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3. Diagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations

Author

Shumilov, Evgenii, Mazzeo, Paolo, Ghandili, Susanne, Künstner, Axel, Weidemann, Sören, Banz, Yara, Ströbel, Philipp, Pollak, Matthias, Kolloch, Lina, Beltraminelli, Helmut, Kerkhoff, Andrea, Mikesch, Jan-Henrik, Schliemann, Christoph, Haase, Detlef, Wulf, Gerald, Legros, Myriam, Lenz, Georg, Feldmeyer, Laurence, Pabst, Thomas, Witte, Hanno, Gebauer, Niklas, and Bacher, Ulrike

Published
2024
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5. In the era of Bortezomib-based Induction, intensification of Melphalan-based conditioning with Bortezomib does not improve Survival Outcomes in newly diagnosed Multiple Myeloma: a study from the Chronic Malignancies Working Party of the EBMT

Author

Beksac, Meral, Eikema, Diderik-Jan, Koster, Linda, Hulin, Cyrille, Poiré, Xavier, Hamladji, Rose-Marie, Gromek, Tomasz, Bazarbachi, Ali, Ozkurt, Zubeyde Nur, Pabst, Thomas, Ben Othman, Tarek, Finke, Jürgen, Pirogova, Olga, Wu, Depei, Hayat, Amjad, Hilgendorf, Inken, Tholouli, Eleni, de Wreede, Liesbeth C., Schönland, Stefan, Garderet, Laurent, Drozd-Sokolowska, Joanna, Raj, Kavita, Hayden, Patrick J., Yakoub-Agha, Ibrahim, and McLornan, Donal P.

Published
2024
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7. Follow-up of the GHSG HD16 trial of PET-guided treatment in early-stage favorable Hodgkin lymphoma

Author

Fuchs, Michael, Jacob, Anne Sophie, Kaul, Helen, Kobe, Carsten, Kuhnert, Georg, Pabst, Thomas, Greil, Richard, Bröckelmann, Paul J., Topp, Max S., Just, Marianne, Hertenstein, Bernd, Soekler, Martin, Vogelhuber, Martin, Zijlstra, Josée M., Keller, Ulrich Bernd, Krause, Stefan W., Dührsen, Ulrich, Meissner, Julia, Viardot, Andreas, Eich, Hans-Theodor, Baues, Christian, Diehl, Volker, Rosenwald, Andreas, Buehnen, Ina, von Tresckow, Bastian, Dietlein, Markus, Borchmann, Peter, Engert, Andreas, and Eichenauer, Dennis A.

Published
2024
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8. Autologous stem cell transplantation in adult patients with intermediate-risk acute myeloid leukemia in first complete remission and no detectable minimal residual disease. A comparative retrospective study with haploidentical transplants of the global committee and the ALWP of the EBMT

Author

Chen, Jia, Labopin, Myriam, Pabst, Thomas, Zhang, Xi, Jiang, Erlie, Tucci, Alessandra, Cornelissen, Jan, Meijer, Ellen, Khevelidze, Irma, Polge, Emmanuelle, Wu, Depei, Mohty, Mohamad, and Gorin, Norbert-Claude

Published
2023
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9. Etoposide plus cytarabine versus cyclophosphamide or melphalan in busulfan-based preparative regimens for autologous stem cell transplantation in adults with acute myeloid leukemia in first complete remission: a study from the Acute Leukemia Working Party of the EBMT

Author

Sanz, Jaime, Labopin, Myriam, Pabst, Thomas, Versluis, Jurjen, Van Gorkom, Gwendolyn, Meijer, Ellen, Gedde-Dahl, Tobias, Montoro, Juan, Arcese, William, Pérez-Simón, Jose Antonio, Schaap, Nicolaas, Maertens, Johan, Vrhovac, Radovan, Lanza, Francesco, Gorin, Norbert Claude, Mohty, Mohamad, and Ciceri, Fabio

Published
2023
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11. Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine

