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2. Surgery or Peroral Esophageal Myotomy for Achalasia

Author

Marano, Luigi, Pallabazzer, Giovanni, Solito, Biagio, Santi, Stefano, Pigazzi, Alessio, De Luca, Raffaele, Biondo, Francesco Giuseppe, Spaziani, Alessandro, Longaroni, Maurizio, Di Martino, Natale, Boccardi, Virginia, and Patriti, Alberto

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Digestive Diseases, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Esophageal Achalasia, Esophageal Sphincter, Lower, Humans, Laparoscopy, Mouth, Natural Orifice Endoscopic Surgery, Treatment Outcome
Abstract

To date very few studies with small sample size have compared peroral esophageal myotomy (POEM) with the current surgical standard of care, laparoscopic Heller myotomy (LHM), in terms of efficacy and safety, and no recommendations have been proposed.To investigate the efficacy and safety of POEM compared with LHM, for the treatment of achalasia.The databases of Pubmed, Medline, Cochrane, and Ovid were systematically searched between January 1, 2005 and January 31, 2015, with the medical subject headings (MeSH) and keywords "achalasia," "POEM," "per oral endoscopic myotomy," and "peroral endoscopic myotomy," "laparoscopic Heller myotomy" (LHM), "Heller myotomy."All types of study designs including adult patients with diagnosis of achalasia were selected. Studies that did not report the comparison between endoscopic and surgical treatment, experimental studies in animal models, single case reports, technical reports, reviews, abstracts, and editorials were excluded.The total number of included patients was 486 (196 in POEM group and 290 in LHM group).There were no differences between POEM and LHM in reduction in Eckardt score (MD = -0.659, 95% CI: -1.70 to 0.38, P = 0.217), operative time (MD = -0.354, 95% CI: -1.12 to 0.41, P = 0.36), postoperative pain scores (MD = -1.86, 95% CI: -5.17 to 1.44, P = 0.268), analgesic requirements (MD = -0.74, 95% CI: -2.65 to 1.16, P = 0.445), and complications (OR = 1.11, 95% CI: 0.5-2.44, P = 0.796). Length of hospital stay was significantly lower for POEM (MD = -0.629, 95% CI: -1.256 to -0.002, P = 0.049). There was a trend toward significant reduction in symptomatic gastroesophageal reflux rate in favors of LHM compared to POEM group (OR = 1.81, 95% CI: 1.11-2.95, P = 0.017).All included studied were not randomized. Furthermore all selected studies did not report the results of follow-up longer than 1 year and most of them included patients who were both treatment naive and underwent previous endoscopic or surgical interventions for achalasia.POEM represents a safe and efficacy procedure comparable to the safety profile of LHM for achalasia at a short-term follow-up. Long-term clinical trials are urgently needed.

Published
2016

3. Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts

Author

Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, Capeloa, Tania, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, and Giordano, Silvia

Published
2018
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4. Supplementary Figure S2 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
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5. Data from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
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6. Supplementary Table S3 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
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7. Supplementary Methods from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
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8. Dynamic Profiling of the Immune Tumor Microenvironment in Locally Advanced Gastric Cancer Treated with Perioperative Chemotherapy

Author

Pecora, Irene, primary, Ugolini, Clara, additional, Giannini, Riccardo, additional, Giordano, Mirella, additional, Vivaldi, Caterina, additional, Lencioni, Monica, additional, Santi, Stefano, additional, Massa, Valentina, additional, Pallabazzer, Giovanni, additional, Catanese, Silvia, additional, Salani, Francesca, additional, Belluomini, Mario Antonio, additional, Vasile, Enrico, additional, Cremolini, Chiara, additional, Fontanini, Gabriella, additional, Masi, Gianluca, additional, and Fornaro, Lorenzo, additional

Published
2023
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9. Esophageal Cancer

Author

Rosati, Riccardo, Pallabazzer, Giovanni, Melis, Alessandra, Solito, Biagio, Fabrini, Maria Grazia, Ginocchi, Laura, Santi, Stefano, Valeri, Andrea, editor, Bergamini, Carlo, editor, Agresta, Ferdinando, editor, and Martellucci, Jacopo, editor

Published
2013
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12. Impact of COVID-19 outbreak on esophageal cancer surgery in Northern Italy: lessons learned from a multicentric snapshot

