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38 results on '"Palomba, Martina"'

1. List of contributors

Author

Abenante, Laura, primary, Alves, Diego, additional, Azeredo, Juliano B., additional, Bagnoli, Luana, additional, Barcellos, Angelita M., additional, Braga, Antonio L., additional, Dias, Ítalo F.C., additional, Hartwig, Daniela, additional, Iwaoka, Michio, additional, Jacob, Raquel G., additional, Lenardão, Eder J., additional, Mangiavacchi, Francesca, additional, Marini, Francesca, additional, Nascimento, José E.R., additional, Pacuła-Miszewska, Agata J., additional, Palomba, Martina, additional, Penteado, Filipe, additional, Perin, Gelson, additional, Rafique, Jamal, additional, Rosati, Ornelio, additional, Saba, Sumbal, additional, Sacramento, Manoela, additional, Sancineto, Luca, additional, Santi, Claudio, additional, Schiesser, Carl H., additional, Schneider, Paulo H., additional, Shimodaira, Shingo, additional, Silva, Márcio S., additional, Soares, Liane K., additional, and Ścianowski, Jacek, additional

Published
2022
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19. Oxone-Mediated Oxidation of Vinyl Selenides in Water

Author

Palomba, Martina, Trappetti, Francesco, Bagnoli, Luana, Santi, Claudio, and Marini, Francesca

Subjects
Selenium, Organochalcogen compounds, Oxidation, Organic Chemistry, Oxone, Synthesis design, Physical and Theoretical Chemistry
Published
2018

22. Organoselenium Chemistry: after 200 years the "Gold Rush" is still open

Author

Santi, Claudio, primary, Marini, Francesca, additional, Bagnoli, Luana, additional, Sancineto, Luca, additional, Palomba, Martina, additional, Monti, Bonifacio, additional, Mangiavacchi, Francesca, additional, Alocchi, Sofia, additional, Begini, Francesca, additional, Capoccia, Lucia, additional, Cappelloni, Gloria, additional, Cardinali, Margherita, additional, Chiericoni, Vittoria, additional, Coarelli, Elisabetta, additional, Della Rina, Lisa, additional, De Monte, Emanuela, additional, Di Salvo, Giulia, additional, Giorgi, Ester, additional, Merlino, Orsola, additional, Nacca, Francesca, additional, Pensa, Marianna, additional, Pompei, Sara, additional, Russo, Agata, additional, Santoni, Paolo, additional, and Scarcella, Elisabetta, additional

Published
2017
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26. Highlight on the reactivity of PhSeZnX

Author

Monti, Bonifacio, Sancineto, Luca, Palomba, Martina, Bagnoli, Luana, Marini, Francesca, Lenardao, Eder, and Santi, Claudio

Subjects
Selenium, Zinc, Michael addition, epoxide, Selenium, Zinc, Nucleohpile, epoxide, Michael addition, Nucleohpile
Published
2015

27. Solvent-free, uncatalyzed asymmetric “ene” reactions of N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines: a general approach to enantiomerically pure α-(trifluoromethyl)tryptamines

Author

Mazzeo, Giuseppe, primary, Longhi, Giovanna, additional, Abbate, Sergio, additional, Palomba, Martina, additional, Bagnoli, Luana, additional, Marini, Francesca, additional, Santi, Claudio, additional, Han, Jianlin, additional, Soloshonok, Vadim A., additional, Di Crescenzo, Emilio, additional, and Ruzziconi, Renzo, additional

Published
2017
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31. Aerobic Allylation of Alcohols with Non-Activated Alkenes Enabled by Light-Driven Selenium-p-Acid Catalysis.

Author

Rode, Katharina, Palomba, Martina, Ortgies, Stefan, Rieger, Rene, and Breder, Alexander

Subjects
*ORGANOCATALYSIS, *ALKENES, *DEHYDROGENATION, *ALLYLATION, *ALCOHOLS (Chemical class), *ACID catalysts, *SELENIUM
Abstract

A new organocatalytic protocol for the aerobic dehydrogenative allylation of alcohols using non-activated alkenes as the allylating reagent and ambient air as the terminal oxidant is established. Mechanistically, the procedure relies on the interplay of a diselane and a photoredox catalyst by means of a light-induced electron transfer process. Under optimized conditions, a broad range of both cyclic and acyclic ethers is accessed with very high functional group tolerance and excellent regioselectivity. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Highlight on the reactivity of PhSeZnX

Author

Santi, Claudio, primary, Monti, Bonifacio, additional, Sancineto, Luca, additional, Palomba, Martina, additional, Bagnoli, Luana, additional, Marini, Francesca, additional, and Lenardao, Eder, additional

Published
2015
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36. Identification of a Dual Autophagy and REV-ERB Inhibitor with in VivoAnticancer Efficacy

Author

Palomba, Martina, Vecchio, Donatella, Allavena, Giulia, Capaccio, Vito, De Mei, Claudia, Scarpelli, Rita, and Grimaldi, Benedetto

Abstract

The autophagy process appears as a promising target for anticancer interventions. Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved autophagy flux inhibitors. Although diverse anticancer clinical trials are providing encouraging results, several limitations associated with the need of high dosage and long-term administration of these autophagy inhibitors are also emerging. We showed that the inhibition of REV-ERB, a nuclear receptor regulating circadian rhythm and metabolism, enhances CQ-mediated cancer cell death and identified a class of dual inhibitors of autophagy and REV-ERB displaying an in vitroanticancer activity against diverse tumor cells greatly higher than CQ. Herein, we describe our lead optimization strategy that led to the identification of compound 24as a dual autophagy and REV-ERB inhibitor, showing improved potency in blocking autophagy, enhanced toxicity against cancer cells, optimal drug-like properties, and efficacy in a mouse xenograft model of melanoma as a single anticancer agent.

Published
2023
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37. Advances in Electrophilic Organochalcogen Reagents

Author

Sancineto, Luca, Palomba, Martina, Bagnoli, Luana, Marini, Francesca, and Santi, Claudio

Abstract

Electrophilic Selenium, Sulfur and Tellurium reagents are widely applied in a number of chemo, regio and stereospecific transformations for the installation of new functional groups in organic electron rich substrates as well as the synthesis of heterocyclic scaffolds. The most recent review articles are here currently updated demonstrating the continuously growing interest in this kind of reagents.

Published
2016

38. Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

Author

Krasowska, Dorota, Iraci, Nunzio, Santi, Claudio, Drabowicz, Józef, Cieslak, Marcin, Kazmierczak-Baranska, Julia, Palomba, Martina, Królewska-Golinska, Karolina, Magiera, Jakub, and Sancineto, Luca

Subjects
3. Good health
Abstract

A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.

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