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Production companies are facing increasing production complexity and demographic change. Therefore, with its decreasing physiological and mental performance prerequisites, the aging workforce is often confronted with overload at the workplace leading to fatigue and work errors in the short term and increasing sick days in the long term. Integrating physiological and mental aspects into existing employee scheduling is one way to maintain employees' health and performance. Incorporating these aspects is often very complex due to the need for multiple disciplines and the lack of supporting methods and tools. Therefore, this paper provides a practical-oriented overview for including physiological and mental aspects in existing employee scheduling. The intercorrelation between workload, individual performance prerequisites and strain, their measurement methods, and standardised alternatives are explained to support industrial practitioners in production management, like planners. A four-step method for integrating physiological and mental aspects in employee scheduling is presented. With the help of this method, the interaction between the ergonomics/human factors departments and production management can be improved, resulting in a more human-oriented employee scheduling. A practical example from manual assembly illustrates the application of the presented approach. [ABSTRACT FROM AUTHOR]

Three classes of direct-acting antivirals targeting the influenza virus matrix protein 2 (M2) ion channel, neuraminidase (NA), or polymerase cap-dependent endonuclease (CEN) are approved to treat influenza in many countries [...]

The recent discovery that dairy cattle can be infected by highly pathogenic avian influenza (HPAI) virus of the H5N1 subtype (2,2), in combination with the virus's propensity to replicate in [...]

BACKGROUND: Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes within the intestinal epithelial cells and impacts on lineage differentiation are largely unknown. OBJECTIVES: Herein, we sought to determine the molecular and cellular changes that occur in the colon in response to uranium bearing dust (UBD) exposure. METHODS: Human colonoids from three biologically distinct donors were acutely exposed to UBD then digested for single cell RNA sequencing to define the molecular changes that occur to specific identities of colonic epithelial cells. Validation in colonoids was assessed using morphological and imaging techniques. RESULTS: Human colonoids acutely exposed to UBD exhibited disrupted proliferation and hyperplastic differentiation of the secretory lineage cell, enteroendocrine cells (EEC). Single-cell RNA sequencing also showed more EEC subtypes present in UBD-exposed colonoids. DISCUSSION: These findings highlight the significance of crypt-based proliferative cells and secretory cell differentiation using human colonoids to model major colonic responses to uranium-bearing particulate dust exposure. https://doi.org/10.1289/EHP13855, Introduction Uranium mining in the United States arose in the 1940s, peaked in the 1970s, and subsided in the late 1980s, with extensive activity concentrated in Navajo, Puebloan, and other [...]