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28 results on '"Pan, Shouguo"'

2. Impact of fine particulate matter on latent tuberculosis infection and active tuberculosis in older adults: a population-based multicentre cohort study

Author

Guo, Tonglei, primary, Tian, Sifan, additional, Xin, Henan, additional, Du, Jiang, additional, Cao, Xuefang, additional, Feng, Boxuan, additional, He, Yijun, additional, He, Yongpeng, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Liu, Zisen, additional, Yan, Jiaoxia, additional, Shen, Lingyu, additional, Di, Yuanzhi, additional, Chen, Yanxiao, additional, Jin, Qi, additional, Pan, Shouguo, additional, Kioumourtzoglou, Marianthi-Anna, additional, Gao, Lei, additional, and Gao, Xu, additional

Published
2024
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3. Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis

Author

Chen, Ray Y, Yu, Xiang, Smith, Bronwyn, Liu, Xin, Gao, Jingcai, Diacon, Andreas H, Dawson, Rodney, Tameris, Michele, Zhu, Hong, Qu, Yahong, Zhang, Ruanqing, Pan, Shouguo, Jin, Xiaowei, Goldfeder, Lisa C, Cai, Ying, Arora, Kriti, Wang, Jing, Vincent, Joel, Malherbe, Stephanus T, Thienemann, Friedrich, Wilkinson, Robert J, Walzl, Gerhard, and Barry, Clifton E, III

Published
2021
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5. Incidence of active tuberculosis in individuals with latent tuberculosis infection in rural China: follow-up results of a population-based, multicentre, prospective cohort study

