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1. Solving Riemann Problems with a Topological Tool (Extended version)

Author

Eschenazi, Cesar S., Lambert, Wanderson J., López-Flores, Marlon M., Marchesin, Dan, Palmeira, Carlos F. B., and Plohr, Bradley J.

Subjects
Mathematics - Analysis of PDEs
Abstract

We have developed a three-dimensional manifold that facilitates finding solutions of Riemann initial value problems. In this paper, we apply this tool to a system of two conservation laws with quadratic flux functions. As this manifold contains points representing potential shock waves, it is named the wave manifold. We calculate and display graphically important curves and surfaces within the wave manifold. Characteristic and sonic surfaces subdivide it into regions according to shock wave admissibility. Admissible regions are further subdivided according to shock curves being local or non-local. Rarefaction, shock, and composite curves, which are untangled within the wave manifold, combine to form wave curves. To solve a Riemann problem, we form and intersect the novel intermediate surface of one wave curve with the other wave curve. Solutions of Riemann problems for several illustrative cases are presented., Comment: 43 pages, 36 figures, submitted. arXiv admin note: text overlap with arXiv:2210.09354

Published
2023

2. BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability

Author

Silva, Maria P., Ferreira, Luísa T., Brás, Natércia F., Torres, Lurdes, Brandão, Andreia, Pinheiro, Manuela, Cardoso, Marta, Resende, Adriana, Vieira, Joana, Palmeira, Carlos, Martins, Gabriela, Silva, Miguel, Pinto, Carla, Peixoto, Ana, Silva, João, Henrique, Rui, Maia, Sofia, Maiato, Helder, Teixeira, Manuel R., and Paulo, Paula

Published
2024
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3. Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis

Author

Nascimento-Gonçalves, Elisabete, Seixas, Fernanda, Palmeira, Carlos, Martins, Gabriela, Fonseca, Carolina, Duarte, José Alberto, Faustino-Rocha, Ana I., Colaço, Bruno, Pires, Maria João, Neuparth, Maria João, Moreira-Gonçalves, Daniel, Fardilha, Margarida, Henriques, Magda C., Patrício, Daniela, Pelech, Steven, Ferreira, Rita, and Oliveira, Paula A.

Published
2024
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4. Topological Tools in the Solution of a Quadratic System of Two Conservation Laws

Author

Eschenazi, Cesar S., Lambert, Wanderson J., López-Flores, Marlon M., Marchesin, Dan, Palmeira, Carlos F. B., Plohr, Bradley J., Castro, Carlos, Editor-in-Chief, Formaggia, Luca, Editor-in-Chief, Groppi, Maria, Series Editor, Larson, Mats G., Series Editor, Lopez Fernandez, Maria, Series Editor, Morales de Luna, Tomás, Series Editor, Pareschi, Lorenzo, Series Editor, Vázquez-Cendón, Elena, Series Editor, Zunino, Paolo, Series Editor, Parés, Carlos, editor, Castro, Manuel J., editor, and Muñoz-Ruiz, María Luz, editor

Published
2024
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5. Decomposition of the Wave Manifold into Lax Admissible Regions and its Application to the Solution of Riemann Problems

Author

Eschenazi, Cesar S., Lambert, Wanderson J., López-Flores, Marlon M., Marchesin, Dan, and Palmeira, Carlos F. B.

Subjects
Mathematics - Analysis of PDEs
Abstract

We utilize a three-dimensional manifold to solve Riemann Problems that arise from a system of two conservation laws with quadratic flux functions. Points in this manifold represent potential shock waves, hence its name wave manifold. This manifold is subdivided into regions according to the Lax admissibility inequalities for shocks. Finally, we present solutions for the Riemann Problems for various cases and exhibit continuity relative to $L$ and $R$ data, despite the fact that the system is not strictly hyperbolic. The usage of this manifold regularizes the solutions despite the presence of an elliptic region., Comment: 42 pages, 48 figures. arXiv admin note: text overlap with arXiv:1908.01870

Published
2022

6. A multivalent CD44 glycoconjugate vaccine candidate for cancer immunotherapy

Author

Freitas, Rui, Miranda, Andreia, Ferreira, Dylan, Relvas-Santos, Marta, Castro, Flávia, Ferreira, Eduardo, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Gonçalves, Martina, Eiras, Mariana, Santos, Beatriz, Palmeira, Carlos, Correia, Margareta P., Oliveira, Maria José, Sarmento, Bruno, Peixoto, Andreia, Santos, Lúcio Lara, Silva, André M.N., and Ferreira, José Alexandre

Published
2024
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8. A metabolic and mitochondrial angle on aging

Author

Duarte, Ana I., primary, Sadowska-Bartosz, Izabela, additional, Karkucinska-Wieckowska, Agnieszka, additional, Lebiedzinska-Arciszewska, Magdalena, additional, Palmeira, Carlos M., additional, Rolo, Anabela P., additional, Kabiri, Yaschar, additional, Zavan, Barbara, additional, Pinton, Paolo, additional, Borges, Fernanda, additional, Zischka, Hans, additional, Jones, John G., additional, Bartosz, Grzegorz, additional, Oliveira, Paulo J., additional, and Wieckowski, Mariusz R., additional

Published
2023
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9. List of contributors

