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12 results on '"Pahapale, Gayatri"'

3. Shell microelectrode arrays (MEAs) for brain organoids

Author

Huang, Qi, primary, Tang, Bohao, additional, Romero, July Carolina, additional, Yang, Yuqian, additional, Elsayed, Saifeldeen Khalil, additional, Pahapale, Gayatri, additional, Lee, Tien-Jung, additional, Morales Pantoja, Itzy E., additional, Han, Fang, additional, Berlinicke, Cynthia, additional, Xiang, Terry, additional, Solazzo, Mallory, additional, Hartung, Thomas, additional, Qin, Zhao, additional, Caffo, Brian S., additional, Smirnova, Lena, additional, and Gracias, David H., additional

Published
2022
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7. Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo

Author

Ghosh, Arijit, primary, Li, Ling, additional, Xu, Liyi, additional, Dash, Ranjeet P., additional, Gupta, Neha, additional, Lam, Jenny, additional, Jin, Qianru, additional, Akshintala, Venkata, additional, Pahapale, Gayatri, additional, Liu, Wangqu, additional, Sarkar, Anjishnu, additional, Rais, Rana, additional, Gracias, David H., additional, and Selaru, Florin M., additional

Published
2020
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8. Multicomponent DNA Polymerization Motor Gels

Author

Shi, Ruohong, primary, Fern, Joshua, additional, Xu, Weinan, additional, Jia, Sisi, additional, Huang, Qi, additional, Pahapale, Gayatri, additional, Schulman, Rebecca, additional, and Gracias, David H., additional

Published
2020
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11. Shell microelectrode arrays (MEAs) for brain organoids.

Author

Qi Huang, Bohao Tang, Romero, July Carolina, Yuqian Yang, Elsayed, Saifeldeen Khalil, Pahapale, Gayatri, Tien-Jung Lee, Pantoja, Itzy E. Morales, Fang Han, Berlinicke, Cynthia, Terry Xiang, Solazzo, Mallory, Hartung, Thomas, Zhao Qin, Caffo, Brian S., Smirnova, Lena, and Gracias, David H.

Subjects
*BIOELECTRONICS, *SEASHELLS, *BIVALVE shells, *GLIAL cell line-derived neurotrophic factor
Abstract

The article discusses research on the development of a shell multielectrode array (MEA) platform for brain organoid recording. Topics explored include the wafer-scale microfabrication process developed to produce shell MEA, the use of human induced pluripotent stem cells to generate brain organoids tested in the study, and the finite element method (FEM) simulation of the programmable folding of three-dimensional (3D) MEA.

Published
2022
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12. Toward single cell tattoos: Biotransfer printing of lithographic gold nanopatterns on live cells.

Author

Kwok KS, Zuo Y, Choi SJ, Pahapale GJ, Gu L, and Gracias DH

Abstract

Lithographic nanopatterning techniques like photolithography, electron-beam lithography, and nanoimprint lithography (NIL) have revolutionized modern-day electronics and optics. Yet, their application for creating nano-bio interfaces is limited by the cytotoxic and two-dimensional nature of conventional fabrication methods. Here, we present a biocompatible and cost-effective transfer process that leverages (a) NIL to define sub-300 nm gold (Au) nanopattern arrays, (b) amine functionalization of Au to transfer the NIL-arrays from a rigid substrate to a soft transfer layer, (c) alginate hydrogel as a flexible, degradable transfer layer, and (d) gelatin conjugation of the Au NIL-arrays to achieve conformal contact with live cells. We demonstrate biotransfer printing of the Au NIL-arrays on rat brains and live cells with high pattern fidelity and cell viability and observed differences in cell migration on the Au NIL-dot and NIL-wire printed hydrogels. We anticipate that this nanolithography-compatible biotransfer printing method could advance bionics, biosensing, and biohybrid tissue interfaces.

Published
2023
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