Author

Hilberink, Jacobien R., van Zeventer, Isabelle A., Chitu, Dana A., Pabst, Thomas, Klein, Saskia K., Stussi, Georg, Griskevicius, Laimonas, Valk, Peter J. M., Cloos, Jacqueline, van de Loosdrecht, Arjan A., Breems, Dimitri, van Lammeren-Venema, Danielle, Boersma, Rinske, Jongen-Lavrencic, Mojca, Fehr, Martin, Hoogendoorn, Mels, Manz, Markus G., Söhne, Maaike, van Marwijk Kooy, Rien, Deeren, Dries, van der Poel, Marjolein W. M., Legdeur, Marie Cecile, Tick, Lidwine, Chalandon, Yves, Ammatuna, Emanuele, Blum, Sabine, Löwenberg, Bob, Ossenkoppele, Gert J., and Huls, Gerwin

Published
2023
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13. Blast damage zone influence on groundwater fluxes through backfilled open pits

Author

Rousseau, Moise and Pabst, Thomas

Subjects
Acid mine drainage -- Environmental aspects, Groundwater flow -- Environmental aspects, Explosions -- Environmental aspects, Mines and mineral resources -- Environmental aspects, Permeability -- Analysis, Earth sciences
Abstract

The blast damage zone (BDZ) surrounding backfilled pits could significantly influence groundwater flow, increase flow-rate through backfilled wastes, and potentially increase the dispersion of contaminants to the environment. A conceptual model of the fracture network of the BDZ was first proposed, which consisted of circular fracture oriented along the pit walls, and with a decreasing density with the distance to it. Realistic model parameters were also estimated based on the literature; BDZ equivalent permeability was analytically derived and used in 3D numerical models of conic open pits considering different backfilling scenarios. A total of 16 500 BDZ models were generated to assess the general influence of the BDZ on the flow and the influence of each parameter (fracture trace and attenuation length and fracture radius, aperture, and anisotropy). Results showed that the BDZ generally contributes to reduce (up to three orders of magnitude) the groundwater flow through backfilled tailings, but contributes to increase (by up to 250%) the flow in backfilled waste rocks, especially for wide and fractured BDZ in small pits. This study therefore suggests that the BDZ could be a self-sufficient containment structure to limit contaminant transports from backfilled tailings to the environment, but increases the risk considering waste rock. Key words: blast damage zone, groundwater flow, open pits, mine waste disposal, numerical modeling, 1. Introduction Mining operations generate large quantities of solid wastes whose storage is a major challenge for the industry (Aubertin et al. 2002, 2016). Tailings and waste rocks, which are [...]

Published
2023
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17. Bayesian interim analysis for prospective randomized studies: reanalysis of the acute myeloid leukemia HOVON 132 clinical trial

Author

van der Maas, Niek G., Versluis, Jurjen, Nasserinejad, Kazem, van Rosmalen, Joost, Pabst, Thomas, Maertens, Johan, Breems, Dimitri, Manz, Markus, Cloos, Jacqueline, Ossenkoppele, Gert J., Floisand, Yngvar, Gradowska, Patrycja, Löwenberg, Bob, Huls, Gerwin, Postmus, Douwe, Pignatti, Francesco, and Cornelissen, Jan J.

Published
2024
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22. Safety and Efficacy of High-Dose Chemotherapy with TreoMel 200 vs. TreoMel 140 in Acute Myeloid Leukemia Patients Undergoing Autologous Stem Cell Transplantation

Author

Eggimann, Matthias, primary, Akhoundova, Dilara, additional, Nilius, Henning, additional, Hoffmann, Michèle, additional, Hayoz, Michael, additional, Aebi, Yolanda, additional, Largiadèr, Carlo R., additional, Daskalakis, Michael, additional, Bacher, Ulrike, additional, and Pabst, Thomas, additional

Published
2024
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23. Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery

Author

Mehl, Julian, primary, Akhoundova, Dilara, additional, Bacher, Ulrike, additional, Jeker, Barbara, additional, Rhyner Agocs, Gaëlle, additional, Ruefer, Axel, additional, Soltermann, Susanne, additional, Soekler, Martin, additional, Winkler, Annette, additional, Daskalakis, Michael, additional, and Pabst, Thomas, additional

Published
2024
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24. Outcomes of pirtobrutinib for relapsed/refractory mantle cell lymphoma in compassionate use program in Europe

Author

Aydilek, Enver, primary, Wulf, Gerald, additional, Schwarz, Friedrich, additional, Bacher, Ulrike, additional, Rummel, Mathias, additional, Stiefel, Olga, additional, Kerkhoff, Andrea, additional, Maulhardt, Markus, additional, Melchardt, Thomas, additional, Pabst, Thomas, additional, Lenz, Georg, additional, and Shumilov, Evgenii, additional

Published
2024
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29. Simulating the effect of climate change on performance of a monolayer cover combined with an elevated water table placed on acid-generating mine tailings

Author

Lieber, Elodie, Demers, Isabelle, Pabst, Thomas, and Bresson, Emilie

Subjects
Acid mine drainage -- Environmental aspects, Tailings (Metallurgy) -- Environmental aspects, Climatic changes -- Influence, Earth sciences
Abstract

Several reclamation approaches were developed in the last decades to control acid mine drainage from tailings storage facilities, including the monolayer cover combined with an elevated water table. Its performance is dependent on water table elevation and tailings saturation and is directly affected by climatic conditions; therefore, climate change needs to be taken into account to design resilient reclamation systems. The objective of this research was to evaluate three approaches to simulate climate change and compare the impact on reclamation performance up to year 2100. Numerical simulations were calibrated using experimental field data, and future weather conditions were established based on three climate change scenarios adapted for local conditions. Results showed that the projected impact of climate change varied depending on the approach used. Simpler and more conservative approaches indicated that reclamation would eventually fail following an increase of droughts during future summers. However, 80 year simulations showed that reclamation failures (evaluated as oxygen flux) could be limited to a few isolated summers and that a well-designed monolayer cover with elevated water table appeared to remain efficient in the long term. Overall, the probability to exceed the oxygen flux target of 1 mol/[m.sup.2]/year did not exceed 2% for the simulated conditions. Key words: acid mine drainage, mine site reclamation, climate change, elevated water table, monolayer cover, numerical simulations. Au cours des dernieres decennies, plusieurs approches de remise en etat ont ete elaborees pour controler le drainage minier acide des installations de stockage des residus, notamment la couverture monocouche combinee a une nappe phreatique elevee. Ses performances dependent de l'elevation de la nappe phreatique et de la saturation des residus, et sont directement affectees par les conditions climatiques. Il faut donc tenir compte du changement climatique pour concevoir des systemes de remise en etat resilients. L'objectif de cette recherche etait d'evaluer trois approches pour simuler le changement climatique et de comparer l'impact sur les performances de remise en etat jusqu'en 2100. Les simulations numeriques ont ete calibrees a l'aide de donnees experimentales de terrain et les conditions meteorologiques futures ont ete etablies sur la base de trois scenarios de changement climatique adaptes aux conditions locales. Les resultats ont montre que l'impact prevu du changement climatique varie selon l'approche utilisee. Des approches plus simples et plus conservatrices indiquaient que la remise en etat echouerait finalement a la suite d'une augmentation des secheresses au cours des etes futurs. En revanche, des simulations sur 80 ans ont montre que les echecs de la remise en etat (evalues par le flux d'oxygene) pouvaient etre limites a quelques etes isoles et qu'une couverture monocouche bien concue avec une nappe phreatique elevee semblait rester efficace a long terme. Globalement, la probabilite de depasser l'objectif de flux d'oxygene de 1 mol/[m.sup.2]/an n'a pas depasse 2 % pour les conditions simulees. [Traduit par la Redaction] Mots-cles : drainage minier acide, remise en etat des sites miniers, changement climatique, nappe phreatique elevee, couverture monocouche, simulations numeriques., 1. Introduction Tailings are produced by mining operations and are usually stored in surface tailings storage facilities (TSF). Tailings often contain significant concentrations of sulfide minerals, which can react with [...]

