Search

Your search keyword '"Pan, Dipanjan"' showing total 740 results
Start Over Author "Pan, Dipanjan"
740 results on '"Pan, Dipanjan"'

1. Erythromer (EM), a Nanoscale Bio-Synthetic Artificial Red Cell

Author

Mittal, Nivesh, Rogers, Stephen, Dougherty, Shannon, Wang, Qihong, Moitra, Parikshit, Brummet, Mary, Cornett, Elyse M., Kaye, Alan D., Shekoohi, Sahar, Buehler, Paul, Spinella, Philip, Pan, Dipanjan, Doctor, Allan, Liu, Henry, editor, Kaye, Alan D., editor, and Jahr, Jonathan S., editor

Published
2022
Full Text
View/download PDF

6. Chemoradiotherapy and nanomedicine: Drug mechanisms and delivery systems.

Author

Molinaro, Matthew, Skrodzki, David, and Pan, Dipanjan

Abstract

Radiotherapy is an invaluable tool in the treatment of cancer. However, when used as a monotherapy, it fails to provide curative outcomes. Chemotherapy drugs are often included to boost the effects of radiation. Key classes of radiosensitizing drugs include platinum compounds, anthracyclines, antimetabolites, taxanes, topoisomerase inhibitors, alkylating agents, and DNA damage repair inhibitors. Chemoradiotherapy suffers from not only systemic toxicities from chemotherapy drugs but also synergistic radiation toxicity as well. It is critical to deliver radiosensitizing molecules to tumor cells while avoiding adjacent healthy tissues. Currently, nanomedicine provides an avenue for tumor specific delivery of radiosensitizers. Nanoscale delivery vehicles can be synthesized from lipids, polymers, or inorganic materials. Additionally, nanomedicine encompasses stimuli responsive particles including prodrug formulation for tumor specific activation. Clinically, nanomedicine and radiotherapy are intertwined with approved formulation including DOXIL and Abraxane. Though many challenges remain, the ongoing progress evidences a promising future for both nanomedicine and chemoradiotherapy. This article is categorized under:Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic DiseaseTherapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular DiseaseTherapeutic Approaches and Drug Discovery > Emerging Technologies [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Nano-Enabled Delivery of Intracellular Therapeutics

Author

Ostadhossein, Fatemeh, Daza, Enrique Alejandro, Frankowski, Daniel, Goatz, Drew, Imgruet, Molly, Kus, Joseph, Lake, Ryan, Modak, Mallika, Olsen, Nick, Schwartz-Duval, Aaron, Zimmer, Alyssa, Kolmodin, Nicholas, Pan, Dipanjan, Bernstein, Peter R., Series editor, Buschauer, Armin, Series editor, Georg, Gunda I., Series editor, Lowe, John A., Series editor, Meanwell, Nicholas A., Series editor, Saxena, Anil Kumar, Series editor, Stilz, Ulrich, Series editor, Supuran, Claudiu T., Series editor, and Pan, Dipanjan, editor

Published
2016
Full Text
View/download PDF

16. Personalized Medicine: Where Do We Go from Here?

Author

Pan, Dipanjan, Bernstein, Peter R., Series editor, Buschauer, Armin, Series editor, Georg, Gunda I., Series editor, Lowe, John A., Series editor, Meanwell, Nicholas A., Series editor, Saxena, Anil Kumar, Series editor, Stilz, Ulrich, Series editor, Supuran, Claudiu T., Series editor, and Pan, Dipanjan, editor

Published
2016
Full Text
View/download PDF

17. Multimodal Imaging and Theranostic Application of Disease-Directed Agents

Author

Caffarini, Joseph, Kelleher, Nathan, Konopka, Christian C., Mazurek, Madeline, Nandyala, Anuradha, Patel, Dwani, Slania, Stephanie, Wang, Sheryl, Yada, Ravi Chandra, Pan, Dipanjan, Bernstein, Peter R., Series editor, Buschauer, Armin, Series editor, Georg, Gunda I., Series editor, Lowe, John A., Series editor, Meanwell, Nicholas A., Series editor, Saxena, Anil Kumar, Series editor, Stilz, Ulrich, Series editor, Supuran, Claudiu T., Series editor, and Pan, Dipanjan, editor

Published
2016
Full Text
View/download PDF

18. Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation

Author

Chang, Huei-Huei, Braswell, Shaneen, George, Jonathan, Gryka, Mark, Kim, Sumin, Kolmodin, Nicolas, Kumar, Manu, Seadler, Benjamin, Sonoiki, Oluwayemisi, Pan, Dipanjan, Bernstein, Peter R., Series editor, Buschauer, Armin, Series editor, Georg, Gunda I., Series editor, Lowe, John A., Series editor, Meanwell, Nicholas A., Series editor, Saxena, Anil Kumar, Series editor, Stilz, Ulrich, Series editor, Supuran, Claudiu T., Series editor, and Pan, Dipanjan, editor

