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6 results on '"Palic, I."'

1. In Vitro Screening of α-Amylase Inhibition by Selected Terpenes from Essential Oils

Author

Jelenkovic, L, Jovanovic, VS, Palic, I, Mitic, V, and Radulovic, M

Subjects
á-Amylase, â-Pinene, Citral, Diabetes, Essential oil, Eugenol, Eukalyptol, Myrcene, Terpenes, Terpineol
Abstract

Purpose: To assess some terpenes from herbal products for possible inhibitory effects on serum α- amylase in order to ascertain their potential usefulness in the prevention and/or treatment of diabetes Type 2.Methods: Solutions of terpenes (citral, eukalyptol, β-pinene, myrcene, eugenol and terpineol) in deonized water were prepared by ultrasonic and manual mixing in four different concentrations ranging from 0.39 – 5.50 µmol cm-3. Commercial sera (with normal-N and high-H enzyme activity) were used as a source of α-amylase. α-Amylase activity was determined by standard methods using an automated analyzer.Results: All the selected terpenes at their maximal concentrations inhibited α-amylase in N-sera in the range 9.68 – 38.70 and 10.71 - 25.00 % for ultrasonic and manual mixing, respectively, while in H-sera, inhibition was in the range 17.10 - 21.05 and 13.58 – 25.92 % for ultrasonic and manual mixing, respectively. Regardless of the concentration of the inhibitor or the method of mixing, citral was the strongest inhibitor of α-amylase.Conclusion: The selected terpenes, in their appropriate concentrations, influence α-amylase activity to varying degrees. Principal component and agglomerative hierarchical analysis reveal that the most significant factor in α-amylase inhibition is the mode of mixing the samples, rather than their concentrations.Keywords: α-Amylase, β-Pinene, Citral, Diabetes, Essential oil, Eugenol, Eukalyptol, Myrcene, Terpenes, Terpineol

Published
2014

2. EXAMINATION OF THE DECREASE IN ACTIVITY OF CLINICALLY SIGNIFICANT ENZYMES IN COMMERCIAL SERUM CAUSED BY TERPENES in vitro.

Author

JELENKOVIC, L. J., STANKOV-JOVANOVIC, V., PALIC, I., MITIC, V., JEVTOVIC-STOIMENOV, T., and RADULOVIC, M.

Subjects
TERPENES synthesis, ESSENTIAL oils, ALKALINE phosphatase, BOTANICAL chemistry, SERUM
Abstract

Essential oils of many plants are widely used with a bias to have only positive effects on the body. Considering that terpenes are dominant ingredients of many essential oils, the influences of selected terpenes (geraniol, nerol, linalool, carvacrol) on the activities of the most important enzymes in clinical practice (creatine kinase, lactate dehydrogenase, amylase, alkaline phosphatase, gamma-glutamyltransferase, aspartate aminotransferase and alanine aminotransferase) are examined in this study. The survey was conducted in vitro with solutions of terpenes at concentrations in the range of 1.82-4.63 mmol/l and in commercial control human serum. Activities are measured by the standard clinical biochemical procedures. A decrease in activity of the enzyme to varying degrees was noted and it was ranged from 1/6 to slightly less than half of the enzyme activity, depending on the type of terpenes, the concentration of their solution, as well as the type of enzyme. The best inhibitor, in the described in vitro conditions, proved to be linalool (lavender), carvacrol (basil, oregano), geraniol (geranium) and the last nerol (orange). The results of this study confirm the initial hypothesis that the terpenes are, undoubtedly, those components of the essential oils that lead to significant inhibition of the clinical enzymes. [ABSTRACT FROM AUTHOR]

Published
2016

4. Chemical composition of the essential oil of micromeria albanica (Griseb. ex K. Maly) Silic

Author

Stojanovic, G, Palic, I, Ursic-Jankovic, J, Vajs, Vlatka, Đoković, Dejan, Stojanovic, G, Palic, I, Ursic-Jankovic, J, Vajs, Vlatka, and Đoković, Dejan

Abstract

The composition of the essential oil of the Balkan peninsula endemic plant Micromeria albanica (Griseb. ex. K. Maly) Silic was analyzed for the first time by GC and GC/MS. The oil, which was present in 0.9% (v/w) yield, was found to contain piperitenone oxide (44.0%) as the major constituent. © 1999, Taylor & Francis Group, LLC. All rights reserved.

Published
1999

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