Author

Kong, Wen, Chen, Cheng, Wang, Yuejin, Gong, Fengqiu, Guo, Lili, Huang, Zhonghui, Shao, Wenjuan, Sun, Ping, Xue, Chunhua, Zhu, Yiqing, Jiang, Weiping, Gui, Yaxiang, Wang, Hao, Yang, Ping, Yao, Ruiyong, Yin, Wenhua, Chao, Nong, Jiang, Tao, Qian, Baima village:Qinxiao, Shi, Hongqin, Tao, Yungen, Wu, Meiqin, Yang, Yuping, Zhang, Dongmei, Zhang, Guoxian, Wang, Jianguo, Chen, Xiaojun, Ding, Zhaosheng, Fu, Huajie, Hang, Li, Huang, Yu, Jiang, Huiping, Jiang, Huaxin, Li, Junlian, Liu, Baoxia, Pan, Lijun, Shao, Caiyun, Tan, Huixia, Tan, Qiuwei, Wang, Weizhong, Yang, Jianping, Yi, Meiqin, Yin, Qianlu, Yuan, Hua, Zhang, Weixing, Zhu, Hong, Fei, Haojun, Jiang, Liwei, Li, Wenhong, Shen, Zhaoer, Sun, Xiaomei, Tang, Wenjuan, Wang, Mingming, Wu, Jinlong, Zhang, Songqing, Zhang, Xiaozhong, Guan, Ling, Guan, Xueling, Liu, Wantong, Cui, Wei, Lei, Zhaokuan, Wang, Yongming, Yu, Yongmin, Song, Liucun, Wang, Tao, Li, Xiaolong, Luo, Jianrong, Wang, Hebin, Liu, Weiguo, Zhang, Fude, Zhang, Fang, Wang, Yongfu, Zhao, Qingna, Liu, Yinbiao, Li, Jianli, Dan, Liujie, Wang, Dakuan, Yan, Jiaoxia, Zhu, Guofu, Liu, Zisen, He, Zhoulun, Yan, Yongfen, Li, Ping, Shang, Huailiang, Heng, Baichao, Liu, Shuli, Ran, Zhe, Jiang, Kun, Zhu, Xin, Wu, Haibin, Liang, Liling, Yuan, Jianhui, Wang, Zhigang, Meng, Aijing, Wang, Jing, Guan, Xia, Yang, Jiannan, Li, Yan, Liu, Haixia, Wang, Wuying, Liu, Xinhao, Qiao, Fuke, Li, Xianmin, Zhao, Herong, Zhu, Chunyuan, Lu, Yanan, Liu, Ning, Peng, Yanan, Wan, Li, Chen, Hairui, Song, Xiaoming, Lou, Qingtao, Wang, Wei, Liu, Changshui, Zhang, Lijuan, Zhang, Zhanjiang, Yuan, Shijie, Yang, Yongxin, Chen, Suqin, Dong, Changjie, Ran, Jianguo, Wu, Weiling, Li, Zhen, Zhang, Hui, Duan, Liujia, Yang, Fan, Liu, Ying, Wang, Kun, Yan, Lina, Ma, Jiangli, Wan, Liuyan, Li, Yanfen, Wang, Han, Yuan, Bing, Du, Ruiling, Zhang, Jie, Zhang, Jingge, Li, Lin, Zhao, Aihua, Wei, Junhong, Zhao, Ning, Zhu, Yonghui, Mao, Wuyi, Luo, Qi, Huang, Zhongpu, Guo, Hongbin, Zheng, Na, Pan, Weiwei, Qin, Meng, Li, Ying, Xiao, Shanshan, Zhang, Yun, Wu, Weiying, Li, Jing, Song, Liusen, Tang, Yi, Yao, Qineng, Yang, Kunyun, Kuang, Meixiong, Bao, Changlin, Xiao, Tao, Wan, Yanping, Wan, Xiaojie, Liu, Binbin, Jiang, Tieliu, Zhang, Xiaoping, Tan, Zhen, Zhang, Xiaobing, Liu, Zhaoguo, Chen, Zhenhua, Wang, Yu, Yu, Yanyan, Dai, Saibo, Hu, PeiLei, Zhang, Chuanfang, Li, Yanhong, Gong, Dehua, Liu, Liqin, Li, Xiaohong, Ling, Jie, Shan, Xinhua, Zhang, Z huo, Deng, Haibing, Zeng, Zhengbiao, Li, Honghua, Zhou, Shuiping, Xu, Ying, Zhang, Can, Chen, Haifeng, Wang, Xiaoling, Chen, Yao, Yang, Sheng, Peng, Weiping, Sun, Huan, Liao, Hui, Xie, Xiping, Liang, Fang, Hu, Cheng, Hu, Siwei, Liu, Xinyu, Peng, Jun, Liu, Wenxin, Liu, Decheng, Liu, Wenbin, Li, Xiangmei, Guo, Hui, Wang, Wen, He, Yujue, Wang, Bo, Zhang, Yaping, Gao, Qiaofen, Zhao, Jianxi, Chen, Weitao, Li, Qing, Mu, Taojun, Liang, Qijun, Gu, Jixiu, Ma, Ling, An, Ning, Li, Junwen, Yao, Qinhua, Liang, Chengzhi, Ge, Xiuqun, Chen, Yalin, Luan, Shumao, Sun, Yanhong, Yang, Ruifang, Ma, Bin, Zhang, Suiqiang, Liang, Fusheng, Tian, Yuan, Zhang, Hongxia, Yang, Fanqin, Lu, Qifeng, Chen, Jun, Dong, Yan, Zhang, Shunsheng, Jin, Ziming, Wang, Jintao, Lan, Jianwei, Zhang, Zhanjun, Wu, Yumin, Shi, Jianlin, Shi, Zhaoping, Chen, Yan, Ding, Jianxin, An, Xiaofeng, Yang, Jun, Ling, Dongdong, Nie, Zhenzhou, Liu, Chunli, Mi, Guangyin, Ma, Jun, Guo, Jiyun, Gao, Lei, Li, Xiangwei, Liu, Jianmin, Wang, Xinhua, Lu, Wei, Bai, Liqiong, Xin, Henan, Zhang, Haoran, Li, Hengjing, Zhang, Zongde, Ma, Yu, Li, Mufei, Feng, Boxuan, Du, Jiang, Sui, Hongtao, Zhao, Rong, Su, Haoxiang, Pan, Shouguo, Shen, Fei, He, Jian, Yang, Shumin, Si, Hongyan, Cheng, Xu, Xu, Zuhui, Tan, Yunhong, Chen, Tianzhu, Xu, Weiguo, Peng, Hong, Wang, Zhijian, Zhu, Tao, Chen, Xiaoyou, Zhou, Xinhua, and Jin, Qi

Published
2017
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7. Algorithms for Screening for Active Tuberculosis among Individuals with Latent Tuberculosis Infection in a Rural Community in China

Author

Xin, Henan, primary, Du, Ying, additional, Cao, Xuefang, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Zhang, Haoran, additional, Feng, Boxuan, additional, He, Yijun, additional, He, Yongpeng, additional, Quan, Zhusheng, additional, Liu, Zisen, additional, Yan, Jiaoxia, additional, Guan, Ling, additional, Guan, Xueling, additional, Shen, Fei, additional, Liu, Jianmin, additional, Jin, Qi, additional, Pan, Shouguo, additional, and Gao, Lei, additional

