Illumina NGS technology during embryogenesis and it adds novel data to the previously published C. capitata EST databases. We expect that it will be useful for a variety of applications such as gene cloning and phylogenetic analyses, as well as to advance genetic research and biotechnological applications in the Medfly and other related Tephritidae.
- Published
- 2014
- Full Text
- View/download PDF
42. Male-specific phosphorylated SR proteins in adult flies of the Mediterranean fruitfly Ceratitis capitata.
- Author
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Saccone G, Louis C, Zhang H, Petrella V, Di Natale M, Perri M, and Salvemini M
- Subjects
- Alternative Splicing, Animals, Ceratitis capitata metabolism, Drosophila melanogaster genetics, Female, Gene Expression Profiling, Insect Proteins metabolism, Male, Phosphoproteins metabolism, Sex Factors, Transcriptome, Ceratitis capitata genetics, Insect Proteins genetics, Phosphoproteins genetics
- Abstract
Alternative splicing is a widely used mechanism of gene regulation in sex determination pathways of Insects. In species from orders as distant as Diptera, Hymenoptera and Coleoptera, female differentiation relies on the activities of conserved splicing regulators, TRA and TRA-2, promoting female-specific expression of the global effector doublesex (dsx). Less understood is to what extent post-translational modifications of splicing regulators plays a role in this pathway. In Drosophila melanogaster phosphorylation of TRA, TRA-2 and the general RBP1 factor by the LAMMER kinase doa (darkener of apricot) is required for proper female sex determination. To explore whether this is a general feature of the pathway we examined sex-specific differences in phosphorylation levels of SR splicing factors in the dipteran species D. melanogaster, Ceratitis capitata (Medfly) and Musca domestica (Housefly). We found a distinct and reproducible pattern of male-specific phosphorylation on protein extracts enriched for SR proteins in C. capitata suggesting that differential phosphorylation may also contribute to the regulation of sex-specific splicing in the Medfly.
- Published
- 2014
- Full Text
- View/download PDF
43. Subtractive and differential hybridization molecular analyses of Ceratitis capitata XX/XY versus XX embryos to search for male-specific early transcribed genes.
- Author
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Salvemini M, D'Amato R, Petrella V, Ippolito D, Ventre G, Zhang Y, and Saccone G
- Subjects
- Animals, Female, Gene Library, Male, Nucleic Acid Hybridization, Sex Factors, Ceratitis capitata genetics, Embryo, Nonmammalian, Gene Expression Regulation, Genes, Insect, Transcription, Genetic
- Abstract
The agricultural pest Ceratitis capitata, also known as the Mediterranean fruit fly or Medfly, is a fruit crop pest of very high economic relevance in different continents. The strategy to separate Ceratitis males from females (sexing) in mass rearing facilities is a useful step before the sterilization and release of male-only flies in Sterile Insect Technique control programs (SIT). The identification of genes having early embryonic male-specific expression, including Y-linked genes, such as the Maleness factor, could help to design novel and improved methods of sexing in combination with transgenesis, aiming to confer conditional female-specific lethality or female-to-male sexual reversal. We used a combination of Suppression Subtractive Hybrydization (SSH), Mirror Orientation Selection (MOS) anddifferential screening hybridization (DSH) techniques to approach the problem of isolating corresponding mRNAs expressed in XX/XY embryos versus XX-only embryos during a narrow developmental window (8-10 hours after egg laying, AEL ). Here we describe a novel strategy we have conceived to obtain relatively large amounts of XX-only embryos staged at 8-10 h AEL and so to extract few micrograms of polyA+ required to apply the complex technical procedure. The combination of these 3 techniques led to the identification of a Y-linked putative gene, CcGm2, sharing high sequence identity to a paralogous gene, CcGm1, localized either on an autosome or on the X chromosome. We propose that CcGm2 is a first interesting putative Y-linked gene which could play a role in sex determination. The function exterted by this gene should be investigated by novel genetic tools, such as CRISPR-CAS9, which will permit to target only the Y-linked paralogue, avoiding to interfere with the autosomal or X-linked paralogue function.
