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3. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M.M., Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W.V., and Duijts, Liesbeth

Published
2014
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4. Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis

Author

Gascon, Mireia, Sunyer, Jordi, Casas, Maribel, Martínez, David, Ballester, Ferran, Basterechea, Mikel, Bonde, Jens Peter, Chatzi, Leda, Chevrier, Cécile, Eggesbø, Merete, Esplugues, Ana, Govarts, Eva, Hannu, Kiviranta, Ibarluzea, Jesús, Kasper-Sonnenberg, Monika, Klümper, Claudia, Koppen, Gudrun, Nieuwenhuijsen, Mark J., Palkovicova, Lubica, Pelé, Fabienne, Polder, Anuschka, Schoeters, Greet, Torrent, Maties, Trnovec, Tomas, Vassilaki, Maria, and Vrijheid, Martine

Published
2014

6. Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts

Author

OBELIX/ENRIECO, Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferran, Bloemen, Karolien, de Boer, Michiel, Chevrier, Cécile, Eggesbø, Merete, Guxens, Mònica, Krämer, Ursula, Legler, Juliette, Martínez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Rémy, Stigum, Hein, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stéphanie, Weihe, Pál, Kuperus, Nynke Weisglas, Wilhelm, Michael, Wittsiepe, Jürgen, and Bonde, Jens Peter

Published
2012

8. Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies

Author

Verner, Marc-Andre, Sonneborn, Dean, Lancz, Kinga, Muckle, Gina, Ayotte, Pierre, Dewailly, Eric, Kocan, Anton, Palkovicova, Lubica, Trnovec, Tomas, Haddad, Sami, Hertz-Picciotto, Irva, and Eggesbo, Merete

Subjects
Persistent organic pollutants -- Research -- Health aspects, Children -- Health aspects, Epidemiology -- Research, Disease susceptibility -- Research, Environmental issues, Health
Abstract

BACKGROUND: Despite experimental evidence that lactational exposure to persistent organic pollutants (POPs) can impact health, results from epidemiologic studies are inconclusive. Inconsistency across studies may reflect the inability of current [...]

Published
2013

9. Birth weight and prenatal exposure to polychiorinated biphenyls (PCBS) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts

Author

Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferran, Bloemen, Karolien, Boer, Michiel de, Chevrier, Cecile, Eggesbo, Merete, Guxens, Monica, Kramer, Ursula, Legler, Juliette, Martinez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Remy, Stigum, Hein, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stephanie, Weihe, Pal, Kuperus, Nynke Weisgias, Wilhelm, Michael, Wittsiepe, Jurgen, and Bonde, Jens Peter

Subjects
Birth weight, Low -- Risk factors -- Research, Polychlorinated biphenyls -- Health aspects -- Environmental aspects -- Research, Pregnant women -- Health aspects, DDT (Insecticide) -- Health aspects -- Environmental aspects -- Research, Environmental issues, Health
Abstract

OBJECTIVES: Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contrasts and appropriate exposure [...]

Published
2012

14. Health impact assessment of waste management facilities in three European countries

Author

Preiss Philipp, Porta Daniela, Palkovicova Lubica, Mitis Francesco, Martuzzi Marco, von Kraus Martin K, de Hoogh Kees, Badaloni Chiara, Forastiere Francesco, Ranzi Andrea, Perucci Carlo A, and Briggs David

