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2. Spatiotemporal modeling of molecular holograms

Author

Qiu, Xiaojie, Zhu, Daniel Y., Lu, Yifan, Yao, Jiajun, Jing, Zehua, Min, Kyung Hoi, Cheng, Mengnan, Pan, Hailin, Zuo, Lulu, King, Samuel, Fang, Qi, Zheng, Huiwen, Wang, Mingyue, Wang, Shuai, Zhang, Qingquan, Yu, Sichao, Liao, Sha, Liu, Chao, Wu, Xinchao, Lai, Yiwei, Hao, Shijie, Zhang, Zhewei, Wu, Liang, Zhang, Yong, Li, Mei, Tu, Zhencheng, Lin, Jinpei, Yang, Zhuoxuan, Li, Yuxiang, Gu, Ying, Ellison, David, Chen, Ao, Liu, Longqi, Weissman, Jonathan S., Ma, Jiayi, Xu, Xun, Liu, Shiping, and Bai, Yinqi

Published
2024
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7. Genomic insights into the secondary aquatic transition of penguins

Author

Cole, Theresa L., Zhou, Chengran, Fang, Miaoquan, Pan, Hailin, Ksepka, Daniel T., Fiddaman, Steven R., Emerling, Christopher A., Thomas, Daniel B., Bi, Xupeng, Fang, Qi, Ellegaard, Martin R., Feng, Shaohong, Smith, Adrian L., Heath, Tracy A., Tennyson, Alan J. D., Borboroglu, Pablo García, Wood, Jamie R., Hadden, Peter W., Grosser, Stefanie, Bost, Charles-André, Cherel, Yves, Mattern, Thomas, Hart, Tom, Sinding, Mikkel-Holger S., Shepherd, Lara D., Phillips, Richard A., Quillfeldt, Petra, Masello, Juan F., Bouzat, Juan L., Ryan, Peter G., Thompson, David R., Ellenberg, Ursula, Dann, Peter, Miller, Gary, Dee Boersma, P., Zhao, Ruoping, Gilbert, M. Thomas P., Yang, Huanming, Zhang, De-Xing, and Zhang, Guojie

Published
2022
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10. A soft selective sweep during rapid evolution of gentle behaviour in an Africanized honeybee

Author

Avalos, Arian, Pan, Hailin, Li, Cai, Acevedo-Gonzalez, Jenny P, Rendon, Gloria, Fields, Christopher J, Brown, Patrick J, Giray, Tugrul, Robinson, Gene E, Hudson, Matthew E, and Zhang, Guojie

Subjects
Human Genome, Biotechnology, Genetics, Africa, Animals, Bees, Evolution, Molecular, Genetic Variation, Genetics, Population, Genome, Insect, Haplotypes, Introduced Species, Phylogeny, Puerto Rico, Selection, Genetic
Abstract

Highly aggressive Africanized honeybees (AHB) invaded Puerto Rico (PR) in 1994, displacing gentle European honeybees (EHB) in many locations. Gentle AHB (gAHB), unknown anywhere else in the world, subsequently evolved on the island within a few generations. Here we sequence whole genomes from gAHB and EHB populations, as well as a North American AHB population, a likely source of the founder AHB on PR. We show that gAHB retains high levels of genetic diversity after evolution of gentle behaviour, despite selection on standing variation. We observe multiple genomic loci with significant signatures of selection. Rapid evolution during colonization of novel habitats can generate major changes to characteristics such as morphological or colouration traits, usually controlled by one or more major genetic loci. Here we describe a soft selective sweep, acting at multiple loci across the genome, that occurred during, and may have mediated, the rapid evolution of a behavioural trait.

