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2. May assisted reproductive techniques outcomes impact on overall health parameters in infertile men?

Author

Belladelli, F., primary, Pozzi, E., additional, Corsini, C., additional, Bertini, A., additional, Raffo, M., additional, Negri, F., additional, Ventimiglia, E., additional, Fallara, G., additional, Boeri, L., additional, Capogrosso, P., additional, Dehò, F., additional, d’Arma, A., additional, Pagliardini, L., additional, Papaleo, E., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2024
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4. P-387 Exploring the Potential of Artificial Intelligence in Providing Infertility Consultations and Answers: can it replace the infertility specialist? A hybrid study.

Author

Buzzaccarini, G, primary, Grecchi, G, additional, Papa, G A, additional, Carnemolla, G, additional, Salmeri, N, additional, Villanacci, R, additional, Giardina, P, additional, D'Alessandro, S, additional, Molgora, M, additional, Marzanati, D, additional, Pagliardini, L, additional, Vanni, V S, additional, Alteri, A, additional, Candiani, M, additional, and Papaleo, E, additional

Published
2023
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5. ‘Guess who’? An Italian multicentric study on pigmentation traits prevalence in endometriosis localizations

Author

Salmeri, N., Ottolina, J., Bartiromo, L., Schimberni, M., Dolci, C., Ferrari, S., Villanacci, R., Arena, S., Berlanda, N., Buggio, L., Di Cello, A., Fuggetta, E., Maneschi, F., Massarotti, C., Mattei, A., Perelli, F., Pino, I., Porpora, M.G., Raimondo, D., Remorgida, V., Seracchioli, R., Ticino, A., Viganò, P., Vignali, M., Zullo, F., Zupi, E., Pagliardini, L., and Candiani, M.

Subjects
Eye Color, Endometriosis, Obstetrics and Gynecology, Pigmentation traits, Somatic phenotypes, Ureteral endometriosis, Phenotype, Reproductive Medicine, Prevalence, Humans, Settore MED/40 - Ginecologia e Ostetricia, Female, Retrospective Studies
Abstract

Previous evidence seems to support the more common presence of certain pigmentation types in women with endometriosis. The aim of this study was to assess the association of certain somatic phenotypes with specific localizations of the disease. The genetic makeup of those somatic traits may will help in better define the disease pathogenesis.Multicentric, retrospective study of women aged 18 to 45 with histologically confirmed endometriosis. 575 patients were recruited at eleven different Italian endometriosis clinics from March 2015 to January 2021. Data regarding clinical and surgical features were recorded following the self-administered endometriosis patient questionnaire and the surgical standard of reports approved by the World Endometriosis Research Foundation (WERF). Pigmentation types/somatic phenotypes frequencies among endometriosis localizations were reported. A logistic regression analysis was performed to determine somatic types independently associated with disease' localizations.Having green eyes increased by ∼4 folds (OR 3.7; 95% CI: 1.42-9.61; p = 0.007) the risk of having a ureteral nodule, whereas brown/black eyes decreased this risk (OR 0.34; 95% CI: 0.13-0.87; p = 0.025). Consistently, the combination of green eyes and blonde/light brown hairs increased the odds of ureteral endometriosis by more than 5 folds (OR 5.40; 95%CI: 2.02-14.49; p = 0.001), even after correction for anthropometric confounders (aOR 5.85; 95% CI: 2.13-16.09; p 0.001).The association between endometriosis and pigmentary traits has been herein confirmed, with the novel finding of the possible predisposition of ureteral endometriosis in patients with green eyes and blonde/light brown hairs. Further investigation on the genetic makeup of somatic traits may provide new inroads also into the molecular aspects of endometriosis leading to a better understanding of this complex disease.

Published
2022

7. The impact of different who reference criteria for semen analysis in clinical practice: who will benefit from the new 2021 cutoffs for normal sperm parameters?

