Search

Your search keyword '"Pagano, Sabrina"' showing total 308 results
Start Over Author "Pagano, Sabrina"
308 results on '"Pagano, Sabrina"'

6. Linking Antibodies Against Apolipoprotein A-1 to Metabolic Dysfunction-Associated Steatohepatitis in Mice.

Author

Pagano, Sabrina, Somm, Emmanuel, Juillard, Catherine, Liaudet, Nicolas, Ino, Frédérique, Ferrari, Johan, Braunersreuther, Vincent, Jornayvaz, François R., and Vuilleumier, Nicolas

Subjects
*FATTY liver, *HEPATIC fibrosis, *HEPATITIS, *HIGH-fat diet, *LABORATORY mice
Abstract

Metabolic dysfunction-associated fatty liver disease (MASLD) is a common liver and health issue associated with heightened cardiovascular disease (CVD) risk, with Cytokeratin 18 (CK-18) as a marker of liver injury across the MASLD to cirrhosis spectrum. Autoantibodies against apolipoprotein A-1 (AAA-1s) predict increased CVD risk, promoting atherosclerosis and liver steatosis in apoE−/− mice, though their impact on liver inflammation and fibrosis remains unclear. This study examined AAA-1s' impact on low-grade inflammation, liver steatosis, and fibrosis using a MASLD mouse model exposed to AAA-1s passive immunization (PI). Ten-week-old male C57BL/6J mice under a high-fat diet underwent PI with AAA-1s or control antibodies for ten days. Compared to controls, AAA-1-immunized mice showed higher plasma CK-18 (5.3 vs. 2.1 pg/mL, p = 0.031), IL-6 (13 vs. 6.9 pg/mL, p = 0.035), IL-10 (27.3 vs. 9.8 pg/mL, p = 0.007), TNF-α (32.1 vs. 24.2 pg/mL, p = 0.032), and liver steatosis (93.4% vs. 73.8%, p = 0.007). Transcriptomic analyses revealed hepatic upregulation of pro-fibrotic mRNAs in AAA-1-recipient mice, though histological changes were absent. In conclusion, short-term AAA-1 PI exacerbated liver steatosis, inflammation, and pro-fibrotic gene expression, suggesting that AAA-1s may play a role in MASLD progression. Further research with prolonged AAA-1 exposure is warranted to clarify their potential role in liver fibrosis and associated complications. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Anti-apolipoprotein A-1 IgG, incident cardiovascular events, and lipid paradox in rheumatoid arthritis

Author

Mongin, Denis; https://orcid.org/0000-0002-4801-8395, Pagano, Sabrina, Lamacchia, Celine, Juillard, Catherine, Antinori-Malaspina, Paola, Dan, Diana, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Möller, Burkhard; https://orcid.org/0000-0001-8769-6167, Gabay, Cem, Finckh, Axel; https://orcid.org/0000-0002-1210-4347, Vuilleumier, Nicolas, Mongin, Denis; https://orcid.org/0000-0002-4801-8395, Pagano, Sabrina, Lamacchia, Celine, Juillard, Catherine, Antinori-Malaspina, Paola, Dan, Diana, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Möller, Burkhard; https://orcid.org/0000-0001-8769-6167, Gabay, Cem, Finckh, Axel; https://orcid.org/0000-0002-1210-4347, and Vuilleumier, Nicolas

Abstract

OBJECTIVE: To validate the prognostic accuracy of anti-apolipoprotein A-1 (AAA1) IgG for incident major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) and study their associations with the lipid paradox at a multicentric scale. METHOD: Baseline AAA1 IgG, lipid profile, atherogenic indexes, and cardiac biomarkers were measured on the serum of 1,472 patients with RA included in the prospective Swiss Clinical Quality Management registry with a median follow-up duration of 4.4 years. MACE was the primary endpoint defined as CV death, incident fatal or non-fatal stroke, or myocardial infarction (MI), while elective coronary revascularization (ECR) was the secondary endpoint. Discriminant accuracy and incidence rate ratios (IRR) were respectively assessed using C-statistics and Poisson regression models. RESULTS: During follow-up, 2.4% (35/1,472) of patients had a MACE, consisting of 6 CV deaths, 11 MIs, and 18 strokes; ECR occurred in 2.1% (31/1,472) of patients. C-statistics indicated that AAA1 had a significant discriminant accuracy for incident MACE [C-statistics: 0.60, 95% confidence interval (95% CI): 0.57-0.98, p = 0.03], mostly driven by CV deaths (C-statistics: 0.77; 95% CI: 0.57-0.98, p = 0.01). IRR indicated that each unit of AAA1 IgG increase was associated with a fivefold incident CV death rate, independent of models' adjustments. At the predefined and validated cut-off, AAA1 displayed negative predictive values above 97% for MACE. AAA1 inversely correlated with total and HDL cholesterol. CONCLUSIONS: AAA1 independently predicts CV deaths, and marginally MACE in RA. Further investigations are requested to ascertain whether AAA1 could enhance CV risk stratification by identifying patients with RA at low CV risk.