Published
2022
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8. Serial testing of latent tuberculosis infection in patients with diabetes mellitus using interferon-gamma release assay, tuberculin skin test, and creation tuberculin skin test

Author

He, Yijun, primary, Cao, Xuefang, additional, Guo, Tonglei, additional, He, Yongpeng, additional, Du, Ying, additional, Zhang, Haoran, additional, Feng, Boxuan, additional, Du, Jiang, additional, Zhang, Bin, additional, Wang, Kun, additional, Yan, Jiaoxia, additional, Wang, Dakuan, additional, Liu, Zisen, additional, Pan, Shouguo, additional, Xin, Henan, additional, and Gao, Lei, additional

Published
2022
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9. Whole transcriptome sequencing reveals neutrophils’ transcriptional landscape associated with active tuberculosis

Author

Geng, Xingzhu, primary, Wu, Xiaolin, additional, Yang, Qianting, additional, Xin, Henan, additional, Zhang, Bin, additional, Wang, Dakuan, additional, Liu, Liguo, additional, Liu, Song, additional, Chen, Qi, additional, Liu, Zisen, additional, Zhang, Mingxia, additional, Pan, Shouguo, additional, Zhang, Xiaobing, additional, Gao, Lei, additional, and Jin, Qi, additional

Published
2022
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10. Association Between Plasma Exosomes S100A9/C4BPA and Latent Tuberculosis Infection Treatment: Proteomic Analysis Based on a Randomized Controlled Study

Author

Du, Ying, primary, Xin, Henan, additional, Cao, Xuefang, additional, Liu, Zisen, additional, He, Yijun, additional, Zhang, Bin, additional, Yan, Jiaoxia, additional, Wang, Dakuan, additional, Guan, Ling, additional, Shen, Fei, additional, Feng, Boxuan, additional, He, Yongpeng, additional, Liu, Jianmin, additional, Jin, Qi, additional, Pan, Shouguo, additional, Zhang, Haoran, additional, and Gao, Lei, additional

Published
2022
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11. The Association between Circulating microRNAs and the Risk of Active Disease Development from Latent Tuberculosis Infection: a Nested Case-Control Study

Author

Xin, Henan, primary, Cao, Xuefang, additional, Du, Ying, additional, Yan, Jiaoxia, additional, He, Rui, additional, Liu, Zisen, additional, Zhang, Haoran, additional, He, Yijun, additional, Zhang, Bin, additional, Wang, Dakuan, additional, Guan, Ling, additional, Shen, Fei, additional, Feng, Boxuan, additional, Quan, Zhusheng, additional, He, Yongpeng, additional, Liu, Jianmin, additional, Jin, Qi, additional, Pan, Shouguo, additional, and Gao, Lei, additional

Published
2022
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12. Performance of Active Case Finding Algorithms Among Individuals with Latent Tuberculosis Infection

Author

Xin, Henan, primary, Du, Ying, additional, Cao, Xuefang, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Zhang, Haoran, additional, Feng, Boxuan, additional, He, Yijun, additional, He, Yongpeng, additional, Quan, Zhusheng, additional, Liu, Zisen, additional, Yan, Jiaoxia, additional, Guan, Ling, additional, Guan, Xueling, additional, Shen, Fei, additional, Liu, Jianmin, additional, Jin, Qi, additional, Pan, Shouguo, additional, and Gao, Lei, additional

Published
2022
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13. Protective Efficacy of 6-Week Regimen of Rifapentine Plus Isoniazid for Latent Tuberculosis Infection Treatment Among Individuals With Prior Tuberculosis Suggested By Radiography Abnormalities: 2-Year Follow-Up of a Randomized Controlled Trial

Author

Zhang, Haoran, primary, Xin, Henan, additional, Du, Ying, additional, Pan, Shouguo, additional, Liu, Jianmin, additional, Cao, Xuefang, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Zisen, additional, Zhang, Bin, additional, Wang, Dakuan, additional, Feng, Boxuan, additional, Guan, Xueling, additional, He, Yijun, additional, He, Yongpeng, additional, Zhang, Zhanjiang, additional, Yan, Jiaoxia, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2022
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14. Protective efficacy of 6-week regimen for latent tuberculosis infection treatment in rural China: 5-year follow-up of a randomised controlled trial