Published
2017

16. Comparative genomics reveals insights into avian genome evolution and adaptation

Author

Zhang, Guojie, Li, Cai, Li, Qiye, Li, Bo, Larkin, Denis M, Lee, Chul, Storz, Jay F, Antunes, Agostinho, Greenwold, Matthew J, Meredith, Robert W, Ödeen, Anders, Cui, Jie, Zhou, Qi, Xu, Luohao, Pan, Hailin, Wang, Zongji, Jin, Lijun, Zhang, Pei, Hu, Haofu, Yang, Wei, Hu, Jiang, Xiao, Jin, Yang, Zhikai, Liu, Yang, Xie, Qiaolin, Yu, Hao, Lian, Jinmin, Wen, Ping, Zhang, Fang, Li, Hui, Zeng, Yongli, Xiong, Zijun, Liu, Shiping, Zhou, Long, Huang, Zhiyong, An, Na, Wang, Jie, Zheng, Qiumei, Xiong, Yingqi, Wang, Guangbiao, Wang, Bo, Wang, Jingjing, Fan, Yu, da Fonseca, Rute R, Alfaro-Núñez, Alonzo, Schubert, Mikkel, Orlando, Ludovic, Mourier, Tobias, Howard, Jason T, Ganapathy, Ganeshkumar, Pfenning, Andreas, Whitney, Osceola, Rivas, Miriam V, Hara, Erina, Smith, Julia, Farré, Marta, Narayan, Jitendra, Slavov, Gancho, Romanov, Michael N, Borges, Rui, Machado, João Paulo, Khan, Imran, Springer, Mark S, Gatesy, John, Hoffmann, Federico G, Opazo, Juan C, Håstad, Olle, Sawyer, Roger H, Kim, Heebal, Kim, Kyu-Won, Kim, Hyeon Jeong, Cho, Seoae, Li, Ning, Huang, Yinhua, Bruford, Michael W, Zhan, Xiangjiang, Dixon, Andrew, Bertelsen, Mads F, Derryberry, Elizabeth, Warren, Wesley, Wilson, Richard K, Li, Shengbin, Ray, David A, Green, Richard E, O’Brien, Stephen J, Griffin, Darren, Johnson, Warren E, Haussler, David, Ryder, Oliver A, Willerslev, Eske, Graves, Gary R, Alström, Per, Fjeldså, Jon, Mindell, David P, Edwards, Scott V, Braun, Edward L, Rahbek, Carsten, Burt, David W, Houde, Peter, and Zhang, Yong

Subjects
Human Genome, Biotechnology, Genetics, Adaptation, Physiological, Animals, Biodiversity, Biological Evolution, Birds, Conserved Sequence, Diet, Evolution, Molecular, Female, Flight, Animal, Genes, Genetic Variation, Genome, Genomics, Male, Molecular Sequence Annotation, Phylogeny, Reproduction, Selection, Genetic, Sequence Analysis, DNA, Synteny, Vision, Ocular, Vocalization, Animal, Avian Genome Consortium, General Science & Technology
Abstract

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion of repetitive elements, large segmental deletions, and gene loss. Avian genomes furthermore show a remarkably high degree of evolutionary stasis at the levels of nucleotide sequence, gene synteny, and chromosomal structure. Despite this pattern of conservation, we detected many non-neutral evolutionary changes in protein-coding genes and noncoding regions. These analyses reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.

Published
2014

17. Enhancing performance of organic photovoltaic and photodetector devices using non-atomically doped ZnO electrodes with superior optical properties.

Author

Su, Ziqi, Pan, Hailin, Lin, Yi, Li, Zheng, Wang, Ming, and Ma, Zaifei

Abstract

Organic photovoltaics (OPVs) and photodetectors (OPDs) are valued for their lightweight, low-cost, and flexible nature, with recent advancements in materials improving device performance. Transparent electrodes play a critical role in these devices, requiring high conductivity and broad spectral transmittance. Conventional indium tin oxide (ITO) faces scarcity issues, spurring exploration of alternatives. Here, we introduce non-atomically doped (NAD) ZnO electrodes with exceptional near-infrared (NIR) transmittance, fabricated via a sol–gel method. We investigate their performance in OPVs and OPDs using three different bulk heterojunction systems. Results reveal ZnO-based devices exhibit heightened short-circuit current density (Jsc) compared to ITO-based ones under solar illumination. Despite slightly lower power conversion efficiency (PCE) due to higher series resistance, NAD-ZnO devices show resilience under LED illumination, outperforming ITO-based devices. Furthermore, photodiode OPD devices utilizing NAD-ZnO electrodes demonstrate significantly enhanced specific detectivity (D*) across all the three systems, indicating their potential for OPD applications. Overall, the superior optical properties and device performance of NAD-ZnO electrodes highlight their promise as replacements for ITO electrodes in organic optoelectronic devices. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Spatially resolved molecular and cellular atlas of the mouse brain