- Published
- 2014
- Full Text
- View/download PDF
44. The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing.
- Author
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Salvemini M, D'Amato R, Petrella V, Aceto S, Nimmo D, Neira M, Alphey L, Polito LC, and Saccone G
- Subjects
- Aedes metabolism, Alternative Splicing, Animals, Drosophila Proteins metabolism, Female, Male, Nerve Tissue Proteins metabolism, RNA Splicing, Transcription Factors metabolism, Aedes genetics, Biological Evolution, Drosophila Proteins genetics, Nerve Tissue Proteins genetics, Sex Determination Processes genetics, Transcription Factors genetics
- Abstract
In Drosophila melanogaster the doublesex (dsx) and fruitless (fru) regulatory genes act at the bottom of the somatic sex determination pathway. Both are regulated via alternative splicing by an upstream female-specific TRA/TRA-2 complex, recognizing a common cis element. dsx controls somatic sexual differentiation of non-neural as well as of neural tissues. fru, on the other hand, expresses male-specific functions only in neural system where it is required to built the neural circuits underlying proper courtship behaviour. In the mosquito Aedes aegypti sex determination is different from Drosophila. The key male determiner M, which is located on one of a pair of homomorphic sex chromosomes, controls sex-specific splicing of the mosquito dsx orthologue. In this study we report the genomic organization and expression of the fru homologue in Ae. aegypti (Aeafru). We found that it is sex-specifically spliced suggesting that it is also under the control of the sex determination pathway. Comparative analyses between the Aeafru and Anopheles gambiae fru (Angfru) genomic loci revealed partial conservation of exon organization and extensive divergence of intron lengths. We find that Aeadsx and Aeafru share novel cis splicing regulatory elements conserved in the alternatively spliced regions. We propose that in Aedes aegypti sex-specific splicing of dsx and fru is most likely under the control of splicing regulatory factors which are different from TRA and TRA-2 found in other dipteran insects and discuss the potential use of fru and dsx for developing new genetic strategies in vector control.
- Published
- 2013
- Full Text
- View/download PDF
45. Left ventricle relative wall thickness and plasma leptin levels: baseline relationships and effects of 4 months of walking training in healthy overweight postmenopausal women.
- Author
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Di Blasio A, Di Donato F, De Stefano A, Gallina S, Granieri M, Napolitano G, Petrella V, Riccardi I, Santarelli F, Valentini P, and Ripari P
- Subjects
- Body Mass Index, Echocardiography, Female, Humans, Middle Aged, Myocardium, Overweight, Postmenopause blood, Postmenopause physiology, Skinfold Thickness, Exercise physiology, Heart Ventricles anatomy & histology, Leptin blood, Walking physiology
- Abstract
Objective: Whether leptin has positive or negative influences on cardiac structure and function in healthy sedentary overweight postmenopausal women is unknown. We investigated the role of leptin in cardiac health and whether aerobic fitness enhancement influences any relationships revealed between leptin and echocardiographic measurements., Methods: Thirty-nine sedentary postmenopausal women were enrolled after an initial screening. The women underwent blood sampling for hormone levels, anthropometric and echocardiographic measurements, dietary habits investigation, and fitness testing, both before and after 4 months of walking training., Results: After the intervention, the women who had an adherence to training of 75% or higher showed significantly reduced percentage fat mass (P = 0.006) and plasma leptin levels (P < 0.001), whereas their maximum oxygen consumption increased significantly (P < 0.001). The women showed a significant reduction in left ventricle relative wall thickness (P = 0.039) and significant increases in both left ventricular end-diastolic diameter (P = 0.040) and left ventricular mass index (P = 0.043). At baseline, a negative correlation was seen between plasma leptin levels and left ventricle relative wall thickness (r = -0.553; P = 0.009). Further negative correlations were seen for the changes in left ventricle relative wall thickness with leptin levels (r = -0.456; P = 0.038) and with tricipital skinfold (r = -0.436; P = 0.05)., Conclusions: In healthy overweight sedentary postmenopausal women with low fitness level, high plasma leptin levels seem to have a protective role against left ventricle relative wall thickness hypertrophy and to participate in its remodeling after 4 months of aerobic training.