Subjects
Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Policies on waste disposal in Europe are heterogeneous and rapidly changing, with potential health implications that are largely unknown. We conducted a health impact assessment of landfilling and incineration in three European countries: Italy, Slovakia and England. Methods A total of 49 (Italy), 2 (Slovakia), and 11 (England) incinerators were operating in 2001 while for landfills the figures were 619, 121 and 232, respectively. The study population consisted of residents living within 3 km of an incinerator and 2 km of a landfill. Excess risk estimates from epidemiological studies were used, combined with air pollution dispersion modelling for particulate matter (PM10) and nitrogen dioxide (NO2). For incinerators, we estimated attributable cancer incidence and years of life lost (YoLL), while for landfills we estimated attributable cases of congenital anomalies and low birth weight infants. Results About 1,000,000, 16,000, and 1,200,000 subjects lived close to incinerators in Italy, Slovakia and England, respectively. The additional contribution to NO2 levels within a 3 km radius was 0.23, 0.15, and 0.14 μg/m3, respectively. Lower values were found for PM10. Assuming that the incinerators continue to operate until 2020, we are moderately confident that the annual number of cancer cases due to exposure in 2001-2020 will reach 11, 0, and 7 in 2020 and then decline to 0 in the three countries in 2050. We are moderately confident that by 2050, the attributable impact on the 2001 cohort of residents will be 3,621 (Italy), 37 (Slovakia) and 3,966 (England) YoLL. The total exposed population to landfills was 1,350,000, 329,000, and 1,425,000 subjects, respectively. We are moderately confident that the annual additional cases of congenital anomalies up to 2030 will be approximately 2, 2, and 3 whereas there will be 42, 13, and 59 additional low-birth weight newborns, respectively. Conclusions The current health impacts of landfilling and incineration can be characterized as moderate when compared to other sources of environmental pollution, e.g. traffic or industrial emissions, that have an impact on public health. There are several uncertainties and critical assumptions in the assessment model, but it provides insight into the relative health impact attributable to waste management.

Published
2011
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15. Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on two thyroid outcomes

Author

Trnovec, Tomas, Jusko, Todd A., Sovcikova, Eva, Lancz, Kinga, Chovancova, Jana, Patayova, Henrieta, Palkovicova, Lubica, Drobna, Beata, Langer, Pavel, Van den Berg, Martin, Dedik, Ladislav, and Wimmerova, Sonna

Subjects
United States. Environmental Protection Agency, Thyroid diseases -- Research -- Diagnosis, Polychlorinated biphenyls -- Research -- Usage, Environmental issues, Health, World Health Organization
Abstract

Background: Toxic equivalency factors (TEFs) are an important component in the risk assessment of dioxin-like human exposures. At present, this concept is based mainly on in vivo animal experiments using oral dosage. Consequently, the current human TEFs derived from mammalian experiments are applicable only for exposure situations in which oral ingestion occurs. Nevertheless, these 'intake' TEFs are commonly--but incorrectly--used by regulatory authorities to calculate 'systemic' toxic equivalents (TEQs) based on human blood and tissue concentrations, which are used as biomarkers for either exposure or effect. Objectives: We sought to determine relative effect potencies (REPs) for systemic human concentrations of dioxin-like mixture components using thyroid volume or serum free thyroxine (FT4) concentration as the outcomes of interest. Methods: We used a benchmark concentration and a regression-based approach to compare the strength of association between each dioxin-like compound and the thyroid end points in 320 adults residing in an organochlorine-polluted area of eastern Slovakia. Results: REPs calculated from thyroid volume and [FT.sub.4] were similar. The regression coefficient (β)-derived REP data from thyroid volume and [FT.sub.4] level were correlated with the World Health Organization (WHO) TEF values (Spearman r = 0.69, p = 0.01 and r = 0.62, p = 0.03, respectively). The calculated REPs were mostly within the minimum and maximum values for in vivo REPs derived by other investigators. Conclusions: Our REPs calculated from thyroid end points realistically reflect human exposure scenarios because they are based on chronic, low-dose human exposures and on biomarkers reflecting body burden. Compared with previous results, our REPs suggest higher sensitivity to the effects of dioxin-like compounds. Key words: dioxin-like polychlorinated biphenyl (DL-PCB), free thyroxine ([FT.sub.4]), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzo-p-furans (PCDFs), relative effect potency (REP), thyroid volume, toxic equivalency factor (TEF). Environ Health Perspect 121:886-892 (2013). http://dx.doi.org/10.1289/ehp.1205739 [Online 10 May 2013], Introduction Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs, furans), and polychlorinated biphenyls (PCBs) are ubiquitous environmental compounds. PCDDs and PCDFs are combustion or industrial by-products with no commercial use, whereas [...]

