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Aims: Altered brain functional connectivity has been proposed as the neurobiological underpinnings of attention-deficit/hyperactivity disorder (ADHD), and the default mode interference hypothesis is one of the most popular neuropsychological models. Here, we explored whether this hypothesis is supported in adults with ADHD and the association with high-risk genetic variants and treatment outcomes., Methods: Voxel-based whole-brain connectome analysis was conducted on resting-state functional MRI data from 84 adults with ADHD and 89 healthy controls to identify functional connectivity substrates corresponding to ADHD-related alterations. The candidate genetic variants and 12-week cognitive behavioral therapy data were leveraged from the same population to assess these associations., Results: We detected breakdowns of functional connectivity in the precuneus and left middle temporal gyrus in adults with ADHD, with exact contributions from decreased connectivity within the default mode, dorsal and ventral attention networks, as well as increased connectivity among them with the middle temporal gyrus serving as a crucial 'bridge'. Additionally, significant associations between the altered functional connectivity and genetic variants in both MAOA and MAOB were detected. Treatment restored brain function, with the amelioration of connectivity of the middle temporal gyrus, accompanied by improvements in ADHD core symptoms., Conclusions: These findings support the interference of default mode on attention in adults with ADHD and its association with genetic risk variants and clinical management, providing insights into the underlying pathogenesis of ADHD and potential biomarkers for treatment evaluation., (© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)

Purpose: To study the accuracy of the intraocular pressure (IOP) after laser in situ keratomileusis (LASIK) with noncontact tonometer (NCT)., Methods: One hundred and eighty cases (256 eyes) myopias that had undergone LASIK were studied. IOP, corneal thickness and corneal curvature were measured before and after LASIK. The correlations were analyzed., Results: The decrease of Iop using NCT was significantly obvious after LASIK (P < 0.001). One year after LASIK mean IOP drop was 6.54 +/- 2.1 mmHg. The reduction of IOP may be related to the decrease in corneal thickness and corneal curvature (P < 0.01). Regression equation for IOP drop (mmHg) = 0.355 + 0.0342X1 + 0.365X2 [X1 = decrease in corneal curvature (D), X2 = ablation depth (microm)], Conclusions: The IOP readings after LASIK were lower than the real IOP values. IOP readings after LASIK were influenced by corneal thickness and refraction degree.