- Published
- 2011
- Full Text
- View/download PDF
46. Effects of the time of day of walking on dietary behaviour, body composition and aerobic fitness in post-menopausal women.
- Author
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Di Blasio A, Di Donato F, Mastrodicasa M, Fabrizio N, Di Renzo D, Napolitano G, Petrella V, Gallina S, and Ripari P
- Subjects
- Body Fat Distribution, Energy Intake, Female, Humans, Middle Aged, Overweight epidemiology, Sedentary Behavior, Time Factors, Body Composition physiology, Feeding Behavior physiology, Physical Fitness physiology, Postmenopause physiology, Walking physiology
- Abstract
Aim: Post-menopause is linked to an increased risk of death from cardiovascular disease. Physical exercise and healthy dietary habits are normally suggested to enhance health. The aim of this study was to verify whether the time of day of walking had different effects on both spontaneous dietary intake and body composition modification in overweight and sedentary post-menopausal women., Methods: Forty-two sedentary post-menopausal women (53.46+/-3.32 yrs) were recruited. Thirty-three completed the study: 29 were suitable for statistical analysis. Of those, 14 walked in the morning (MG) and 15 in the early evening (EG). Body composition, dietary habits and predicted VO2max were investigated. Food intake was analysed for energy, macronutrients and daily distribution., Results: The Mann-Whitney test showed that according to the time of day of walking there were different fat mass (FM) reductions and dietary behaviour responses. EG reduced FM greater than MG and showed a major increase in morning energy intake (EI). Sub-samples did not differ in total EI, daily macronutrient portioning and daily meals variations. The variation of FM was correlated with that of proteins (r=-0.352), morning EI (r=-0.367) and aerobic performance (r=0.369). Both MG and EG improved their aerobic performance., Conclusion: The positive effects of walking on health could be optimised by its evening execution because it could also be linked to spontaneous dietary habit modification.
- Published
- 2010
47. Mask continuous positive airway pressure in AIDS.
- Author
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DeVita MA, Friedman Y, and Petrella V
- Subjects
- Critical Care, Humans, Hypoxia etiology, Monitoring, Physiologic, Pneumonia, Pneumocystis etiology, Positive-Pressure Respiration instrumentation, Positive-Pressure Respiration methods, Respiratory Insufficiency etiology, Treatment Outcome, Acquired Immunodeficiency Syndrome complications, Hypoxia therapy, Pneumonia, Pneumocystis therapy, Positive-Pressure Respiration standards, Respiratory Insufficiency therapy
- Abstract
FMCPAP and NCPAP therapy is an effective modality for treating patients with PCP, hypoxia, and respiratory insufficiency. The therapy decreases intrapulmonary shunting and improves oxygenation. It is safe and, in some cases, can be provided outside of an intensive care unit. The major benefit of MCPAP is that it postpones (and sometimes obviates) the need for intubation and mechanical ventilation. This may provide adequate time for a trial of therapy, education, ethical discussions, and completion of personal matters by patients. It is conceivable that failure to respond to MCPAP may provide prognostic information to help guide further therapy. Further outcome studies are needed to clarify this issue. Adding MCPAP to mechanical ventilation and conventional mask oxygen therapy increases the options that practitioners can use to provide the best titrated care for their patients.
- Published
- 1993
48. [Bamifylline in the therapy of asthmatic syndromes. Efficacy and side effects vs delayed-action theophylline anhydride].