Author

Xin, Henan, primary, Cao, Xuefang, additional, Zhang, Haoran, additional, Feng, Boxuan, additional, Du, Ying, additional, Zhang, Bin, additional, Wang, Dakuan, additional, Liu, Zisen, additional, Guan, Ling, additional, Shen, Fei, additional, Guan, Xueling, additional, Yan, Jiaoxia, additional, He, Yijun, additional, He, Yongpeng, additional, Quan, Zhusheng, additional, Pan, Shouguo, additional, Liu, Jianmin, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2021
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15. Latent Tuberculosis Infection Among Individuals with Pulmonary Fibrosis in Rural China: A Screening Study

Author

Xin, Henan, primary, Zhang, Haoran, additional, Cao, Xuefang, additional, Liu, Jianmin, additional, Pan, Shouguo, additional, Du, Ying, additional, Feng, Boxuan, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Guan, Xueling, additional, Zhang, Zhanjiang, additional, Yan, Jiaoxia, additional, Quan, Zhusheng, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2021
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16. The Association Between Mycobacteria-Specific Antigen-Induced Cytokines and Host Response to Latent Tuberculosis Infection Treatment in a Chinese Population

Author

Cao, Xuefang, primary, Xin, Henan, additional, Zhang, Haoran, additional, Liu, Jianmin, additional, Pan, Shouguo, additional, Du, Ying, additional, Feng, Boxuan, additional, Quan, Zhusheng, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Guan, Xueling, additional, Yan, Jiaoxia, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2021
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17. Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis

Author

Liu, Liguo, primary, Deng, Jiaheng, additional, Yang, Qianting, additional, Wei, Candong, additional, Liu, Bo, additional, Zhang, Haoran, additional, Xin, Henan, additional, Pan, Shouguo, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Pang, Yu, additional, Chen, Xinchun, additional, Gao, Lei, additional, Zheng, Jianhua, additional, Liu, Rongmei, additional, and Jin, Qi, additional

Published
2021
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18. Urinary metabolomic analysis to identify potential markers for the diagnosis of tuberculosis and latent tuberculosis

Author

Deng, Jiaheng, primary, Liu, Liguo, additional, Yang, Qianting, additional, Wei, Candong, additional, Zhang, Haoran, additional, Xin, Henan, additional, Pan, Shouguo, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Liu, Bo, additional, Gao, Lei, additional, Liu, Rongmei, additional, Pang, Yu, additional, Chen, Xinchun, additional, Zheng, Jianhua, additional, and Jin, Qi, additional

Published
2021
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19. The Effect of Wechat-Based Training on Improving the Village Doctors’ Knowledge of Tuberculosis Management: A Pre-And-Post Intervention Study from China

Author

Xin, Henan, primary, Zhang, Haoran, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Cao, Xuefang, additional, Feng, Boxuan, additional, Quan, Zhusheng, additional, Du, Ying, additional, He, Yijun, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Jianmin, additional, Liu, Zisen, additional, Pan, Shouguo, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2021
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20. The effect of WeChat-based training on improving the village doctors’ knowledge of tuberculosis management: a pre-and-post intervention study from China

Author

Gao, Lei, primary, Xin, Henan, additional, Zhang, Haoran, additional, Cao, Xuefang, additional, Feng, Boxuan, additional, Quan, Zhusheng, additional, Du, Ying, additional, He, Yijun, additional, Wang, Dakuan, additional, Zhang, Bin, additional, Jin, Qi, additional, Liu, Zisen, additional, Pan, Shouguo, additional, Guan, Ling, additional, Shen, Fei, additional, and Liu, Jianmin, additional

Published
2020
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21. The Prevalence of Chest Radiography Abnormalities Suggestive of Inactive Tuberculosis and Their Burden of Tuberculosis Infection Among Rural Residents: A Population-Based Screening Study

Author

Xin, Henan, primary, Zhang, Haoran, additional, Cao, Xuefang, additional, Liu, Jianmin, additional, Pan, Shouguo, additional, Du, Ying, additional, Feng, Boxuan, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Guan, Xueling, additional, Zhang, Zhanjiang, additional, Yan, Jiaoxia, additional, Quan, Zhusheng, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2020
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22. Serial testing of Mycobacterium tuberculosis infection in Chinese village doctors by QuantiFERON-TB Gold Plus, QuantiFERON-TB Gold in-Tube and T-SPOT.TB