Author

Rebecchi, Fabrizio, primary, Arolfo, Simone, additional, Ugliono, Elettra, additional, Morino, Mario, additional, Asti, Emanuele, additional, Bonavina, Luigi, additional, Borghi, Felice, additional, Coratti, Andrea, additional, Cossu, Andrea, additional, De Manzoni, Giovanni, additional, De Pascale, Stefano, additional, Ferrari, Giovanni Carlo, additional, Fumagalli Romario, Uberto, additional, Giacopuzzi, Simone, additional, Gualtierotti, Monica, additional, Guglielmetti, Massimo, additional, Merigliano, Stefano, additional, Pallabazzer, Giovanni, additional, Parise, Paolo, additional, Peri, Andrea, additional, Pietrabissa, Andrea, additional, Rosati, Riccardo, additional, Santi, Stefano, additional, Tribuzi, Angela, additional, Valmasoni, Michele, additional, Viganò, Jacopo, additional, and Weindelmayer, Jacopo, additional

Published
2020
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13. A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.

Author

UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, Corso, Simona, Isella, Claudio, Bellomo, Sara E, Apicella, Maria, Durando, Stefania, Migliore, Cristina, Ughetto, Stefano, D'Errico, Laura, Menegon, Silvia, Moya-Rull, Daniel, Cargnelutti, Marilisa, De Miranda Capeloa, Tania Isabel, Conticelli, Daniela, Giordano, Jessica, Venesio, Tiziana, Balsamo, Antonella, Marchiò, Caterina, Degiuli, Maurizio, Reddavid, Rossella, Fumagalli, Uberto, De Pascale, Stefano, Sgroi, Giovanni, Rausa, Emanuele, Baiocchi, Gian Luca, Molfino, Sarah, Pietrantonio, Filippo, Morano, Federica, Siena, Salvatore, Sartore-Bianchi, Andrea, Bencivenga, Maria, Mengardo, Valentina, Rosati, Riccardo, Marrelli, Daniele, Morgagni, Paolo, Rausei, Stefano, Pallabazzer, Giovanni, De Simone, Michele, Ribero, Dario, Marsoni, Silvia, Sottile, Antonino, Medico, Enzo, Cassoni, Paola, Sapino, Anna, Pectasides, Eirini, Thorner, Aaron R, Nag, Anwesha, Drinan, Samantha D, Wollison, Bruce M, Bass, Adam J, Giordano, Silvia, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, Corso, Simona, Isella, Claudio, Bellomo, Sara E, Apicella, Maria, Durando, Stefania, Migliore, Cristina, Ughetto, Stefano, D'Errico, Laura, Menegon, Silvia, Moya-Rull, Daniel, Cargnelutti, Marilisa, De Miranda Capeloa, Tania Isabel, Conticelli, Daniela, Giordano, Jessica, Venesio, Tiziana, Balsamo, Antonella, Marchiò, Caterina, Degiuli, Maurizio, Reddavid, Rossella, Fumagalli, Uberto, De Pascale, Stefano, Sgroi, Giovanni, Rausa, Emanuele, Baiocchi, Gian Luca, Molfino, Sarah, Pietrantonio, Filippo, Morano, Federica, Siena, Salvatore, Sartore-Bianchi, Andrea, Bencivenga, Maria, Mengardo, Valentina, Rosati, Riccardo, Marrelli, Daniele, Morgagni, Paolo, Rausei, Stefano, Pallabazzer, Giovanni, De Simone, Michele, Ribero, Dario, Marsoni, Silvia, Sottile, Antonino, Medico, Enzo, Cassoni, Paola, Sapino, Anna, Pectasides, Eirini, Thorner, Aaron R, Nag, Anwesha, Drinan, Samantha D, Wollison, Bruce M, Bass, Adam J, and Giordano, Silvia

