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Non-Relational Database Management Systems (NoSQL) arise as an alternative solution to problems not efficiently solved by traditional Database Management Systems (DBMS). NoSQL, unlike the relational model, does not respond to a Data Base type, but represents a set of Database types, with different implementations and characteristics to represent the information. This work represents the continuation of previous studies and aims to compare and analyse 4 local NoSQL Database engines, 2 NoSQL Database as a Service engines in the cloud and a Relational Database engine, using different schemas and under large data volume.

Domotics integrates a set of systems for home or office automation in order to improve comfort, security, energy savings, communication facilities and entertainment possibilities for the user. In turn, Domotics is closely related to the most recent concept of the Internet of Things, which proposes the interconnection of everyday objects in a home or office through the Internet. In this work, a 3D mobile application called 3D-Domotic is presented. This application allows to recreating the three-dimensional structure of a house and remotely control the electronic devices in it. These devices are located in their actual physical location, and are controlled directly on the model of the house, in a simple and completely visual way. Device status is monitored in real time, simplifying the control of the house.

The continuous growth of the computing power of mobile devices and their relative low cost are some of the reasons for their great expansion. Currently, for example, in Argentina 9 out of 10 people own a smartphone. This trend, locally and globally, has been accompanied by the evolution of the software industry for these devices with the leadership of two operating systems: Android and iOS. This segmentation has generated the need to have mobile applications for both platforms and consequently different development approaches have emerged in response to this need.

The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus replicates and activates human macrophages, the pathogenic Lassa virus replicates but fails to activate human macrophages. Less is known in regard to the impact of New World arenavirus infection on the human macrophage immune response. Macrophage activation is critical for controlling infections but could also be usurped favoring immune evasion. Therefore, it is crucial to understand how the JUNV infection modulates macrophage plasticity to clarify its role in AHF pathogenesis. With this aim in mind, we compared infection with the attenuated Candid 1 (C#1) or the pathogenic P strains of the JUNV virus in human macrophage cultures. The results showed that both JUNV strains similarly replicated and induced morphological changes as early as 1 day post-infection. However, both strains differentially induced the expression of CD71, the receptor for cell entry, the activation and maturation molecules CD80, CD86, and HLA-DR and selectively modulated cytokine production. Higher levels of TNF-α, IL-10, and IL-12 were detected with C#1 strain, while the P strain induced only higher levels of IL-6. We also found that C#1 strain infection skewed macrophage polarization to M1, whereas the P strain shifted the response to an M2 phenotype. Interestingly, the MERTK receptor, that negatively regulates the immune response, was down-regulated by C#1 strain and up-regulated by P strain infection. Similarly, the target genes of MERTK activation, the cytokine suppressors SOCS1 and SOCS3, were also increased after P strain infection, in addition to IRF-1, that regulates type I IFN levels, which were higher with C#1 compared with P strain infection. Together, this differential activation/polarization pattern of macrophages elicited by P strain suggests a more evasive immune response and may have important implications in the pathogenesis of AHF and underpinning the development of new potential therapeutic strategies, Facultad de Ciencias Exactas, Instituto de Biotecnologia y Biologia Molecular, Centro de Investigación y Desarrollo en Fermentaciones Industriales