Author

Han, Lei, primary, Liu, Zhen, additional, Jing, Zehua, additional, Liu, Yuxuan, additional, Chang, Huizhong, additional, Lei, Junjie, additional, Peng, Yujie, additional, Wang, Kexin, additional, Xu, Yuanfang, additional, Liu, Wei, additional, Wu, Zihan, additional, Li, Qian, additional, Shi, Xiaoxue, additional, Zheng, Mingyuan, additional, Wang, He, additional, Deng, Juan, additional, Zhong, Yanqing, additional, Pan, Hailin, additional, Lin, Junkai, additional, Zhang, Ruiyi, additional, Chen, Yu, additional, Wu, Jinhua, additional, Xu, Mingrui, additional, Ren, Biyu, additional, Cheng, Mengnan, additional, Yu, Qian, additional, Song, Xinxiang, additional, Lu, Yanbing, additional, Tang, Yuanchun, additional, Yuan, Nini, additional, Sun, Suhong, additional, An, Yingjie, additional, Ding, Wenqun, additional, Sun, Xing, additional, Wei, Yanrong, additional, Zhang, Shuzhen, additional, Dou, Yannong, additional, Zhao, Yun, additional, Han, Luyao, additional, Zhu, Qianhua, additional, Xu, Junfeng, additional, Wang, Shiwen, additional, Chen, Hanbo, additional, Wang, Dan, additional, Bai, Yinqi, additional, Liang, Yikai, additional, Liu, Yuan, additional, Chen, Mengni, additional, Xie, Chun, additional, Bo, Binshi, additional, Li, Mei, additional, Zhang, Xinyan, additional, Ting, Wang, additional, Chen, Zhenhua, additional, Fang, Jiao, additional, Li, Shuting, additional, Jiang, Yujia, additional, Tan, Xing, additional, Zuo, Guolong, additional, Xie, Yue, additional, Li, Huanhuan, additional, Tao, Quyuan, additional, Li, Yan, additional, Liu, Jianfeng, additional, Liu, Yuyang, additional, Hao, Mingkun, additional, Wang, Jingjing, additional, Wen, Huiying, additional, Liu, Jiabing, additional, Yan, Yizhen, additional, Zhang, Hui, additional, Sheng, Yifan, additional, Han, Min, additional, Yu, Shui, additional, Liao, Xiaoyan, additional, Jiang, Xuyin, additional, Wang, Guangling, additional, Liu, Huanlin, additional, Wang, Congcong, additional, Feng, Ning, additional, Liu, Xin, additional, Ma, Kailong, additional, Xu, Xiangjie, additional, Han, Tianyue, additional, Cao, Huateng, additional, Zheng, Huiwen, additional, Chen, Yadong, additional, Lu, Haorong, additional, Yu, Zixian, additional, Zhang, Jinsong, additional, Wang, Bo, additional, Wang, Zhifeng, additional, Xie, Qing, additional, Pan, Shanshan, additional, Liu, Chuanyu, additional, Xu, Chan, additional, Cui, Luman, additional, Li, Yuxiang, additional, Liu, Shiping, additional, Liao, Sha, additional, Chen, Ao, additional, Wu, Qing-Feng, additional, Wang, Jian, additional, Liu, Zhiyong, additional, Sun, Yidi, additional, Mulder, Jan, additional, Yang, Huanming, additional, Wang, Xiaofei, additional, Li, Chao, additional, Yao, Jianhua, additional, Xu, Xun, additional, Liu, Longqi, additional, Shen, Zhiming, additional, Wei, Wu, additional, and Sun, Yan-Gang, additional

Published
2023
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22. Genomic signatures of evolutionary transitions from solitary to group living

Author

Kapheim, Karen M., Pan, Hailin, Li, Cai, Salzberg, Steven L., Puiu, Daniela, Magoc, Tanja, Robertson, Hugh M., Hudson, Matthew E., Venkat, Aarti, Fischman, Brielle J., Hernandez, Alvaro, Yandell, Mark, Ence, Daniel, Holt, Carson, Yocum, George D., Kemp, William P., Bosch, Jordi, Waterhouse, Robert M., Zdobnov, Evgeny M., Stolle, Eckart, Kraus, F. Bernhard, Helbing, Sophie, Moritz, Robin F. A., Glastad, Karl M., Hunt, Brendan G., Goodisman, Michael A. D., Hauser, Frank, Grimmelikhuijzen, Cornelis J. P., Pinheiro, Daniel Guariz, Nunes, Francis Morais Franco, Soares, Michelle Prioli Miranda, Tanaka, Érica Donato, Simões, Zilá Luz Paulino, Hartfelder, Klaus, Evans, Jay D., Barribeau, Seth M., Johnson, Reed M., Massey, Jonathan H., Southey, Bruce R., Hasselmann, Martin, Hamacher, Daniel, Biewer, Matthias, Kent, Clement F., Zayed, Amro, Blatti, Charles, Sinha, Saurabh, Johnston, J. Spencer, Hanrahan, Shawn J., Kocher, Sarah D., Wang, Jun, Robinson, Gene E., and Zhang, Guojie

