7 results on '"PTSD RISK"'
Search Results
2. Faktor Determinan Sosial Risiko Post Traumatic Stress Disorder (PTSD) Pasca Kejadian Bencana Tsunami Selat Sunda
- Author
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Helia Rachma and Thresya Febrianti
- Subjects
family support ,mental illness ,ptsd risk ,tsuami disaster ,volunteer support. ,Medicine ,Medicine (General) ,R5-920 - Abstract
The Tsunami of the Sunda Strait in December 2018 resulted in many losses, fatalities, and infrastructure. The psychological impact that often occurs during a catastrophic event is Post Traumatic Stress Disorder (PTSD) and if a teenager experiences it will have an impact on life in the future. The purpose of this study was to analyse the social determinants associated with PTSD in post-Tsunami Banten. This research is a quantitative study with a cross-sectional study design with a sample size of 125. The sampling technique uses Proportional to Size (PPS) and Simple Random Sampling. Data analysis using Fisher's Exact test. Factors related to the risk of Post Traumatic Stress Disorder (PTSD) are family support (p-value 0,0420,05) and peer support (p-value 0,0210,05) significantly related to the risk of Post Traumatic Stress Disorder in adolescents in SMPN 2 Labuan. However, volunteer support and support of religious leaders do not have a significant relationship with the risk of Post Traumatic Stress Disorder (PTSD). Support of family and friends are risk factors PTSD in adolescents at SMPN 2 Labuan after the Sunda Strait tsunami disaster in December 2018. There needs to be socialization related to post-disaster mental health management to parents and peers.
- Published
- 2021
- Full Text
- View/download PDF
3. Neurobiological Risk Factors and Predictors of Vulnerability and Resilience to PTSD
- Author
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Bar-Shai, Marina, Klein, Ehud, Safir, Marilyn P., editor, Wallach, Helene S., editor, and Rizzo, Albert 'Skip", editor
- Published
- 2015
- Full Text
- View/download PDF
4. Vulnerability to PTSD: Psychosocial and Demographic Risk and Resilience Factors
- Author
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Bar-Shai, Marina, Klein, Ehud, Safir, Marilyn P., editor, Wallach, Helene S., editor, and Rizzo, Albert 'Skip", editor
- Published
- 2015
- Full Text
- View/download PDF
5. Does trauma event type matter in the assessment of traumatic load?
- Author
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Daniela Conrad, Sarah Wilker, Anett Pfeiffer, Birke Lingenfelder, Tracie Ebalu, Hartmut Lanzinger, Thomas Elbert, Iris-Tatjana Kolassa, and Stephan Kolassa
- Subjects
posttraumatic stress disorder ,traumatic events ,random forest conditional interference ,least absolute shrinkage and selection operator ,ptsd risk ,ranking ,prediction ,Psychiatry ,RC435-571 - Abstract
Background: The likelihood of developing Posttraumatic Stress Disorder (PTSD) depends on the interaction of individual risk factors and cumulative traumatic experiences. Hence, the identification of individual susceptibility factors warrants precise quantification of trauma exposure. Previous research indicated that some traumatic events may have more severe influences on mental health than others; thus, the assessment of traumatic load may be improved by weighting event list items rather than calculating the simple sum score. Objective: We compared two statistical methods, Random Forests using Conditional Interference (RF-CI) and Least Absolute Shrinkage and Selection Operator (LASSO), based on their ability to rank traumatic experiences according to their importance for predicting lifetime PTSD. Methods: Statistical models were initially fitted in a sample of N1 = 441 survivors of the Northern Ugandan rebel war. The ability to correctly predict lifetime PTSD was then tested in an independent sample of N2 = 211, and subsequently compared with predictions by the simple sum score of different traumatic event types experienced. Results: Results indicate that RF-CI and LASSO allow for a ranking of traumatic events according to their predictive importance for lifetime PTSD. Moreover, RF-CI showed slightly better prediction accuracy than the simple sum score, followed by LASSO when comparing prediction results in the validation sample. Conclusion: Given the expense in time and calculation effort by RF-CI and LASSO, and the relatively low increase in prediction accuracy by RF-CI, we recommend using the simple sum score to measure the environmental factor traumatic load, e.g., in analyses of gene × environment interactions.