Abstract

Gastric cancer is the world's third leading cause of cancer mortality. In spite of significant therapeutic improvements, the clinical outcome for patients with advanced gastric cancer is poor; thus, the identification and validation of novel targets is extremely important from a clinical point of view. We generated a wide, multilevel platform of gastric cancer models, comprising 100 patient-derived xenografts (PDX), primary cell lines, and organoids. Samples were classified according to their histology, microsatellite stability, Epstein-Barr virus status, and molecular profile. This PDX platform is the widest in an academic institution, and it includes all the gastric cancer histologic and molecular types identified by The Cancer Genome Atlas. PDX histopathologic features were consistent with those of patients' primary tumors and were maintained throughout passages in mice. Factors modulating grafting rate were histology, TNM stage, copy number gain of tyrosine kinases/ genes, and microsatellite stability status. PDX and PDX-derived cells/organoids demonstrated potential usefulness to study targeted therapy response. Finally, PDX transcriptomic analysis identified a cancer cell-intrinsic microsatellite instability (MSI) signature, which was efficiently exported to gastric cancer, allowing the identification, among microsatellite stable (MSS) patients, of a subset of MSI-like tumors with common molecular aspects and significant better prognosis. In conclusion, we generated a wide gastric cancer PDX platform, whose exploitation will help identify and validate novel "druggable" targets and optimize therapeutic strategies. Moreover, transcriptomic analysis of gastric cancer PDXs allowed the identification of a cancer cell-intrinsic MSI signature, recognizing a subset of MSS patients with MSI transcriptional traits, endowed with better prognosis. SIGNIFICANCE: This study reports a multilevel platform of gastric cancer PDXs and identifies a MSI gastric signature that coul

Published
2019

14. Impact of COVID-19 outbreak on esophageal cancer surgery in Northern Italy: lessons learned from a multicentric snapshot.

Author

Rebecchi, Fabrizio, Arolfo, Simone, Ugliono, Elettra, Morino, Mario, Asti, Emanuele, Bonavina, Luigi, Borghi, Felice, Coratti, Andrea, Cossu, Andrea, Manzoni, Giovanni De, Pascale, Stefano De, Ferrari, Giovanni Carlo, Romario, Uberto Fumagalli, Giacopuzzi, Simone, Gualtierotti, Monica, Guglielmetti, Massimo, Merigliano, Stefano, Pallabazzer, Giovanni, Parise, Paolo, and Peri, Andrea

Subjects
COVID-19 pandemic, ESOPHAGEAL cancer, COVID-19, ESOPHAGUS diseases, NEOADJUVANT chemotherapy, ONCOLOGIC surgery
Abstract

Coronavirus Disease-19 (COVID-19) outbreak has significantly burdened healthcare systems worldwide, leading to reorganization of healthcare services and reallocation of resources. The Italian Society for Study of Esophageal Diseases (SISME) conducted a national survey to evaluate changes in esophageal cancer management in a region severely struck by COVID-19 pandemic. A web-based questionnaire (26 items) was sent to 12 SISME units. Short-term outcomes of esophageal resections performed during the lockdown were compared with those achieved in the same period of 2019. Six (50%) centers had significant restrictions in their activity. However, overall number of resections did not decrease compared to 2019, while a higher rate of open esophageal resections was observed (40 vs. 21.7%; P  = 0.034). Surgery was delayed in 24 (36.9%) patients in 6 (50%) centers, mostly due to shortage of anesthesiologists, and occupation of intensive care unit beds from intubated COVID-19 patients. Indications for neoadjuvant chemo (radio) therapy were extended in 14% of patients. Separate COVID-19 hospital pathways were active in 11 (91.7%) units. COVID-19 screening protocols included nasopharyngeal swab in 91.7%, chest computed tomography scan in 8.3% and selective use of lung ultrasound in 75% of units. Postoperative interstitial pneumonia occurred in 1 (1.5%) patient. Recovery from COVID-19 pandemic was characterized by screening of patients in all units, and follow-up outpatient visits in only 33% of units. This survey shows that clinical strategies differed considerably among the 12 SISME centers. Evidence-based guidelines are needed to support the surgical esophageal community and to standardize clinical practice in case of further pandemics. [ABSTRACT FROM AUTHOR]