Published
2015

25. Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics

Author

Qiu, Xiaojie, primary, Zhu, Daniel Y., additional, Yao, Jiajun, additional, Jing, Zehua, additional, Zuo, Lulu, additional, Wang, Mingyue, additional, Min, Kyung Hoi (Joseph), additional, Pan, Hailin, additional, Wang, Shuai, additional, Liao, Sha, additional, Lai, Yiwei, additional, Hao, Shijie, additional, Lu, Yuancheng Ryan, additional, Hill, Matthew, additional, Martin-Rufino, Jorge D., additional, Weng, Chen, additional, Riera-Escandell, Anna Maria, additional, Chen, Mengnan, additional, Wu, Liang, additional, Zhang, Yong, additional, Wei, Xiaoyu, additional, Li, Mei, additional, Huang, Xin, additional, Xiang, Rong, additional, Yang, Zhuoxuan, additional, Liu, Chao, additional, Xia, Tianyi, additional, Liang, Yingxin, additional, Xu, Junqiang, additional, Hu, Qinan, additional, Hu, Yuhui, additional, Zhu, Hongmei, additional, Li, Yuxiang, additional, Chen, Ao, additional, Esteban, Miguel A., additional, Gu, Ying, additional, Lauffenburger, Douglas A., additional, Xu, Xun, additional, Liu, Longqi, additional, Weissman, Jonathan S., additional, Liu, Shiping, additional, and Bai, Yinqi, additional

Published
2022
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26. Complementary symbiont contributions to plant decomposition in a fungus-farming termite

Author

Poulsen, Michael, Hu, Haofu, Li, Cai, Chen, Zhensheng, Xu, Luohao, Otani, Saria, Nygaard, Sanne, Nobre, Tania, Klaubauf, Sylvia, Schindler, Philipp M., Hauser, Frank, Pan, Hailin, Yang, Zhikai, Sonnenberg, Anton S. M., de Beer, Z. Wilhelm, Zhang, Yong, Wingfield, Michael J., Grimmelikhuijzen, Cornelis J. P., de Vries, Ronald P., Korb, Judith, Aanen, Duur K., Wang, Jun, Boomsma, Jacobus J., and Zhang, Guojie

Published
2014

29. Adaptation and Cryptic Pseudogenization in Penguin Toll-Like Receptors

Author

Fiddaman, Steven R., Vinkler, Michal, Spiro, Simon G., Levy, Hila, Emerling, Christopher A., Boyd, Amy C., Dimopoulos, Evangelos A., Vianna, Juliana A., Cole, Theresa L., Pan, Hailin, Fang, Miaoquan, Zhang, Guojie, Hart, Tom, Frantz, Laurent A. F., Smith, Adrian L., Fiddaman, Steven R., Vinkler, Michal, Spiro, Simon G., Levy, Hila, Emerling, Christopher A., Boyd, Amy C., Dimopoulos, Evangelos A., Vianna, Juliana A., Cole, Theresa L., Pan, Hailin, Fang, Miaoquan, Zhang, Guojie, Hart, Tom, Frantz, Laurent A. F., and Smith, Adrian L.

Abstract

Penguins (Sphenisciformes) are an iconic order of flightless, diving seabirds distributed across a large latitudinal range in the Southern Hemisphere. The extensive area over which penguins are endemic is likely to have fostered variation in pathogen pressure, which in turn will have imposed differential selective pressures on the penguin immune system. At the front line of pathogen detection and response, the Toll-like receptors (TLRs) provide insight into host evolution in the face of microbial challenge. TLRs respond to conserved pathogen-associated molecular patterns and are frequently found to be under positive selection, despite retaining specificity for defined agonist classes. We undertook a comparative immunogenetics analysis of TLRs for all penguin species and found evidence of adaptive evolution that was largely restricted to the cell surface-expressed TLRs, with evidence of positive selection at, or near, key agonist-binding sites in TLR1B, TLR4, and TLR5. Intriguingly, TLR15, which is activated by fungal products, appeared to have been pseudogenized multiple times in the Eudyptes spp., but a full-length form was present as a rare haplotype at the population level. However, in vitro analysis revealed that even the full-length form of Eudyptes TLR15 was nonfunctional, indicating an ancestral cryptic pseudogenization prior to its eventual disruption multiple times in the Eudyptes lineage. This unusual pseudogenization event could provide an insight into immune adaptation to fungal pathogens such as Aspergillus, which is responsible for significant mortality in wild and captive bird populations.

