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21 results on '"Palma Benedetta Dalla"'

1. P-180 PYGO2 is upregulated in multiple myeloma patients with 1q21+: a potential novel therapeutic target

Author

Garcia, Jessica Burroughs, primary, Iannozzi, Nicolas Thomas, additional, Storti, Paola, additional, Marchica, Valentina, additional, Franceschi, Valentina, additional, Toscani, Denise, additional, Lungu, Oxana, additional, Raimondi, Vincenzo, additional, Agnelli, Luca, additional, Todaro, Giannalisa, additional, Sammarelli, Gabriella, additional, Scita, Matteo, additional, Librale, Federica, additional, Palma, Benedetta Dalla, additional, Pruneri, Giancarlo, additional, Donofrio, Gaetano, additional, and Giuliani, Nicola, additional

Published
2023
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2. Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma

Author

Garcia, Jessica Burroughs, primary, Storti, Paola, additional, Iannozzi, Nicolas Thomas, additional, Marchica, Valentina, additional, Agnelli, Luca, additional, Toscani, Denise, additional, Franceschi, Valentina, additional, Todaro, Giannalisa, additional, Sammarelli, Gabriella, additional, Notarfranchi, Laura, additional, Scita, Matteo, additional, Palma, Benedetta Dalla, additional, Raimondi, Vincenzo, additional, Lungu, Oxana, additional, Pruneri, Giancarlo, additional, Donofrio, Gaetano, additional, and Giuliani, Nicola, additional

Published
2023
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3. EBV-positive mucocutaneous ulcer arising in a post-hematopoietic cell transplant patient: A difficult diagnosis

Author

Falcioni Federica, Giaimo Mariateresa, Rinalidi Amelia, Palma Benedetta Dalla, Rienzo Gianluca Di, Vallisa Daniele, Prezioso Lucia, Cambo Benedetta, Copelli Valerio, Crafa Pellegrino, and Tafuni Alessandro

Subjects
Community and Home Care, Hematopoietic cell, business.industry, Mucocutaneous zone, Disease, respiratory system, medicine.disease, medicine.disease_cause, respiratory tract diseases, Pneumonia, Immunology, EBV Positive, Medicine, Transplant patient, Respiratory system, business, Coronavirus
Abstract

The coronavirus disease-2019 (COVID-19) is primarily a disease of the respiratory system and is manifested by an infectious pneumonia, with fever, cough and breathlessness as the most common presenting symptoms.

Published
2021
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5. Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response.

Author

Storti, Paola, Marchica, Valentina, Vescovini, Rosanna, Franceschi, Valentina, Russo, Luca, Notarfranchi, Laura, Raimondi, Vincenzo, Toscani, Denise, Garcia, Jessica Burroughs, Costa, Federica, Palma, Benedetta Dalla, Iannozzi, Nicolas Thomas, Sammarelli, Gabriella, Donofrio, Gaetano, and Giuliani, Nicola

Subjects
SARS-CoV-2 Omicron variant, MONOCLONAL gammopathies, BOOSTER vaccines, MULTIPLE myeloma, HUMORAL immunity
Abstract

The humoral and cellular response to SARS-CoV-2 mRNA full vaccination and booster dose as well as the impact of the spike variants, including Omicron, are still unclear in patients with multiple myeloma (MM) and those with pre-malignant monoclonal gammopathies. In this study, involving 40 patients, we found that MM patients with relapsed-refractory disease (MMR) had reduced spike-specific antibody levels and neutralizing titers after SARS-CoV-2 vaccination. The five analyzed variants, remarkably Omicron, had a significant negative impact on the neutralizing ability of the vaccine-induced antibodies in all patients with MM and smoldering MM. Moreover, lower spike-specific IL-2-producing CD4+ T cells and reduced cytotoxic spike-specific IFN-γ and TNF-α-producing CD8+ T cells were found in MM patients as compared to patients with monoclonal gammopathy of undetermined significance. We found that a heterologous booster immunization improved SARS-CoV-2 spike humoral and cellular responses in newly diagnosed MM (MMD) patients and in most, but not all, MMR patients. After the booster dose, a significant increase of the neutralizing antibody titers against almost all the analyzed variants was achieved in MMD. However, in MMR patients, Omicron retained a negative impact on neutralizing ability, suggesting further approaches to potentiating the effectiveness of SARS-CoV-2 vaccination in these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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6. The transcriptomic profile of CD138+ cells from patients with early progression from smoldering to active multiple myeloma remains substantially unchanged

Author

Storti, Paola, primary, Agnelli, Luca, additional, Palma, Benedetta dalla, additional, Todoerti, Katia, additional, Marchica, Valentina, additional, Accardi, Fabrizio, additional, Sammarelli, Gabriella, additional, Deluca, Federica, additional, Toscani, Denise, additional, Costa, Federica, additional, Vicario, Emanuela, additional, Todaro, Giannalisa, additional, Martella, Eugenia, additional, Neri, Antonino, additional, and Giuliani, Nicola, additional