Published
2022
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33. Chimeric antigen receptor‐T cell therapy shows similar efficacy and toxicity in patients with diffuse large B‐cell lymphoma aged 70 and older compared to younger patients: A multicenter cohort study

Author

Berning, Philipp, primary, Shumilov, Evgenii, additional, Maulhardt, Markus, additional, Boyadzhiev, Hristo, additional, Kerkhoff, Andrea, additional, Call, Simon, additional, Reicherts, Christian, additional, Saidy, Anna O., additional, Aydilek, Enver, additional, Hoffmann, Michèle, additional, Novak, Urban, additional, Daskalakis, Michael, additional, Schmitz, Norbert, additional, Stelljes, Matthias, additional, Wulf, Gerald, additional, Bacher, Ulrike, additional, Lenz, Georg, additional, and Pabst, Thomas, additional

Published
2024
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35. Abstract TP225: Prevalence of Patent Foramen Ovale in Patients With Cancer-Related Stroke

Author

Steinauer, Fabienne, primary, Bücke, Philipp, additional, Göcmen, Jayan, additional, Mujanovic, Adnan, additional, Kaesmacher, Johannes, additional, Meinel, Thomas, additional, Seiffge, David, additional, Buffle, Eric, additional, Navi, Babak, additional, Fischer, Urs, additional, Arnold, Marcel, additional, Pabst, Thomas, additional, Berger, Martin, additional, Jung, Simon, additional, and Beyeler, Morin, additional

Published
2024
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36. Europ. Zivilprozess- und Kollisionsrecht EuZPR/EuIPR, EG-VollstrTitel (Band 2/1)

Author

Thomas Rauscher, Urs Peter Gruber, Bettina Heiderhoff, Jan Hein, Gerald Mäsch, Steffen Pabst, Thomas Rauscher, István Varga, Matthias Weller, Denise Wiedemann, Thomas Rauscher, Urs Peter Gruber, Bettina Heiderhoff, Jan Hein, Gerald Mäsch, Steffen Pabst, Thomas Rauscher, István Varga, Matthias Weller, Denise Wiedemann and Thomas Rauscher, Urs Peter Gruber, Bettina Heiderhoff, Jan Hein, Gerald Mäsch, Steffen Pabst, Thomas Rauscher, István Varga, Matthias Weller, Denise Wiedemann, Thomas Rauscher, Urs Peter Gruber, Bettina Heiderhoff, Jan Hein, Gerald Mäsch, Steffen Pabst, Thomas Rauscher, István Varga, Matthias Weller, Denise Wiedemann

Published
2022

40. Development of a Score for Prediction of Occult Malignancy in Stroke Patients (Occult-5 Score)

Author

Beyeler, Morin, Birner, Barbara, Branca, Mattia, Meinel, Thomas, Vynckier, Jan, Buffle, Eric, Scutelnic, Adrian, Heldner, Mirjam R., Bücke, Philipp, Seiffge, David, Mordasini, Pascale, Dobrocky, Tomas, Piechowiak, Eike I., Kaesmacher, Johannes, Gralla, Jan, Mattle, Heinrich P., Arnold, Marcel, Fischer, Urs, Pabst, Thomas, Berger, Martin D., and Jung, Simon

Published
2022
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41. Addition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial

Author

Dimopoulos, Meletios A, Richardson, Paul G, Bahlis, Nizar J, Grosicki, Sebastian, Cavo, Michele, Beksaç, Meral, Legieć, Wojciech, Liberati, Anna M, Goldschmidt, Hartmut, Belch, Andrew, Magen, Hila, Larocca, Alessandra, Laubach, Jacob P, Petrucci, Maria T, Reece, Donna, White, Darrell, Mateos, María-Victoria, Špička, Ivan, Lazaroiu, Mihaela, Berdeja, Jesús, Kaufman, Jonathan L, Jou, Ying-Ming, Ganetsky, Alex, Popa McKiver, Mihaela, Lonial, Sagar, Weisel, Katja, Sandhu, Irwindeep, Podhorecka, Monika, Palumbo, Antonio, Shacham-Abulafia, Adi, Vaxman, Iuliana, Shpilberg, Ofer, Besemer, Britta, Martelli, Maurizio, Foà, Roberto, De Fabritiis, Paolo, Caravita di Toritto, Tommaso, Gheorghita, Emanuil, Oriol, Albert, Rowlings, Philip, Emanuele, Angelucci, Carella, Angelo M, Offidani, Massimo, Bladé, Joan, Casado, Luis F, Oakervee, Heather, Panelli, Victoria, Meza, Luis, Kühr, Thomas, Granell, Miguel, Benson, Don, Nair, Rajesh, Holden, Viran, Reeves, James, Jr., Eek, Richard W, Walker, Patricia A, Catalano, John, Rosta, András, Lech-Marańda, Ewa, Samaras, Christy, Reiman, Anthony, Weaver, Robert, Acs, Peter, Grigg, Andrew, De Prijck, Bernard, Louzada, Martha, Minuk, Leonard, Sebag, Michael, Klausmann, Martine, Welslau, Manfred, Hellmann, Andrzej, Danaila, Catalin, Becker, Pamela, Bensinger, William, Porterfield, Bruce, Modiano, Manuel, Schultz, Stephen M, Manges, Robert, Lee, Huey-Shin Cindy, Gray, James X, Wright, Matthew P, Vekemans, Marie-Christine, Hamed, Aryan, Gasztonyi, Zoltán, Mikala, Gábor, Masszi, Tamás, Gamberi, Barbara, Kuliczkowski, Kazimierz, Usnarska-Zubkiewicz, Lidia, Bengoechea, Enrique, Gutiérrez, María AE, García, Miguel TH, San-Miguel, Jesús, Driessen, Christoph, Behl, Rajesh, Brenner, Warren, Gray, Carl, Hansen, Vincent, Moezi, Mehdi, Cortes, Hector V, Yen, Charles, Gressot, Laurent, Horvath, Noemi, D'Rozario, James M, Latimer, Maya, Kyrtsonis, Maria-Christine, Chubar, Evgeni, Mittelman, Moshe, Baldini, Luca, Tosi, Patrizia, Vacca, Angelo, Jędrzejczak, Wiesław W, Robak, Tadeusz, Lahuerta, Juan J, Carney, Jennifer, Chen, Franklin, Hirsch, Robert, Ruiz, Marco, Alencar, Alvaro, Jagasia, Madan, Kasbari, Samer, Kuriakose, Philip, Mahmood, Aftab, Chaudhry, Madhu, Cohen, Gary, Noga, Stephen, Roa, Sch, Jakubowiak, Andrzej, Rosenbaum, Cara, Delforge, Michel, Delrieu, Vanessa, Doyen, Chantal, Dries, Deeren, Demuynck, Hilde, Schots, Rik, Maisnar, Vladimir, Blau, Igor W, Dürk, Heinz A, Kerkhoff, Andrea, Kropff, Martin, Munder, Markus, Röllig, Christoph, Scheid, Christof, Symeonidis, Argiris S, Illés, Árpád, Coyne, Mark, O'Gorman, Peter, Hayden, Patrick, O'Dwyer, Michael, Ben-Yehuda, Dina, Braester, Andrei, Nemets, Anatoly, Lugassy, Gilles, Cohen, Yossi, Rahimi-Levene, Naomi, Bosi, Alberto, Pezzatti, Sara, Rossini, Fausto, Pogliani, Enrico M, Pinto, Antonello, Komarnicki, Mieczysław, Borsaru, Gabriela, Stoia, Razvan, Afanasyev, Boris, Goñi, María A, Carboneras, Ana V, Ali, Sarah, Rubenstein, S. Eric, Caputto, Salvador, Cosgriff, Thomas, Fanning, Suzanne, Khojasteh, Ali, Liman, Andrew, Malcolm, Albert, Vrindavanam, Nandagopal, Patel, Ravindranath, Belani, Rajesh, Shieh, Marie, Stockerl-Goldstein, Keith, Strnad, Charles, Stuart, Robert, Chhabra, Saurabh, Costa, Luciano, Jhangiani, Haresh, Augustson, Bradley, Filshie, Robin, Johnston, Amanda, Hertzberg, Mark S, Mineur, Philippe, Fox, Susan, Kotb, Rami, Dao, Vi, LeBlanc, Richard, Gregora, Evzen, Brioli, Annamaria, Mügge, Lars-Olof, Hänel, Mathias, Langer, Christian, Kapsali, Eleni, Briasoulis, Evangelos, Kyriakou, Despoina, Hardan, Izhar, Horowitz, Netanel A, Clotilde, Cangialosi, Fabbiano, Francesco, Castagnari, Barbara, Ciceri, Fabio, Musuraca, Gerardo, Deptała, Andrzej, Kłoczko, Janusz, Balea, Marius, Vladareanu, Ana-Maria, Rossiev, Victor, Alegre, Adrián, Encinas, Cristina, Gayoso, Jorge, Pabst, Thomas, Rabin, Neil, Arledge, Sherri, Cabanillas, Fernando, Catlett, Joseph, Chidiac, Tarek, Clarkson, David, Dhodapkar, Madhav, Geils, George, Jr., Khan, Cyrus MA, Sahovic, Entezam, Khasawneh, Mohamad, Sehgal, Rajesh, Ballester, Oscar, Levy, Moshe, Fay, Joseph, Liem, Kiem, Lunning, Matthew, Vose, Julie, Faber, Edward, Jr., MacFarlane, Donald, Hohl, Raymond, Mahmood, Tariq, Bhaskar, Birbal, Mims, Martha, Oliff, Ira, Paner, Agne, Maciejewski, John, Padmanabhan, Arvinda, Richard, Robert, Sanyal, Amit, Schiller, Gary, Staszewski, Harry, Stevens, Don, Vaughn, Christopher, and Windsor, Kevin