Published
2024

11. People living with HIV display increased anti-apolipoprotein A1 auto-antibodies, inflammation, and kynurenine metabolites: a case–control study

Author

Frias, Miguel A., primary, Pagano, Sabrina, additional, Bararpour, Nasim, additional, Sidibé, Jonathan, additional, Kamau, Festus, additional, Fétaud-Lapierre, Vanessa, additional, Hudson, Peter, additional, Thomas, Aurélien, additional, Lecour, Sandrine, additional, Strijdom, Hans, additional, and Vuilleumier, Nicolas, additional

Published
2024
Full Text
View/download PDF

12. Anti-apolipoprotein A-1 autoantibodies are associated with immunodeficiency and systemic inflammation in HIV patients

Author

Aubert, V., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Bucher, H.C., Burton-Jeangros, C., Calmy, A., Cavassini, M., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francioli, P., Furrer, H., Fux, C.A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H.H., Hirschel, B., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Kind, C., Klimkait, T., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schöni-Affolter, F., Schüpbach, J., Speck, R., Taffé, P., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Satta, Nathalie, Pagano, Sabrina, Montecucco, Fabrizio, Gencer, Baris, Mach, François, Kaiser, Laurent, Calmy, Alexandra, and Vuilleumier, Nicolas

Published
2018
Full Text
View/download PDF

24. 3D Photogrammetric Survey, Raking Light Photography and Mapping of Degradation Phenomena of the Early Renaissance Wall Paintings by Saturnino Gatti—Case Study of the St. Panfilo Church in Tornimparte (L’Aquila, Italy)

Author

Lanteri, Luca, primary, Calandra, Sara, additional, Briani, Francesca, additional, Germinario, Chiara, additional, Izzo, Francesco, additional, Pagano, Sabrina, additional, Pelosi, Claudia, additional, and Santo, Alba Patrizia, additional

Published
2023
Full Text
View/download PDF

27. Archaeometric Characterisation and Assessment of Conservation State of Coins: The Case-Study of a Selection of Antoniniani from the Hoard of Cumae (Campania Region, Southern Italy)

Author

Pagano, Sabrina, primary, Balassone, Giuseppina, additional, Germinario, Chiara, additional, Grifa, Celestino, additional, Izzo, Francesco, additional, Mercurio, Mariano, additional, Munzi, Priscilla, additional, Pappalardo, Lucia, additional, Spagnoli, Emanuela, additional, Verde, Maria, additional, and De Bonis, Alberto, additional

Published
2023
Full Text
View/download PDF

29. Multilayer Technology of Decorated Plasters from the domus of Marcus Vipsanus Primigenius at Abellinum (Campania Region, Southern Italy): An Analytical Approach

Author

Pagano, Sabrina, primary, Germinario, Chiara, additional, Alberghina, Maria Francesca, additional, Covolan, Marina, additional, Mercurio, Mariano, additional, Musmeci, Daniela, additional, Piovesan, Rebecca, additional, Santoriello, Alfonso, additional, Schiavone, Salvatore, additional, and Grifa, Celestino, additional

Published
2022
Full Text
View/download PDF

30. Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA

Author

Schmiedeberg, Kristin, primary, Abela, Irene A, additional, Pikor, Natalia Barbara, additional, Vuilleumier, Nicolas, additional, Schwarzmueller, Magdalena, additional, Epp, Selina, additional, Pagano, Sabrina, additional, Grabherr, Sarah, additional, Patterson, Angelica Brooke, additional, Nussberger, Madalina, additional, Trkola, Alexandra, additional, Ludewig, Burkhard, additional, von Kempis, Johannes, additional, and Rubbert-Roth, Andrea, additional

Published
2022
Full Text
View/download PDF

32. Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients.