Published
2019
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7. IL21R expressing CD14 + CD16 + monocytes expand in multiple myeloma patients leading to increased osteoclasts

Author

Bolzoni, Marina, primary, Ronchetti, Domenica, additional, Storti, Paola, additional, Donofrio, Gaetano, additional, Marchica, Valentina, additional, Costa, Federica, additional, Agnelli, Luca, additional, Toscani, Denise, additional, Vescovini, Rosanna, additional, Todoerti, Katia, additional, Bonomini, Sabrina, additional, Sammarelli, Gabriella, additional, Vecchi, Andrea, additional, Guasco, Daniela, additional, Accardi, Fabrizio, additional, Palma, Benedetta Dalla, additional, Gamberi, Barbara, additional, Ferrari, Carlo, additional, Neri, Antonino, additional, Aversa, Franco, additional, and Giuliani, Nicola, additional

Published
2017
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8. Neurofibromatosis type I and multiple myeloma coexistence: A possible link?

Author

Accardi, Fabrizio, Marchica, Valentina, Mancini, Cristina, Maredi, Elena, Racano, Costantina, Notarfranchi, Laura, Martorana, Davide, Storti, Paola, Martella, Eugenia, Palma, Benedetta Dalla, Craviotto, Luisa, De Filippo, Massimo, Percesepe, Antonio, Aversa, Franco, and Giuliani, Nicola

Subjects
NEUROFIBROMATOSIS 1, MULTIPLE myeloma, DYSPLASIA
Abstract

The association between Neurofibromatosis type I (NF1) and multiple myeloma (MM), a plasma cell, dyscrasia is very rare. Here we put to the attention of the scientific community two new cases. The first one is a patient with active MM whereas the second with smoldering MM. Both patients present typical features of NF1 but skeletal alterations were present only in the second case including dysplasia, marked scoliosis and osteoporosis. MM osteolytic lesions were absent in both patients. In addition to the clinical diagnosis of NF1, a molecular testing for NF1 gene mutations has been performed finding that patient one was heterozygous for the c.6855C>A (Tyr2285Ter) mutation, while patient two was heterozygous for the c.7838dupC (Lys2614GlufsTer20) mutation. The two mutations were diagnosed both in genomic DNA from peripheral blood and from MM cells. The potential link between NF1 mutation and the increased risk of MM is discussed in the report. [ABSTRACT FROM AUTHOR]

Published
2018
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10. Relationship Between Presence Of Osteolytic Lesions, Cytogenetic Features and Bone Marrow Levels Of Cytokines and Chemokines In Multiple Myeloma Patients: Role Of Chemokine (C-C motif) Ligand 20

Author

Giuliani, Nicola, primary, Palma, Benedetta Dalla, additional, Guasco, Daniela, additional, Pedrazzoni, Mario, additional, Bolzoni, Marina, additional, Sammarelli, Gabriella, additional, Storti, Paola, additional, Spolzino, Angelica, additional, Craviotto, Luisa, additional, De Filippo, Massimo, additional, Ruffini, Livia, additional, and Aversa, Franco, additional

Published
2013
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11. The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors.

Author

Toscani, Denise, Palumbo, Carla, Palma, Benedetta Dalla, Ferretti, Marzia, Bolzoni, Marina, Marchica, Valentina, Sena, Paola, Martella, Eugenia, Mancini, Cristina, Ferri, Valentina, Costa, Federica, Accardi, Fabrizio, Craviotto, Luisa, Aversa, Franco, and Giuliani, Nicola

Abstract

Multiple myeloma (MM) is characterized by severely imbalanced bone remodeling. In this study, we investigated the potential effect of proteasome inhibitors (PIs), a class of drugs known to stimulate bone formation, on the mechanisms involved in osteocyte death induced byMMcells. First, we performed a histological analysis of osteocyte viability on bone biopsies on a cohort of 37MMpatients with symptomatic disease. A significantly higher number of viable osteocytes was detected in patients treated with a bortezomib (BOR)-based regimen compared with those treated without BOR. Interestingly, both osteocyte autophagy and apoptosis were affected in vivo by BOR treatment. Thereafter, we checked the in vitro effect of BOR to understand the mechanisms whereby BOR maintains osteocyte viability in bone fromMM patients. We found that osteocyte and preosteocyte autophagic death was triggered during coculturing with MM cells. Our evaluation was conducted by analyzing either autophagy markers microtubule-associated protein light chain 3 beta (LC3B) and SQSTM1/sequestome 1 (p62) levels, or the cell ultrastructure by transmission electron microscopy. PIs were found to increase the basal levels of LC3 expression in the osteocytes while blunting the myeloma-induced osteocyte death. PIs also reduced the autophagic death of osteocytes induced by high-dose dexamethasone (DEX) and potentiated the anabolic effect of PTH(1-34). Our data identify osteocyte autophagy as a new potential target in MM bone disease and support the use of PIs to maintain osteocyte viability and improve bone integrity in MM patients. [ABSTRACT FROM AUTHOR]