Published
2022

30. Solution-Processed ZnO with Conductivity over 1000 S cm–1for ITO-Free Organic Photovoltaics

Author

Pan, Hailin, Wang, Jie, Chen, Zhi, Su, Ziqi, Tang, Zheng, and Ma, Zaifei

Abstract

Developing transparent conductors to replace indium tin oxide (ITO) is a critical objective in the field of organic optoelectronics. Non-atomically doped (NAD) ZnO thin films, while currently exhibiting limited conductivity, are highly promising candidates due to their unique advantages, such as having complete transparency in both the visible and near-infrared spectral regions, solution processability, and the desired surface electronic properties. In this work, the impact of surface modification by insulating polymers on the ultraviolet-enhanced conductivity of NAD-ZnO films is investigated. It was found that polymer modifiers that are rich in amino and hydroxyl groups are effective at increasing the concentration of oxygen vacancies and the conductivity of NAD-ZnO films. The highest conductivity of over 1000 S cm–1, which is more than twice as high as the previous record for NAD-ZnO films, is achieved using polyethylenimine ethoxylated (PEIE) to modify NAD-ZnO films. Subsequently, the replacement of ITO in organic photovoltaic devices by a ZnO/PEIE electrode is realized. The ZnO/PEIE-based OPV devices that were created exhibit performances comparable to those of ITO-based devices under simulated solar illumination and performances better than those achieved with ITO-based devices under simulated indoor illumination. These results make NAD-ZnO a promising candidate for the widespread replacement of ITO in optoelectronic devices.

Published
2023
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32. Adaptation and Cryptic Pseudogenization in Penguin Toll-Like Receptors

Author

Fiddaman, Steven R, primary, Vinkler, Michal, additional, Spiro, Simon G, additional, Levy, Hila, additional, Emerling, Christopher A, additional, Boyd, Amy C, additional, Dimopoulos, Evangelos A, additional, Vianna, Juliana A, additional, Cole, Theresa L, additional, Pan, Hailin, additional, Fang, Miaoquan, additional, Zhang, Guojie, additional, Hart, Tom, additional, Frantz, Laurent A F, additional, and Smith, Adrian L, additional

Published
2021
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33. RESEARCH ARTICLE: Comparative genomics reveals insights into avian genome evolution and adaptation

Author

Zhang, Guojie, Li, Cai, Li, Qiye, Li, Bo, Larkin, Denis M., Lee, Chul, Storz, Jay F., Antunes, Agostinho, Greenwold, Matthew J., Meredith, Robert W., Ödeen, Anders, Cui, Jie, Zhou, Qi, Xu, Luohao, Pan, Hailin, Wang, Zongji, Jin, Lijun, Zhang, Pei, Hu, Haofu, Yang, Wei, Hu, Jiang, Xiao, Jin, Yang, Zhikai, Liu, Yang, Xie, Qiaolin, Yu, Hao, Lian, Jinmin, Wen, Ping, Zhang, Fang, Li, Hui, Zeng, Yongli, Xiong, Zijun, Liu, Shiping, Zhou, Long, Huang, Zhiyong, An, Na, Wang, Jie, Zheng, Qiumei, Xiong, Yingqi, Wang, Guangbiao, Wang, Bo, Wang, Jingjing, Fan, Yu, da Fonseca, Rute R., Alfaro-Núñez, Alonzo, Schubert, Mikkel, Orlando, Ludovic, Mourier, Tobias, Howard, Jason T., Ganapathy, Ganeshkumar, Pfenning, Andreas, Whitney, Osceola, Rivas, Miriam V., Hara, Erina, Smith, Julia, Farré, Marta, Narayan, Jitendra, Slavov, Gancho, Romanov, Michael N, Borges, Rui, Machado, João Paulo, Khan, Imran, Springer, Mark S., Gatesy, John, Hoffmann, Federico G., Opazo, Juan C., Håstad, Olle, Sawyer, Roger H., Kim, Heebal, Kim, Kyu-Won, Kim, Hyeon Jeong, Cho, Seoae, Li, Ning, Huang, Yinhua, Bruford, Michael W., Zhan, Xiangjiang, Dixon, Andrew, Bertelsen, Mads F., Derryberry, Elizabeth, Warren, Wesley, Wilson, Richard K, Li, Shengbin, Ray, David A., Green, Richard E., OʼBrien, Stephen J., Griffin, Darren, Johnson, Warren E., Haussler, David, Ryder, Oliver A., Willerslev, Eske, Graves, Gary R., Alström, Per, Fjeldså, Jon, Mindell, David P., Edwards, Scott V., Braun, Edward L., Rahbek, Carsten, Burt, David W., Houde, Peter, Zhang, Yong, Yang, Huanming, Wang, Jian, Consortium, Avian Genome, Jarvis, Erich D., Gilbert, M. Thomas P., and Wang, Jun