Author

Abrantes, Margarida, primary, Alves, Raquel, additional, Anugula, Sharath, additional, Aran, Veronica, additional, Badimon, Lina, additional, Barreto, Jorge N., additional, Bartosz, Grzegorz, additional, Borges, Fernanda, additional, Borrás, Consuelo, additional, Botelho, Maria Filomena, additional, Bousquet, Jean, additional, Brehm, António M.D., additional, Brito, Gerly A.C., additional, Bultje, Daan, additional, Cabral, Ana Cristina, additional, Caetano, André, additional, Canhão, Helena, additional, Carreira, Isabel Marques, additional, Carriazo, Ana Maria, additional, Carvalho, Cristina, additional, Carvalho, Eugenia, additional, Castel-Branco, Margarida, additional, Chen, Yaohua, additional, Coelho-Filho, João M., additional, Constâncio, Vera, additional, Correia e Silva, António, additional, Costa, Deiziane V.S., additional, Costa, Elísio, additional, Costa, Inês, additional, Cunha-Oliveira, Teresa, additional, de Carvalho, Paulo, additional, De Luca, Vicenzo, additional, de Natale, Edoardo R., additional, Dias, Jorge, additional, Dias, Ronaldo P., additional, Duarte, Ana I., additional, Farrel, John, additional, Fernandez-Llimos, Fernando, additional, Ferreira, Lino, additional, Ferrucci, Luigi, additional, Figueiredo, Isabel Vitoria, additional, Ford, Jamie K., additional, Franceschi, Claudio, additional, Freitas, Alex A., additional, Furlan de Brito, Maja, additional, Giacomin, Karla C., additional, Girao, Henrique, additional, Gkikas, Ilias, additional, Gomes, Bárbara, additional, Gomes, Rodrigo M., additional, Gonçalves, Ana Cristina, additional, Goulden, Peter, additional, Grant, Marcus, additional, Grilo, Luís F., additional, Guldemond, Nick, additional, Henriques, Jorge, additional, Heringer, Manoela, additional, Illario, Maddalena, additional, Jerónimo, Carmen, additional, Jones, John G., additional, Jorge, Joana, additional, Kabiri, Yaschar, additional, Karkucinska-Wieckowska, Agnieszka, additional, Kelly, George, additional, Kirkland, James L., additional, Kitaeva, Kristina, additional, Kiyasov, Andrey, additional, Korolchuk, Viktor I., additional, Laranjo, Mafalda, additional, LaRocca, Thomas J., additional, Lavrador, Marta, additional, Lebiedzinska-Arciszewska, Magdalena, additional, Li, Zhiquan, additional, Liu, Yuezhong, additional, Lourenço, Alexandre, additional, Ma, Lina, additional, Malva, João O., additional, Martens, Christopher R., additional, Mas-Bargues, Cristina, additional, Matafome, Paulo, additional, Melo, Joana Barbosa, additional, Mendonça, Maria L. Lima, additional, Metaxakis, Athanasios, additional, Middleton, Lefkos T., additional, Moreira, Paula I., additional, Nascimento, Judite M., additional, Neto, Vivaldo M., additional, Oliveira, Paulo J., additional, Ori, Alessandro, additional, Oriá, Reinaldo B., additional, Ozanne, Susan E., additional, Padeiro, Miguel, additional, Padro, Teresa, additional, Palmeira, Carlos M., additional, Pan, Yiming, additional, Paredes, Simão, additional, Passos, João F., additional, Pereira, Edith, additional, Pereira, Francisco B., additional, Pereira, Susana P., additional, Pinton, Paolo, additional, Pires, Joana F., additional, Pires, Salomé, additional, Polidori, M. Cristina, additional, Politis, Marios, additional, Raimundo, Nuno, additional, Ramalho-Santos, João, additional, Rasmussen, Lene Juel, additional, Regateiro, Fernando J., additional, Reis, Dario D., additional, Ribeiro, Caio, additional, Ribeiro, Ilda Patrícia, additional, Ribeiro-Rodrigues, Teresa M., additional, Rizvanov, Albert, additional, Rocha, Teresa, additional, Röhr, Susanne, additional, Rolo, Anabela P., additional, Román-Domínguez, Aurora, additional, Romero-Ortuno, Roman, additional, Rosa, Manuel Santos, additional, Rutland, Catrin, additional, Sadowska-Bartosz, Izabela, additional, Santana, Paula, additional, Santinha, Deolinda, additional, Santos, Marcos, additional, Sarmento Ribeiro, Ana Bela, additional, Semedo, Deisa S.R.C., additional, Sequeira, João, additional, Sierra, Felipe, additional, Silva, Maria Natalina L., additional, Solana, Rafael, additional, Solovyeva, Valeriya, additional, Spínola, Hélder, additional, Tavares, Renata S., additional, Tavernarakis, Nektarios, additional, Tchkonia, Tamar, additional, Theng, Yin-Leng, additional, Traver-Salcedo, Vicente, additional, Udeh-Momoh, Chi, additional, Verma, Rakhi, additional, Victorelli, Stella, additional, Vilaça, Andreia, additional, Vilahur, Gemma, additional, Viña, José, additional, von Zglinicki, Thomas, additional, Wahl, Devin, additional, Werle, Berenice Maria, additional, Wieckowski, Mariusz R., additional, Wilson, Heather, additional, Wissler Gerdes, Erin O., additional, Wozniak, Lucyna A., additional, Zavan, Barbara, additional, Zhu, Yi, additional, and Zischka, Hans, additional

