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1. Third molar maturity index (I3M) assessment according to different geographical zones: a large multi-ethnic study sample

Author

Angelakopoulos, Nikolaos, De Luca, Stefano, Oliveira-Santos, Inês, Ribeiro, Isabella Lima Arrais, Bianchi, Ilenia, Balla, Sudheer B., Kis, Hatice Cansu, Jiménez, Lourdes Gómez, Zolotenkova, Galina, Yusof, Mohd Yusmiaidil Putera, Selmanagić, Aida Hadzić, Pandey, Hemlata, Pereira, Palmela C., da Nóbrega, Johnys Berton Medeiros, Kalani, Hettiarachchi, Mieke, Sylvia M., Kumagai, Akiko, Gulsahi, Ayse, Zelić, Ksenija, Marinković, Nemanja, Kelmendi, Jeta, Galić, Ivan, Vázquez, Israel Soriano, Spinas, Enrico, Velezmoro-Montes, Ymelda Wendy, Moukarzel, Maria, Toledo, Jorge Pinares, El-Bakary, Amal Abd El-Salam, and Cameriere, Roberto

Published
2023
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2. P601 Intestinal ultrasound correlates with clinical, biochemical, endoscopic and histologic biomarkers in patients with Ulcerative Colitis: a cross-sectional study

Author

Bravo, A, primary, Revés, J, additional, Nascimento, C, additional, Abreu, B, additional, Bargas, A, additional, Bragança, S, additional, Rafael, M A, additional, Estevinho, M, additional, Silva, J, additional, Guedes, A, additional, Borralho, P, additional, Glória, L, additional, Roque Ramos, L, additional, Palmela, C, additional, Torres, J, additional, and Frias-Gomes, C, additional

Published
2024
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6. P333 Early intestinal ultrasound remission is associated with endoscopic healing after one year of infliximab therapy in Crohn’s disease: a multicentre prospective study

Author

Revés, J, primary, Morão, B, additional, Nascimento, C, additional, Frias-Gomes, C, additional, Cúrdia Gonçalves, T, additional, Freitas, M, additional, Castro, F, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2023
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7. DOP15 Intestinal ultrasound correlates with colonoscopy and biomarkers, and can be used in a tight monitoring approach to assess response to therapy in Crohn's disease: a multicentre prospective study

Author

Morão, B, primary, Revés, J, additional, Nascimento, C, additional, Frias Gomes, C, additional, Cúrdia Gonçalves, T, additional, Freitas, M, additional, Castro, F, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2023
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9. Third molar maturity index (I3M) assessment according to different geographical zones: a large multi-ethnic study sample

Author

Angelakopoulos, Nikolaos, primary, De Luca, Stefano, additional, Oliveira-Santos, Inês, additional, Ribeiro, Isabella Lima Arrais, additional, Bianchi, Ilenia, additional, Balla, Sudheer B., additional, Kis, Hatice Cansu, additional, Jiménez, Lourdes Gómez, additional, Zolotenkova, Galina, additional, Yusof, Mohd Yusmiaidil Putera, additional, Selmanagić, Aida Hadzić, additional, Pandey, Hemlata, additional, Pereira, Palmela C., additional, da Nóbrega, Johnys Berton Medeiros, additional, Kalani, Hettiarachchi, additional, Mieke, Sylvia M., additional, Kumagai, Akiko, additional, Gulsahi, Ayse, additional, Zelić, Ksenija, additional, Marinković, Nemanja, additional, Kelmendi, Jeta, additional, Galić, Ivan, additional, Vázquez, Israel Soriano, additional, Spinas, Enrico, additional, Velezmoro-Montes, Ymelda Wendy, additional, Moukarzel, Maria, additional, Toledo, Jorge Pinares, additional, El-Bakary, Amal Abd El-Salam, additional, and Cameriere, Roberto, additional

Published
2022
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10. Third molar maturity index (I