Published
2013
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16. Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals: analysis of three European mother-child cohorts

Author

de Cock, Marijke, de Boer, Michiel R, Govarts, Eva, Iszatt, Nina, Palkovicova, Lubica, Lamoree, Marja H, Schoeters, Greet, Eggesbø, Merete, Trnovec, Tomas, Legler, Juliette, van de Bor, Margot, de Cock, Marijke, de Boer, Michiel R, Govarts, Eva, Iszatt, Nina, Palkovicova, Lubica, Lamoree, Marja H, Schoeters, Greet, Eggesbø, Merete, Trnovec, Tomas, Legler, Juliette, and van de Bor, Margot

Abstract

BACKGROUND: Various studies report interactions between thyroid hormones and early life chemical exposure. Our objective was to analyse associations between markers of endocrine disrupting chemical exposure and thyroid function in newborns, determined in heel prick blood spots.METHODS: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1784) were pooled for the purpose of this study. Data on Thyroid Stimulating Hormone (TSH) was obtained from national neonatal screening registries, and cord plasma and/or breast milk was collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.RESULTS: Median TSH concentrations were 1.00, 1.10, and 2.76 mU/l, for the Belgian, Norwegian, and the Slovak cohort, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p'-DDE), children in the third exposure quartiles had a 12 - 15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.CONCLUSION: Early life exposure to PCB-153, and p,p'-DDE was associated with newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.

Published
2017
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17. Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: analysis of three European mother–child cohorts

Author

de Cock, Marijke, primary, de Boer, Michiel R, additional, Govarts, Eva, additional, Iszatt, Nina, additional, Palkovicova, Lubica, additional, Lamoree, Marja H, additional, Schoeters, Greet, additional, Eggesbø, Merete, additional, Trnovec, Tomas, additional, Legler, Juliette, additional, and van de Bor, Margot, additional

Published
2017
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18. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

Voort, Agnes M. M. Sonnenschein-van der Arends, Lidia R. de Jongste, Johan C. Annesi-Maesano, Isabella Arshad, S. Hasan and Barros, Henrique Basterrechea, Mikel Bisgaard, Hans Chatzi, Leda Corpeleijn, Eva Correia, Sofia Craig, Leone C. and Devereux, Graham Dogaru, Cristian Dostal, Miroslav Duchen, Karel Eggesbo, Merete van der Ent, C. Kors Fantini, Maria P. and Forastiere, Francesco Frey, Urs Gehring, Ulrike Gori, Davide van der Gugten, Anne C. Hanke, Wojciech Henderson, A. John Heude, Barbara Iniguez, Carmen Inskip, Hazel M. and Keil, Thomas Kelleher, Cecily C. Kogevinas, Manolis and Kreiner-Moller, Eskil Kuehni, Claudia E. Kuepers, Leanne K. and Lancz, Kinga Larsen, Pernille S. Lau, Susanne Ludvigsson, Johnny Mommers, Monique Andersen, Anne-Marie Nybo and Palkovicova, Lubica Pike, Katharine C. Pizzi, Costanza and Polanska, Kinga Porta, Daniela Richiardi, Lorenzo Roberts, Graham Schmidt, Anne Sram, Radim J. Sunyer, Jordi Thijs, Carel Torrent, Maties Viljoen, Karien Wijga, Alet H. and Vrijheid, Martine Jaddoe, Vincent W. V. Duijts, Liesbeth

Abstract

Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P

Published
2014

19. Levels of leptin and adiponectin in children environmentally exposed to PCBs

Author

Wimmerova Sona, Rausova Katarina, Trnovec Tomáš, Šovcíková Eva, Palkovicova Lubica, Patayova Henrieta, Lancz Kinga, and Chovancová Jana

Subjects
medicine.medical_specialty, Food intake, Adiponectin, business.industry, Leptin, digestive, oral, and skin physiology, Regulator, Adipokine, medicine.disease, Obesity, Endocrinology, Energy expenditure, Internal medicine, medicine, General Earth and Planetary Sciences, business, hormones, hormone substitutes, and hormone antagonists, General Environmental Science
Abstract

Background Adipocytes secrete metabolically active proteins known as adipokines, the major ones being leptin and adiponectin. Leptin is the regulator of food intake and energy expenditure at the hy...

