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5. Commissioning experience and beam physics measurements at the SwissFEL Injector Test Facility

Author

Schietinger, T., Pedrozzi, M., Aiba, M., Arsov, V., Bettoni, S., Beutner, B., Calvi, M., Craievich, P., Dehler, M., Frei, F., Ganter, R., Hauri, C. P., Ischebeck, R., Ivanisenko, Y., Janousch, M., Kaiser, M., Keil, B., Löhl, F., Orlandi, G. L., Loch, C. Ozkan, Peier, P., Prat, E., Raguin, J. -Y., Reiche, S., Schilcher, T., Wiegand, P., Zimoch, E., Anicic, D., Armstrong, D., Baldinger, M., Baldinger, R., Bertrand, A., Bitterli, K., Bopp, M., Brands, H., Braun, H. H., Brönnimann, M., Brunnenkant, I., Chevtsov, P., Chrin, J., Citterio, A., Divall, M. Csatari, Dach, M., Dax, A., Ditter, R., Divall, E., Falone, A., Fitze, H., Geiselhart, C., Guetg, M. W., Hämmerli, F., Hauff, A., Heiniger, M., Higgs, C., Hugentobler, W., Hunziker, S., Janser, G., Kalantari, B., Kalt, R., Kim, Y., Koprek, W., Korhonen, T., Krempaska, R., Laznovsky, M., Lehner, S., Pimpec, F. Le, Lippuner, T., Lutz, H., Mair, S., Marcellini, F., Marinkovic, G., Menzel, R., Milas, N., Pal, T., Pollet, P., Portmann, W., Rezaeizadeh, A., Ritt, S., Rohrer, M., Schär, M., Schebacher, L., Scherrer, St., Schmidt, V. Schlott T., Schulz, L., Smit, B., Stadler, M., Steffen, B., Stingelin, L., Sturzenegger, W., Treyer, D. M., Trisorio, A., Tron, W., Vicario, C., Zennaro, R., and Zimoch, D.

Subjects
Physics - Accelerator Physics
Abstract

The SwissFEL Injector Test Facility operated at the Paul Scherrer Institute between 2010 and 2014, serving as a pilot plant and testbed for the development and realization of SwissFEL, the X-ray Free-Electron Laser facility under construction at the same institute. The test facility consisted of a laser-driven rf electron gun followed by an S-band booster linac, a magnetic bunch compression chicane and a diagnostic section including a transverse deflecting rf cavity. It delivered electron bunches of up to 200 pC charge and up to 250 MeV beam energy at a repetition rate of 10 Hz. The measurements performed at the test facility not only demonstrated the beam parameters required to drive the first stage of an FEL facility, but also led to significant advances in instrumentation technologies, beam characterization methods and the generation, transport and compression of ultra-low-emittance beams. We give a comprehensive overview of the commissioning experience of the principal subsystems and the beam physics measurements performed during the operation of the test facility, including the results of the test of an in-vacuum undulator prototype generating radiation in the vacuum ultraviolet and optical range., Comment: 60 pages, 70 figures; final version as published, except with table of contents and Fig. 68 in full resolution

Published
2016
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11. Effect of LO Phase Noise on Front-end Receiver Performance

Author

Kumar, Manish, Pal, T. K., Prasad, B. S. V., Arun Kumar, G., Bhanja, Sukhendu, Majumder, Arijit, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Bera, Rabindranath, editor, Sarkar, Subir Kumar, editor, and Chakraborty, Swastika, editor

Published
2018
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34. Oral Health Perception Regarding First Dental Visit of In-vitro Fertilised Children: Exploring New Horizons.

Author

Kar, Sudipta, Zahir, Shabnam, Kumar Lahiri, Pratik, Datta, Piyali, Banerjee, Ishita, Pal, T. K., Seal, S. L., and Kumar Kundu, Gautam

Subjects
ORAL health, DENTAL care utilization, HEALTH behavior, REPRODUCTIVE health
Abstract

Introduction: Difficulty in conceiving is a widespread problem. World Health Organisation (WHO) classifies infertility as a disease which deserves treatment as like any other medical condition. Invitro Fertilisation-Embryo Transfer (IVF-ET) is the fertilisation of an ovum outside the body and the transfer of the fertilised ovum to the uterus of a woman, is one of the popular treatment modalities of infertility. Aim: To evaluate the relationship between oral health behaviour of IVF children and spontaneously conceived children. Materials and Methods: A random sample of 107 IVF childrenwere and 169 spontaneously conceived children were included in this cross sectional observational study conducted at The Institute of Reproductive Medicine (IRM) Kolkata, West Bengal, India; Guru Nanak Institute of Dental Sciences & Research (GNIDSR), Kolkata, West Bengal, India and various educational institutions which are situated in West Bengal during June 2018 to 2020. Oral health behaviour of both groups was analysed with suitable statistical analysis i.e. Chi-square test. Statistical software Statistical Package for the Social Sciences (SPSS) version 20.0 (SPSS Inc, Chicago, IL, USA) was used for the analysis. The statistical significance level for all applied tests was set to be 0.05. Results: Statistically significant oral health behaviour pattern was observed between oral health behaviour of the IVF and spontaneously conceived children. The result was found to be significant at p<0.05. Conclusion: This study may invite further scope for more cross sectional and longitudinal study for the researcher. Hopefully this kind of study will bring positive assurance to numerous parents of IVF children. [ABSTRACT FROM AUTHOR]