Author

Wozniak, Hannah, Le Terrier, Christophe, Primmaz, Steve, Suh, Noémie, Lenglet, Sébastien, Thomas, Aurélien, Vuilleumier, Nicolas, Pagano, Sabrina, de Watteville, Aude, Stringhini, Silvia, Guessous, Idris, Quintard, Hervé, Heidegger, Claudia Paula, and Pugin, Jérôme

Abstract

The primary objective of this study was to compare the plasma levels of copper, selenium, and zinc between critically ill COVID-19 patients and less severe COVID-19 patients. The secondary objective was to investigate the association of these trace element levels with adverse outcomes, including the duration of mechanical ventilation, occurrence of septic shock, and mortality in critically ill COVID-19 patients. All COVID-19 patients admitted to the ICU of the Geneva University Hospitals between 9 March 2020 and 19 May 2020 were included in the study. Plasma levels of copper, selenium and zinc were measured on admission to the ICU and compared with levels measured in COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. To analyze the association of trace elements with clinical outcomes, multivariate linear and logistic regressions were performed. Patients in the ICU had significantly lower levels of selenium and zinc and higher levels of copper compared to COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. In ICU patients, lower zinc levels tended to be associated with more septic shock and increased mortality compared to those with higher zinc levels (p = 0.07 for both). Having lower copper or selenium levels was associated with a longer time under mechanical ventilation (p = 0.01 and 0.04, respectively). These associations remained significant in multivariate analyses (p = 0.03 for copper and p = 0.04 for selenium). These data support the need for interventional studies to assess the potential benefit of zinc, copper and selenium supplementation in severe COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

33. A banquet scene in a tomb of Cuma (southern Italy): the study of wall paintings to shed light on Roman technological skills in ‘building for eternity’

Author

Germinario, Chiara, primary, Pagano, Sabrina, additional, Mercurio, Mariano, additional, Izzo, Francesco, additional, De Bonis, Alberto, additional, Morra, Vincenzo, additional, Munzi, Priscilla, additional, Leone, Marcella, additional, Conca, Elisa, additional, and Grifa, Celestino, additional

Published
2022
Full Text
View/download PDF

35. Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA

Author

Schmiedeberg, Kristin, Abela, Irene A; https://orcid.org/0000-0002-5566-8628, Pikor, Natalia Barbara, Vuilleumier, Nicolas, Schwarzmueller, Magdalena, Epp, Selina, Pagano, Sabrina, Grabherr, Sarah, Patterson, Angelica Brooke, Nussberger, Madalina, Trkola, Alexandra, Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X, von Kempis, Johannes, Rubbert-Roth, Andrea; https://orcid.org/0000-0002-9016-2833, Schmiedeberg, Kristin, Abela, Irene A; https://orcid.org/0000-0002-5566-8628, Pikor, Natalia Barbara, Vuilleumier, Nicolas, Schwarzmueller, Magdalena, Epp, Selina, Pagano, Sabrina, Grabherr, Sarah, Patterson, Angelica Brooke, Nussberger, Madalina, Trkola, Alexandra, Ludewig, Burkhard; https://orcid.org/0000-0002-7685-573X, von Kempis, Johannes, and Rubbert-Roth, Andrea; https://orcid.org/0000-0002-9016-2833

Published
2022

38. Autoantibodies against apolipoprotein A‐1 after COVID‐19 predict symptoms persistence

Author

L’Huillier, Arnaud G., primary, Pagano, Sabrina, additional, Baggio, Stephanie, additional, Meyer, Benjamin, additional, Andrey, Diego O., additional, Nehme, Mayssam, additional, Guessous, Idris, additional, Eberhardt, Christiane S., additional, Huttner, Angela, additional, Posfay‐Barbe, Klara M., additional, Yerly, Sabine, additional, Siegrist, Claire‐Anne, additional, Kaiser, Laurent, additional, and Vuilleumier, Nicolas, additional