Published
2023
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10. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital, Chew, Yap Ching, Guo, Wei, Yang, Xiaojing, Maybury-Lewis, Sun, Tian, Xiao, Ross, Jaime M., Coppotelli, Giuseppe, Meer, Margarita V., Rogers-Hammond, Ryan, Vera, Daniel L., Lu, Yuancheng Ryan, Pippin, Jeffrey W., Creswell, Michael L., Dou, Zhixun, Xu, Caiyue, Mitchell, Sarah J., Das, Abhirup, O’Connell, Brendan L., Thakur, Sachin, Kane, Alice E., Su, Qiao, Mohri, Yasuaki, Nishimura, Emi K., Schaevitz, Laura, Garg, Neha, Balta, Ana-Maria, Rego, Meghan A., Gregory-Ksander, Meredith, Jakobs, Tatjana C., Zhong, Lei, Wakimoto, Hiroko, El Andari, Jihad, Grimm, Dirk, Mostoslavsky, Raul, Wagers, Amy J., Tsubota, Kazuo, Bonasera, Stephen J., Palmeira, Carlos M., Seidman, Jonathan G., Seidman, Christine E., Wolf, Norman S., Kreiling, Jill A., Sedivy, John M., Murphy, George F., Green, Richard E., Garcia, Benjamin A., Berger, Shelley L., Oberdoerffer, Philipp, Shankland, Stuart J., Gladyshev, Vadim N., Ksander, Bruce R., Pfenning, Andreas R., Rajman, Luis A., and Sinclair, David A.

Published
2023
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12. SNHG1: Redefining the Landscape of Hepatocellular Carcinoma through Long Noncoding RNAs.

Author

Fonseca, Tiago S., Martins, Rui Miguel, Rolo, Anabela P., and Palmeira, Carlos M.

Subjects
LINCRNA, OVERALL survival, CELL migration, HEPATOCELLULAR carcinoma, SURVIVAL rate
Abstract

Hepatocellular carcinoma (HCC) represents a global health concern, ranking as the sixth most common malignancy worldwide and the third leading cause of cancer-related mortality. Despite advances in research, the diagnosis and prognosis of such malignancy remain challenging. Alpha-fetoprotein, the current serum biomarker used in the management of HCC, has limited sensitivity and specificity, making early detection and effective management more difficult. Thus, new management approaches in diagnosis and prognosis are needed to improve the outcome and survival of HCC patients. SNHG1 is a long noncoding RNA mainly expressed in the cell and cytoplasm of cells and is consistently upregulated in tissues and cell lines of HCC, where it acts as an important regulator of various processes: modulation of p53 activity, sponging of microRNAs with consequent upregulation of their target mRNAs, regulation of fatty acid, iron and glucose metabolism, and interaction with immune cells. The deregulation of these processes results in abnormal cell division, angiogenesis, and apoptosis, thus promoting various aspects of tumorigenesis, including proliferation, invasion, and migration of cells. Clinically, a higher expression of SNHG1 predicts poorer clinical outcomes by significantly correlating with bigger, less differentiated, and more aggressive tumors, more advanced disease stages, and lower overall survival in HCC patients. This article comprehensively summarizes the current understanding of the multifaceted roles of SNHG1 in the pathogenesis of HCC, while also highlighting its clinicopathological correlations, therefore concluding that it has potential as a biomarker in HCC diagnosis and prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Loss of epigenetic information as a cause of mammalian aging

Author

Yang, Jae-Hyun, primary, Hayano, Motoshi, additional, Griffin, Patrick T., additional, Amorim, João A., additional, Bonkowski, Michael S., additional, Apostolides, John K., additional, Salfati, Elias L., additional, Blanchette, Marco, additional, Munding, Elizabeth M., additional, Bhakta, Mital, additional, Chew, Yap Ching, additional, Guo, Wei, additional, Yang, Xiaojing, additional, Maybury-Lewis, Sun, additional, Tian, Xiao, additional, Ross, Jaime M., additional, Coppotelli, Giuseppe, additional, Meer, Margarita V., additional, Rogers-Hammond, Ryan, additional, Vera, Daniel L., additional, Lu, Yuancheng Ryan, additional, Pippin, Jeffrey W., additional, Creswell, Michael L., additional, Dou, Zhixun, additional, Xu, Caiyue, additional, Mitchell, Sarah J., additional, Das, Abhirup, additional, O’Connell, Brendan L., additional, Thakur, Sachin, additional, Kane, Alice E., additional, Su, Qiao, additional, Mohri, Yasuaki, additional, Nishimura, Emi K., additional, Schaevitz, Laura, additional, Garg, Neha, additional, Balta, Ana-Maria, additional, Rego, Meghan A., additional, Gregory-Ksander, Meredith, additional, Jakobs, Tatjana C., additional, Zhong, Lei, additional, Wakimoto, Hiroko, additional, El Andari, Jihad, additional, Grimm, Dirk, additional, Mostoslavsky, Raul, additional, Wagers, Amy J., additional, Tsubota, Kazuo, additional, Bonasera, Stephen J., additional, Palmeira, Carlos M., additional, Seidman, Jonathan G., additional, Seidman, Christine E., additional, Wolf, Norman S., additional, Kreiling, Jill A., additional, Sedivy, John M., additional, Murphy, George F., additional, Green, Richard E., additional, Garcia, Benjamin A., additional, Berger, Shelley L., additional, Oberdoerffer, Philipp, additional, Shankland, Stuart J., additional, Gladyshev, Vadim N., additional, Ksander, Bruce R., additional, Pfenning, Andreas R., additional, Rajman, Luis A., additional, and Sinclair, David A., additional

Published
2024
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15. Contributors

