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45 results on '"Paladini, A.C."'

3. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam

Author

Fernandez, S.P., Wasowski, C., and Paladini, A.C.

Subjects
Research, Drug synergism -- Research, Valeriana -- Research, Antianxiety agents -- Research, Flavonoids -- Research, Hesperidin -- Research, Diazepam -- Research, Bioflavonoids -- Research, Flavones -- Research
Abstract

Fernandez SP, Wasowski C, Paladini AC, Marder M. Eur J Pharmacol 2005;512:189-198. It has been recently reported the presence in Valeriana of the flavone 6-methylapigenin and the flavanone glycoside hesperidin. [...]

Published
2005

13. Isolation, Characterization and C-Terminal Sequence of Ovine Growth Hormone.

Author

Dellacha, J.M., Enero, M.A., Santomé, J.A., and Paladini, A.C.

Subjects
SOMATOTROPIN, SHEEP, PEPTIDES, PITUITARY gland, CHROMATOGRAPHIC analysis, BIOCHEMISTRY
Abstract

1. A procedure is described for the isolation of ovine growth hormone which involves: extraction of frozen pituitaries with borate buffer at pH 8.4, fractionation by ammonium sulphate precipitation and chromatography on DEAE cellulose. This is followed by removal of various impurities by isoelectric precipitation and by the addition of ethanol. The last step consists in a gel-filtration through a column of Sephadex G-100. 2. The protein obtained is homogeneous judged by free electrophoresis, ultracentrifugation, analytical dialysis and C-terminal amino acid analysis; only polyacrylamide gel electrophoresis reveals two minor components accompanying a major anionic band. It has an isoelectric pH of 6.3 and a weight average molecular weight of 20300. 3. The comparison of the amino acid compositions and of the tryptic peptide maps of ovine and bovine growth hormones indicates great homology between these two proteins. The C-terminal amino acid sequence in ovine growth hormone is as follows: (Phe,Glu,Gly)-AlaSer-Cys-Ala-Phe-OH. [ABSTRACT FROM AUTHOR]

Published
1970
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14. Sedative and hypnotic properties of Salvia guaraniticaSt. Hil. and of its active principle, Cirsiliol

Author

Viola, H., Wasowski, C., Marder, M., Wolfman, C., Paladini, A.C., and Medina, J.H.

Abstract

Salvia guaraniticaSt. Hil. is a traditional medicinal plant used in Latin America as sedative. We have recently demonstrated the presence of cirsiliol in its extracts and found that this flavonoid is a competitive low affinity benzodiazepine receptor ligand (Marder et al., 1996). This report describes the pharmacological properties of Salvia guaraniticaextracts and of its active principle, cirsiliol. A partially purified fraction of this plant, administered intraperitoneally in mice (in a dose equivalent to 3 g of the fresh plant), exhibited sedative and hypnotic effects as measured in the hole board and in the pentobarbital-induced sleep tests, respectively. On the other hand, this fraction had no anxiolytic or myorelaxant effects. In the pentobarbital-induced sleep test, cirsiliol (2–10mg/kg, i. p.) exhibited a dose-dependent hypnotic action. In contrast, it did not produce myorelaxant (up to 30mg/kg) or anticonvulsant (up to 10mg/kg) effects. Cirsiliol was found to be more potent in displacing 3H Zolpidem binding (Ki= 20 LiM) than 3H flunitrazepam binding (Ki= 200 μM) to benzodiazepine receptors from rat cerebral cortex.

Published
1997
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27. The amino acid sequence of bovine growth hormone

Author

Santomé, J.A., primary, Dellacha, J.M., additional, Paladini, A.C., additional, Wolfenstein, C.E.M., additional, Peña, C., additional, Poskus, E., additional, Daurat, S.T., additional, Biscoglio, M.J., additional, de Sesé, Z.M.M., additional, and de Sangüesa, A.V.F., additional

Published
1971
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