Published
2016
Full Text
View/download PDF

22. Nanomedicine and nanobiotechnology in India.

Author

Pan, Dipanjan

Abstract

Nanomedicine, an interdisciplinary field combining nanotechnology and medicine, has gained immense attention in recent years due to its potential in revolutionizing healthcare. India, being an emerging hub for scientific research and development, has made significant strides in nanomedicine research. This special issue is dedicated to the exciting research that are being conducted by the leading Indian scientists in various Indian institutions. This article is categorized under:Biology‐Inspired Nanomaterials > Lipid‐Based StructuresTherapeutic Approaches and Drug Discovery > Emerging Technologies [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Ensemble and single-particle level fluorescent fine-tuning of carbon dots via positional changes of amines toward “supervised” oral microbiome sensing

Author

Ostadhossein, Fatemeh, primary, Moitra, Parikshit, additional, Alafeef, Maha, additional, Sar, Dinabandhu, additional, D’Souza, Shannon, additional, Benig, Lily F., additional, Nelappana, Michael, additional, Huang, Xuedong, additional, Soares, Julio, additional, Zhang, Kai, additional, and Pan, Dipanjan, additional

Published
2023
Full Text
View/download PDF

27. Molecular Imaging with Spectral CT Nanoprobes

Author

Pan, Dipanjan, Schmieder, Anne H., SenPan, Angana, Yang, Xiaoxia, Wickline, Samuel A., Roessl, Ewald, Proksa, Roland, Schirra, Carsten O., Lanza, Gregory M., Bulte, Jeff W.M., editor, and Modo, Michel M.J., editor

Published
2017
Full Text
View/download PDF

32. Context-Responsive Nanoparticle Derived from Synthetic Zwitterionic Ionizable Phospholipids in Targeted CRISPR/Cas9 Therapy for Basal-like Breast Cancer

Author

Moitra, Parikshit, Skrodzki, David, Molinaro, Matthew, Gunaseelan, Nivetha, Sar, Dinabandhu, Aditya, Teresa, Dahal, Dipendra, Ray, Priyanka, and Pan, Dipanjan

Abstract

The majority of triple negative breast cancers (TNBCs) are basal-like breast cancers (BLBCs), which tend to be more aggressive, proliferate rapidly, and have poor clinical outcomes. A key prognostic biomarker and regulator of BLBC is the Forkhead box C1 (FOXC1) transcription factor. However, because of its functional placement inside the cell nucleus and its structural similarity with other related proteins, targeting FOXC1 for therapeutic benefit, particularly for BLBC, continues to be difficult. We envision targeted nonviral delivery of CRISPR/Cas9 plasmid toward the efficacious knockdown of FOXC1. Keeping in mind the challenges associated with the use of CRISPR/Cas9 in vivo, including off-targeting modifications, and effective release of the cargo, a nanoparticle with context responsive properties can be designed for efficient targeted delivery of CRISPR/Cas9 plasmid. Consequently, we have designed, synthesized, and characterized a zwitterionic amino phospholipid-derived transfecting nanoparticle for delivery of CRISPR/Cas9. The construct becomes positively charged only at low pH, which encourages membrane instability and makes it easier for nanoparticles to exit endosomes. This has enabled effective in vitro and in vivo downregulation of protein expression and genome editing. Following this, we have used EpCAM aptamer to make the system targeted toward BLBC cell lines and to reduce its off-target toxicity. The in vivo efficacy, biodistribution, preliminary pharmacokinetics, and biosafety of the optimized targeted CRISPR nanoplatform is then validated in a rodent xenograft model. Overall, we have attempted to knockout the proto-oncogenic FOXC1 expression in BLBC cases by efficient delivery of CRISPR effectors via a context-responsive nanoparticle delivery system derived from a designer lipid derivative. We believe that the nonviral approach for in vitro and in vivo delivery of CRISPR/Cas9 targeted toward FOXC1, studied herein, will greatly emphasize the therapeutic regimen for BLBC.

Published
2024
Full Text
View/download PDF

34. Diagnosis of COVID-19 with simultaneous accurate prediction of cardiac abnormalities from chest computed tomographic images.