Author

Nikolaos, Angelakopoulos, Stefano, De Luca, Inês, Oliveira-Santos, Isabella Lima Arrais, Ribeiro, Ilenia, Bianchi, Sudheer B, Balla, Hatice Cansu, Kis, Lourdes Gómez, Jiménez, Galina, Zolotenkova, Mohd Yusmiaidil Putera, Yusof, Aida Hadzić, Selmanagić, Hemlata, Pandey, Palmela C, Pereira, Johnys Berton Medeiros, da Nóbrega, Hettiarachchi, Kalani, Sylvia M, Mieke, Akiko, Kumagai, Ayse, Gulsahi, Ksenija, Zelić, Nemanja, Marinković, Jeta, Kelmendi, Ivan, Galić, Israel Soriano, Vázquez, Enrico, Spinas, Ymelda Wendy, Velezmoro-Montes, Maria, Moukarzel, Jorge Pinares, Toledo, Amal Abd El-Salam, El-Bakary, and Roberto, Cameriere

Abstract

Identification of living undocumented individuals highlights the need for accurate, precise, and reproducible age estimation methods, especially in those cases involving minors. However, when their country of origin is unknown, or it can be only roughly estimated, it is extremely difficult to apply assessment policies, procedures, and practices that are accurate and child-sensitive. The main aim of this research is to optimize the correct classification of adults and minors by establishing new cut-off values for four different continents (Africa, America, Asia, and Europe). For this purpose, a vast sample of 10,701 orthopantomographs (OPTs) from four continents was evaluated. For determination and subsequent validation of the new third molar maturity index (I

Published
2022

15. Third molar maturity index (I3M) assessment according to different geographical zones: a large multi-ethnic study sample.

Author

Angelakopoulos, Nikolaos, De Luca, Stefano, Oliveira-Santos, Inês, Ribeiro, Isabella Lima Arrais, Bianchi, Ilenia, Balla, Sudheer B., Kis, Hatice Cansu, Jiménez, Lourdes Gómez, Zolotenkova, Galina, Yusof, Mohd Yusmiaidil Putera, Selmanagić, Aida Hadzić, Pandey, Hemlata, Pereira, Palmela C., da Nóbrega, Johnys Berton Medeiros, Kalani, Hettiarachchi, Mieke, Sylvia M., Kumagai, Akiko, Gulsahi, Ayse, Zelić, Ksenija, and Marinković, Nemanja

Subjects
THIRD molars, COUNTRY of origin (Immigrants), AFRICANS, CONTINGENCY tables, MINORS
Abstract

Identification of living undocumented individuals highlights the need for accurate, precise, and reproducible age estimation methods, especially in those cases involving minors. However, when their country of origin is unknown, or it can be only roughly estimated, it is extremely difficult to apply assessment policies, procedures, and practices that are accurate and child-sensitive. The main aim of this research is to optimize the correct classification of adults and minors by establishing new cut-off values for four different continents (Africa, America, Asia, and Europe). For this purpose, a vast sample of 10,701 orthopantomographs (OPTs) from four continents was evaluated. For determination and subsequent validation of the new third molar maturity index (I3M) cut-off values by world regions, a cross-validation by holdout method was used and contingency tables (confusion matrices) were generated. The lower third molar maturity indexes, from both left and right side (I3ML and I3MR) and the combination of both sides (I3ML_I3MR) were calculated. The new cut-off values, that aim to differentiate between a minor and an adult, with more than 74.00% accuracy for all populations were as follows (I3ML; I3MR; I3ML_I3MR, respectively): Africa = (0.10; 0.10; 0.10), America = (0.10; 0.09; 0.09), Asia = (0.15; 0.17; 0.14), and Europe = (0.09; 0.09; 0.09). The higher sensitivity (Se) was detected for the I3ML for male African people (91%) and the higher specificity (Sp) of all the parameters (I3ML; I3MR; I3ML_I3MR) for Europeans both male and female (> 91%). The original cut-off value (0.08) is still useful, especially in discriminating individuals younger than 18 years old which is the goal of the forensic methods used for justice. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Third molar maturity index (I3M) assessment according to different geographical zones: a large multi-ethnic study sample

Author

Nikolaos Angelakopoulos, Stefano De Luca, Inês Oliveira-Santos, Isabella Lima Arrais Ribeiro, Ilenia Bianchi, Sudheer B. Balla, Hatice Cansu Kis, Lourdes Gómez Jiménez, Galina Zolotenkova, Mohd Yusmiaidil Putera Yusof, Aida Hadzić Selmanagić, Hemlata Pandey, Palmela C. Pereira, Johnys Berton Medeiros da Nóbrega, Hettiarachchi Kalani, Sylvia M. Mieke, Akiko Kumagai, Ayse Gulsahi, Ksenija Zelić, Nemanja Marinković, Jeta Kelmendi, Ivan Galić, Israel Soriano Vázquez, Enrico Spinas, Ymelda Wendy Velezmoro-Montes, Maria Moukarzel, Jorge Pinares Toledo, Amal Abd El-Salam El-Bakary, and Roberto Cameriere

