1. Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality
- Author
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David Macias-Verde, Javier Burgos-Burgos, and Pedro C. Lara
- Subjects
0301 basic medicine ,ARDS ,CO, Carbon monoxide ,Inflammasomes ,Air Microbiology ,Na+,K+-ATPase, Sodium-potassium adenosine triphosphatase ,MERS, Middle east respiratory syndrome ,DAMP, Damage-associated molecular pattern ,DNA, Deoxyribonucleic acid ,0302 clinical medicine ,Sv, Sievert ,TSNA, Tobacco-specific nitrosamines ,Air Pollution, Radioactive ,PAMP, Pathogen-associated molecular pattern ,SO2, Sulfur dioxide ,µSv, microSievert ,media_common ,education.field_of_study ,IFN-γ, Interferon-gamma ,TNF-α, Tumor necrosis factor-alpha ,Inflammasome ,General Medicine ,GSDMD, Gasdermin D ,Pollution ,CO2, Carbon dioxide ,TGF-β, Transforming growth factor beta ,Causality ,Radioactivity ,medicine.symptom ,K+, Potassium ion ,Alzheimer’s disease ,medicine.drug ,NO2, Nitrogen dioxide ,media_common.quotation_subject ,Climate Change ,Indoor bioaerosol ,Population ,Inflammation ,AD, Alzheimer’s disease ,Models, Biological ,COVID-19, Coronavirus disease-2019 ,Article ,WHO, World Health Organization ,mSv, miliSievert ,03 medical and health sciences ,USEPA, United States Environmental Protection Agency ,ACE-2, Angiotensin-converting enzyme-2 ,Environmental health ,NLR Family, Pyrin Domain-Containing 3 Protein ,ARDS, Acute respiratory distress syndrome ,medicine ,Humans ,PM10, Particulate matter with diameter <10 µm ,SARS-COV-2, Severe acute respiratory syndrome coronavirus-2 ,Particle Size ,education ,Pandemics ,Neuroinflammation ,Aerosols ,THP-1, Tamm-Horsfall Protein-1 ,TLR, Toll like receptor ,business.industry ,SARS-CoV-2 ,Ca2+, Calcium ion ,COVID-19 ,NF-κB, Nuclear factor-kappa B ,Pneumonia ,medicine.disease ,HSPCs, Hematopoietic stem/progenitor cells ,NLRP3 inflammasome ,oAβ, Oligomeric amyloid beta ,030104 developmental biology ,NLRP3, Nucleotide binding domain and repeated inflammation of leucine-rich protein 3 ,PM2.5, Particulate matter with diameter < 2.5 µm ,mBq, miliBecquerel ,ORF, Open reading frame ,Particulate Matter ,Nervous System Diseases ,business ,030217 neurology & neurosurgery ,AT1, angiotensin II receptor type 1 ,ROS, Reactive oxygen species - Abstract
We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.
- Published
- 2020