Author

Boeri, L., primary, Pozzi, E., additional, Belladelli, F., additional, Fallara, G., additional, Raffo, M., additional, Corsini, C., additional, Candela, L., additional, Costa, A., additional, Cignoli, D., additional, Scihfano, N., additional, D’Arma, A., additional, Capogrosso, P., additional, Ventimiglia, E., additional, Pagliardini, L., additional, Papaleo, E., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2022
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14. The effect of historical CMV infection on sperm parameters in white-European infertile men: Findings from a real-life cross-sectional study

Author

Belladelli, F., primary, Fallara, G., additional, Pozzi, E., additional, Corsini, C., additional, Raffo, M., additional, Candela, L., additional, Costa, A., additional, Cignoli, D., additional, Schifano, N., additional, D'Arma, A., additional, Capogrosso, P., additional, Boeri, L., additional, Ventimiglia, E., additional, Matloob, R., additional, Pagliardini, L., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2022
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15. Low birth weight is associated with sperm dna fragmentation and assisted reproductive technology outcomes in primary infertile men – results of a cross-sectional study

Author

Boeri, L., primary, Belladelli, F., additional, Pozzi, E., additional, Fallara, G., additional, Raffo, M., additional, Corsini, C., additional, Candela, L., additional, Costa, A., additional, Cignoli, D., additional, Schifano, N., additional, D'Arma, A., additional, Capogrosso, P., additional, Ventimiglia, E., additional, Pagliardini, L., additional, Papaleo, E., additional, Mirone, V., additional, Dehó, F., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2022
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17. VP36.01: Impact of high follicular progesterone on birthweight of neonate following frozen‐thawed embryo transfer: a multicentre cross‐sectional study

Author

Quartucci, A., primary, Papaleo, E., additional, Pagliardini, L., additional, Cavoretto, P.I., additional, Campo, G., additional, Dallagiovanna, C., additional, Reschini, M., additional, Viganò, P., additional, Somigliana, E., additional, Blockeel, C., additional, Racca, A., additional, and Vanni, V.S., additional

Published
2021
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27. Endometriosis: seeking optimal management in women approaching menopause

Author

Alio, L., primary, Angioni, S., additional, Arena, S., additional, Bartiromo, L., additional, Bergamini, V., additional, Berlanda, N., additional, Bonanni, V., additional, Bonin, C., additional, Buggio, L., additional, Candiani, M., additional, Centini, G., additional, D'Alterio, M. N., additional, De Stefano, F., additional, Di Cello, A., additional, Exacoustos, C., additional, Fedele, L., additional, Frattaruolo, M. P., additional, Geraci, E., additional, Lavarini, E., additional, Lazzeri, L., additional, Luisi, S., additional, Maiorana, A., additional, Makieva, S., additional, Maneschi, F., additional, Martire, F., additional, Massarotti, C., additional, Mattei, A., additional, Muzii, L., additional, Ottolina, J., additional, Pagliardini, L., additional, Perandini, A., additional, Perelli, F., additional, Pino, I., additional, Porpora, M. G., additional, Remorgida, V., additional, Scagnelli, G., additional, Seracchioli, R., additional, Solima, E., additional, Somigliana, E., additional, Sorrenti, G., additional, Ticino, A., additional, Venturella, R., additional, Viganò, P., additional, Vignali, M., additional, Zullo, F., additional, and Zupi, E., additional

Published
2019
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36. Anti-Mullerian hormone-to-testosterone ratio is predictive of positive sperm retrieval in men with idiopathic non-obstructive azoospermia

Author

Alfano, M., primary, Ventimiglia, E., additional, Locatelli, I., additional, Capogrosso, P., additional, Cazzaniga, W., additional, Pederzoli, F., additional, Frego, N., additional, Matloob, R., additional, Saccà, A., additional, Boeri, L., additional, Pagliardini, L., additional, Viganò, P., additional, Nebuloni, M., additional, Pontillo, M., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2018
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42. Vitamin D status in women with uterine leiomyomas

Author

Paffoni A, Somigliana E, Vigano' P, Benaglia L, Cardellicchio L, Pagliardini L, Papaleo E, Fedele L., CANDIANI , MASSIMO, Paffoni, A, Somigliana, E, Vigano', P, Benaglia, L, Cardellicchio, L, Pagliardini, L, Papaleo, E, Candiani, Massimo, and Fedele, L.