Subjects
610 Medizin und Gesundheit, Pathology and Forensic Medicine
Abstract

Identification of living undocumented individuals highlights the need for accurate, precise, and reproducible age estimation methods, especially in those cases involving minors. However, when their country of origin is unknown, or it can be only roughly estimated, it is extremely difficult to apply assessment policies, procedures, and practices that are accurate and child-sensitive. The main aim of this research is to optimize the correct classification of adults and minors by establishing new cut-off values for four different continents (Africa, America, Asia, and Europe). For this purpose, a vast sample of 10,701 orthopantomographs (OPTs) from four continents was evaluated. For determination and subsequent validation of the new third molar maturity index (I3M) cut-off values by world regions, a cross-validation by holdout method was used and contingency tables (confusion matrices) were generated. The lower third molar maturity indexes, from both left and right side (I3ML and I3MR) and the combination of both sides (I3ML_I3MR) were calculated. The new cut-off values, that aim to differentiate between a minor and an adult, with more than 74.00% accuracy for all populations were as follows (I3ML; I3MR; I3ML_I3MR, respectively): Africa = (0.10; 0.10; 0.10), America = (0.10; 0.09; 0.09), Asia = (0.15; 0.17; 0.14), and Europe = (0.09; 0.09; 0.09). The higher sensitivity (Se) was detected for the I3ML for male African people (91%) and the higher specificity (Sp) of all the parameters (I3ML; I3MR; I3ML_I3MR) for Europeans both male and female (> 91%). The original cut-off value (0.08) is still useful, especially in discriminating individuals younger than 18 years old which is the goal of the forensic methods used for justice.

Published
2022
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18. P499 Accessing ultrasonographic transmural healing in patients with Crohn’s disease after induction therapy with infliximab: should we aim for higher infliximab trough levels?

Author

Morão, B, primary, Frias Gomes, C, additional, Revés, J, additional, Cúrdia Gonçalves, T, additional, Freitas, M, additional, Castro, F, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2022
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20. P375 Faecal calprotectin variation after induction therapy with infliximab to predict clinical, endoscopic and ultrasonographic remission in Crohn’s disease patients

Author

Revés, J, primary, Morão, B, additional, Gomes, C F, additional, Nascimento, C, additional, Abreu, N, additional, Gonçalves, T C, additional, Castro, F, additional, Freitas, M, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2022
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21. P145 Ultrasonographic parameters associated with mucosal healing 1 year after infliximab therapy in Crohn’s Disease: a multicentric and prospective study

Author

Nascimento, C, primary, Frias Gomes, C, additional, Morão, B, additional, Cúrdia Gonçalves, T, additional, Dias de Castro, F, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Rosa, C, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Cravo, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2022
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23. Comparison of the third molar maturity index (I3M) between left and right lower third molars to assess the age of majority

Author

Angelakopoulos, N., Galić, I., Pereira, Palmela C., and Repositório da Universidade de Lisboa

Abstract

Submitted by Luiza Baptista (luiza.baptista@fmd.ulisboa.pt) on 2022-01-12T12:28:32Z No. of bitstreams: 1 Angelakopoulos2021_Article_ComparisonOfTheThirdMolarMatur.pdf: 1003198 bytes, checksum: 2e69b35d76e73e67de4c6f2e1125e869 (MD5) Made available in DSpace on 2022-01-12T12:29:21Z (GMT). No. of bitstreams: 1 Angelakopoulos2021_Article_ComparisonOfTheThirdMolarMatur.pdf: 1003198 bytes, checksum: 2e69b35d76e73e67de4c6f2e1125e869 (MD5) Previous issue date: 2021 info:eu-repo/semantics/publishedVersion

Published
2021

25. P152 Bowel ultrasound as an early monitoring tool to assess disease activity in Crohn’s disease patients after induction therapy with infliximab