Published
2013

20. Prenatal exposure to PCB-153, p,p′-DDE and birth outcomes in 9000 mother–child pairs: Exposure–response relationship and effect modifiers

Author

Casas, Maribel, primary, Nieuwenhuijsen, Mark, additional, Martínez, David, additional, Ballester, Ferran, additional, Basagaña, Xavier, additional, Basterrechea, Mikel, additional, Chatzi, Leda, additional, Chevrier, Cécile, additional, Eggesbø, Merete, additional, Fernandez, Mariana F., additional, Govarts, Eva, additional, Guxens, Mònica, additional, Grimalt, Joan O., additional, Hertz-Picciotto, Irva, additional, Iszatt, Nina, additional, Kasper-Sonnenberg, Monika, additional, Kiviranta, Hannu, additional, Kogevinas, Manolis, additional, Palkovicova, Lubica, additional, Ranft, Ulrich, additional, Schoeters, Greet, additional, Patelarou, Evridiki, additional, Petersen, Maria Skaalum, additional, Torrent, Maties, additional, Trnovec, Tomas, additional, Valvi, Damaskini, additional, Toft, Gunnar Vase, additional, Weihe, Pál, additional, Weisglas-Kuperus, Nynke, additional, Wilhelm, Michael, additional, Wittsiepe, Jürgen, additional, Vrijheid, Martine, additional, and Bonde, Jens Peter, additional

Published
2015
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21. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Abstract

Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <.05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood ast

Published
2014

22. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Published
2014

23. Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood:A Meta-Analysis

Author

Gascon, Mireia, Sunyer, Jordi, Casas, Maribel, Martínez, David, Ballester, Ferran, Basterrechea, Mikel, Bonde, Jens Peter, Chatzi, Leda, Chevrier, Cécile, Eggesbø, Merete, Esplugues, Ana, Govarts, Eva, Hannu, Kiviranta, Ibarluzea, Jesús, Kasper-Sonnenberg, Monika, Klümper, Claudia, Koppen, Gudrun, Nieuwenhuijsen, Mark J, Palkovicova, Lubica, Pelé, Fabienne, Polder, Anuschka, Schoeters, Greet, Torrent, Maties, Trnovec, Tomas, Vassilaki, Maria, Vrijheid, Martine, Gascon, Mireia, Sunyer, Jordi, Casas, Maribel, Martínez, David, Ballester, Ferran, Basterrechea, Mikel, Bonde, Jens Peter, Chatzi, Leda, Chevrier, Cécile, Eggesbø, Merete, Esplugues, Ana, Govarts, Eva, Hannu, Kiviranta, Ibarluzea, Jesús, Kasper-Sonnenberg, Monika, Klümper, Claudia, Koppen, Gudrun, Nieuwenhuijsen, Mark J, Palkovicova, Lubica, Pelé, Fabienne, Polder, Anuschka, Schoeters, Greet, Torrent, Maties, Trnovec, Tomas, Vassilaki, Maria, and Vrijheid, Martine

Abstract

BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.

Published
2014

24. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M. M, Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchén, Karel, Eggesbo, Merete, Kors van der Ent, C., Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, AnneC., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iniguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, CecilyC., Kogevinas, Manolis, Kreiner-Moller, Eskil, Kuehni, Claudia E., Kuepers, LeanneK., Lancz, Kinga, Larsen, PernilleS., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, RadimJ., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, VincentW . V., Duijts, Liesbeth, Sonnenschein-van der Voort, Agnes M. M, Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchén, Karel, Eggesbo, Merete, Kors van der Ent, C., Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, AnneC., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iniguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, CecilyC., Kogevinas, Manolis, Kreiner-Moller, Eskil, Kuehni, Claudia E., Kuepers, LeanneK., Lancz, Kinga, Larsen, PernilleS., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, RadimJ., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, VincentW . V., and Duijts, Liesbeth

Abstract

Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age less than 37 weeks) and low birth weight (less than 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P less than. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weigh

Published
2014
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25. Preterm birth, infant weight gain, and childhood asthma risk:a meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Abstract

BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower b

Published
2014

26. EnviRisk. Report providing an economic assessment of protocols looking at available options

Author

Liu, Hai-Ying, Bartonova, Alena, Loh, Miranda, Palkovicova, Lubica, and Sram, Radim

Subjects
Miljøøkonomi, Miljø, samfunn og helse
Abstract

The aim of this report is to provide the relevant information for assessing the available options for exposure protocols in the view of providing a cost-benefit recommendation for exposure and health impact assessment. It includes: (i) define the exposure scenarios, methods and protocols for both PAHs and PCBs; (ii) summarize the data needs and describe the available data; (iii) analyze the cost for data and information gathering relevant for methods and protocols in several countries.