Published
2022
Full Text
View/download PDF

39. Anti‐SARS-CoV‐2 mRNA vaccines as inducers of humoral response against apolipoprotein A‐1?

Author

Vuilleumier, Nicolas, Pagano, Sabrina, Ludewig, Burkhard, Schmiedeberg, Kristin, Haller, Christoph, Kempis, Johannes, and Rubbert‐Roth, Andrea

Subjects
ddc:616, Anti-SARS-CoV-2 mRNA vaccines, Apolipoprotein A-1, Autoantibodies
Abstract

Background: COVID-19 and some anti-SARS-CoV-2 vaccines trigger a humoral autoimmune response against a broad range of endogenous components, which may affect recipients' prognosis in predisposed individuals. Autoantibodies directed against apolipoprotein A-1 (AAA1 IgG) the major protein fraction of High Density Lipoprotein have been shown to be raised in COVID-19 and in rheumatoid arthritis (RA) patients and other populations where they have been associated with poorer outcomes. We wanted to assess the impact of anti-SARS-CoV-2 mRNA-based vaccination on AAA1 autoimmune biomarkers in RA patients.Methods: 20 healthy controls and 77 RA mRNA-based vaccinated patients were collected at baseline, 3 weeks after the first vaccination, 2 and 8 weeks after the second vaccination. AAA1 and SARS-CoV-2 serologies were measured by immunoassays. Systemic and local symptoms occurring during the vaccination protocol were recorded.Results: mRNA-based vaccination induced a significant increase in median AAA1 IgG levels in both healthy controls and RA patients overtime. However, in both populations, these medians trend did not translate into significant increase in AAA1 IgG seropositivity rates despite evolving from 5 to 10% in healthy controls, and from 9 to 12.9% in RA patients. No associations were retrieved between AAA1 IgG and symptoms of any kind during the vaccination protocol.Conclusions: mRNA-based vaccination seems to induce a light AAA1 IgG response in immunocompetent individuals within 2 months after the last injection. Although we did not observe any warning signs, the formal demonstration of the harmlessness of such biological warrants further studies.

Published
2022

40. GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

Author

Guillamat-Prats, Raquel, primary, Hering, Daniel, additional, Rami, Martina, additional, Haerdner, Carmen, additional, Santovito, Donato, additional, Rinne, Petteri, additional, Bindila, Laura, additional, Hristov, Michael, additional, Pagano, Sabrina, additional, Vuilleumier, Nicolas, additional, Schmid, Sofie, additional, Janjic, Aleksandar, additional, Enard, Wolfgang, additional, Weber, Christian, additional, Maegdefessel, Lars, additional, Faussner, Alexander, additional, Hilgendorf, Ingo, additional, and Steffens, Sabine, additional

Published
2022
Full Text
View/download PDF

43. GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

Author

Guillamat-Prats, Raquel, primary, Hering, Daniel, additional, Rami, Martina, additional, Härdtner, Carmen, additional, Santovito, Donato, additional, Rinne, Petteri, additional, Bindila, Laura, additional, Hristov, Michael, additional, Pagano, Sabrina, additional, Vuilleumier, Nicolas, additional, Schmid, Sofie, additional, Janjic, Aleksandar, additional, Enard, Wolfgang, additional, Weber, Christian, additional, Maegdefessel, Lars, additional, Faussner, Alexander, additional, Hilgendorf, Ingo, additional, and Steffens, Sabine, additional

Published
2021
Full Text
View/download PDF

44. Bariatric Surgery Leads to a Reduction in Antibodies to Apolipoprotein A-1: a Prospective Cohort Study

Author

Adam, Safwaan, primary, Ho, Jan H., additional, Liu, Yifen, additional, Siahmansur, Tarza, additional, Iqbal, Zohaib, additional, Pagano, Sabrina, additional, Azmi, Shazli, additional, Dhage, Shaishav S., additional, Donn, Rachelle, additional, Ammori, Basil J., additional, Syed, Akheel A., additional, Durrington, Paul N., additional, Malik, Rayaz A., additional, Vuilleumier, Nicolas, additional, and Soran, Handrean, additional