Published
2022
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43. Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome

Author

Grob, Tim, Al Hinai, Adil S.A., Sanders, Mathijs A., Kavelaars, François G., Rijken, Melissa, Gradowska, Patrycja L., Biemond, Bart J., Breems, Dimitri A., Maertens, Johan, van Marwijk Kooy, Marinus, Pabst, Thomas, de Weerdt, Okke, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Huls, Gerwin A., Cornelissen, Jan J., Beverloo, H. Berna, Löwenberg, Bob, Jongen-Lavrencic, Mojca, and Valk, Peter J.M.

Published
2022
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46. Evaluation of Posaconazole Serum Concentrations Achieved With Delayed-release Tablets and Oral Suspension in Patients Undergoing Intensive Chemotherapy for Acute Myeloid Leukemia and Myelodysplastic Syndrome.

Author

Muehlberg, Leonora, Pabst, Thomas, Largiadèr, Carlo, Aebi, Yolanda, Hayoz, Michael, Muehlethaler, Konrad, Zimmerli, Stefan, and Hirzel, Cédric

Subjects
*ACUTE myeloid leukemia, *MYELODYSPLASTIC syndromes, *CANCER chemotherapy, *MUCOSITIS, *PRELEUKEMIA
Abstract

Data on posaconazole serum levels of patients on prophylaxis with delayed-release tablets or oral suspension during intensive chemotherapy for acute myeloid leukemia and myelodysplastic syndrome are scarce. In this analysis, the proportion of patients with acute myeloid leukemia/myelodysplastic syndrome achieving posaconazole target concentrations with delayed-release tablets was higher than with oral suspension. [ABSTRACT FROM AUTHOR]

Published
2024
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