Published
2009

27. Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE):a meta-analysis within 12 European Birth Cohorts

Author

Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferran, Bloemen, Karolien, de Boer, Michiel, Chevrier, Cécile, Eggesbø, Merete, Guxens, Mònica, Krämer, Ursula, Legler, Juliette, Martínez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Rémy, Stigum, Hein, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stéphanie, Weihe, Pál, Kuperus, Nynke Weisglas, Wilhelm, Michael, Wittsiepe, Jürgen, Bonde, Jens Peter, Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferran, Bloemen, Karolien, de Boer, Michiel, Chevrier, Cécile, Eggesbø, Merete, Guxens, Mònica, Krämer, Ursula, Legler, Juliette, Martínez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Rémy, Stigum, Hein, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stéphanie, Weihe, Pál, Kuperus, Nynke Weisglas, Wilhelm, Michael, Wittsiepe, Jürgen, and Bonde, Jens Peter

Abstract

Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contrasts and appropriate exposure assessment are warranted. Within the framework of the EU (European Union) ENRIECO (ENvironmental Health RIsks in European Birth Cohorts) and EU OBELIX (OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight.

Published
2012

33. P-407

Author

Patayova, Henrieta, primary, Palkovicova, Lubica, additional, Rausova, Katarina, additional, reichrtova, Eva, additional, Stoian, Irina, additional, Sounders, Margaret, additional, Ursínyova, Monika, additional, Kocan, Anton, additional, and Wimmerova, Sona, additional

Published
2012
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34. Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development

Author

Dutta, Sisir K., primary, Mitra, Partha S., additional, Ghosh, Somiranjan, additional, Zang, Shizhu, additional, Sonneborn, Dean, additional, Hertz-Picciotto, Irva, additional, Trnovec, Tomas, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Ghimbovschi, Svetlana, additional, and Hoffman, Eric P., additional

Published
2012
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35. Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: Correlations between gene expression and disease risk

Author

Mitra, Partha Sarathi, primary, Ghosh, Somiranjan, additional, Zang, Shizhu, additional, Sonneborn, Dean, additional, Hertz-Picciotto, Irva, additional, Trnovec, Tomas, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Ghimbovschi, Svetlana, additional, Hoffman, Eric P., additional, and Dutta, Sisir K., additional

Published
2012
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37. VALIDATION OF SIGNATURE BIOMARKERS BY HIGH-THROUGHPUT TAQMAN® LOW DENSITY ARRAY (TLDA) IN PCB-EXPOSED SLOVAK POPULATION

Author

Ghosh, Somiranjan, primary, Mitra, Partha Sarathi, additional, Malve, Piyush, additional, Trnovec, Toma s, additional, Palkovicova, Lubica, additional, Sovcikova, Eva, additional, Hertz-Picciotto, Irva, additional, Sonneborn, Dean, additional, Ghimbovschi, Svetlana, additional, Hoffman, Eric P., additional, and Dutta, Sisir K., additional

Published
2011
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40. Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants

Author

Jusko, Todd A., primary, De Roos, Anneclaire J., additional, Schwartz, Stephen M., additional, Lawrence, B. Paige, additional, Palkovicova, Lubica, additional, Nemessanyi, Tomas, additional, Drobna, Beata, additional, Fabisikova, Anna, additional, Kocan, Anton, additional, Jahnova, Eva, additional, Kavanagh, Terrance J., additional, Trnovec, Tomas, additional, and Hertz-Picciotto, Irva, additional

Published
2011
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41. Prenatal PCB Exposure and Thyroid Function at Birth

Author

Palkovicova, Lubica, primary, Patayova, Henrieta, additional, Rausova, Katarina, additional, Babjakova, Jana, additional, Chovancova, Jana, additional, Conka, Kamil, additional, Fabisikova, Anna, additional, Sovcikova, Eva, additional, and Trnovec, Tomas, additional

Published
2011
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47. Health Impact Assessment of Waste Management Facilities in Three European Countries

Author

Forastiere, Francesco, primary, Badaloni, Chiara, additional, de Hoogh, Cornelis, additional, von Kraus, Martin Krayer, additional, Martuzzi, Marco, additional, Mitis, Francesco, additional, Palkovicova, Lubica, additional, Porta, Daniela, additional, Preiss, Philipp, additional, Ranzi, Andrea, additional, Perucci, Carlo Alberto, additional, and Briggs, David, additional

Published
2009
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