1. Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A report of two cases.
- Author
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Mendes Correa MC, Leal FE, Villas Boas LS, Witkin SS, de Paula A, Tozetto Mendonza TR, Ferreira NE, Curty G, de Carvalho PS, Buss LF, Costa SF, da Cunha Carvalho FM, Kawakami J, Taniwaki NN, Paiao H, da Silva Bizário JC, de Jesus JG, Sabino EC, Romano CM, Grepan RMZ, and Sesso A
- Subjects
- Animals, Chlorocebus aethiops, Female, Humans, Middle Aged, SARS-CoV-2 pathogenicity, Vero Cells ultrastructure, Vero Cells virology, Viral Load, Virus Shedding, COVID-19 immunology, COVID-19 virology, SARS-CoV-2 growth & development, Virus Cultivation
- Abstract
It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of 20 days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset., (© 2021 Wiley Periodicals LLC.)
- Published
- 2021
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