Author

Zhang, Haoran, primary, Xin, Henan, additional, Wang, Dakuan, additional, Pan, Shouguo, additional, Liu, Zisen, additional, Cao, Xuefang, additional, Wang, Jinxing, additional, Li, Xiangwei, additional, Feng, Boxuan, additional, Li, Mufei, additional, Yang, Qianting, additional, Zhang, Mingxia, additional, Jin, Qi, additional, and Gao, Lei, additional

Published
2019
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23. Short-course regimens of rifapentine plus isoniazid to treat latent tuberculosis infection in older Chinese patients: a randomised controlled study

Author

Gao, Lei, primary, Zhang, Haoran, additional, Xin, Henan, additional, Liu, Jianmin, additional, Pan, Shouguo, additional, Li, Xiangwei, additional, Guan, Ling, additional, Shen, Fei, additional, Liu, Zisen, additional, Wang, Dakuan, additional, Guan, Xueling, additional, Yan, Jiaoxia, additional, Li, Hengjing, additional, Feng, Boxuan, additional, Cao, Xuefang, additional, Chen, Yu, additional, Cui, Wei, additional, Zhang, Zongde, additional, Ma, Yu, additional, Chen, Xiaoyou, additional, Zhou, Xinhua, additional, and Jin, Qi, additional

Published
2018
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24. Incidence of active tuberculosis in individuals with latent tuberculosis infection in rural China: follow-up results of a population-based, multicentre, prospective cohort study