Author

Aggarwal, Manoj, primary, Akingbasote, James, additional, Anadón, Arturo, additional, Anger, Gregory J., additional, Archibong, Anthony E., additional, Ares, Irma, additional, Aschner, Michael, additional, Avila, Daiana S., additional, Bailey, Denise C., additional, Barlow, Norman J., additional, Beedanagari, Sudheer, additional, Beltyukov, P.P., additional, Bischoff, Karyn, additional, Boeck, Carina Rodrigues, additional, Bracken, William M., additional, Brehm, Emily, additional, Breyer, Richard M., additional, Bright-Ponte, Susan, additional, Brockett, Mirjana Milosevic, additional, Campagnolo, Luisa, additional, Carney, Edward W., additional, Charrette, Andrew, additional, Chebekoue, Sandrine Fleur, additional, Chiang, Catheryne, additional, Chou, Wei-Chun, additional, Cleal, Jane K., additional, Cole, Toby B., additional, Cook, Daniel, additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Curras-Collazo, Margarita, additional, Dai, Wanying, additional, Dao, Khoi, additional, Da Silva, Rosane Souza, additional, Davis, T. Zane, additional, Dominguez, Francisco, additional, Doss, Robin B., additional, Dziwenka, Margitta M., additional, Enright, Brian, additional, Estevan, Carmen, additional, Evans, Timothy J., additional, Fan, Anna M., additional, Farina, Marcelo, additional, Fenton, Suzanne E., additional, Filazi, Ayhan, additional, Fitsanakis, Vanessa A., additional, FitzGerald, Rex, additional, Flaskos, John, additional, Flaws, Jodi A., additional, Flora, S.J.S., additional, Ganjam, Vekataseshu K., additional, Gardner, Dale R., additional, Garg, Ramesh C., additional, Garrick, Jacqueline M., additional, Garry, Vincent F., additional, Gelineau-van Waes, Janee, additional, Godfrey, Keith M., additional, Golubentseva, Yu V., additional, González-Martín, Roberto, additional, Green, Benedict T., additional, Guerri, Consuelo, additional, Gulati, Kavita, additional, Gupta, P.K., additional, Gupta, Ramesh C., additional, Gupta, Rekha K., additional, Guthrie, Najla, additional, Hall, Jeffery O., additional, Hargreaves, Alan J., additional, Harris, Kenneth J., additional, Hill, Bridgett N., additional, Hilmas, Corey J., additional, Hoberman, Alan M., additional, Hougaard, Karin S., additional, Ince, Sinan, additional, Iyer, Poorni R., additional, Jacobsen, Nicklas R., additional, Kalpana, Starling, additional, Kandimalla, Ramesh, additional, Kanthasamy, Arthi, additional, Kanthasamy, Anumantha, additional, Khlebnikova, N.S., additional, Klüver, Nils, additional, Kodavanti, Prasada Rao S., additional, Krishnan, Kannan, additional, Kulkarni, Shaila, additional, Kuzukiran, Ozgur, additional, Lall, Rajiv, additional, Legradi, Jessica, additional, Lewis, Rohan M., additional, Lewis, Elise M., additional, Li, Xin, additional, Lin, Pinpin, additional, Loganathan, Bommanna G., additional, Machado, Ivo F., additional, Mahadevan, Brinda, additional, Makris, Susan L., additional, Malik, Jitendra K., additional, Marreilha dos Santos, Ana Paula, additional, Marsillach, Judit, additional, Martínez-Larrañaga, María Rosa, additional, Martínez, María Aránzazu, additional, Matouskova, Klara, additional, McClellan, Roger O., additional, Milatovic, Dejan, additional, Mohammed, Ali Mustafa, additional, Montine, Thomas J., additional, Møller, Peter, additional, Multani, Pushpinder Kaur, additional, Ni, Mingwei, additional, Nikolaidis, Efstathios, additional, Novilla, Meliton N., additional, Padilla, Stephanie, additional, Palmeira, Carlos M., additional, Pamies, David, additional, Panner Selvam, Manesh Kumar, additional, Pascual, María, additional, Patwa, Jayant, additional, Phillips, Ashley, additional, Piquette-Miller, Micheline, additional, Popov, V.B., additional, Pratt, M. Margaret, additional, Protasova, G.A., additional, Rai, Nishant, additional, Ramalho-Santos, João, additional, Ramesh, Aramandla, additional, Ray, Kausik, additional, Ray, Arunabha, additional, Ren, Aiguo, additional, Renaud, Stephen J., additional, Roberts, Drucilla J., additional, Rongzhu, Lu, additional, Sachana, Magdalini, additional, Sahlman, Heidi, additional, Saini, Nitin, additional, Saini, Vandna, additional, Shabasheva, L.V., additional, Sharma, Abha, additional, Sikka, Suresh C., additional, Silva, Marilyn Helen, additional, Simsek, Ilker, additional, Singh Kalra, Rajkumar, additional, Sinha, Anita, additional, Sogorb, Miguel A., additional, Soldin, Offie P., additional, Song, Chunjuan, additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Stoker, Tammy E., additional, Stonecipher, Clinton A., additional, Szlapinski, Sandra, additional, Tanabe, Shihori, additional, Tatiparthi, Arun, additional, Teixeira da Rocha, João Batista, additional, Thokchom, Suresh Kumar, additional, Tornesi, Belen, additional, Torous, Vanda, additional, Truran, Peter, additional, Valdez, Matthew C., additional, Vandenberg, Laura N., additional, Vargesson, Neil, additional, Vilanova, Eugenio, additional, Vähäkangas, Kirsi H., additional, Vulimiri, Suryanarayana V., additional, Warner, Genoa R., additional, Welch, Kevin D., additional, Williams, Daniel C., additional, Woldemeskel, Moges, additional, Yang, Jae-Ho, additional, Yin, Zhaobao, additional, Ying, Xiaoyou, additional, Yurdakok-Dikmen, Begum, additional, Zaja-Milatovic, Snjezana, additional, and Zhou, Changqing, additional

Published
2022
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16. Contributors

