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34 results on '"Pan, Baolong"'

6. FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma.

Author

Pan, Baolong, Li, Yan, Han, Huiyun, Zhang, Lu, Hu, Xuemei, Pan, Yanyu, and Peng, Zhuohui

Abstract

Cisplatin (CDDP) is a commonly used chemotherapeutic for osteosarcoma (OS) patients, and drug resistance remains as a major hurdle to undermine the treatment outcome. Here, we investigated the potential involvement of FoxG1 and BNIP3 in CDDP resistance of OS cells. FoxG1 and BNIP3 expression levels were detected in the CDDP‐sensitive and CDDP‐resistant OS tumors and cell lines. Mitophagy was observed through transmission electron microscope analysis. The sensitivity to CDDP in OS cells upon FoxG1 overexpression was examined in cell and animal models. We found that FoxG1 and BNIP3 showed significant downregulation in the CDDP‐resistant OS tumor samples and cell lines. CDDP‐resistant OS tumor specimens and cells displayed impaired mitophagy. FoxG1 overexpression promoted BNIP3 expression, enhanced mitophagy in CDDP‐resistant OS cells, and resensitized the resistant cells to CDDP treatment in vitro and in vivo. Our data highlighted the role of the FoxG1/BNIP3 axis in regulating mitophagy and dictating CDDP resistance in OS cells, suggesting targeting FoxG1/BNIP3‐dependent mitophagy as a potential strategy to overcome CDDP resistance in OS. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Association Between Serum Magnesium Levels and Glycemic Control in Type 2 Diabetes.

Author

Luo, Beibei, Pan, Baolong, Zhao, Guancheng, Li, Jiefen, and Sun, Li

Subjects
GLYCEMIC control, TYPE 2 diabetes, GLYCOSYLATED hemoglobin, LOGISTIC regression analysis, HIGH density lipoproteins
Abstract

Introduction: Serum magnesium is a crucial mineral within the human body. It is imperative for diabetic patients to maintain optimal serum magnesium levels. We focus on the relationship between glycemic control and serum magnesium in type 2 diabetes mellitus (T2DM). Methods: The retrospective, observational, cross-sectional study comprised 1694 patients recruited from the People's Hospital of Yuxi. Fasting blood samples were collected for analysis, accompanied by the recording of participants' demographic characteristics. Patients were categorized into two groups based on whether their glycosylated hemoglobin (HbA1c) levels < 7%. A t-test was employed to identify significant differences between the two groups. Correlation coefficients were calculated using Pearson's method. A Logistic regression analysis was conducted to assess the association between variables and glycemic control. A linear regression analysis was performed to assess the relationship between serum magnesium levels and HbA1c. Results: Patients with poor glycemic control exhibited elevated age, low-density lipoprotein (LDL-C), fasting plasma glucose (FPG), and homeostasis model assessment (HOMA-IR) compared to those with good glycemic control (P < 0.001). Additionally, total cholesterol (TC) levels were significantly higher in patients with poor glycemic control. Conversely, high-density lipoprotein (HDL-C) and serum magnesium levels were lower in patients with poor glycemic control. Serum magnesium levels exhibited negative correlations with HOMA-IR (r = − 0.05, P < 0.05), HbA1c (r = − 0.29, P < 0.05), and FPG (r = − 0.20, P < 0.05). Moreover, serum magnesium was significantly associated with reduced odds of glycemic control (OR = 0.0005, 95% CI 0.0001– 0.0027, P < 0.001). Conclusion: The serum magnesium level in patients with T2DM is closely associated with glycemic control. [ABSTRACT FROM AUTHOR]

Published
2024
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12. A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

Author

Zhao, Le, Yin, Jinzhu, Huan, Jiaping, Han, Xiao, Zhao, Dan, Song, Jing, Wang, Linping, Zhang, Huifang, Pan, Baolong, Niu, Qiao, and Lu, Xiaoting

Abstract

The correlation between metals and hypertension, such as sodium, zinc, potassium, and magnesium, has been confirmed, while the relationship between aluminum and hypertension is not very clear. This study aimed to evaluate the correlation between plasma aluminum and hypertension in electrolytic aluminum workers by the Bayesian networks (BN). In 2019, 476 male workers in an aluminum factory were investigated. The plasma aluminum concentration of workers was measured by inductively coupled plasma mass spectrometry. The influencing factors on the prevalence of hypertension were analyzed by the BN. The prevalence of hypertension was 23.9% in 476 male workers. The risk of hypertension from plasma aluminum in the Q2, Q3, and Q4 groups was 5.20 (1.90–14.25), 6.92 (2.51–19.08), and 7.33 (2.69–20.01), respectively, compared with that in the Q1 group. The risk of hypertension from the duration of exposure to aluminum of >10 years was 2.23 (1.09–4.57), compared without aluminum exposure. Area under the curve was 0.80 of plasma aluminum and the duration of exposure to aluminum was based on covariates, indicating that aluminum exposure had important predictive value in the prevalence of hypertension in the occupational population. The results of the study using the BN model showed that if the plasma aluminum of all participants was higher than Q4 (≥47.86 µg/L) and the participants were drinking, smoking, diabetes, central obesity, dyslipidemia, and aged >50 years, the proportion of hypertension was 71.2%. The prevalence of hypertension increased significantly with the increase of plasma aluminum level. The Bayesian networks (BN) model showing marginal probabilities. (A) The BN model for hypertension and hypertension‐related factors. (B) The BN model for hypertension for those plasma aluminum higher than Q4 ( ≥ 47.86 µg/L) and all the participants reported drinking, smoking, diabetes, central obesity, dyslipidemia, and aged >50 years. Exploring the association between high‐concentration aluminum exposure and hypertension risk in occupational populations.Using a BN model to demonstrate the influence of blood aluminum concentration on the prevalence of hypertension.Revealing high‐risk groups for hypertension among aluminum workers. Exploring the association between high‐concentration aluminum exposure and hypertension risk in occupational populations. Using a BN model to demonstrate the influence of blood aluminum concentration on the prevalence of hypertension. Revealing high‐risk groups for hypertension among aluminum workers.