Published
2014
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34. Supplemental Material, sj-pdf-2-ang-10.1177_00033197211028023 - Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study

Author

Wei, Mengqiu, Liu, Jun, Pan, Hailin, Zhou, Ziting, and Guo, Kai

Subjects
Cardiology
Abstract

Supplemental Material, sj-pdf-2-ang-10.1177_00033197211028023 for Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study by Mengqiu Wei, Jun Liu, Hailin Pan, Ziting Zhou and Kai Guo in Angiology

Published
2021
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35. Supplemental Material, sj-pdf-1-ang-10.1177_00033197211028023 - Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study

Author

Wei, Mengqiu, Liu, Jun, Pan, Hailin, Zhou, Ziting, and Guo, Kai

Subjects
Cardiology
Abstract

Supplemental Material, sj-pdf-1-ang-10.1177_00033197211028023 for Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study by Mengqiu Wei, Jun Liu, Hailin Pan, Ziting Zhou and Kai Guo in Angiology

Published
2021
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42. Correction to: High-coverage genomes to elucidate the evolution of penguins

Author

Pan, Hailin, primary, Cole, Theresa L, primary, Bi, Xupeng, primary, Fang, Miaoquan, primary, Zhou, Chengran, primary, Yang, Zhengtao, primary, Ksepka, Daniel T, primary, Hart, Tom, primary, Bouzat, Juan L, primary, Argilla, Lisa S, primary, Bertelsen, Mads F, primary, Boersma, P Dee, primary, Bost, Charles-Andre, primary, Cherel, Yves, primary, Dann, Peter, primary, Fiddaman, Steven R, primary, Howard, Pauline, primary, Labuschagne, Kim, primary, Mattern, Thomas, primary, Miller, Gary, primary, Parker, Patricia, primary, Phillips, Richard A, primary, Quillfeldt, Petra, primary, Ryan, Peter G, primary, Taylor, Helen, primary, Thompson, David R, primary, Young, Melanie J, primary, Ellegaard, Martin R, primary, Gilbert, M Thomas P, primary, Sinding, Mikkel-Holger S, primary, Pacheco, George, primary, Shepherd, Lara D, primary, Tennyson, Alan J D, primary, Grosser, Stefanie, primary, Kay, Emily, primary, Nupen, Lisa J, primary, Ellenberg, Ursula, primary, Houston, David M, primary, Reeve, Andrew Hart, primary, Johnson, Kathryn, primary, Masello, Juan F, primary, Stracke, Thomas, primary, McKinlay, Bruce, primary, Garc´ıa Borboroglu, Pablo, primary, Zhang, De-Xing, primary, and Zhang, Guojie, primary

Published
2020
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43. Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study.

Author

Wei, Mengqiu, Liu, Jun, Pan, Hailin, Zhou, Ziting, and Guo, Kai

Subjects
BIOMARKERS, ACADEMIC medical centers, ACQUISITION of data methodology, LEUCOCYTES, CROSS-sectional method, RETROSPECTIVE studies, CORONARY artery disease, MEDICAL records, NON-ST elevated myocardial infarction, DISEASE risk factors
Abstract

Many studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2) is associated with metabolic disorders, which is a risk factor of arteriosclerosis. We assessed the level of LECT-2 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and included patients with non-CAD, patients with stable angina pectoris (SAP), patients with unstable angina (UA), patients with non-ST-segment elevation myocardial infarction (NSTEMI) and patients with ST-segment elevation myocardial infarction (STEMI). The serum level of LECT-2 was higher in patients with CAD than in patients with non-CAD and was an independent predictor for CAD. Subgroup analysis showed that compared with the SAP group, the UA, NSTEMI, and STEMI groups had higher serum levels of LECT-2. In addition, the level of LECT-2 was related to the SYNTAX score and SYNTAX II score. Finally, patients with acute myocardial infarction (AMI) with elevated levels of LECT-2 had a higher risk of major adverse cardiovascular events (MACEs) within 12 months than those with lower levels of LECT-2. Plasma LECT-2 levels may be useful for the diagnosis of CAD and as predictors of MACE in patients with AMI. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway

Author

Li,Zhengming, Yang,Pijian, Liang,Yuzhen, Xia,Ning, Li,Yingrong, Su,Hongye, and Pan,Hailin

Subjects
food and beverages, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity]
Abstract

Zhengming Li1,*, Pijian Yang2,*, Yuzhen Liang1,*, Ning Xia2,*, Yingrong Li1, Hongye Su1, Hailin Pan1 1Department of Endocrinology and Metabolism, Second Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department of Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzhen LiangDepartment of Endocrinology and Metabolism, Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, People’s Republic of ChinaEmail liangyuzhen26@163.comNing XiaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning 530021, People’s Republic of ChinaEmail xianinggxmu@163.comBackground: Liraglutide reduces blood glucose, body weight and blood lipid levels. Hormone-sensitive lipase (HSL) is a key enzyme in lipolysis. Evidence from our and other studies have demonstrated that adenylate cyclase 3 (AC3) is associated with obesity and can be upregulated by liraglutide in obese mice. In the present study, we investigated whether hepatic HSL activity is regulated by liraglutide and characterized the effect of liraglutide in the AC3/protein kinase A (PKA)/HSL signalling pathway.Methods: Obese mice or their lean littermates were treated with liraglutide or saline for 8weeks. Serum was collected for the measurement of insulin and lipids. We investigated hepatic AC3, HSL and phosphorylated HSL Ser-660 (p-HSL(S660)) protein expression levels andAC3 and HSL mRNA expression levels and cyclic adenosine monophosphate (cAMP), PKA activity in liver tissue.Results: Liraglutide treatment decreased triglycerides (TGs) and free fatty acids (FFAs), increased glycerol, and upregulated hepatic AC3 and p-HSL(s660) levels and cAMP and PKA activities.Conclusion: The results suggest that liraglutide can upregulates AC3/PKA/HSL pathway and may promotes lipolysis.Keywords: liraglutide, obesity, lipolysis, adenylate cyclase 3, hormone-sensitive lipase

Published
2019

46. Population genetics reveals the selection of honey bee aggression behaviour

Author

Pan, Hailin and Pan, Hailin

Abstract

Honey bees are famous eusocial insects with specialized reproduction and labour divisions. They are also important and primary pollinators and produce numerous values in agriculture. The honey bee is not only a classical model organism for investigating the evolution of eusociality but also a perfect biological subject for aggression behaviour analysis. This thesis mainly centred on honey bee aggression levels as well as the solitary alkali bee genome. The first two chapters focused on honey bee aggression level analysis. Chapter one described the re-sequencing of 90 individual honey bees contain three sub-groups (Africanized honey bee, European honey bee and gentle Africanized honey bee). Each sub-group was sequenced with 30 male individuals. Africanized honey bees show highly aggressive behaviour, while the other two display more gentle behaviour. By comparing genotype differences among these three sub-groups, we speculated that the gentle Africanized honey bee has undergone a soft selective sweep selection over an approximately 12-year period. Chapter two continued the study from chapter one. A total of 210 female gentle Africanized honey bee individuals from 10 colonies were collected. Each colony provided 10 foragers, 10 soldiers and the queen. The aggression levels of each colony were recorded during sample collection. We found that several loci had a significant correlation with colony aggression levels. The first two chapters provided a glimpse to understand the genetic mechanism of honey bee aggression levels. The last chapter presented a comparative genome analysis of an alkali bee, which is a basal Halictidae species. By low-coverage resequencing of 19 individuals, we identified 479 positively selected genes and recent population bottlenecks. Because the alkali bee is the basal solitary Halictidae species, these genomic data could be used as the ancestor states of sociality evolution and promote eusocial evolution research.