Author

Gao, Lei, primary, Li, Xiangwei, additional, Liu, Jianmin, additional, Wang, Xinhua, additional, Lu, Wei, additional, Bai, Liqiong, additional, Xin, Henan, additional, Zhang, Haoran, additional, Li, Hengjing, additional, Zhang, Zongde, additional, Ma, Yu, additional, Li, Mufei, additional, Feng, Boxuan, additional, Du, Jiang, additional, Sui, Hongtao, additional, Zhao, Rong, additional, Su, Haoxiang, additional, Pan, Shouguo, additional, Guan, Ling, additional, Shen, Fei, additional, He, Jian, additional, Yang, Shumin, additional, Si, Hongyan, additional, Cheng, Xu, additional, Xu, Zuhui, additional, Tan, Yunhong, additional, Chen, Tianzhu, additional, Xu, Weiguo, additional, Peng, Hong, additional, Wang, Zhijian, additional, Zhu, Tao, additional, Chen, Xiaoyou, additional, Zhou, Xinhua, additional, Guan, Xueling, additional, Jin, Qi, additional, Kong, Wen, additional, Chen, Cheng, additional, Wang, Yuejin, additional, Gong, Fengqiu, additional, Guo, Lili, additional, Huang, Zhonghui, additional, Shao, Wenjuan, additional, Sun, Ping, additional, Xue, Chunhua, additional, Zhu, Yiqing, additional, Jiang, Weiping, additional, Gui, Yaxiang, additional, Wang, Hao, additional, Yang, Ping, additional, Yao, Ruiyong, additional, Yin, Wenhua, additional, Chao, Nong, additional, Jiang, Tao, additional, Qian, Baima village:Qinxiao, additional, Shi, Hongqin, additional, Tao, Yungen, additional, Wu, Meiqin, additional, Yang, Yuping, additional, Zhang, Dongmei, additional, Zhang, Guoxian, additional, Wang, Jianguo, additional, Chen, Xiaojun, additional, Ding, Zhaosheng, additional, Fu, Huajie, additional, Hang, Li, additional, Huang, Yu, additional, Jiang, Huiping, additional, Jiang, Huaxin, additional, Li, Junlian, additional, Liu, Baoxia, additional, Pan, Lijun, additional, Shao, Caiyun, additional, Tan, Huixia, additional, Tan, Qiuwei, additional, Wang, Weizhong, additional, Yang, Jianping, additional, Yi, Meiqin, additional, Yin, Qianlu, additional, Yuan, Hua, additional, Zhang, Weixing, additional, Zhu, Hong, additional, Fei, Haojun, additional, Jiang, Liwei, additional, Li, Wenhong, additional, Shen, Zhaoer, additional, Sun, Xiaomei, additional, Tang, Wenjuan, additional, Wang, Mingming, additional, Wu, Jinlong, additional, Zhang, Songqing, additional, Zhang, Xiaozhong, additional, Liu, Wantong, additional, Cui, Wei, additional, Lei, Zhaokuan, additional, Wang, Yongming, additional, Yu, Yongmin, additional, Song, Liucun, additional, Wang, Tao, additional, Li, Xiaolong, additional, Luo, Jianrong, additional, Wang, Hebin, additional, Liu, Weiguo, additional, Zhang, Fude, additional, Zhang, Fang, additional, Wang, Yongfu, additional, Zhao, Qingna, additional, Liu, Yinbiao, additional, Li, Jianli, additional, Dan, Liujie, additional, Wang, Dakuan, additional, Yan, Jiaoxia, additional, Zhu, Guofu, additional, Liu, Zisen, additional, He, Zhoulun, additional, Yan, Yongfen, additional, Li, Ping, additional, Shang, Huailiang, additional, Heng, Baichao, additional, Liu, Shuli, additional, Ran, Zhe, additional, Jiang, Kun, additional, Zhu, Xin, additional, Wu, Haibin, additional, Liang, Liling, additional, Yuan, Jianhui, additional, Wang, Zhigang, additional, Meng, Aijing, additional, Wang, Jing, additional, Guan, Xia, additional, Yang, Jiannan, additional, Li, Yan, additional, Liu, Haixia, additional, Wang, Wuying, additional, Liu, Xinhao, additional, Qiao, Fuke, additional, Li, Xianmin, additional, Zhao, Herong, additional, Zhu, Chunyuan, additional, Lu, Yanan, additional, Liu, Ning, additional, Peng, Yanan, additional, Wan, Li, additional, Chen, Hairui, additional, Song, Xiaoming, additional, Lou, Qingtao, additional, Wang, Wei, additional, Liu, Changshui, additional, Zhang, Lijuan, additional, Zhang, Zhanjiang, additional, Yuan, Shijie, additional, Yang, Yongxin, additional, Chen, Suqin, additional, Dong, Changjie, additional, Ran, Jianguo, additional, Wu, Weiling, additional, Li, Zhen, additional, Zhang, Hui, additional, Duan, Liujia, additional, Yang, Fan, additional, Liu, Ying, additional, Wang, Kun, additional, Yan, Lina, additional, Ma, Jiangli, additional, Wan, Liuyan, additional, Li, Yanfen, additional, Wang, Han, additional, Yuan, Bing, additional, Du, Ruiling, additional, Zhang, Jie, additional, Zhang, Jingge, additional, Li, Lin, additional, Zhao, Aihua, additional, Wei, Junhong, additional, Zhao, Ning, additional, Zhu, Yonghui, additional, Mao, Wuyi, additional, Luo, Qi, additional, Huang, Zhongpu, additional, Guo, Hongbin, additional, Zheng, Na, additional, Pan, Weiwei, additional, Qin, Meng, additional, Li, Ying, additional, Xiao, Shanshan, additional, Zhang, Yun, additional, Wu, Weiying, additional, Li, Jing, additional, Song, Liusen, additional, Tang, Yi, additional, Yao, Qineng, additional, Yang, Kunyun, additional, Kuang, Meixiong, additional, Bao, Changlin, additional, Xiao, Tao, additional, Wan, Yanping, additional, Wan, Xiaojie, additional, Liu, Binbin, additional, Jiang, Tieliu, additional, Zhang, Xiaoping, additional, Tan, Zhen, additional, Zhang, Xiaobing, additional, Liu, Zhaoguo, additional, Chen, Zhenhua, additional, Wang, Yu, additional, Yu, Yanyan, additional, Dai, Saibo, additional, Hu, PeiLei, additional, Zhang, Chuanfang, additional, Li, Yanhong, additional, Gong, Dehua, additional, Liu, Liqin, additional, Li, Xiaohong, additional, Ling, Jie, additional, Shan, Xinhua, additional, Zhang, Z huo, additional, Deng, Haibing, additional, Zeng, Zhengbiao, additional, Li, Honghua, additional, Zhou, Shuiping, additional, Xu, Ying, additional, Zhang, Can, additional, Chen, Haifeng, additional, Wang, Xiaoling, additional, Chen, Yao, additional, Yang, Sheng, additional, Peng, Weiping, additional, Sun, Huan, additional, Liao, Hui, additional, Xie, Xiping, additional, Liang, Fang, additional, Hu, Cheng, additional, Hu, Siwei, additional, Liu, Xinyu, additional, Peng, Jun, additional, Liu, Wenxin, additional, Liu, Decheng, additional, Liu, Wenbin, additional, Li, Xiangmei, additional, Guo, Hui, additional, Wang, Wen, additional, He, Yujue, additional, Wang, Bo, additional, Zhang, Yaping, additional, Gao, Qiaofen, additional, Zhao, Jianxi, additional, Chen, Weitao, additional, Li, Qing, additional, Mu, Taojun, additional, Liang, Qijun, additional, Gu, Jixiu, additional, Ma, Ling, additional, An, Ning, additional, Li, Junwen, additional, Yao, Qinhua, additional, Liang, Chengzhi, additional, Ge, Xiuqun, additional, Chen, Yalin, additional, Luan, Shumao, additional, Sun, Yanhong, additional, Yang, Ruifang, additional, Ma, Bin, additional, Zhang, Suiqiang, additional, Liang, Fusheng, additional, Tian, Yuan, additional, Zhang, Hongxia, additional, Yang, Fanqin, additional, Lu, Qifeng, additional, Chen, Jun, additional, Dong, Yan, additional, Zhang, Shunsheng, additional, Jin, Ziming, additional, Wang, Jintao, additional, Lan, Jianwei, additional, Zhang, Zhanjun, additional, Wu, Yumin, additional, Shi, Jianlin, additional, Shi, Zhaoping, additional, Chen, Yan, additional, Ding, Jianxin, additional, An, Xiaofeng, additional, Yang, Jun, additional, Ling, Dongdong, additional, Nie, Zhenzhou, additional, Liu, Chunli, additional, Mi, Guangyin, additional, Ma, Jun, additional, and Guo, Jiyun, additional