Author

Morão, B, primary, Nascimento, C, additional, Frias Gomes, C, additional, Gonçalves, T, additional, Castro, F, additional, Moreira, M J, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Cravo, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2021
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26. P505 Early therapeutic drug monitoring after induction therapy with infliximab: correlation with intestinal ultrasound

Author

Nascimento, C, primary, Morão, B, additional, Frias Gomes, C, additional, Cúrdia Gonçalves, T, additional, Castro, F, additional, Moreira, M, additional, Cotter, J, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Coelho, R, additional, Macedo, G, additional, Macedo, C, additional, Ferreira, M, additional, Cravo, M, additional, Glória, L, additional, Torres, J, additional, and Palmela, C, additional

Published
2021
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29. Patients with inflammatory bowel disease are not at increased risk of covid-19: A large multinational cohort study

Author

Allocca, M. Chaparro, M. Gonzalez, H.A. Bosca-Watts, M.M. Palmela, C. D’amico, F. Zacharopoulou, E. Kopylov, U. Ellul, P. Bamias, G. Ntelis, V. Lahat, A. Mantzaris, G.J. Papaconstantinou, I. Katsanos, K. Uspenskaya, Y. Christodoulou, D. Horin, S.B. Peyrin-Biroulet, L. Torres, J. Sebastian, S. Gisbert, J.P. Danese, S. Fiorino, G.

Abstract

The impact of COVID-19 on inflammatory bowel disease (IBD) patients under pharmacological immunosuppression is still not clearly understood. We investigated the incidence of COVID-19 and the impact of immunosuppression and containment measures on the risk of SARS-CoV-2 infection in a large IBD cohort, from a multicenter cohort from 21st of February to 30th of June, 2020. Ninety-seven patients with IBD (43 UC, 53 CD, one unclassified IBD) and concomitant COVID-19 over a total of 23,879 patients with IBD were enrolled in the study. The cumulative incidence of SARS-CoV-2 infection in patients with IBD vs. the general population was 0.406% and 0.402% cases, respectively. Twenty-three patients (24%) were hospitalized, 21 (22%) had pneumonia, four (4%) were admitted to the Intensive Care Unit, and one patient died. Lethality in our cohort was 1% compared to 9% in the general population. At multivariable analysis, age > 65 years was associated with increased risk of pneumonia and hospitalization (OR 11.6, 95% CI 2.18–62.60; OR 5.1, 95% CI 1.10–23.86, respectively), treatment with corticosteroids increased the risk of hospitalization (OR 7.6, 95% CI 1.48–40.05), whereas monoclonal antibodies were associated with reduced risk of pneumonia and hospitalization (OR 0.1, 95% CI 0.04–0.52; OR 0.3, 95% CI 0.10–0.90, respectively). The risk of COVID-19 in patients with IBD is similar to the general population. National lockdown was effective in preventing infection in our cohort. Advanced age and treatment with corticosteroids impacted negatively on the outcome of COVID-19, whereas monoclonal antibodies did not seem to have a detrimental effect. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2020

31. P492 Use of bowel ultrasound to assess disease activity in Crohn’s disease patients after induction therapy with infliximab

Author

Frias Gomes, C, primary, Neto Nascimento, C, additional, Pereira, F, additional, Caldeira, A, additional, Sousa, R, additional, Arieira, C, additional, Xavier, S, additional, Monteiro, S, additional, Dias de Castro, F, additional, Leite, S, additional, Cotter, J, additional, Santos, A A, additional, Cravo, M, additional, Torres, J, additional, and Palmela, C, additional

Published
2020
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33. P176 Expert consensus on acquisition and reporting of intestinal ultrasonography activity in Crohn’s disease. A prospective inter-rater agreement study

Author

Wilkens, R T, primary, Nylund, K, additional, Petersen, F, additional, De Voogd, F, additional, Maaser, C, additional, Kucharzik, T, additional, Maconi, G, additional, Allocca, M, additional, Lu, C, additional, Palmela, C, additional, Vaughan, R, additional, Christensen, B, additional, and Novak, K L, additional

Published
2020
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34. Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition

Author

Goncalves J, Santos M, Acurcio R, Iria I, Gouveia L, Brito P, Santos ACC, Barbas A, Galvao J, Barbosa I, da Silva FA, Alcobia A, Cavaco M, Cardoso M, Alves JD, Carey J, Dorner T, Fonseca JE, Palmela C, Torres J, Vieira CL, Trabuco D, Fiorino G, Strik A, Yavzori M, Rosa I, Correia L, Magro F, D'Haens G, Ben-Horin S, Lakatos P, Danese S, Goncalves, J, Santos, M, Acurcio, R, Iria, I, Gouveia, L, Brito, P, Santos, Acc, Barbas, A, Galvao, J, Barbosa, I, da Silva, Fa, Alcobia, A, Cavaco, M, Cardoso, M, Alves, Jd, Carey, J, Dorner, T, Fonseca, Je, Palmela, C, Torres, J, Vieira, Cl, Trabuco, D, Fiorino, G, Strik, A, Yavzori, M, Rosa, I, Correia, L, Magro, F, D'Haens, G, Ben-Horin, S, Lakatos, P, and Danese, S

Published
2018

37. Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease.

Author

Colombel J.-F., Palmela C., Parker C.E., Silverberg O.M., Upadhyaya S.D., Nguyen T.M., Boyapati R.K., Torres J., Colombel J.-F., Palmela C., Parker C.E., Silverberg O.M., Upadhyaya S.D., Nguyen T.M., Boyapati R.K., and Torres J.

Abstract

Background: Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinician concerns regarding safety, adverse events, cost and national regulations. Withdrawal of immunosuppressant and biologic drugs in patients with quiescent CD may limit adverse events and reduce healthcare costs. Alternatively, stopping these drug therapies may result in negative outcomes such as disease relapse, drug desensitization, bowel damage and need for surgery. Objective(s): To assess the feasibility and safety of discontinuing immunosuppressant or biologic drugs, administered alone or in combination, in patients with quiescent CD. Search Method(s): We searched CENTRAL, MEDLINE, Embase and the Cochrane IBD Group Specialized Register from inception to 19 December 2017. We also searched the reference lists of potentially relevant manuscripts and conference proceedings to identify additional studies. Selection Criteria: Randomized controlled trials (RCTs) and prospective cohort studies that followed patients for a minimum duration of six months after drug discontinuation were considered for inclusion. The patient population of interest was adults (> 18 years) with CD (as defined by conventional clinical, endoscopic or histologic criteria) who had achieved remission while receiving immunosuppressant or biologic drugs administered alone or in combination. Patients then discontinued the drug regimen following a period of maintenance therapy of at least six months. The comparison was usual care (i.e. continuation of the drug regimen). Data Collection and Analysis: The primary outco

Published
2018

38. Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

Author

Goncalves, J., primary, Santos, M., additional, Acurcio, R., additional, Iria, I., additional, Gouveia, L., additional, Matos Brito, P., additional, Catarina Cunha-Santos, A., additional, Barbas, A., additional, Galvão, J., additional, Barbosa, I., additional, Aires da Silva, F., additional, Alcobia, A., additional, Cavaco, M., additional, Cardoso, M., additional, Delgado Alves, J., additional, Carey, J. J., additional, Dörner, T., additional, Eurico Fonseca, J., additional, Palmela, C., additional, Torres, J., additional, Lima Vieira, C., additional, Trabuco, D., additional, Fiorino, G., additional, Strik, A., additional, Yavzori, M., additional, Rosa, I., additional, Correia, L., additional, Magro, F., additional, D'Haens, G., additional, Ben-Horin, S., additional, Lakatos, P. L., additional, and Danese, S., additional

Published
2018
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39. P545 Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition

Author

Goncalves, J, primary, Santos, M, additional, Acurcio, R, additional, Iria, I, additional, Gouveia, L, additional, Brito, P, additional, Cunha Santos, A C, additional, Barbas, A, additional, Galvão, J, additional, Barbosa, I, additional, Aires da Silva, F, additional, Alcobia, A, additional, Cavaco, M, additional, Cardoso, M, additional, Delgado Alves, J, additional, Carey, J, additional, Dorner, T, additional, Eurico Fonseca, J, additional, Palmela, C, additional, Torres, J, additional, Lima Vieira, C, additional, Trabuco, D, additional, Fiorino, G, additional, Strik, A, additional, Yavzori, M, additional, Rosa, I, additional, Correia, L, additional, Magro, F, additional, D'Haens, G, additional, Ben-Horin, S, additional, Lakatos, P, additional, and Danese, S, additional

Published
2018
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42. Withdrawal of drug therapy for patients with quiescent Crohn's disease.