Published
2021
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15. A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, additional, Bellomo, Sara E., additional, Apicella, Maria, additional, Durando, Stefania, additional, Migliore, Cristina, additional, Ughetto, Stefano, additional, D’Errico, Laura, additional, Menegon, Silvia, additional, Moya-Rull, Daniel, additional, Cargnelutti, Marilisa, additional, Capelôa, Tânia, additional, Conticelli, Daniela, additional, Giordano, Jessica, additional, Venesio, Tiziana, additional, Balsamo, Antonella, additional, Marchiò, Caterina, additional, Degiuli, Maurizio, additional, Reddavid, Rossella, additional, Fumagalli, Uberto, additional, De Pascale, Stefano, additional, Sgroi, Giovanni, additional, Rausa, Emanuele, additional, Baiocchi, Gian Luca, additional, Molfino, Sarah, additional, Pietrantonio, Filippo, additional, Morano, Federica, additional, Siena, Salvatore, additional, Sartore-Bianchi, Andrea, additional, Bencivenga, Maria, additional, Mengardo, Valentina, additional, Rosati, Riccardo, additional, Marrelli, Daniele, additional, Morgagni, Paolo, additional, Rausei, Stefano, additional, Pallabazzer, Giovanni, additional, De Simone, Michele, additional, Ribero, Dario, additional, Marsoni, Silvia, additional, Sottile, Antonino, additional, Medico, Enzo, additional, Cassoni, Paola, additional, Sapino, Anna, additional, Pectasides, Eirini, additional, Thorner, Aaron R., additional, Nag, Anwesha, additional, Drinan, Samantha D., additional, Wollison, Bruce M., additional, Bass, Adam J., additional, and Giordano, Silvia, additional

Published
2019
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17. Incidence and treatment of mediastinal leakage after esophagectomy: Insights from the multicenter study on mediastinal leaks study

Author

Fumagalli, Uberto, primary, Baiocchi, Gian Luca, additional, Celotti, Andrea, additional, Parise, Paolo, additional, Cossu, Andrea, additional, Bonavina, Luigi, additional, Bernardi, Daniele, additional, Manzoni, Giovanni de, additional, Weindelmayer, Jacopo, additional, Verlato, Giuseppe, additional, Santi, Stefano, additional, Pallabazzer, Giovanni, additional, Portolani, Nazario, additional, Degiuli, Maurizio, additional, Reddavid, Rossella, additional, and Pascale, Stefano de, additional

Published
2019
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18. Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

Author

UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, De Miranda Capeloa, Tania Isabel, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, Giordano, Silvia, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, De Miranda Capeloa, Tania Isabel, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, and Giordano, Silvia

Abstract

Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development of novel therapeutic strategies for gastric cancer. More than 30% of PDXs generated from gastric carcinoma samples developed human B-cell lymphomas instead of gastric cancer. These lymphomas were monoclonal, Epstein Barr Virus (EBV) positive, originated tumorigenic cell cultures and displayed a mutational burden and an expression profile distinct from gastric adenocarcinomas. The ability of grafted samples to develop lymphomas did not correlate with patient outcome, nor with the histotype, the lymphocyte infiltration level, or the EBV status of the original gastric tumor, impeding from foreseeing lymphoma onset. Interestingly, lymphoma development was significantly more frequent when primary rather than metastatic samples were grafted. Notably, the development of such lympho-proliferative disease could be prevented by a short rituximab treatment upon mice implant, without negatively affecting gastric carcinoma engraftment. Due to the high frequency of human lymphoma onset, our data show that a careful histologic analysis is mandatory when generating gastric cancer PDXs. Such care would avoid misleading results that could occur if testing of putative gastric cancer therapies is performed in lymphoma PDXs. We propose rituximab treatment of mice to prevent lymphoma development in PDX models, averting the loss of human-derived samples.

Published
2018

19. PS01.167: MUMELE STUDY: MULTICENTER STUDY ON INCIDENCE OF MEDIASTINAL LEAKS AFTER ESOPHAGECTOMY

Author

Fumagalli Romario, Uberto, primary, Celotti, Andrea, additional, De Pascale, Stefano, additional, Rosati, Riccardo, additional, Cossu, Andrea, additional, Parise, Paolo, additional, Bonavina, Luigi, additional, Bernardi, Daniele, additional, Degiuli, Maurizio, additional, Reddavid, Rossella, additional, De Manzoni, Giovanni, additional, Weindelmayer, Jacopo, additional, Portolani, Nazario, additional, Baiocchi, Gianluca, additional, Santi, Stefano, additional, and Pallabazzer, Giovanni, additional

Published
2018
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21. Surgery or Peroral Esophageal Myotomy for Achalasia: A Systematic Review and Meta-Analysis.