Published
2021
Full Text
View/download PDF

47. SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1

Author

Pagano, Sabrina, primary, Yerly, Sabine, additional, Meyer, Benjamin, additional, Juillard, Catherine, additional, Suh, Noémie, additional, Le Terrier, Christophe, additional, Daguer, Jean‐Pierre, additional, Farrera‐Soler, Lluc, additional, Barluenga, Sofia, additional, Piumatti, Giovanni, additional, Hartley, Oliver, additional, Lemaitre, Barbara, additional, Eberhardt, Christiane S., additional, Siegrist, Claire‐Anne, additional, Eckerle, Isabella, additional, Stringhini, Silvia, additional, Guessous, Idris, additional, Kaiser, Laurent, additional, Pugin, Jerome, additional, Winssinger, Nicolas, additional, and Vuilleumier, Nicolas, additional

Published
2021
Full Text
View/download PDF

48. Autoantibodies against apolipoprotein A‐1 after COVID‐19 predict symptoms persistence.

Author

L'Huillier, Arnaud G., Pagano, Sabrina, Baggio, Stephanie, Meyer, Benjamin, Andrey, Diego O., Nehme, Mayssam, Guessous, Idris, Eberhardt, Christiane S., Huttner, Angela, Posfay‐Barbe, Klara M., Yerly, Sabine, Siegrist, Claire‐Anne, Kaiser, Laurent, and Vuilleumier, Nicolas

Subjects
*COVID-19, *AUTOANTIBODIES, *REGRESSION analysis, *POST-acute COVID-19 syndrome, *SYMPTOMS, *APOLIPOPROTEIN E4
Abstract

Background: SARS‐CoV‐2 infection triggers different auto‐antibodies, including anti‐apolipoprotein A‐1 IgGs (AAA1), which could be of concern as mediators of persistent symptoms. We determined the kinetics of AAA1 response over after COVID‐19 and the impact of AAA1 on the inflammatory response and symptoms persistence. Methods: All serologies were assessed at one, three, six and twelve months in 193 hospital employees with COVID‐19. ROC curve analyses and logistic regression models (LRM) were used to determine the prognostic accuracy of AAA1 and their association with patient‐reported COVID‐19 symptoms persistence at 12 months. Interferon (IFN)‐α and‐γ production by AAA1‐stimulated human monocyte‐derived macrophages (HMDM) was assessed in vitro. Results: AAA1 seropositivity was 93% at one month and declined to 15% at 12 months after COVID‐19. Persistent symptoms at 12 months were observed in 45.1% of participants, with a predominance of neurological (28.5%), followed by general (15%) and respiratory symptoms (9.3%). Over time, strength of correlations between AAA1 and anti‐SARS‐COV2 serologies decreased, but remained significant. From the 3rd month on, AAA1 levels predicted persistent respiratory symptoms (area under the curves 0.72‐0.74; p < 0.001), independently of disease severity, age and gender (adjusted odds ratios 4.81–4.94; p = 0.02), while anti‐SARS‐CoV‐2 serologies did not. AAA1 increased IFN‐α production by HMDMs (p = 0.03), without affecting the IFN‐γ response. Conclusion: COVID‐19 induces a marked though transient AAA1 response, independently predicting one‐year persistence of respiratory symptoms. By increasing IFN‐α response, AAA1 may contribute to persistent symptoms. If and how AAA1 levels assessment could be of use for COVID‐19 risk stratification remains to be determined. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

49. The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Author

Montecucco, Fabrizio, Di Marzo, Vincenzo, da Silva, Rafaela F., Vuilleumier, Nicolas, Capettini, Luciano, Lenglet, Sébastien, Pagano, Sabrina, Piscitelli, Fabiana, Quintao, Silvia, Bertolotto, Maria, Pelli, Graziano, Galan, Katia, Pilet, Lucie, Kuzmanovic, Kristina, Burger, Fabienne, Pane, Bianca, Spinella, Giovanni, Braunersreuther, Vincent, Gayet-Ageron, Angèle, Pende, Aldo, Viviani, Giorgio Luciano, Palombo, Domenico, Dallegri, Franco, Roux-Lombard, Pascale, Santos, Robson A.S., Stergiopulos, Nikos, Steffens, Sabine, and Mach, François

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results