Published
2013

44. An Italian association study and meta-analysis with previous GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibility loci for endometriosis

Author

Pagliardini L, Gentilini D, Vigano’ P, Panina Bordignon P, Busacca M, CANDIANI , MASSIMO, Di Blasio AM, PANINA, PAOLA, Pagliardini, L, Gentilini, D, Vigano’, P, Panina Bordignon, P, Busacca, M, Candiani, Massimo, Di Blasio, Am, and Panina, Paola

Subjects
Oncology, medicine.medical_specialty, Endometriosis, Single-nucleotide polymorphism, Genome-wide association study, Polymorphism, Single Nucleotide, White People, Gene Frequency, Wnt4 Protein, Internal medicine, Genetics, medicine, Odds Ratio, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Genetics (clinical), Alleles, Genetic association, business.industry, Odds ratio, medicine.disease, Fibronectins, Phenotype, Italy, Meta-analysis, Female, RNA, Long Noncoding, business, Genome-Wide Association Study
Abstract

Background Although endometriosis may benefit from primary prevention measures, the epidemiological risk factors identified are equivocal. Two genome-wide association studies (GWAS) have been conducted for endometriosis in two different ethnic populations but results are still to be replicated consistently and across various ethnicities. To confirm the association of GWAS-derived susceptibility loci, we conducted a replication Italian case-control study and a meta-analysis. Methods An independent set of 305 laparoscopically-proven endometriosis patients and 2710 controls were recruited. Four SNPs— CDKN2BAS rs1333049, rs7521902 close to WNT4 , rs12700667 in an inter-genic region on 7p15.2 and fibronectin 1 rs1250248—were selected for this association study. Results Rs1333049 risk allele G frequency resulted significantly higher in endometriosis patients compared with controls (OR 1.32, 95% CI 1.11 to 1.57), confirming the role of this locus also in the Caucasian population. The meta-analysis showed that rs7521902 was associated with endometriosis at a genome-wide significance (pmeta=2.23×10−9) while for rs1250248, a genome-wide significant pmeta value of 3.89×10−9 was detected only in association with severe forms. An epistatic interaction between rs7521902 and rs1250248 (OR 1.56, p=1.19×10−2) was found especially in presence of ovarian disease (OR=2.15, p=3.12×10−4). Conclusions We confirm WNT4 , CDKN2BAS and FN1 as the first identified common loci for endometriosis.

Published
2012

45. Responses to Corticotrophin-Releasing Hormone and Dexamethasone in a Large Series of Human Adrenocorticotrophic Hormone-Secreting Pituitary Adenomas In Vitro Reveal Manifold Corticotroph Tumoural Phenotypes

Author

Pecori Giraldi, F., Pagliardini, L., Cassarino, M. F., Losa, M., Lasio, G., Cavagnini, F., Pecori Giraldi, F., Pagliardini, L., Cassarino, M. F., Losa, M., Lasio, G., and Cavagnini, F.

Subjects
Adenoma, Male, Time Factor, Animal, Corticotropin-Releasing Hormone, Glucocorticoid negative feedback, Endocrinology, Diabetes and Metabolism, Drug Evaluation, Preclinical, Dexamethasone, Endocrine and Autonomic System, ACTH, Tumor Burden, Cellular and Molecular Neuroscience, ACTH-Secreting Pituitary Adenoma, Phenotype, Endocrinology, Adrenocorticotropic Hormone, Retrospective Studie, Tumor Cells, Cultured, Rat, Cushing's disease, Female, Cohort Studie, Corticotrophin-releasing hormone, Human
Abstract