Author

Marano, Luigi, Marano, Luigi, Pallabazzer, Giovanni, Solito, Biagio, Santi, Stefano, Pigazzi, Alessio, De Luca, Raffaele, Biondo, Francesco Giuseppe, Spaziani, Alessandro, Longaroni, Maurizio, Di Martino, Natale, Boccardi, Virginia, Patriti, Alberto, Marano, Luigi, Marano, Luigi, Pallabazzer, Giovanni, Solito, Biagio, Santi, Stefano, Pigazzi, Alessio, De Luca, Raffaele, Biondo, Francesco Giuseppe, Spaziani, Alessandro, Longaroni, Maurizio, Di Martino, Natale, Boccardi, Virginia, and Patriti, Alberto

Abstract

To date very few studies with small sample size have compared peroral esophageal myotomy (POEM) with the current surgical standard of care, laparoscopic Heller myotomy (LHM), in terms of efficacy and safety, and no recommendations have been proposed.To investigate the efficacy and safety of POEM compared with LHM, for the treatment of achalasia.The databases of Pubmed, Medline, Cochrane, and Ovid were systematically searched between January 1, 2005 and January 31, 2015, with the medical subject headings (MeSH) and keywords "achalasia," "POEM," "per oral endoscopic myotomy," and "peroral endoscopic myotomy," "laparoscopic Heller myotomy" (LHM), "Heller myotomy."All types of study designs including adult patients with diagnosis of achalasia were selected. Studies that did not report the comparison between endoscopic and surgical treatment, experimental studies in animal models, single case reports, technical reports, reviews, abstracts, and editorials were excluded.The total number of included patients was 486 (196 in POEM group and 290 in LHM group).There were no differences between POEM and LHM in reduction in Eckardt score (MD = -0.659, 95% CI: -1.70 to 0.38, P = 0.217), operative time (MD = -0.354, 95% CI: -1.12 to 0.41, P = 0.36), postoperative pain scores (MD = -1.86, 95% CI: -5.17 to 1.44, P = 0.268), analgesic requirements (MD = -0.74, 95% CI: -2.65 to 1.16, P = 0.445), and complications (OR = 1.11, 95% CI: 0.5-2.44, P = 0.796). Length of hospital stay was significantly lower for POEM (MD = -0.629, 95% CI: -1.256 to -0.002, P = 0.049). There was a trend toward significant reduction in symptomatic gastroesophageal reflux rate in favors of LHM compared to POEM group (OR = 1.81, 95% CI: 1.11-2.95, P = 0.017).All included studied were not randomized. Furthermore all selected studies did not report the results of follow-up longer than 1 year and most of them included patients who were both treatment naive and underwent previous endoscopic or surgical interventions

Published
2016

22. Prognostic Significance of 2-Deoxy-2-[18F]-Fluoro-D-Glucose PET/CT in Patients With Locally Advanced Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy Before Surgery

Author

Giorgetti, Assuero, primary, Pallabazzer, Giovanni, additional, Ripoli, Andrea, additional, Solito, Biagio, additional, Genovesi, Dario, additional, Lencioni, Monica, additional, Fabrini, Maria Grazia, additional, D’Imporzano, Simone, additional, Pieraccini, Laura, additional, Marzullo, Paolo, additional, and Santi, Stefano, additional

Published
2016
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23. Ectopic pancreas in the gastric antrum: A spectrum of imaging findings

Author

Solito, Biagio, primary, Santi, Stefano, additional, Gambaccini, Dario, additional, Laino, Gabriella, additional, D’Imporzano, Simone, additional, Pallabazzer, Giovanni, additional, Bellini, Massimo, additional, Costa, Francesco, additional, Filice, Maria Elena, additional, Donati, Valentina, additional, Giusti, Patrizia, additional, and Marchi, Santino, additional

Published
2013
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26. PS01.167: MUMELE STUDY: MULTICENTER STUDY ON INCIDENCE OF MEDIASTINAL LEAKS AFTER ESOPHAGECTOMY.

