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16. Principles and Design of Bionic Hydrogel Adhesives for Skin Wound Treatment.

Author

Wang, Chunxiao, Zhang, Xinyu, Fan, Yinuo, Yu, Shuhan, Liu, Man, Feng, Linhan, Sun, Qisen, and Pan, Panpan

Subjects
BIONICS, HYDROGELS, BIOPOLYMERS, SKIN injuries, WOUND healing, ADHESIVES, SKIN, TISSUES
Abstract

Over millions of years of evolution, nature has developed a myriad of unique features that have inspired the design of adhesives for wound healing. Bionic hydrogel adhesives, capable of adapting to the dynamic movements of tissues, possess superior biocompatibility and effectively promote the healing of both external and internal wounds. This paper provides a systematic review of the design and principles of these adhesives, focusing on the treatment of skin wounds, and explores the feasibility of incorporating nature-inspired properties into their design. The adhesion mechanisms of bionic adhesives are analyzed from both chemical and physical perspectives. Materials from natural and synthetic polymers commonly used as adhesives are detailed regarding their biocompatibility and degradability. The multifunctional design elements of hydrogel adhesives for skin trauma treatment, such as self-healing, drug release, responsive design, and optimization of mechanical and physical properties, are further explored. The aim is to overcome the limitations of conventional treatments and offer a safer, more effective solution for the application of bionic wound dressings. [ABSTRACT FROM AUTHOR]

Published
2024
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30. A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

Author

Zhi Xin, Cui Jin, Liu Chao, Zhang Zheng, Cao Liehu, Pan Panpan, Weng Weizong, Zhai Xiao, Zhao Qingjie, Hu Honggang, Qin Longjuan, Chen Xiao, and Su Jiacan

Subjects
RPS5, matrine derivative, RANKL, osteoclasts, AKT pathway, Therapeutics. Pharmacology, RM1-950
Abstract

Post-menopausal osteoporosis (PMOP) is a metabolic bone disorder characterized by low bone mass and micro-architectural deterioration of bone tissue. The over-activated osteoclastogenesis, which plays an important role in osteoporosis, has become an important therapeutic target. M54 was a bioactive derivative of the Chinese traditional herb matrine. We found that M54 could suppress RANKL-induced osteoclastogenesis in bone marrow mononuclear cells and RAW264.7 cells through suppressing NF-κB, PI3K/AKT, and MAPKs pathways activity in vitro, and prevent ovariectomy-induced bone loss in vivo. Our previous study has proved that ribosomal protein S5 (RPS5) was a direct target of M19, based on which M54 was synthesized. Thus we deduced that M54 also targeted RPS5. During osteoclastogenesis, the RPS5 level in RAW264.7 cells was significantly down-regulated while M54 could maintain its level. After RPS5 was silenced, the inhibitory effects of M54 on osteoclastogenesis were partially compromised, indicating that M54 took effects through targeting RPS5. In summary, M54 was a potential clinical medicine for post-menopause osteoporosis treatment, and RPS5 is a possible key protein in PMOP.

Published
2018
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48. Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages

Author

Chen, Xiao, primary, Cui, Jin, additional, Zhai, Xiao, additional, Zhang, Jun, additional, Gu, Zhengrong, additional, Zhi, Xin, additional, Weng, Weizong, additional, Pan, Panpan, additional, Cao, Liehu, additional, Ji, Fang, additional, Wang, Zhiwei, additional, and Su, Jiacan, additional

Published
2018
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