1. DNA methylation signatures associated with prognosis of gastric cancer
- Author
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Dai, Jin, Nishi, Akihiro, Li, Zhe-Xuan, Zhang, Yang, Zhou, Tong, You, Wei-Cheng, Li, Wen-Qing, and Pan, Kai-Feng
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Human Genome ,Clinical Research ,Genetics ,Digestive Diseases ,2.1 Biological and endogenous factors ,4.1 Discovery and preclinical testing of markers and technologies ,Aetiology ,Detection ,screening and diagnosis ,Adolescent ,Adult ,Biomarkers ,Tumor ,CpG Islands ,DNA Methylation ,Datasets as Topic ,Epigenesis ,Genetic ,Follow-Up Studies ,Gastric Mucosa ,Gene Expression Regulation ,Neoplastic ,Humans ,Male ,Prognosis ,Progression-Free Survival ,Risk Assessment ,Stomach Neoplasms ,Young Adult ,Bioinformatics ,Biomarkers ,Epigenetics ,Gastric cancer ,Heterogeneity ,Methylation ,Precision medicine ,Survival ,The Cancer Genome Atlas ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Epidemiology - Abstract
BackgroundFew studies have examined prognostic outcomes-associated molecular signatures other than overall survival (OS) for gastric cancer (GC). We aimed to identify DNA methylation biomarkers associated with multiple prognostic outcomes of GC in an epigenome-wide association study.MethodsBased on the Cancer Genome Atlas (TCGA), DNA methylation loci associated with OS (n = 381), disease-specific survival (DSS, n = 372), and progression-free interval (PFI, n = 383) were discovered in training set subjects (false discovery rates
- Published
- 2021