Author

Abdolghaffari, Amir Hossein, primary, Abdollahi, Mohammad, additional, Alberdi, Elena, additional, Asghari, Mohammad Hossein, additional, Baskaran, Vallikannan, additional, Bernatoniene, Jurga, additional, Bhoomika, S., additional, Bouchez, C.L., additional, Camougrand, Nadine, additional, Capetillo-Zarate, Estibaliz, additional, Castela, Ana C., additional, Cecchini, Alessandra Lourenço, additional, Chattipakorn, Nipon, additional, Chattipakorn, Siriporn C., additional, Chayanika, G., additional, Cino, Jaco, additional, Coelho, Patrícia, additional, Cossarizza, Andrea, additional, Cuvellier, S., additional, Dave, A., additional, De Gaetano, Anna, additional, de Oliveira, Marcos Roberto, additional, Devin, Anne, additional, Di Meo, Sergio, additional, Duvezin-Caubet, S., additional, Farruggio, Serena, additional, Fasciolo, Gianluca, additional, Fenton, Valeska, additional, Gerk, Phillip M., additional, Ghosh, Noyel, additional, Gonçalves, Vanessa F., additional, Grossini, Elena, additional, Hassani, Shokoufeh, additional, Hebert-Chatelain, Etienne, additional, Jakstas, Valdas, additional, Jayapala, Naveen, additional, Kalvala, Anil Kumar, additional, Kennedy, Brian, additional, Kim, Hyeyoung, additional, Kim, Suhn Hyung, additional, Kopustinskiene, Dalia Marija, additional, Kosuru, Ramoji, additional, Kumar, Ashutosh, additional, Lagoa, Ricardo, additional, Legros, Sabastian, additional, Leurcharusmee, Prangmalee, additional, Luiz, Rodrigo Cabral, additional, Machado, Ivo F., additional, Maghsoudi, Armin Salek, additional, Manning, Jaylin, additional, Manon, Stéphen, additional, Marotta, Patrizia, additional, Marques-da-Silva, Dorinda, additional, Mathews, Valuparampil Varghese, additional, Matute, Calos, additional, Mazat, J.P., additional, Mistry, Mahima, additional, Molinié, T., additional, Moloudizargari, Milad, additional, Momtaz, Saeideh, additional, Moradi, Fereshteh, additional, Morkuniene, Ramune, additional, Nair, Raveendran Harikumaran, additional, Napolitano, Gaetana, additional, Pain, P., additional, Panella, Massimiliano, additional, Palmeira, Carlos M., additional, Panneerselvam, Chermakani, additional, Parvez, Suhel, additional, Paumard, P., additional, Perumal, Madan Kumar, additional, Pillai, Prakash P., additional, Pinti, Marcello, additional, Plafker, Scott M., additional, Potalivo, Emily, additional, Rabelo, Ana Carolina Silveira, additional, Rahul, K., additional, Rajasekar, Janani, additional, Ransac, S., additional, Rego, Ana Cristina Carvalho, additional, Rigoulet, M., additional, Rocha, Selena, additional, Rodrigues, Joaquim Rui, additional, Rolo, Anabela P., additional, Ruiz, Asier, additional, Sánchez-Gómez, Maria Victoria, additional, Sawaddiruk, Passakorn, additional, Sil, Parames C., additional, Singh, Sanjay, additional, Solodka, Kateryna, additional, Soni, S., additional, Sreepriya, Meenakshisundaram, additional, Stuart, Jeffrey A., additional, Sudhandiran, Ganapasam, additional, Syamala, Soumyakrishnan, additional, Tabassum, Heena, additional, Tan, Sijie, additional, Teodoro, João S., additional, Vadivel, Dinesh Babu, additional, Venditti, Paola, additional, Vijay Kumar, A., additional, Vijayakumar, Mahalingam Rajamanickam, additional, Vineetha, Radhakrishnan Chandraprabha, additional, Wong, Esther, additional, and Zyla, Katarzyna, additional

Published
2022
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19. Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors

Author

Nikolaou, Panagiota-Efstathia, primary, Lambrinidis, George, additional, Georgiou, Maria, additional, Karagiannis, Dimitrios, additional, Efentakis, Panagiotis, additional, Bessis-Lazarou, Pavlos, additional, Founta, Konstantina, additional, Kampoukos, Stavros, additional, Konstantin, Vasilis, additional, Palmeira, Carlos M., additional, Davidson, Sean M., additional, Lougiakis, Nikolaos, additional, Marakos, Panagiotis, additional, Pouli, Nicole, additional, Mikros, Emmanuel, additional, and Andreadou, Ioanna, additional

Published
2023
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20. Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

Author

Peixoto, Andreia, Ferreira, Dylan, Azevedo, Rita, Freitas, Rui, Fernandes, Elisabete, Relvas-Santos, Marta, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Teixeira, Beatriz, Paulo, Paula, Lima, Luís, Palmeira, Carlos, Martins, Gabriela, Oliveira, Maria José, Silva, André M. N., Santos, Lúcio Lara, and Ferreira, José Alexandre

Published
2021
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26. Mitohormesis

Author

Machado, Ivo F., primary, Teodoro, João S., additional, Castela, Ana C., additional, Palmeira, Carlos M., additional, and Rolo, Anabela P., additional

Published
2021
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27. List of contributors