Author

Romario, Uberto Fumagalli, Celotti, Andrea, Pascale, Stefano De, Rosati, Riccardo, Cossu, Andrea, Parise, Paolo, Bonavina, Luigi, Bernardi, Daniele, Degiuli, Maurizio, Reddavid, Rossella, Manzoni, Giovanni De, Weindelmayer, Jacopo, Portolani, Nazario, Baiocchi, Gianluca, Santi, Stefano, and Pallabazzer, Giovanni

Subjects
ESOPHAGECTOMY, ENDOSCOPY, MORTALITY
Abstract

Background Mediastinal anastomotic leak (ML) represent one of the most feared complication of esophageal resection. The incidence of ML, and of the associated mortality rate and the treatment strategy are variously reported. A standard strategy for diagnosis and treatment is difficult to establish Methods In order to evaluate the incidence, predictive factors, treatment and mortality of ML in 7 Italian surgical centers with interest in esophageal surgery (5 high volume centers) a retrospective study including all esophagectomies (E) with intrathoracic esophagogastric anastomosis performed in a 3 year period (2014–2017), was planned. ML were defined according to the classification proposed by the Esophagectomy Complications Consensus Group. Results The data of 501 E were collected. Overall incidence of ML was 11.8%. Surgical approach significantly influenced the rate of ML: leakage rate was highest for totally minimally invasive (TMIE) and lowest for hybrid esophagectomy (HE) (respectively 20 and 9%). No other predictive factor was found. Overall 30 and 90 day (d) mortality rate (M) were respectively 1,4% and 3,2%; 30 and 90 d M for leaks were respectively 5% and 15,3%; 90 d M for TMIE and HE were 5,9% and 1,8% respectively. Endoscopy was the first line treatment in 49% of leaks, with a need for retreatment in 17,2% of cases. Surgery was needed globally in 44,1% of ML. Endoscopic treatment appeared to have the lowest M (6,9%). Removal of the gastric tube with stoma formation was necessary in 8 cases (13.6%). Conclusion The incidence of mediastinal leaks after esophagectomy in the MUMELE study is high mainly in TMIE group. General and specific (leak) mortality rate is however low. Early 'aggressive' treatment of severe leaks is mandatory, with no hesitation to redo surgery if first attempt of conservative management fails. Disclosure All authors have declared no conflicts of interest. [ABSTRACT FROM AUTHOR]

Published
2018
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27. Impact of COVID-19 outbreak on esophageal cancer surgery in Northern Italy: lessons learned from a multicentric snapshot

Author

Monica Gualtierotti, Riccardo Rosati, Luigi Bonavina, Michele Valmasoni, Stefano Santi, Andrea Peri, Andrea Pietrabissa, Stefano De Pascale, Mario Morino, Emanuele Asti, Andrea Coratti, J. Viganò, Fabrizio Rebecchi, Angela Tribuzi, Simone Giacopuzzi, Giovanni Ferrari, Felice Borghi, Jacopo Weindelmayer, Stefano Merigliano, Massimo Guglielmetti, Andrea Cossu, Uberto Fumagalli Romario, Giovanni de Manzoni, Simone Arolfo, Paolo Parise, Giovanni Pallabazzer, Elettra Ugliono, Rebecchi, Fabrizio, Arolfo, Simone, Ugliono, Elettra, Morino, Mario, Asti, Emanuele, Bonavina, Luigi, Borghi, Felice, Coratti, Andrea, Cossu, Andrea, De Manzoni, Giovanni, De Pascale, Stefano, Ferrari, Giovanni Carlo, Fumagalli Romario, Uberto, Giacopuzzi, Simone, Gualtierotti, Monica, Guglielmetti, Massimo, Merigliano, Stefano, Pallabazzer, Giovanni, Parise, Paolo, Peri, Andrea, Pietrabissa, Andrea, Rosati, Riccardo, Santi, Stefano, Tribuzi, Angela, Valmasoni, Michele, Viganò, Jacopo, and Weindelmayer, Jacopo

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Esophageal Neoplasms, law.invention, Disease Outbreaks, surgery, 03 medical and health sciences, 0302 clinical medicine, law, Health care, Pandemic, medicine, Humans, survey, esophageal cancer, COVID-19, management, Pandemics, Digestive System Surgical Procedures, AcademicSubjects/MED00260, Surgeons, business.industry, Esophageal disease, SARS-CoV-2, Gastroenterology, Outbreak, General Medicine, Esophageal cancer, medicine.disease, Intensive care unit, Northern italy, Surgery, Italy, 030220 oncology & carcinogenesis, Communicable Disease Control, 030211 gastroenterology & hepatology, Original Article, business
Abstract

