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169 results on '"Pacini, Simone"'

4. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer

Author

Fernandez, Harvey R., Gadre, Shreyas M., Tan, Mingjun, Graham, Garrett T., Mosaoa, Rami, Ongkeko, Martin S., Kim, Kyu Ah, Riggins, Rebecca B., Parasido, Erika, Petrini, Iacopo, Pacini, Simone, Cheema, Amrita, Varghese, Rency, Ressom, Habtom W, Zhang, Yuwen, Albanese, Christopher, Üren, Aykut, Paige, Mikell, Giaccone, Giuseppe, and Avantaggiati, Maria Laura

Published
2018
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9. CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats

Author

Lai, Michele, primary, Maori, Eyal, additional, Quaranta, Paola, additional, Matteoli, Giulia, additional, Maggi, Fabrizio, additional, Sgarbanti, Marco, additional, Crucitta, Stefania, additional, Pacini, Simone, additional, Turriziani, Ombretta, additional, Antonelli, Guido, additional, Heeney, Jonathan L., additional, Freer, Giulia, additional, and Pistello, Mauro, additional

Published
2021
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11. The HIV-1 provirus excised by a single CRISPR/Cas9 RNA guide persists in the host cell and may be reactivated

Author

Lai, Michele, primary, Maori, Eyal, additional, Quaranta, Paola, additional, Matteoli, Giulia, additional, Maggi, Fabrizio, additional, Sgarbanti, Marco, additional, Crucitta, Stefania, additional, Pacini, Simone, additional, Turriziani, Ombretta, additional, Freer, Giulia, additional, Antonelli, Guido, additional, Heeney, Jonathan L., additional, and Pistello, Mauro, additional

Published
2020
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13. Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma

Author

Pacini, Simone, primary, Montali, Marina, additional, Mazziotta, Francesco, additional, Schifone, Claudia P., additional, Macchia, Lucia, additional, Carnicelli, Vittoria, additional, Panvini, Francesca M., additional, Barachini, Serena, additional, Notarfranchi, Laura, additional, Previti, Giovanni Battista, additional, Buda, Gabriele, additional, and Petrini, Mario, additional

Published
2019
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27. Melanocortin Receptor-4 and Glioblastoma Cells: Effects of the Selective Antagonist ML00253764 Alone and in Combination with Temozolomide In Vitro and In Vivo

Author

Vaglini, Francesca, primary, Pardini, Carla, additional, Di Desidero, Teresa, additional, Orlandi, Paola, additional, Pasqualetti, Francesco, additional, Ottani, Alessandra, additional, Pacini, Simone, additional, Giuliani, Daniela, additional, Guarini, Salvatore, additional, and Bocci, Guido, additional

Published
2017
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38. Impaired function of gamma-delta lymphocytes in melanoma patients

Author

Petrini, Iacopo, Pacini, Simone, Galimberti, Sara, Taddei, Mr, Romanini, A, and Petrini, Mario

Subjects
Adult, Cytotoxicity, Immunologic, Male, Skin Neoplasms, Bone Density Conservation Agents, Diphosphonates, Imidazoles, Receptors, Antigen, T-Cell, gamma-delta, Middle Aged, Flow Cytometry, Zoledronic Acid, Immunophenotyping, Case-Control Studies, Cell Line, Tumor, Humans, Interleukin-2, Female, Lymphocyte Count, Lymphocytes, Melanoma
Abstract

Melanoma is an immunogenic tumour but, despite the wide range of immunotherapies tested, only few promising results have been reported to date. Both in vitro and in xenograft models, γδ lymphocyte-mediated cytotoxicity against melanoma cells has been reported. IL-2/zoledronate treatment can expand γδ cells in vitro and in animal models. This could represent an immunotherapeutic strategy against melanoma. To evaluate the feasibility of this approach, we studied γδ lymphocyte phenotype from patients with melanoma, their ability to be expanded by IL-2/zoledronate and their cytotoxic activity against SK-MEL-30 cell line.Peripheral blood samples were collected from 30 patients with melanoma and 10 healthy donors. Percentage of γδ lymphocytes and CD45RO+CD27+, CD45RA+CD27-, CD57+, Vγ9Vδ2 subpopulations were evaluated by flow cytometry. IL-2/zoledronate γδ cell expansion rate and their cytotoxicity against SK-MEL-30 cell line were studied.A percentage decrease in circulating Vγ9Vδ2 and an increase in CD45RA+CD27- and CD57+ γδ lymphocytes were observed in melanoma. IL-2/zoledronate expansion rate did not differ between controls and patients with melanoma but cytotoxicity against SK-MEL-30 appeared reduced.Our results show that γδ cell function is impaired in patients with advanced melanoma and suggest a possible role in tumour progression.