Author

Ahmad, Abul H., primary, Akingbasote, James, additional, Anadón, Arturo, additional, Anand, Rashmi, additional, Anantharam, Vellareddy, additional, András, Csaba, additional, Ares, Irma, additional, Avdonin, Pavel V., additional, Ay, Muhammet, additional, Banerjee, Aryamitra, additional, Barnett, Reid E., additional, Belinskaia, Daria A., additional, Bertero, Alessia, additional, Bharti, Vijay K., additional, Bian, Wan-Ping, additional, Bischoff, Karyn L., additional, Caloni, Francesca, additional, Castela, Ana Catarina, additional, Chand, Naresh, additional, Chanderbhan, Ronald F., additional, Charli, Adhithiya, additional, Charrette, Andrew, additional, Chen, Si, additional, Chen, Tao, additional, Choudhuri, Supratim, additional, Choudhury, Soumen, additional, Coccini, Teresa, additional, Cope, Rhian B., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Damodaran, Tirupapuliyur, additional, Darvesh, Altaf S., additional, Dhruw, Leena, additional, Dormán, György, additional, Doss, Robin B., additional, DuBourdieu, Dan, additional, Dziwenka, Margitta, additional, Eades, Joshua, additional, Esch, Harald L., additional, Filazi, Ayhan, additional, Fitsanakis, Vanessa A., additional, Flachner, Beáta, additional, Fossati, Paola, additional, Gambaryan, Stepan P., additional, Garg, Ramesh C., additional, Garg, Satish K., additional, Gil, Fernando, additional, Goncharov, Nikolay V., additional, Gulati, Kavita, additional, Guo, Lei, additional, Guo, Xiaoqing, additional, Gupta, Bhanushree, additional, Gupta, Ramesh C., additional, Guthrie, Najla, additional, Gwaltney-Brant, Sharon M., additional, Hajdú, István, additional, Hartsel, Joshua A., additional, Hazzah, Trina, additional, Hernández, Antonio F., additional, Hickory, Brian, additional, Hilmas, Corey J., additional, Hoeng, Julia, additional, Jain, Amul, additional, Jenkins, Richard O., additional, Jin, Huajun, additional, Joshi, Jagdish Chandra, additional, Kalinovsky, Tatiana, additional, Kalpana, Starling, additional, Kalidindi, Sanyasi R., additional, Kanthasamy, Anumantha G., additional, Kanthasamy, Arthi, additional, Kaore, Navinchandra M., additional, Kaore, Shilpa N., additional, Kapoor, Vijay Kumar, additional, Kaur, Gurjot, additional, Kolanos, Renata, additional, Korf, Ekaterina A., additional, Krishna, Gopala, additional, Krishna, Mayur, additional, Kuča, Kamil, additional, Kudryavtsev, Igor V., additional, Kumar, Amit, additional, Kumar, Dinesh, additional, Kumar, Prafull, additional, Lall, Rajiv, additional, La Mesa, Camillo, additional, Latino, Diogo A.R.S., additional, Lehmann, Leane, additional, Li, Xilin, additional, Machado, Ivo F., additional, Makriyannis, Alexandros, additional, Malik, Jitendra K., additional, Martín-Domingo, M. Concepción, additional, Martínez, María-Aránzazu, additional, Martínez-Larrañaga, María-Rosa, additional, Mei, Nan, additional, Messinis, Dimitris E., additional, Mindukshev, Igor V., additional, Negi, Poonam, additional, Niedzwiecki, Aleksandra, additional, Ning, Baitang, additional, Novozhilov, Artem V., additional, Palmeira, Carlos Marques, additional, Papas, Andreas M., additional, Pei, De-Sheng, additional, Peitsch, Manuel C., additional, Peterson, Jeffrey D., additional, Pistollato, Francesca, additional, Pitt, Jason, additional, Pitt, Yiuka, additional, Pospisil, Pavel, additional, Poussin, Carine, additional, Pradhan, Aanchal, additional, Prakash, Atul, additional, Prasad, Sahdeo, additional, Rahal, Anu, additional, Rai, Nishant, additional, Raina, Rajinder, additional, Rath, Matthias, additional, Ray, Arunabha, additional, Rehman, Sana, additional, Richter, Gary, additional, Risuleo, Gianfranco, additional, Roberts, Ashley, additional, Rolo, Anabela Pinto, additional, Roomi, M. Waheed, additional, Sachana, Magdalini, additional, Satoh, Tetsuo, additional, Serebriakova, Maria K., additional, Sharma, Rahul, additional, Shukla, Amit, additional, Sinha, Anita, additional, Sinha, Priynak, additional, Spicer, Leon J, additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Sudnitsyna, Julia S., additional, Taku, Ila, additional, Talukder, Jamil, additional, Teodoro, João Soeiro, additional, Thokchom, Suresh Kumar, additional, Trulioff, Andrey S., additional, Ukolov, Anton I., additional, Umegaki, Keizo, additional, Verma, Pankaj, additional, Verma, Pawan K., additional, Wan, Dan, additional, Wilson-Frank, Christina, additional, Woldemeskel, Moges, additional, Wu, Qinghua, additional, Yang, Mildred S., additional, Yurdakok-Dikmen, Begum, additional, Zaja-Milatovic, Snjezana, additional, and Zoltani, Csaba K., additional

Published
2021
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29. Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications

Author

Neves, Manuel, Azevedo, Rita, Lima, Luís, Oliveira, Marta I., Peixoto, Andreia, Ferreira, Dylan, Soares, Janine, Fernandes, Elisabete, Gaiteiro, Cristiana, Palmeira, Carlos, Cotton, Sofia, Mereiter, Stefan, Campos, Diana, Afonso, Luís Pedro, Ribeiro, Ricardo, Fraga, Avelino, Tavares, Ana, Mansinho, Hélder, Monteiro, Eurico, Videira, Paula A., Freitas, Paulo P., Reis, Celso A., Santos, Lúcio Lara, Dieguez, Lorena, and Ferreira, José Alexandre

Published
2019
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31. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Author