Patients with Cushing's disease are known to present a variable secretory response to stimulatory and inhibitory challenges. Evaluation of the secretory behaviour of pituitary adrenocorticotrophic hormone (ACTH)-secreting adenomas in vitro aids in the comprehension of its behaviour in vivo; however, given the small size of these tumours and the consequent paucity of material available to in vitro studies, a comprehensive study on the secretory behaviour of human corticotroph tumours has not yet been performed. The present study aimed to assess the spectrum of responses to the two main corticotroph modulators, corticotrophin-releasing hormone (CRH) and dexamethasone, in a large series of human ACTH-secreting pituitary tumours. Seventy-two ACTH-secreting pituitary tumours were collected during surgery and established in culture. Specimens were incubated with 10nm CRH and/or 10nm dexamethasone for 4h and 24h. Secretion in unstimulated, control wells was set at 100% and changes in ACTH concentrations by at least 20% were considered as responses. Parallel experiments in 12 rat anterior pituitary primary cultures were evaluated. A marked ACTH increase was observed during incubation with CRH in 70% of tumoural specimens at 4h (range 124-3500% of control wells) and in 57% at 24h (range 122-3323%). Dexamethasone reduced ACTH secretion in almost 50% of tumours (range 78-2% of control at 4h; 76-3% at 24h), whereas it did not affect ACTH medium levels in 30% of specimens and induced a paradoxical ACTH increase in 20% of tumours (range 130-327% of control at 4h; 156-348% at 24h). By comparison, CRH uniformly increased ACTH levels in rat anterior pituitary primary cultures (mean 745±84% at 4h; 347±25% at 24h), whereas dexamethasone decreased ACTH levels by 40-50% in all experiments. In conclusion, the present study of a large series of human ACTH-secreting pituitary tumours in vitro revealed a considerable variability in the responses to CRH and dexamethasone. This finding indicates the existence of multiple corticotroph tumoural phenotypes and may account for the different responses to physiological and pharmacological modulators in vivo. © 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.