Author

Moitra, Moumita, Alafeef, Maha, Narasimhan, Arjun, Kakaria, Vikram, Moitra, Parikshit, and Pan, Dipanjan

Subjects
TOMOGRAPHY, COVID-19 testing, MACHINE learning, COVID-19, DEEP learning, DEEP brain stimulation
Abstract

COVID-19 has potential consequences on the pulmonary and cardiovascular health of millions of infected people worldwide. Chest computed tomographic (CT) imaging has remained the first line of diagnosis for individuals infected with SARS-CoV-2. However, differentiating COVID-19 from other types of pneumonia and predicting associated cardiovascular complications from the same chest-CT images have remained challenging. In this study, we have first used transfer learning method to distinguish COVID-19 from other pneumonia and healthy cases with 99.2% accuracy. Next, we have developed another CNN-based deep learning approach to automatically predict the risk of cardiovascular disease (CVD) in COVID-19 patients compared to the normal subjects with 97.97% accuracy. Our model was further validated against cardiac CT-based markers including cardiac thoracic ratio (CTR), pulmonary artery to aorta ratio (PA/A), and presence of calcified plaque. Thus, we successfully demonstrate that CT-based deep learning algorithms can be employed as a dual screening diagnostic tool to diagnose COVID-19 and differentiate it from other pneumonia, and also predicts CVD risk associated with COVID-19 infection. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

35. Synthesis of an enediyne carbon-allotrope surface for photo-thermal degradation of DNA.

Author

Misra, Santosh K., Ye, Mao, Moitra, Parikshit, Dighe, Ketan, Sharma, Abhinav, Daza, Enrique A., Schwartz-Duval, Aaron S., Ostadhossein, Fatemeh, and Pan, Dipanjan

Subjects
HOSPITAL waste disposal, WATER purification, WASTE products, HEAT radiation & absorption, DNA
Abstract

The improper disposal of hospital waste products containing genetic materials poses a serious safety threat. We present herein an environmentally friendly technology using a graphene-based novel carbon-allotropic surface to remediate such wastes. The used carbon-allotrope is decorated with an enediyne (EDE-1) enriched aromatic pi-conjugated structure to create an efficient and active surface for cleaving DNA strands. Under controlled exposure of ultraviolet (UV) radiation and heat, the developed surface influences genetic degradation without disturbing the bacterial populations present downstream of the water treatment system. The designed material has been extensively characterized using physicochemical and biological tools. Our results indicate that this approach can possibly be introduced in large scale hospital waste disposal streams for remediating genetic hazards and thereby developing a portable self-contained system. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

36. Data from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

Author

Ross, Michael H., primary, Esser, Alison K., primary, Fox, Gregory C., primary, Schmieder, Anne H., primary, Yang, Xiaoxia, primary, Hu, Grace, primary, Pan, Dipanjan, primary, Su, Xinming, primary, Xu, Yalin, primary, Novack, Deborah V., primary, Walsh, Thomas, primary, Colditz, Graham A., primary, Lukaszewicz, Gabriel H., primary, Cordell, Elizabeth, primary, Novack, Joshua, primary, Fitzpatrick, James A. J., primary, Waning, David L., primary, Mohammad, Khalid S., primary, Guise, Theresa A., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

37. Suppl Figure 6 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

38. Suppl Figure 2 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

39. Supplemental Information from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

Author

Ross, Michael H., primary, Esser, Alison K., primary, Fox, Gregory C., primary, Schmieder, Anne H., primary, Yang, Xiaoxia, primary, Hu, Grace, primary, Pan, Dipanjan, primary, Su, Xinming, primary, Xu, Yalin, primary, Novack, Deborah V., primary, Walsh, Thomas, primary, Colditz, Graham A., primary, Lukaszewicz, Gabriel H., primary, Cordell, Elizabeth, primary, Novack, Joshua, primary, Fitzpatrick, James A. J., primary, Waning, David L., primary, Mohammad, Khalid S., primary, Guise, Theresa A., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

40. Suppl Figure 3 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

41. Supplementary Data from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

42. Supplemental Figure S3 from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

Author

Ross, Michael H., primary, Esser, Alison K., primary, Fox, Gregory C., primary, Schmieder, Anne H., primary, Yang, Xiaoxia, primary, Hu, Grace, primary, Pan, Dipanjan, primary, Su, Xinming, primary, Xu, Yalin, primary, Novack, Deborah V., primary, Walsh, Thomas, primary, Colditz, Graham A., primary, Lukaszewicz, Gabriel H., primary, Cordell, Elizabeth, primary, Novack, Joshua, primary, Fitzpatrick, James A. J., primary, Waning, David L., primary, Mohammad, Khalid S., primary, Guise, Theresa A., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

43. Suppl Figure 4 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

44. Suppl Figure 5 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

45. Suppl Figure 1 from VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival

Author

Fontana, Francesca, primary, Scott, Michael J., primary, Allen, John S., primary, Yang, Xiaoxia, primary, Cui, Grace, primary, Pan, Dipanjan, primary, Yanaba, Noriko, primary, Fiala, Mark A., primary, O'Neal, Julie, primary, Schmieder-Atteberry, Anne H., primary, Ritchey, Julie, primary, Rettig, Michael, primary, Simons, Kathleen, primary, Fletcher, Steven, primary, Vij, Ravi, primary, DiPersio, John F., primary, and Lanza, Gregory M., primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results