192 results on '"Paglialunga, Sabina"'
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2. Innovative Approaches to Optimize Clinical Transporter Drug–Drug Interaction Studies.
3. Should You Run a Dedicated TQT Study? Sponsor and Regulatory Considerations on Substitution Pathways to Assess QT Liability.
4. Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events
5. Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24‐Hour Holter Electrocardiogram Recordings
6. Ablating The Rab-GTPase Activating Protein TBC1D1 Predisposes Rats To High Fat Diet-Induced Cardiomyopathy: 2392 Board #56 May 31 9:30 AM - 11:00 AM
7. Rifampin Drug–Drug–Interaction Studies: Reflections on the Nitrosamine Impurities Issue.
8. Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo
9. Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats
10. Rifampin Drug–Drug–Interaction Studies: Reflections on the Nitrosamine Impurities Issue
11. C5L2 receptor disruption enhances the development of diet-induced insulin resistance in mice
12. In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice
13. Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling
14. Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans
15. Intestinally derived lipids: Metabolic regulation and consequences—An overview
16. High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII
17. Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet
18. Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice
19. Acylation-stimulating protein/C5L2-neutralizing antibodies alter triglyceride metabolism in vitro and in vivo
20. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
21. Mitochondrial Function and Protein Expression in C5L2KO Mouse Skeletal Muscle after 10 Weeks of High-Fat Diet Intake
22. Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration
23. Ablating the Rab‐GTPase activating protein TBC1D1 predisposes rats to high‐fat diet‐induced cardiomyopathy
24. Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required
25. The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet–Induced Diabetes
26. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
27. Evaluating cardiac risk: exposure response analysis in early clinical drug development
28. Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives
29. Assay validation and clinical performance of chronic inflammatory and chemokine biomarkers of NASH fibrosis
30. QT Assessment in Early Drug Development: The Long and the Short of It
31. PS3 - 17. Maternal high-fat intake and the effect of imprinting on hepatic mitochondrial function in offspring
32. PS5 - 26. Exposure to a high fat diet during early development increases the susceptibility to cardiac lipid accumulation
33. Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives.
34. Rate of Diabetes in Maricopa County, AZ
35. Cystatin C Is a More Reliable Biomarker for Determining eGFR to Support Drug Development Studies
36. Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects
37. Evaluation of HbA1c screening during outreach events for prediabetes subject recruitment for clinical research
38. Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats
39. PS14 - 70. C5L2- a potential regulator of skeletal muscle lipid accumulation
40. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass
41. Update and trends on pharmacokinetic studies in patients with impaired renal function: practical insight into application of the FDA and EMA guidelines
42. Adding to the spectrum of insulin sensitive populations for mixed meal tolerance test glucose reliability assessment
43. Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring
44. Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease
45. Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion
46. Follow the Yellow Brick Road: The Pathway for NAFLD and NASH Drug Development in Early Phase Clinical Trials
47. Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice
48. Repression of ADP Transport by Palmitoyl‐CoA is Attenuated by Exercise Training in Humans
49. TBC1D1, a Rab‐GTPase Activating Protein, is Critical for Maintaining β‐cell Mass and Glucose Homeostasis
50. Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans
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