Published
2017
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25. Annual risk of tuberculosis infection in rural China: a population-based prospective study

Author

Gao, Lei, primary, Bai, Liqiong, additional, Liu, Jianmin, additional, Lu, Wei, additional, Wang, Xinhua, additional, Li, Xiangwei, additional, Du, Jiang, additional, Chen, Xinchun, additional, Zhang, Haoran, additional, Xin, Henan, additional, Sui, Hongtao, additional, Li, Hengjing, additional, Su, Haoxiang, additional, He, Jian, additional, Pan, Shouguo, additional, Peng, Hong, additional, Xu, Zuhui, additional, Catanzaro, Antonino, additional, Evans, Thomas G., additional, Zhang, Zongde, additional, Ma, Yu, additional, Li, Mufei, additional, Feng, Boxuan, additional, Li, Zhen, additional, Guan, Ling, additional, Shen, Fei, additional, Wang, Zhijian, additional, Zhu, Tao, additional, Yang, Shumin, additional, Si, Hongyan, additional, Wang, Yi, additional, Tan, Yunhong, additional, Chen, Tianzhu, additional, Chen, Chen, additional, Xia, Yinyin, additional, Cheng, Shiming, additional, Xu, Weiguo, additional, and Jin, Qi, additional

Published
2016
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26. Latent tuberculosis infection in rural China: baseline results of a population-based, multicentre, prospective cohort study

Author

Gao, Lei, primary, Lu, Wei, additional, Bai, Liqiong, additional, Wang, Xinhua, additional, Xu, Jinsheng, additional, Catanzaro, Antonino, additional, Cárdenas, Vicky, additional, Li, Xiangwei, additional, Yang, Yu, additional, Du, Jiang, additional, Sui, Hongtao, additional, Xia, Yinyin, additional, Li, Mufei, additional, Feng, Boxuan, additional, Li, Zhen, additional, Xin, Henan, additional, Zhao, Rong, additional, Liu, Jianmin, additional, Pan, Shouguo, additional, Shen, Fei, additional, He, Jian, additional, Yang, Shumin, additional, Si, Hongyan, additional, Wang, Yi, additional, Xu, Zuhui, additional, Tan, Yunhong, additional, Chen, Tianzhu, additional, Xu, Weiguo, additional, Peng, Hong, additional, Wang, Zhijian, additional, Zhu, Tao, additional, Zhou, Feng, additional, Liu, Haiying, additional, Zhao, Yanlin, additional, Cheng, Shiming, additional, and Jin, Qi, additional

Published
2015
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27. Protective efficacy of 6-week regimen for latent tuberculosis infection treatment in rural China: 5-year follow-up of a randomised controlled trial.