Published
2011

48. Female (in)fertility

Author

Saad, H., primary, Khalil, E., additional, Bora, S. A., additional, Parikh, J., additional, Abdalla, H., additional, Thum, M. Y., additional, Bina, V., additional, Roopa, P., additional, Shyamala, S., additional, Anupama, A., additional, Tournaye, H., additional, Polyzos, N. P., additional, Guzman, L., additional, Nelson, S. M., additional, Lourenco, B., additional, Sousa, A. P., additional, Almeida-Santos, T., additional, Ramalho-Santos, J., additional, Okhowat, J., additional, Wirleitner, B., additional, Neyer, T., additional, Bach, M., additional, Murtinger, M., additional, Zech, N. H., additional, Nwoye, M., additional, Corona, R., additional, Blockeel, C., additional, Stoop, D., additional, Camus, M., additional, Rajikin, M. H., additional, Kamsani, Y. S., additional, Chatterjee, A., additional, Nor-Ashikin, M. N. K., additional, Nuraliza, A. S., additional, Scaravelli, G., additional, D'Aloja, P., additional, Bolli, S., additional, De Luca, R., additional, Spoletini, R., additional, Fiaccavento, S., additional, Speziale, L., additional, Vigiliano, V., additional, Farquhar, C., additional, Brown, J., additional, Arroll, N., additional, Gupta, D., additional, Boothroyd, C., additional, Al Bassam, M., additional, Moir, J., additional, Johnson, N., additional, Pantasri, T., additional, Robker, R. L., additional, Wu, L. L., additional, Norman, R. J., additional, Buzaglo, K., additional, Velez, M., additional, Shaulov, T., additional, Sylvestre, C., additional, Kadoch, I. J., additional, Krog, M., additional, Prior, M., additional, Carlsen, E., additional, Loft, A., additional, Pinborg, A., additional, Andersen, A. N., additional, Dolleman, M., additional, Verschuren, W. M. M., additional, Eijkemans, M. J. C., additional, Dolle, M. E. T., additional, Jansen, E. H. J. M., additional, Broekmans, F. J. M., additional, Van der Schouw, Y. T., additional, Fainaru, O., additional, Pencovich, N., additional, Hantisteanu, S., additional, Barzilay, I., additional, Ellenbogen, A., additional, Hallak, M., additional, Cavagna, M., additional, Baruffi, R. L. R., additional, Petersen, C. G., additional, Mauri, A. L., additional, Massaro, F. C., additional, Ricci, J., additional, Nascimento, A. M., additional, Vagnini, L. D., additional, Pontes, A., additional, Oliveira, J. B. A., additional, Franco, J. G., additional, Canas, M. C. T., additional, Nicoletti, A., additional, Martins, A. M. V. C., additional, Lichtblau, I., additional, Olivennes, F., additional, Aubriot, F. A., additional, Junca, A. M., additional, Belloc, S., additional, Cohen-Bacrie, M., additional, Cohen-Bacrie, P., additional, de Mouzon, J., additional, Nandy, T., additional, Caragia, A., additional, Balestrini, S., additional, Zosmer, A., additional, Sabatini, L., additional, Al-Shawaf, T., additional, Seshadri, S., additional, Khalaf, Y., additional, Sunkara, S. K., additional, Joy, J., additional, Lambe, M., additional, Lutton, D., additional, Nicopoullos, J., additional, Faris, R., additional, Behre, H. M., additional, Howles, C. M., additional, Longobardi, S., additional, Chimote, N., additional, Mehta, B., additional, Nath, N., additional, Chimote, N. M., additional, Mine, K., additional, Yoshida, A., additional, Yonezawa, M., additional, Ono, S., additional, Abe, T., additional, Ichikawa, T., additional, Tomiyama, R., additional, Nishi, Y., additional, Kuwabara, Y., additional, Akira, S., additional, Takeshita, T., additional, Shin, H., additional, Song, H. S., additional, Lim, H. J., additional, Hauzman, E., additional, Kohls, G., additional, Barrio, A., additional, Martinez-Salazar, J., additional, Iglesias, C., additional, Velasco, J. A. G., additional, Tejada, M. I., additional, Maortua, H., additional, Mendoza, R., additional, Prieto, B., additional, Martinez-Bouzas, C., additional, Diez-Zapirain, M., additional, Martinez-Zilloniz, N., additional, Matorras, R., additional, Amaro, A., additional, Bianco, B., additional, Christofolini, J., additional, Mafra, F. A., additional, Barbosa, C. P., additional, Christofolini, D. M., additional, Pesce, R., additional, Gogorza, S., additional, Ochoa, C., additional, Gil, S., additional, Saavedra, A., additional, Ciarmatori, S., additional, Perman, G., additional, Pagliardini, L., additional, Papaleo, E., additional, Corti, L., additional, Vanni, V. S., additional, Ottolina, J., additional, de Michele, F., additional, Marca, A. L., additional, Vigano, P., additional, Candiani, M., additional, Li, L., additional, Yin, Q., additional, Huang, L., additional, Huang, J., additional, He, Z., additional, Yang, D., additional, Tiplady, S., additional, Ledger, W., additional, Godbert, S., additional, Hart, S., additional, Johnson, S., additional, Wong, A. W. Y., additional, Kong, G. W. S., additional, Haines, C. J., additional, Franik, S., additional, Nelen, W., additional, Kremer, J., additional, Gillett, W. R., additional, Lamont, J. M., additional, Peek, J. C., additional, Herbison, G. P., additional, Sung, N. Y., additional, Hwang, Y. I., additional, Choi, M. H., additional, Song, I. O., additional, Kang, I. S., additional, Koong, M. K., additional, Lee, J. S., additional, Yang, K. M., additional, Celtemen, M. B., additional, Telli, P., additional, Karakaya, C., additional, Bozkurt, N., additional, Gursoy, R. H., additional, Younis, J. S., additional, Ben-Ami, M., additional, Pundir, J., additional, Pundir, V., additional, Omanwa, K., additional, and El-Toukhy, T., additional

Published
2013
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