Coronavirus Disease-19 (COVID-19) outbreak has significantly burdened healthcare systems worldwide, leading to reorganization of healthcare services and reallocation of resources. The Italian Society for Study of Esophageal Diseases (SISME) conducted a national survey to evaluate changes in esophageal cancer management in a region severely struck by COVID-19 pandemic. A web-based questionnaire (26 items) was sent to 12 SISME units. Short-term outcomes of esophageal resections performed during the lockdown were compared with those achieved in the same period of 2019. Six (50%) centers had significant restrictions in their activity. However, overall number of resections did not decrease compared to 2019, while a higher rate of open esophageal resections was observed (40 vs. 21.7%; P = 0.034). Surgery was delayed in 24 (36.9%) patients in 6 (50%) centers, mostly due to shortage of anesthesiologists, and occupation of intensive care unit beds from intubated COVID-19 patients. Indications for neoadjuvant chemo (radio) therapy were extended in 14% of patients. Separate COVID-19 hospital pathways were active in 11 (91.7%) units. COVID-19 screening protocols included nasopharyngeal swab in 91.7%, chest computed tomography scan in 8.3% and selective use of lung ultrasound in 75% of units. Postoperative interstitial pneumonia occurred in 1 (1.5%) patient. Recovery from COVID-19 pandemic was characterized by screening of patients in all units, and follow-up outpatient visits in only 33% of units. This survey shows that clinical strategies differed considerably among the 12 SISME centers. Evidence-based guidelines are needed to support the surgical esophageal community and to standardize clinical practice in case of further pandemics.

Published
2020

28. Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts

Author

Ivana Sarotto, Andrea Bertotti, Francesco Sassi, Michele De Simone, Monica Mangioni, Stefano Rausei, Maurizio Degiuli, Alberto Pisacane, Sarah Molfino, Anna Sapino, Daniele Marrelli, Tania Capeloa, Uberto Fumagalli, Enzo Medico, Laura Casorzo, Franco Roviello, Luca Saragoni, Antonino Sottile, Marilisa Cargnelutti, Claudio Isella, Simona Corso, Stefania Durando, Cristina Migliore, Riccardo Rosati, Silvia Menegon, Silvia Giordano, Giovanni de Manzoni, Maria Apicella, Adam J. Bass, Paola Cassoni, Stefano Ughetto, Giovanni Sgroi, Giovanni Pallabazzer, Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, Capeloa, Tania, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, and Giordano, Silvia

Subjects
0301 basic medicine, Cancer Research, Lymphoma, Carcinogenesis, Disease, SCID, medicine.disease_cause, lcsh:RC254-282, Mice, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, hemic and lymphatic diseases, medicine, Animals, Humans, B-Lymphocytes, Transplantation, Heterologous, Animal, business.industry, B-Cell, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Epstein–Barr virus, 030104 developmental biology, Disease Models, Animal, Female, Heterografts, Lymphoma, B-Cell, Mice, Inbred NOD, Mice, SCID, Neoplasm Transplantation, Rituximab, Transplantation, Heterologous, 030220 oncology & carcinogenesis, Disease Models, Monoclonal, Cancer research, Inbred NOD, business, medicine.drug
Abstract

Patient-Derived Xenografts (PDXs), entailing implantation of cancer specimens in immunocompromised mice, are emerging as a valuable translational model that could help validate biologically relevant targets and assist the clinical development of novel therapeutic strategies for gastric cancer. More than 30% of PDXs generated from gastric carcinoma samples developed human B-cell lymphomas instead of gastric cancer. These lymphomas were monoclonal, Epstein Barr Virus (EBV) positive, originated tumorigenic cell cultures and displayed a mutational burden and an expression profile distinct from gastric adenocarcinomas. The ability of grafted samples to develop lymphomas did not correlate with patient outcome, nor with the histotype, the lymphocyte infiltration level, or the EBV status of the original gastric tumor, impeding from foreseeing lymphoma onset. Interestingly, lymphoma development was significantly more frequent when primary rather than metastatic samples were grafted. Notably, the development of such lympho-proliferative disease could be prevented by a short rituximab treatment upon mice implant, without negatively affecting gastric carcinoma engraftment. Due to the high frequency of human lymphoma onset, our data show that a careful histologic analysis is mandatory when generating gastric cancer PDXs. Such care would avoid misleading results that could occur if testing of putative gastric cancer therapies is performed in lymphoma PDXs. We propose rituximab treatment of mice to prevent lymphoma development in PDX models, averting the loss of human-derived samples.

Published
2018

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