Published
2024

48. Breast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers

Author

Stjepanovic N., Lubinski J., Moller P., Randall Armel S., Foulkes W. D., Tung N., Neuhausen S. L., Kotsopoulos J., Sun P., Sun S., Eisen A., Narod S. A., Senter L., Couch C. E. F., Fruscio R., Weitzel J. N., Olopade O., Singer C. F., Pal T., Huzarski T., Cybulski C., Sweet K., Zakalik D., Wood M., McKinnon W., Elser C., Wiesner G., Friedman E., Meschino W., Snyder C., Metcalfe K., Poll A., Warner E., Kim R., Demsky R., Ainsworth P., Steele L., Saal H., Serfas K., Panchal S., Cullinane C. A., Reilly R. E., Blum J. L., Kwong A., Rayson D., Cajal T. R., Dungan J., Yerushalmi R., Ginsburg O., Schraeder I., Cohen S., LemireLemire E., Zovato S., Rastelli A., Gronwald J., McCuaig J., Karlan B., Bordeleau L., Stjepanovic, N, Lubinski, J, Moller, P, Randall Armel, S, Foulkes, W, Tung, N, Neuhausen, S, Kotsopoulos, J, Sun, P, Sun, S, Eisen, A, Narod, S, Senter, L, Couch, C, Fruscio, R, Weitzel, J, Olopade, O, Singer, C, Pal, T, Huzarski, T, Cybulski, C, Sweet, K, Zakalik, D, Wood, M, Mckinnon, W, Elser, C, Wiesner, G, Friedman, E, Meschino, W, Snyder, C, Metcalfe, K, Poll, A, Warner, E, Kim, R, Demsky, R, Ainsworth, P, Steele, L, Saal, H, Serfas, K, Panchal, S, Cullinane, C, Reilly, R, Blum, J, Kwong, A, Rayson, D, Cajal, T, Dungan, J, Yerushalmi, R, Ginsburg, O, Schraeder, I, Cohen, S, Lemirelemire, E, Zovato, S, Rastelli, A, Gronwald, J, Mccuaig, J, Karlan, B, and Bordeleau, L

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Heterozygote, medicine.medical_treatment, Ovariectomy, Genes, BRCA2, Genes, BRCA1, Breast Neoplasms, 03 medical and health sciences, Breast cancer screening, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Humans, Cumulative incidence, Genetic Predisposition to Disease, Prospective Studies, skin and connective tissue diseases, Prospective cohort study, Mastectomy, Aged, Aged, 80 and over, BRCA2 Protein, medicine.diagnostic_test, business.industry, BRCA1 Protein, Incidence, Oophorectomy, Cancer, Hormone replacement therapy (menopause), Middle Aged, BRCA1, medicine.disease, BRCA2, Prophylactic Surgery, 3. Good health, Prospective, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, Female, business
Abstract

Purpose: It is not known whether the risk of breast cancer among BRCA1 and BRCA2 mutation carriers after age 60 is high enough to justify intensive screening or prophylactic surgery. Thus, we conducted a prospective analysis of breast cancer risk in BRCA1 and BRCA2 mutation carriers from age 60 until age 80. Methods: Subjects had no history of cancer and both breasts intact at age 60 (n = 699). Women were followed until a breast cancer diagnosis, prophylactic bilateral mastectomy or death. We calculated the annual cancer rate and cumulative incidence of breast cancer (invasive and in situ) from age 60 to age 80. We assessed the associations between hormone replacement therapy, family history of breast cancer and bilateral oophorectomy and breast cancer risk. Results: Over a mean follow-up of 7.9years, 61 invasive and 20 in situ breast cancers were diagnosed in the cohort. The mean annual rate of invasive breast cancer was 1.8% for BRCA1 mutation carriers and 1.7% for BRCA2 mutation carriers. The cumulative risk of invasive breast cancer from age 60 to 80 was 20.1% for women with a BRCA1 mutation and was 17.3% for women with a BRCA2 mutation. Hormone replacement therapy, family history and oophorectomy were not associated with breast cancer risk. Conclusions: Findings from this large prospective study indicate that the risk of developing breast cancer remains high after age 60 in both BRCA1 and BRCA2 mutation carriers. These findings warrant further evaluation of the role of breast cancer screening in older mutation carriers.

Published
2020

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