- Published
- 2017
- Full Text
- View/download PDF
6. Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity
- Author
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Dewleen G. Baker, Uzair Haji, Imanuel Lerman, Clara Snijders, Agorastos Agorastos, Thomas D. Geracioti, George P. Chrousos, Tobias Moeller-Bertram, Piyush M. Patel, Donald A. Barkauskas, Richard L. Hauger, Promovendi MHN, and RS: MHeNs - R3 - Neuroscience
- Subjects
Male ,Endocrinology, Diabetes and Metabolism ,medicine.disease_cause ,Systemic inflammation ,Stress Disorders, Post-Traumatic ,Plasma ,0302 clinical medicine ,Endocrinology ,Cerebrospinal fluid ,Circadian system ,Chronic stress ,Blood-brain-barrier ,DNA METHYLATION ,Veterans ,GENE-EXPRESSION ,Combat Disorders ,Cerebrospinal fluid (CSF) ,biology ,Posttraumatic stress disorder (PTSD) ,C-REACTIVE PROTEIN ,Circadian Rhythm ,Psychiatry and Mental health ,medicine.anatomical_structure ,Military Personnel ,Cytokines ,medicine.symptom ,Adult ,medicine.medical_specialty ,PTSD RISK ,Neuroimmunomodulation ,IMMUNE ,Blood–brain barrier ,Stress ,Trauma ,03 medical and health sciences ,Young Adult ,Combat stress reaction ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,Interleukin 6 ,PRO-INFLAMMATORY CYTOKINES ,Biological Psychiatry ,Endocrine and Autonomic Systems ,business.industry ,Interleukin-6 ,CENTRAL-NERVOUS-SYSTEM ,MAJOR DEPRESSION ,Immune dysregulation ,030227 psychiatry ,DEPLOYED MARINES ,Immune system ,Case-Control Studies ,Interleukin-6 (IL-6) ,Serial sampling ,biology.protein ,PITUITARY-ADRENAL AXIS ,business ,030217 neurology & neurosurgery - Abstract
Background: Acute and chronic stress can lead to a dysregulation of the immune response. Growing evidence suggests peripheral immune dysregulation and low-grade systemic inflammation in posttraumatic stress disorder (PTSD), with numerous reports of elevated plasma interleukin-6 (IL-6) levels. However, only a few studies have assessed IL-6 levels in the cerebrospinal fluid (CSF). Most of those have used single time-point measurements, and thus cannot take circadian level variability and CSF-plasma IL-6 correlations into account.Methods: This study used time-matched, sequential 24-h plasma and CSF measurements to investigate the effects of combat stress and PTSD on physiologic levels and biorhythmicity of IL-6 in 35 male study volunteers, divided in 3 groups: (PTSD = 12, combat controls, CC = 12, and non-deployed healthy controls, HC = 11).Results: Our findings show no differences in diurnal mean concentrations of plasma and CSF IL-6 across the three comparison groups. However, a significantly blunted circadian rhythm of plasma IL-6 across 24 h was observed in all combat-zone deployed participants, with or without PTSD, in comparison to HC. CSF IL-6 rhythmicity was unaffected by combat deployment or PTSD.Conclusions: Although no significant group differences in mean IL-6 concentration in either CSF or plasma over a 24-h timeframe was observed, we provide first evidence for a disrupted peripheral IL-6 circadian rhythm as a sequel of combat deployment, with this disruption occurring in both PTSD and CC groups. The plasma IL-6 circadian blunting remains to be replicated and its cause elucidated in future research.
- Published
- 2019
7. Does trauma event type matter in the assessment of traumatic load?
- Author
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Conrad, Daniela, Wilker, Sarah, Pfeiffer, Anett, Lingenfelder, Birke, Ebalu, Tracie, Lanzinger, Hartmut, Elbert, Thomas, Kolassa, Iris-Tatjana, and Kolassa, Stephan
- Subjects
POST-traumatic stress disorder ,OVERUSE injuries ,DISEASE susceptibility ,RANDOM forest algorithms ,MENTAL health - Abstract
Background: The likelihood of developing Posttraumatic Stress Disorder (PTSD) depends on the interaction of individual risk factors and cumulative traumatic experiences. Hence, the identification of individual susceptibility factors warrants precise quantification of trauma exposure. Previous research indicated that some traumatic events may have more severe influences on mental health than others; thus, the assessment of traumatic load may be improved by weighting event list items rather than calculating the simple sum score. Objective: We compared two statistical methods, Random Forests using Conditional Interference (RF-CI) and Least Absolute Shrinkage and Selection Operator (LASSO), based on their ability to rank traumatic experiences according to their importance for predicting lifetime PTSD. Methods: Statistical models were initially fitted in a sample ofN1 = 441 survivors of the Northern Ugandan rebel war. The ability to correctly predict lifetime PTSD was then tested in an independent sample ofN2 = 211, and subsequently compared with predictions by the simple sum score of different traumatic event types experienced. Results: Results indicate that RF-CI and LASSO allow for a ranking of traumatic events according to their predictive importance for lifetime PTSD. Moreover, RF-CI showed slightly better prediction accuracy than the simple sum score, followed by LASSO when comparing prediction results in the validation sample. Conclusion: Given the expense in time and calculation effort by RF-CI and LASSO, and the relatively low increase in prediction accuracy by RF-CI, we recommend using the simple sum score to measure the environmental factor traumatic load, e.g., in analyses of gene × environment interactions. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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