Es difícil plasmar en pocas páginas todos los detalles y consideraciones que permitieron elaborar esta tesis. Trataré de reflexionar en lo más relevante. En primer lugar, destacar la creciente importancia de la Ingeniería de Requerimientos en la construcción de Software. Años atrás, tanto la literatura como la industria del Software, sólo consideraban la Ingeniería de Software como un todo omitiendo la Ingeniería de Requerimientos como disciplina. Uno de los propósitos más importantes de la Ingeniería de Requerimientos es obtener una Especificación de Requerimientos que establezca claramente “qué” se quiere resolver, minimizando los errores de interpretación acerca del dominio del problema. Gran parte de esto está relacionado con la Elicitación, etapa inicial en todo proceso de Requerimientos. Diferentes técnicas son aplicables para obtener la Especificación de Requerimientos de Software. La técnica de Metas u Objetivos es una de la más aceptada dentro de la comunidad de Ingeniería de Requerimientos y posee una larga tradición en el campo de los Sistemas de Información [Davis87] [Kendall91]. El propósito inicial fue analizar los enfoques orientados a objetivos más importantes y establecer un denominador común (en este caso, una carencia), constituyendo así un elemento esencial sobre el cual se pudo elaborar este trabajo. Posteriormente, se eligió un enfoque sobre el cual suplir esta carencia. Se seleccionó GBRAM, ya que es un enfoque ampliamente reconocido, referente en el tema de objetivos y con bibliografía ampliamente disponible. Pero lo más sugestivo fue que el esquema de los objetivos obtenidos con GBRAM conducían, en algún sentido, a pensar en Escenarios. Esta intuición despertó un interés especial y fue quizás una de las mayores motivaciones. A partir del hallazgo de esta “similitud”, se analizaron diversos escenarios (particularmente todos los escenarios de [Bertolami01] y [Leite96]) y desde ellos se planteó la generación de objetivos con el esquema GBRAM. Con esa meta, se plantearon un conjunto de reglas de identificación de las componentes de los Objetivos basadas en las componentes de los Escenarios. Esas reglas se clasificaron en término de las componentes de Escenarios y salvo excepciones, resultan sencillas de operar. Además, poseen la ventaja de ser explicitadas en términos suficientemente rigurosos para la Ingeniería de Requerimientos, a pesar de no ser formales. Se aplicaron a todos los escenarios que previamente se habían analizado y en todos los casos el resultado fue satisfactorio. Por último, se definió un mecanismo de aplicación de reglas, eliminando cualquier duda respecto a cómo y cuándo aplicar cada una de ellas. Este mecanismo es un algoritmo en pseudocódigo, simple, pero necesario para la aplicación de reglas. Los resultados obtenidos confirman fuertemente una analogía semántica entre la información contenida en los Escenarios y la información necesaria para representar Objetivos. Es probable que pueda juzgarse que la intuición de similitud semántica entre el enfoque de Escenarios y Objetivos no sea nueva, pero no se han hallado trabajos que muestren o comprueben fehacientemente dicha analogía, y es precisamente en esta tesis donde se intenta dar un sustento razonable a esa similitud. En resumen, el presente trabajo refleja la posibilidad de identificar Objetivos a partir de Escenarios, estableciendo una metodología de Elicitación de Objetivos a partir de Escenarios. Por lo tanto, la contribución realizada es la definición de un Proceso de Elicitación de Objetivos., Es revisado por: http://sedici.unlp.edu.ar/handle/10915/9615, Facultad de Informática

The purpose of software development is meeting both functional and non-functional requirements. In mobile device applications, non-functional requirements are more relevant due to the restrictions inherent to these devices. One of these restrictions is the availability of limited storage space. Therefore, the size of a mobile application affects user preference for use. In this article, we assess how the choice of a mobile application development approach affects the final size of the application; we focus our analysis on text-, audio- and video-based applications and access to the camera in the device.

The development frameworks and the power efficiency in mobile devices have been studied separately. This paper deals with both topics together to determine how the selection of a development framework can impact on energy consumption of a mobile application. The focus is on applications with high processing load, audio and video playback. The results were analyzed and conclusions were reached.

A digest can be defined as a regulations repository which is manipulated by organizations for extended time periods. The search for information in this repositories can be tedious without assistance from an ad-hoc software application. This work presents the development of a Digest Software System with its architecture and integration with other base tools. Finally, two study cases are presented where the developed product is used.

Currently there are several frameworks for the development of 3D mobile applications, but all of them have a common issue: performance is a critical aspect to consider, even more relevant than in desktop computers, which generally have a greater computing power. The profiling or performance analysis tools that these frameworks have can help, to some extent, to determine the possible existence of bottlenecks in the execution of applications. However, this type of tool has certain limitations such as covering only a spectrum of the possible causes of the problem or limiting the analysis to certain scenarios in particular. This article proposes an evaluation and impact measurement of the key features related with performance on 3D mobile applications.

The purpose of software development is meeting both functional and non-functional requirements. In mobile device applications, non-functional requirements are more relevant due to the restrictions inherent to these devices. The performance of a mobile application affects user preference for use. In this article, we present a performance study of the approaches used to develop software for mobile devices for the two currently more commonly used operating systems: iOS and Android. The results obtained are analyzed, and conclusions supported by the tests carried out are drawn.

Mobile devices have changed how we conceive software. There is a great range of development alternatives. In this paper, four different multi-platform development approaches (mobile web applications, hybrid, interpreted, and cross-compiled) are analyzed, and their most significant features through a case study are discussed.

The need for sharing information among mobile devices exists in many applications, and almost every data exchange between these devices involve the same requirements: a means for discovering other mobile devices in a wireless network, establishing logical connections, communicating application data, and gathering information related to the physical connection. This paper presents a multiplatform open-source developer-oriented framework that acts as a support layer for host discovery, data communication among devices, and quality of service monitoring. Its purpose is to simplify the issues related to networking for mobile application developers. Currently, the framework is implemented for different platforms, such as Android, J2SE, and J2ME.

Context-Aware Software Systems adapt their response to the execution context. Therefore, context information processing is fundamental, since it determines the behavior of the application. Thus, a mechanism for the collection, representation and validation of context information should be provided. In this paper, an extension of Loucopoulos' requirements engineering process incorporating context information processing is presented. Two real-world study cases from the home and building automation fields of application are presented.