Published
2012

41. Tendon and bone repair by mesenchymal cells

Author

Steafano Giannotti, Mario Petrini, Michele Lisanti, Pacini Simone, Rita Fazzi, Giulio Guido, and Trombi Luisa

Subjects
Pharmacology, Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Mesenchymal stem cell, medicine, General Medicine, Bone healing, business, Tendon
Published
2008

45. Human Mesenchymal Stromal Cell Enhanced Morphological Polarization by Contact Interaction with Polyethylene Terephthalate Nanogratings

Author

Antonini, Sara, primary, Cappelluti, Martino, additional, Meucci, Sandro, additional, Jacchetti, Emanuela, additional, Vittorio, Orazio, additional, Parchi, Paolo, additional, Lisanti, Michele, additional, Pacini, Simone, additional, Petrini, Mario, additional, Beltram, Fabio, additional, and Cecchini, Marco, additional

Published
2014
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48. Bone and bone marrow interactions: hematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide III. Action on human megakaryocytopoiesis: focus on essential thrombocythemia

Author

Fazzi, R, Galimberti, Sara, Pacini, Simone, Testi, Rossana, Azzara', Antonio, Orciuolo, E, Trombi, Luisa, Metelli, M. R., and Petrini, Mario

Subjects
Histones, Platelet-Derived Growth Factor, Transforming Growth Factor beta1, Structure-Activity Relationship, Osteoblasts, Bone Marrow, Cytokines, Humans, Intercellular Signaling Peptides and Proteins, Endorphins, Megakaryocytes, Cell Proliferation, Thrombocythemia, Essential
Abstract

The increase of megakaryocytes and platelets that characterizes essential thrombocythemia (ET) appears to be secondary to a deregulation of megakaryocytopoiesis. The carboxy-terminal fragment of osteogenic growth peptide (OGP10-14) promotes bone formation and hemopoiesis, while it inhibits megakaryocytopoiesis. In this paper we show that treatment with synthetic OGP10-14 (sOGP10-14) induces a significant reduction of mid and large colony-forming unit-megakaryocytes (CFU-Mk) in ET patients as well as in controls, and is associated with a significant inhibition of thrombopoietin (TPO)-primed MO-7e megakaryoblastic cells proliferation. These actions appear to be related to sOGP10-14 modulation of TGF-beta(1) synthesis and/or secretion, although a direct effect on TGF-beta receptor expression cannot be excluded.

Published
2003

50. Mesangiogenic Progenitor Cells Derived from One Novel CD64brightCD31brightCD14neg Population in Human Adult Bone Marrow.

Author

Pacini, Simone, Barachini, Serena, Montali, Marina, Carnicelli, Vittoria, Fazzi, Rita, Parchi, Paolo, and Petrini, Mario

Subjects
*PROGENITOR cells, *CELLS, *STEM cells, *THYMOCYTES, *CD31 antigen
Abstract

Mesenchymal stromal cells (MSCs) have been the object of extensive research for decades, due to their intrinsic clinical value. Nonetheless, the unambiguous identification of a unique in vivo MSC progenitor is still lacking, and the hypothesis that these multipotent cells could possibly arise from different in vivo precursors has been gaining consensus in the last years. We identified a novel multipotent cell population in human adult bone marrow that we first named Mesodermal Progenitor Cells (MPCs) for the ability to differentiate toward the mesenchymal lineage, while still retaining angiogenic potential. Despite extensive characterization, MPCs positioning within the differentiation pathway and whether they can be ascribed as possible distinctive progenitor of the MSC lineage is still unclear. In this study, we describe the ex vivo isolation of one novel bone marrow subpopulation ( Pop#8) with the ability to generate MPCs. Multicolor flow cytometry in combination with either fluorescence-activated cell sorting or magnetic-activated cell sorting were applied to characterize Pop#8 as CD64brightCD31brightCD14neg. We defined Pop#8 properties in culture, including the potential of Pop#8-derived MPCs to differentiate into MSCs. Gene expression data were suggestive of Pop#8 in vivo involvement in hematopoietic stem cell niche constitution/maintenance. Pop#8 resulted over three logs more frequent than other putative MSC progenitors, corroborating the idea that most of the controversies regarding culture-expanded MSCs could be the consequence of different culture conditions that select or promote particular subpopulations of precursors. [ABSTRACT FROM AUTHOR]

Published
2016
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