Published
2020

47. Adaptation and Cryptic Pseudogenization in Penguin Toll-Like Receptors.

Author

Fiddaman, Steven R, Vinkler, Michal, Spiro, Simon G, Levy, Hila, Emerling, Christopher A, Boyd, Amy C, Dimopoulos, Evangelos A, Vianna, Juliana A, Cole, Theresa L, Pan, Hailin, Fang, Miaoquan, Zhang, Guojie, Hart, Tom, Frantz, Laurent A F, and Smith, Adrian L

Subjects
IMMUNOGENETICS, PSEUDOGENES, WILDLIFE diseases, IMMUNOLOGY, HAPLOTYPES
Abstract

Penguins (Sphenisciformes) are an iconic order of flightless, diving seabirds distributed across a large latitudinal range in the Southern Hemisphere. The extensive area over which penguins are endemic is likely to have fostered variation in pathogen pressure, which in turn will have imposed differential selective pressures on the penguin immune system. At the front line of pathogen detection and response, the Toll-like receptors (TLRs) provide insight into host evolution in the face of microbial challenge. TLRs respond to conserved pathogen-associated molecular patterns and are frequently found to be under positive selection, despite retaining specificity for defined agonist classes. We undertook a comparative immunogenetics analysis of TLRs for all penguin species and found evidence of adaptive evolution that was largely restricted to the cell surface-expressed TLRs, with evidence of positive selection at, or near, key agonist-binding sites in TLR1B , TLR4 , and TLR5. Intriguingly, TLR15 , which is activated by fungal products, appeared to have been pseudogenized multiple times in the Eudyptes spp. but a full-length form was present as a rare haplotype at the population level. However, in vitro analysis revealed that even the full-length form of Eudyptes TLR15 was nonfunctional, indicating an ancestral cryptic pseudogenization prior to its eventual disruption multiple times in the Eudyptes lineage. This unusual pseudogenization event could provide an insight into immune adaptation to fungal pathogens such as Aspergillus , which is responsible for significant mortality in wild and captive bird populations. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Analysis of the influence of the vane width on the fluid transmission performance in the vane-type tank

Author

Yong Li, Wei Rui, Pan Hailin, and Baotang Zhuang

Subjects
Materials science, Mechanics, Transmission performance
Abstract

Fuel tanks are a core component in satellites that manage the propellant. This study numerically analyzed the fluid transport with parallel guide vanes in a vane type surface tension tank. In this paper, the numerical simulation analysis is carried out for the fluid transmission performance of the parallel vane of the new generation plate surface tension tank, and the influence of vane width on the transmission performance of vane is studied. The results show that, in the whole capillary flow stage, the liquid flow rate increases with the increase of the width a of the guide plate.

Published
2020
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49. High-coverage genomes to elucidate the evolution of penguins

Author

Pan, Hailin, primary, Cole, Theresa L, primary, Bi, Xupeng, primary, Fang, Miaoquan, primary, Zhou, Chengran, primary, Yang, Zhengtao, primary, Ksepka, Daniel T, primary, Hart, Tom, primary, Bouzat, Juan L, primary, Argilla, Lisa S, primary, Bertelsen, Mads F, primary, Boersma, P Dee, primary, Bost, Charles-André, primary, Cherel, Yves, primary, Dann, Peter, primary, Fiddaman, Steven R, primary, Howard, Pauline, primary, Labuschagne, Kim, primary, Mattern, Thomas, primary, Miller, Gary, primary, Parker, Patricia, primary, Phillips, Richard A, primary, Quillfeldt, Petra, primary, Ryan, Peter G, primary, Taylor, Helen, primary, Thompson, David R, primary, Young, Melanie J, primary, Ellegaard, Martin R, primary, Gilbert, M Thomas P, primary, Sinding, Mikkel-Holger S, primary, Pacheco, George, primary, Shepherd, Lara D, primary, Tennyson, Alan J D, primary, Grosser, Stefanie, primary, Kay, Emily, primary, Nupen, Lisa J, primary, Ellenberg, Ursula, primary, Houston, David M, primary, Reeve, Andrew Hart, primary, Johnson, Kathryn, primary, Masello, Juan F, primary, Stracke, Thomas, primary, McKinlay, Bruce, primary, Borboroglu, Pablo García, primary, Zhang, De-Xing, primary, and Zhang, Guojie, primary

Published
2019
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50. Draft Genome Assembly and Population Genetics of an Agricultural Pollinator, the Solitary Alkali Bee (Halictidae: Nomia melanderi)

Author

Kapheim, Karen M, primary, Pan, Hailin, additional, Li, Cai, additional, Blatti, Charles, additional, Harpur, Brock A, additional, Ioannidis, Panagiotis, additional, Jones, Beryl M, additional, Kent, Clement F, additional, Ruzzante, Livio, additional, Sloofman, Laura, additional, Stolle, Eckart, additional, Waterhouse, Robert M, additional, Zayed, Amro, additional, Zhang, Guojie, additional, and Wcislo, William T, additional

Published
2019
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