Author

Khanna R., Colombel J.-F., Upadhyaya S.D., Jairath V., Feagan B.G., Boyapati R., Torres J., Palmela C., Parker C.E., Silverberg O.M., Khanna R., Colombel J.-F., Upadhyaya S.D., Jairath V., Feagan B.G., Boyapati R., Torres J., Palmela C., Parker C.E., and Silverberg O.M.

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this review is to assess the feasibility and safety of discontinuing immunosuppressant or biologic drugs, administered alone or in combination, in patients with quiescent CD.Copyright © 2017 The Cochrane Collaboration.

Published
2017

45. The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease

Author

Torres, J, primary, Palmela, C, additional, Brito, H, additional, Bao, X, additional, Ruiqi, H, additional, Moura-Santos, P, additional, Pereira da Silva, J, additional, Oliveira, A, additional, Vieira, C, additional, Perez, K, additional, Itzkowitz, SH, additional, Colombel, JF, additional, Humbert, L, additional, Rainteau, D, additional, Cravo, M, additional, Rodrigues, CM, additional, and Hu, J, additional

Published
2017
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49. The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease

Author

Torres, J, Palmela, C, Brito, H, Bao, X, Ruiqi, H, Moura-Santos, P, Pereira da Silva, J, Oliveira, A, Vieira, C, Perez, K, Itzkowitz, SH, Colombel, JF, Humbert, L, Rainteau, D, Cravo, M, Rodrigues, CM, and Hu, J

Abstract

Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia. Alterations in the gut microbiota and/or gut bile acids could account for the increase in this risk. However, no studies have yet investigated the net result of cholestasis and a potentially altered bile acid pool interacting with a dysbiotic gut flora in the inflamed colon of PSC-IBD. The aim of this study was to compare the gut microbiota and stool bile acid profiles, as well as and their correlation in patients with PSC-IBD and inflammatory bowel disease alone. Thirty patients with extensive colitis (15 with concomitant primary sclerosing cholangitis) were prospectively recruited and fresh stool samples were collected. The microbiota composition in stool was profiled using bacterial 16S rRNA sequencing. Stool bile acids were assessed by high-performance liquid chromatography tandem mass spectrometry. The total stool bile acid pool was significantly reduced in PSC-IBD. Although no major differences were observed in the individual bile acid species in stool, their overall combination allowed a good separation between PSC-IBD and inflammatory bowel disease. Compared with inflammatory bowel disease alone, PSC-IBD patients demonstrated a different gut microbiota composition with enrichment in Ruminococcusand Fusobacteriumgenus compared with inflammatory bowel disease. At the operational taxonomic unit level major shifts were observed within the Firmicutes(73%) and Bacteroidetesphyla (17%). Specific microbiota-bile acid correlations were observed in PSC-IBD, where 12% of the operational taxonomic units strongly correlated with stool bile acids, compared with only 0.4% in non-PSC-IBD. Patients with PSC-IBD had distinct microbiota and microbiota-stool bile acid correlations as compared with inflammatory bowel disease. Whether these changes are associated with, or may predispose to, an increased risk of colorectal neoplasia needs to be further clarified.

Published
2018
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50. Career satisfaction of medical residents in Portugal | Satisfação com a especialidade entre os internos da formação específica em Portugal

Author

Martins, M. J., Laíns, I., Bruno Brochado, Oliveira-Santos, M., Pinto Teixeira, P., Brandão, M., Cerqueira, R. J., Castro-Ferreira, R., Bernardes, C., Nobre Menezes, M., Soares Baptista, B., Ladeiras-Lopes, R., Cruz Rei, M., Pires Da Rosa, G., Martins, J. L., Mendonça Sanches, M., Ferreira-Pinto, M. J., Rato, M., Costa E Silva, M., Policiano, C., Beato, J., Barbosa-Breda, J., Pimentel Torres, J., Leal, I., Aguiar Rosa, S., Carvalho Ribeiro, B., Rego Costa, F., Palmela, C., Cúrdia Gonçalves, T., Morais, L., and Reis Marques, T.

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