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6 results on '"Pašková, Andrea"'

1. Neuroactive Pregnanolone Isomers during Pregnancy

Author

Pařízek, Antonín, Hill, Martin, Kancheva, Radmila, Havlíková, Helena, Kancheva, Lyudmila, Cindr, Josef, Pašková, Andrea, Pouzar, Vladimír, Černý, Ivan, Drbohlav, Pavel, Hájek, Zdenĕk, and Stárka, Luboslav

Published
2005

2. The role of neuroactive steroids in pregnancy and their importance in prenatal diagnosticsSteroidogenesis in the third trimester of pregnancy and mechanisms leading to the start of labor

Author

Pašková, Andrea, Pařízek, Antonín, Procházka, Martin, and Tošner, Jindřich

Subjects
enzymy steroidogeneze, umbilical blood, steroids, porod, steroidy, labor, GC-MS, pupečníková krev, enzymes of steroidogenesis
Abstract

Steroid hormones act through two mechanisms. The first is the classical genomic level, which acts at a relatively slow pace from hours to days. The second non-genomic mechanism of steroid activity can influence cellular function during seconds or even milliseconds. During pregnancy both mechanisms take place. Steroid hormones that act non-genomically and influence neuronal excitability are called neuroactive steroids. The aim of this study was to measure the levels of steroid hormones and examine their relationship to the physiology and pathophysiology of pregnancy. The physiological importance of increased placental progesterone production, lowered production of 5B-pregnanone steroids and increased activity of steroid sulfotransferase with gestational age have been intensely discussed. On the basis of our results, we have proposed an alternative mechanism of maternal progesterone synthesis during pregnancy (progesterone, or the gestagen stabilizing activity of the myometrium = continuation of pregnancy). In contrast to previous results our observations indicate that gestagens arise from precursors in the fetus (from pregnenolone sulfate). This mechanism is closely connected with the distribution of placental oxido-reductase. Data from this study show an increasing trend in the conversion of...

Published
2013

3. Steroid profiling in pregnancy: A focus on the human fetus

Author

Hill, Martin, primary, Pašková, Andrea, additional, Kančeva, Radmila, additional, Velíková, Marta, additional, Kubátová, Jana, additional, Kancheva, Lyudmila, additional, Adamcová, Karolína, additional, Mikešová, Michaela, additional, Žižka, Zdeněk, additional, Koucký, Michal, additional, Šarapatková, Hana, additional, Kačer, Viktor, additional, Matucha, Petr, additional, Meloun, Milan, additional, and Pařízek, Antonín, additional

Published
2014
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4. The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment

Author

Hill, Martin, primary, Pařízek, Antonín, additional, Velíková, Marta, additional, Kubátová, Jana, additional, Kancheva, Radmila, additional, Dušková, Michaela, additional, Šimůnková, Kateřina, additional, Klímková, Michaela, additional, Pašková, Andrea, additional, Žižka, Zdeněk, additional, Jirásek, Jan Evangelista, additional, Jirkovská, Marie, additional, and Stárka, Luboslav, additional

Published
2010
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5. Steroid metabolome in fetal and maternal body fluids in human late pregnancy

Author

Hill, Martin, primary, Pařízek, Antonín, additional, Cibula, David, additional, Kancheva, Radmila, additional, Jirásek, Jan Evangelista, additional, Jirkovská, Marie, additional, Velíková, Marta, additional, Kubátová, Jana, additional, Klímková, Michaela, additional, Pašková, Andrea, additional, Žižka, Zdeněk, additional, Kancheva, Lyudmila, additional, Kazihnitková, Hana, additional, Zamrazilová, Ludmila, additional, and Stárka, Luboslav, additional

Published
2010
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6. Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor

Author

Hill, Martin, primary, Pařízek, Antonín, additional, Kancheva, Radmila, additional, Dušková, Michaela, additional, Velíková, Marta, additional, Kříž, Lubomír, additional, Klímková, Michaela, additional, Pašková, Andrea, additional, Žižka, Zdeněk, additional, Matucha, Petr, additional, Meloun, Milan, additional, and Stárka, Luboslav, additional

Published
2010
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