Gomes, Ana, Price, Nathan, Ling, Alvin, Moslehi, Javid, Montgomery, Magdalene, Rajman, Luis, White, James, Teodoro, João, Wrann, Christiane, Hubbard, Basil, Mercken, Evi, Palmeira, Carlos, de Cabo, Rafael, Rolo, Anabela, Turner, Nigel, Bell, Eric, and Sinclair, David

Subjects
AMP-Activated Protein Kinases, Aging, Animals, Cell Nucleus, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Mitochondria, Muscle, Skeletal, NAD, Oxidative Phosphorylation, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Reactive Oxygen Species, Sirtuin 1, Transcription Factors
Abstract

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. We trace the cause to an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication that is induced by a decline in nuclear NAD(+) and the accumulation of HIF-1α under normoxic conditions, with parallels to Warburg reprogramming. Deleting SIRT1 accelerates this process, whereas raising NAD(+) levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. Thus, a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible.

Published
2013

35. Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis

Author

Nascimento-Gonçalves, Elisabete, primary, Seixas, Fernanda, additional, Palmeira, Carlos, additional, Martins, Gabriela, additional, Fonseca, Carolina, additional, Duarte, José Alberto, additional, Faustino-Rocha, Ana I., additional, Colaço, Bruno, additional, Pires, Maria João, additional, Neuparth, Maria João, additional, Moreira-Gonçalves, Daniel, additional, Fardilha, Margarida, additional, Henriques, Magda C., additional, Patrício, Daniela, additional, Pelech, Steven, additional, Ferreira, Rita, additional, and Oliveira, Paula A., additional

Published
2023
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38. Hydrolytic Activity of Mitochondrial F1FO‑ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors.

Author

Nikolaou, Panagiota-Efstathia, Lambrinidis, George, Georgiou, Maria, Karagiannis, Dimitrios, Efentakis, Panagiotis, Bessis-Lazarou, Pavlos, Founta, Konstantina, Kampoukos, Stavros, Konstantin, Vasilis, Palmeira, Carlos M., Davidson, Sean M., Lougiakis, Nikolaos, Marakos, Panagiotis, Pouli, Nicole, Mikros, Emmanuel, and Andreadou, Ioanna

Published
2023
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39. Contributors

Author

Anadón, Arturo, primary, Anantharam, Vellareddy, additional, Archibong, Anthony E., additional, Ares, Irma, additional, Aulbach, Adam D., additional, Awasthee, Nikee, additional, Banerjee, Aryamitra, additional, Banks, Leah D., additional, Barile, Frank A., additional, Beedanagari, Sudheer R., additional, Belantis, Charalampos, additional, Bergamaschi, Enrico, additional, Bhandari, Sadikshya, additional, Bhatia, Sneha P., additional, Bischoff, Karyn, additional, Borts, David J., additional, Brehm, Emily, additional, Chandra Gupta, Subash, additional, Chatterjee, Saurabh, additional, Chiang, Catheryne, additional, Chintalapati, Anirudh J., additional, Cohn, P., additional, Coppock, Robert W., additional, Costa, Lucio G., additional, Damodaran, Tirupapuliyur V., additional, D'Souza, Clinton, additional, Dettbarn, Wolf-D., additional, Devlin, Amy A., additional, Doss, Robin B., additional, Dwivedi, Shiwangi, additional, Dziwenka, Margitta M., additional, Estévez, Jorge, additional, Fabricant, Daniel S., additional, Fan, A.M., additional, Fitsanakis, Vanessa A., additional, Flaskos, John, additional, Flaws, Jodi A., additional, Flora, Swaran J.S., additional, Ford, Sue M., additional, Fortin, Jessica S., additional, Fragou, Domniki, additional, Gad, Shayne C., additional, Galateanu, Bianca, additional, Gardner, Dale R., additional, Georgiadis, George, additional, Gil, Fernando, additional, Goel, Saryu, additional, Gulumian, Mary, additional, Gupta, P.K., additional, Gupta, Ramesh C., additional, Gupta, Rekha K., additional, Gwaltney-Brant, Sharon, additional, Hargreaves, Alan J., additional, Harris, Kelly L., additional, Harris, Kenneth J., additional, Hatfield, Holly E., additional, Hayes, Wallace A., additional, Heretis, Ioannis, additional, Hernández, Antonio F., additional, Hilmas, Corey J., additional, Hood, Darryl B., additional, Huuskonen, Pasi, additional, Jacobson, Stewart B., additional, James-Yi, Sandra A., additional, Jin, Huajun, additional, Kanno, Jun, additional, Kanthasamy, Arthi, additional, Kanthasamy, Anumantha G., additional, Kaore, Shilpa N., additional, Kaore, Navinchandra M., additional, Kaphalia, Bhupendra S., additional, Karttunen, Vesa, additional, Kaur, Gurjot, additional, Kaur, Ravneet, additional, Kodavanti, Prasada Rao S., additional, Kodavanti, Urmila P., additional, Kontadakis, George A., additional, Krishna, Gopala, additional, Krishna, Priya A., additional, Krishna, Kavya A., additional, Kummu, Maria, additional, Kymionis, George D., additional, Lall, Rajiv, additional, Lin, P., additional, Loganathan, Bommanna G., additional, Loikkanen, Jarkko, additional, Lotti, Marcello, additional, Lynes, Michael A., additional, Mahadevan, Brinda, additional, Malik, Jitendra K., additional, Mamoulakis, Charalampos, additional, Mantey, Jane A., additional, Martínez-Larrañaga, María Rosa, additional, Martínez, María Aránzazu, additional, Mavridis, Charalampos, additional, McClellan, Roger O., additional, Meador, Vincent P., additional, Mikkelsen, Lars Friis, additional, Milatovic, Dejan, additional, Miller Mukherjee, Ida R., additional, Mukherjee, Anupama, additional, Multani, Pushpinder Kaur, additional, Myllynen, Päivi, additional, Myöhänen, Kirsi, additional, Negga, Rekek, additional, Negrei, Carolina, additional, Novilla, Meliton N., additional, Padilla, Stephanie, additional, Palmeira, Carlos M., additional, Panter, Kip E., additional, Pasanen, Markku, additional, Patrick, Daniel J., additional, Pavanello, Sofia, additional, Pedersen, Henrik Duelund, additional, Pelkonen, Olavi, additional, Pellizzon, Michael A., additional, Pitt, Jason, additional, Plaka, Argyro, additional, Ramesh, Aramandla, additional, Rattan, Saniya, additional, Repo, Jenni, additional, Ricci, Matthew R., additional, Rolo, Anabela P., additional, Sachana, Magdalini, additional, Sahlman, Heidi, additional, Saini, Nitin, additional, Saini, Vandana, additional, Savolainen, Kai, additional, Seth, Ratanesh Kumar, additional, Sharma, Abha, additional, Sharma, Anurag, additional, Sieppi, Elina, additional, Silva, Rui, additional, Sinha, Anita, additional, Skamagkas, Iordanis, additional, Snow, Samantha J., additional, Sogorb, Miguel A., additional, Srivastava, Ajay, additional, Stice, Szabina A., additional, Storvik, Markus, additional, Szabo, David T., additional, Teodoro, João S., additional, Tsatsakis, Aristidis M., additional, Tsiaoussis, John, additional, Vähäkangas, Kirsi, additional, Verma, Sumit Singh, additional, Vilanova, Eugenio, additional, Vulimiri, Suryanarayana V., additional, Warner, Genoa R., additional, Welch, Kevin D., additional, Wilson-Frank, Christina, additional, You, S.H., additional, Zaja-Milatovic, Snjezana, additional, Zisis, Ioannis E., additional, and Zoltani, Csaba K., additional