Author

Xin H, Cao X, Zhang H, Feng B, Du Y, Zhang B, Wang D, Liu Z, Guan L, Shen F, Guan X, Yan J, He Y, He Y, Quan Z, Pan S, Liu J, Jin Q, and Gao L

Subjects
Antitubercular Agents therapeutic use, China epidemiology, Follow-Up Studies, Humans, Isoniazid therapeutic use, Rural Population, Latent Tuberculosis drug therapy, Latent Tuberculosis epidemiology
Abstract

Background: Enlarging tuberculosis (TB) preventive treatment among at-risk populations is a critical component of the End TB Strategy. There is an urgent need to develop suitable latent tuberculosis infection (LTBI) testing and treatment tools according to the local TB epidemic and available resources worldwide., Methods: Based on an open-label randomised controlled trial conducted since 2015 in China among rural residents aged 50-70 years with LTBI, the protective efficacy of a 6-week twice-weekly regimen of rifapentine plus isoniazid was further evaluated in a 5-year follow-up survey., Results: 1298 treated participants and 1151 untreated controls were included in the 5-year protective efficacy analysis. In the per-protocol analysis, the incidence rate was 0.49 (95% CI 0.30-0.67) per 100 person-years in the untreated control group and 0.19 (95% CI 0.07-0.32) per 100 person-years in the treated group; the protection rate was 61.22%. Subgroup analysis showed that the protection rate was 76.82% in the per-protocol analysis among participants with baseline interferon (IFN)-γ levels in the highest quartile (≥3.25 IU·mL -1 ). Multiple logistic regression analysis indicated that participants with baseline body mass index <18.5 kg·m -2 and with pulmonary fibrotic lesions had increased hazard of developing active disease with an adjusted hazard ratio (aHR) of 3.64 (95% CI 1.20-11.00) and 5.99 (95% CI 2.20-16.27), respectively. In addition, individuals with higher baseline IFN-γ levels showed an increased risk of TB occurrence (aHR 2.27, 95% CI 1.13-4.58)., Conclusions: Our findings suggest the 6-week twice-weekly regimen of rifapentine plus isoniazid for LTBI treatment might be an optional tool for TB control in the Chinese population., Competing Interests: Conflict of interest: All co-authors disclose no conflicts of interest., (Copyright ©The authors 2022.)

Published
2022
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28. Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial.

Author

Chen RY, Via LE, Dodd LE, Walzl G, Malherbe ST, Loxton AG, Dawson R, Wilkinson RJ, Thienemann F, Tameris M, Hatherill M, Diacon AH, Liu X, Xing J, Jin X, Ma Z, Pan S, Zhang G, Gao Q, Jiang Q, Zhu H, Liang L, Duan H, Song T, Alland D, Tartakovsky M, Rosenthal A, Whalen C, Duvenhage M, Cai Y, Goldfeder LC, Arora K, Smith B, Winter J, and Barry Iii CE

Abstract

Background : By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those without baseline cavity on chest x-ray and whose month 2 sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but was still significantly worse than the 6-month arm (1.6%, P<0.01).  We hypothesize that PET/CT characteristics at baseline, PET/CT changes at one month, and markers of residual bacterial load will identify patients with tuberculosis who can be cured with 4 months (16 weeks) of standard treatment. Methods : This is a prospective, multicenter, randomized, phase 2b, noninferiority clinical trial of pulmonary tuberculosis participants. Those eligible start standard of care treatment. PET/CT scans are done at weeks 0, 4, and 16 or 24. Participants who do not meet early treatment completion criteria (baseline radiologic severity, radiologic response at one month, and GeneXpert-detectable bacilli at four months) are placed in Arm A (24 weeks of standard therapy). Those who meet the early treatment completion criteria are randomized at week 16 to continue treatment to week 24 (Arm B) or complete treatment at week 16 (Arm C). The primary endpoint compares the treatment success rate at 18 months between Arms B and C. Discussion : Multiple biomarkers have been assessed to predict TB treatment outcomes. This study uses PET/CT scans and GeneXpert (Xpert) cycle threshold to risk stratify participants. PET/CT scans are not applicable to global public health but could be used in clinical trials to stratify participants and possibly become a surrogate endpoint. If the Predict TB trial is successful, other immunological biomarkers or transcriptional signatures that correlate with treatment outcome may be identified., Trial Registration: NCT02821832., Competing Interests: Competing interests: No competing interests were disclosed.

Published
2017
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