- Author
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Alciato P, Cantone PA, Fico D, Gagliardini R, and Petrella V
- Subjects
- Administration, Oral, Adult, Aged, Aged, 80 and over, Bronchodilator Agents administration & dosage, Bronchodilator Agents adverse effects, Delayed-Action Preparations, Female, Humans, Lung Diseases, Obstructive drug therapy, Male, Middle Aged, Syndrome, Theophylline administration & dosage, Theophylline adverse effects, Asthma drug therapy, Bronchodilator Agents therapeutic use, Theophylline analogs & derivatives, Theophylline therapeutic use
- Abstract
Two homogeneous groups of 8 patients suffering from bronchial asthma or chronic obstructive bronchial pneumonia were treated with slow release theophylline anhydride or bamiphylline respectively, both products being given orally twice a day. The results showed that both drugs possess a powerful bronchodilatory action and therefore have a beneficial effect on subjective symptoms. Statistical analysis confirmed the absence of any significant difference between the two xanthine derivatives, both of which were well-tolerated though bamiphylline offered a slight advantage in this respect. In fact there were no side effects at all in the bamiphylline group whereas there was one case of moderate gastric intolerance in the group given theophylline anhydride, though it was not severe enough to warrant suspension of the treatment or reduction of the dose.
- Published
- 1990
49. Role of the liver in regulation of ketone body production during sepsis.
- Author
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Wannemacher RW Jr, Pace JG, Beall RA, Dinterman RE, Petrella VJ, and Neufeld HA
- Subjects
- Acyl Coenzyme A metabolism, Adipose Tissue metabolism, Animals, Fasting, Fatty Acids, Nonesterified blood, Francisella tularensis, Lipid Mobilization, Male, Rats, Serum Albumin metabolism, Ketone Bodies metabolism, Liver metabolism, Pneumococcal Infections metabolism, Sepsis metabolism, Tularemia metabolism
- Abstract
During caloric deprivation, the septic host may fail to develop ketonemia as an adaptation to starvation. Because the plasma ketone body concentration is a function of the ratio of hepatic production and peripheral usage, a pneumococcal sepsis model was used in rats to measure the complex metabolic events that could account for this failure, including the effects of infection on lipolysis and esterification in adipose tissue, fatty acid transport in plasma and the rates of hepatic ketogenesis and whole body oxidation of ketones. Some of the studies were repeated with tularemia as the model infection. From these studies, it was concluded that during pneumococcal sepsis, the failure of rats to become ketonemic during caloric deprivation was the result of reduced ketogenic capacity of the liver and a possibly decreased hepatic supply of fatty acids. The latter appeared to be a secondary consequence of a severe reduction in circulating plasma albumin, the major transport protein for fatty acids, with no effect on the degree of saturation of the albumin with free fatty acids. Also, the infection had no significant effect on the rate of lipolysis or release of fatty acids from adipose tissue. Ketone body usage (oxidation) was either unaffected or reduced during pneumococcal sepsis in rats. Thus, a reduced rate of ketone production in the infected host was primarily responsible for the failure to develop starvation ketonemia under these conditions. The liver of the infected rat host appears to shuttle the fatty acids away from beta-oxidation and ketogenesis and toward triglyceride production, with resulting hepatocellular fatty metamorphosis.
- Published
- 1979
- Full Text
- View/download PDF
50. [Behavior of blood composition in chronic liver diseases].
- Author
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Petrella V, Massara G, Buschini M, and Silvera F
- Subjects
- Anemia blood, Chronic Disease, Erythrocyte Count, Erythrocytes, Abnormal analysis, Hemorrhage complications, Hepatitis blood, Hepatitis pathology, Humans, Liver pathology, Liver Cirrhosis blood, Liver Cirrhosis pathology, Liver Diseases pathology, Anemia etiology, Liver Diseases blood
- Abstract
On the basis of data from hospitalised patients with chronic liver pathology, the relationship between the type and severity of the disease and the nature and extent of changes in blood composition was studied. It is concluded that a direct relationship exists between liver pathology and haemopathy which can be attributed to various aetiopathogenetic factors. The severity of the liver pathology is the main factor, independently of its aetiology.
- Published
- 1985
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