Published
2016
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12. Trascriptome Analysis of Bone Marrow CD14+ Monocytes Revealed Differential Expression Profiles in Symptomatic Multiple Myeloma (MM) Compared to Smoldering MM and Monoclonal Gammopathy of Undetermined Significance

Author

Peronaci, Marco, primary, Storti, Paola, additional, Ronchetti, Domenica, additional, Agnelli, Luca, additional, Bolzoni, Marina, additional, Guasco, Daniela, additional, Toscani, Denise, additional, Palma, Benedetta Dalla, additional, Bonomini, Sabrina, additional, Sammarelli, Gabriella, additional, Craviotto, Luisa, additional, Neri, Antonino, additional, Aversa, Franco, additional, and Giuliani, Nicola, additional

Published
2012
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13. Proteasome Inhibitors Block Myeloma-Induced Osteocyte Death in Vitro and in Vivo in Multiple Myeloma Patients

Author

Toscani, Denise, primary, Palma, Benedetta Dalla, additional, Palumbo, Carla, additional, Ferretti, Marzia, additional, Bolzoni, Marina, additional, Guasco, Daniela, additional, Mancini, Cristina, additional, Martella, Eugenia, additional, Lazzaretti, Mirca, additional, Pedrazzoni, Mario, additional, Aversa, Franco, additional, and Giuliani, Nicola, additional

Published
2012
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15. In Vitro and In Vivo Evidences of Osteocyte Involvement In Myeloma-Induced Osteolysis

Author

Giuliani, Nicola, primary, Storti, Paola, additional, Abeltino, Manuela, additional, Bolzoni, Marina, additional, Ferretti, Marzia, additional, Lazzaretti, Mirca, additional, Palma, Benedetta Dalla, additional, Todoerti, Katia, additional, Martella, Eugenia, additional, Agnelli, Luca, additional, Neri, Antonino, additional, Rizzoli, Vittorio, additional, and Palumbo, Carla, additional

Published
2010
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16. Increased Osteocyte Apoptosis in Multiple Myeloma Patients: A Potential Role in Bone Remodeling Alterations Related to Osteolytic Bone Lesions.

Author

Giuliani, Nicola, primary, Ferretti, Marzia, additional, Abeltino, Manuela, additional, Mancini, Cristina, additional, Martella, Eugenia, additional, Palma, Benedetta Dalla, additional, Bolzoni, Marina, additional, Sgobba, Valentina, additional, Storti, Paola, additional, Rizzoli, Vittorio, additional, and Palumbo, Carla, additional

Published
2009
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18. Trascriptome Analysis of Bone Marrow CD14+Monocytes Revealed Differential Expression Profiles in Symptomatic Multiple Myeloma (MM) Compared to Smoldering MM and Monoclonal Gammopathy of Undetermined Significance

Author

Peronaci, Marco, Storti, Paola, Ronchetti, Domenica, Agnelli, Luca, Bolzoni, Marina, Guasco, Daniela, Toscani, Denise, Palma, Benedetta Dalla, Bonomini, Sabrina, Sammarelli, Gabriella, Craviotto, Luisa, Neri, Antonino, Aversa, Franco, and Giuliani, Nicola

Abstract

Abstract 1811

Published
2012
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20. Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma.

Author

Garcia JB, Storti P, Iannozzi NT, Marchica V, Agnelli L, Toscani D, Franceschi V, Todaro G, Sammarelli G, Notarfranchi L, Scita M, Palma BD, Raimondi V, Lungu O, Pruneri G, Donofrio G, and Giuliani N

Subjects
Humans, Chromosome Aberrations, Gene Amplification, RNA-Binding Proteins genetics, Proteasome Endopeptidase Complex metabolism, Multiple Myeloma diagnosis, Multiple Myeloma genetics, Smoldering Multiple Myeloma
Published
2024
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21. The transcriptomic profile of CD138 + cells from patients with early progression from smoldering to active multiple myeloma remains substantially unchanged.

Author

Storti P, Agnelli L, Palma BD, Todoerti K, Marchica V, Accardi F, Sammarelli G, Deluca F, Toscani D, Costa F, Vicario E, Todaro G, Martella E, Neri A, and Giuliani N

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Multiple Myeloma pathology, Multiple Myeloma therapy, Gene Expression Regulation, Neoplastic, Multiple Myeloma metabolism, Neoplasm Proteins biosynthesis, Syndecan-1 biosynthesis, Transcriptome
Published
2019
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