Published
2024
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15. Forecasting and analysis of the effect of lifestyle on cognitive dysfunction induced by occupational aluminum exposure based on Bayesian networks

Author

Zhao, Dan, primary, Han, Xiao, additional, Huan, Jiaping, additional, Gao, Dan, additional, Wang, Tianshu, additional, Song, Jing, additional, Wang, Linping, additional, Zhang, Huifang, additional, Luo, Tiane, additional, Pan, Baolong, additional, Niu, Qiao, additional, and Lu, Xiaoting, additional

Published
2023
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16. Development of Novel Heterobifunctional Degraders and Antifungal Agents

Author

PAN, BAOLONG

Subjects
Organic chemistry not elsewhere classified, Medicinal and biomolecular chemistry not elsewhere classified
Abstract

This thesis explores distinct but overlapping approaches to contemporary drug discovery. PROTAC drugs are an emerging therapeutic approach where molecules hijack the ubiquitin-proteasome system to degrade disease-implicated proteins. Fragment-based and structure-based drug design principles were applied to develop PROTACs targeting two target proteins − BRD4, a prominent cancer target and Mpro, a critical enzyme for SARS-CoV-2 replication. Mpro-degrading PROTACs were developed that may provide a new paradigm for drug development against SARS-CoV-2 and other viral infectious diseases. Lastly, the concept of phenotypic drug discovery and open-source research was enacted for the development of novel antifungal agents.

Published
2023
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20. Interaction of polycyclic aromatic hydrocarbon exposure and high-fasting plasma glucose on lung function decline in coke oven workers: a cross-lagged panel analysis

Author

Liu, Lu, primary, Feng, Quan, additional, Wang, Yong, additional, Zhao, Xinyu, additional, Guo, Shugang, additional, Guo, Lan, additional, Liu, Gaisheng, additional, Jiang, Liuquan, additional, Li, Qiang, additional, Pan, Baolong, additional, Nie, Jisheng, additional, and Yang, Jin, additional

Published
2022
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24. miR-29a/b1 Regulates BACE1 in Aluminum-Induced Aβ Deposition in Vitro

Author

Li, Huan, primary, Liu, Qun, additional, Xue, Xingli, additional, Lu, Xiaoting, additional, Song, Jing, additional, He, Chanting, additional, Hao, Yanxia, additional, Nie, Jisheng, additional, Zhang, Qinli, additional, Zhao, Yue, additional, Pan, Baolong, additional, Wang, Linping, additional, and Niu, Qiao, additional

Published
2021
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34. [Effect of chronic aluminum exposure on neuron apoptosis and expression of P53 phosphorylation in rats].

Author

Pan B, Guo S, Guo L, Li X, and Niu Q

Subjects
Aluminum Chloride, Aluminum Compounds toxicity, Animals, Cerebral Cortex metabolism, Chlorides toxicity, Male, Neurons cytology, Phosphorylation, Rats, Rats, Sprague-Dawley, Aluminum toxicity, Apoptosis, Neurons drug effects, Tumor Suppressor Protein p53 metabolism
Abstract

Objective: To explore the role of P53 phosphorylation in neuron apoptosis of rats by chronic aluminum exposure., Methods: A total of male 40 SD rats were divided randomly into 4 groups (n = 10/dose), the exposed groups were fed with normal diet with different concentration of AlCl3 · 6H2O for 6 months respectively. The dosage of low, middle and high groups were 10.73, 107.33, 1073.33 mg/kg in sequence. The control group received normal diet. The neuron apoptosis was measured by method of Tunel. The expressions of P53 and pP53-ser15 protein in the cortex were detected by Western-blot., Results: Tunel staining showed that the low, middle and high group rats had increased apoptosis rate than control group (P < 0.01). Western-blot test demonstrated that the expression of P53 protein in the cortex of high group rats were significantly higher than the control and low groups (P < 0.05). The expression of pP53-ser15 protein in the cortex of middle and high group rats were also higher than the control and low groups (P < 0.05)., Conclusion: Chronic aluminum exposure can lead to over expression of P53 and pP53-ser15 protein in cerebral cortex, which maybe one of the most important mechanisms of neuron apoptosis induced by AlCl3.

Published
2015

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