Published
2019
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44. Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Author

Lopes, Cátia R., primary, Silva, Joana S., additional, Santos, Joana, additional, Rodrigues, Matilde S., additional, Madeira, Daniela, additional, Oliveira, Andreia, additional, Moreira-de-Sá, Ana, additional, Lourenço, Vanessa S., additional, Gonçalves, Francisco Q., additional, Silva, Henrique B., additional, Simões, Ana Patrícia, additional, Rolo, Anabela P., additional, Canas, Paula M., additional, Tomé, Ângelo R., additional, Palmeira, Carlos M., additional, Lopes, João Pedro, additional, Cunha, Rodrigo A., additional, Agostinho, Paula, additional, and Ferreira, Samira G., additional

Published
2023
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47. Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia–Reperfusion Injury: Discovery and In Vitroand In VivoEvaluation of Novel Inhibitors

Author

Nikolaou, Panagiota-Efstathia, Lambrinidis, George, Georgiou, Maria, Karagiannis, Dimitrios, Efentakis, Panagiotis, Bessis-Lazarou, Pavlos, Founta, Konstantina, Kampoukos, Stavros, Konstantin, Vasilis, Palmeira, Carlos M., Davidson, Sean M., Lougiakis, Nikolaos, Marakos, Panagiotis, Pouli, Nicole, Mikros, Emmanuel, and Andreadou, Ioanna

Abstract

F1FO-ATP synthase is the mitochondrial complex responsible for ATP production. During myocardial ischemia, it reverses its activity, hydrolyzing ATP and leading to energetic deficit and cardiac injury. We aimed to discover novel inhibitors of ATP hydrolysis, accessing the druggability of the target within ischemia(I)/reperfusion(R) injury. New molecular scaffolds were revealed using ligand-based virtual screening methods. Fifty-five compounds were tested on isolated murine heart mitochondria and H9c2 cells for their inhibitory activity. A pyrazolo[3,4-c]pyridine hit structure was identified and optimized in a hit-to-lead process synthesizing nine novel derivatives. Three derivatives significantly inhibited ATP hydrolysis in vitro, while in vivo, they reduced myocardial infarct size (IS). The novel compound 31was the most effective in reducing IS, validating that inhibition of F1FO-ATP hydrolytic activity can serve as a target for cardioprotection during ischemia. Further examination of signaling pathways revealed that the cardioprotection mechanism is related to the increased ATP content in the ischemic myocardium and increased phosphorylation of PKA and phospholamban, leading to the reduction of apoptosis.

Published
2023
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49. Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5

Author

Suenkel, Benjamin, primary, Valente, Sergio, additional, Zwergel, Clemens, additional, Weiss, Sandra, additional, Di Bello, Elisabetta, additional, Fioravanti, Rossella, additional, Aventaggiato, Michele, additional, Amorim, João A., additional, Garg, Neha, additional, Kumar, Surinder, additional, Lombard, David B., additional, Hu, Tuo, additional, Singh, Pankaj K., additional, Tafani, Marco, additional, Palmeira, Carlos M., additional, Sinclair, David, additional, Mai, Antonello, additional, and Steegborn, Clemens, additional

Published
2022
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50. Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

Author

Morais, Mariana, primary, Machado, Vera, additional, Dias, Francisca, additional, Figueiredo, Patrícia, additional, Palmeira, Carlos, additional, Martins, Gabriela, additional, Fernandes, Rui, additional, Malheiro, Ana Rita, additional, Mikkonen, Kirsi S, additional, Teixeira, Ana Luísa, additional, and Medeiros, Rui, additional

Published
2022
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