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18 results on '"Pan, Xianmei"'

7. Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B

Author

Pan, Xianmei, primary, Wan, Rentao, additional, Wang, Yuman, additional, Liu, Silin, additional, He, Yu, additional, Deng, Bo, additional, Luo, Shangfei, additional, Chen, Yuan, additional, Wen, Lizhen, additional, Hong, Tianying, additional, Xu, Han, additional, Bian, Yifei, additional, Xia, Mingfeng, additional, and Li, Jing, additional

Published
2022
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9. A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE−/− mice.

Author

Wu, Bo, Zhong, Yuanzhi, Chen, Jinmin, Pan, Xianmei, Fan, Xianglin, Chen, Peier, Fu, Chenxing, Ou, Caiwen, and Chen, Minsheng

Subjects
DRUG delivery systems, PEPTIDES, MATRIX metalloproteinases, ATHEROSCLEROSIS, INTEGRINS, ISOFLAVONES
Abstract

We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug (i.e., puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug (i.e., puerarin) in vivo. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair

Author

Chen, Peng, primary, Zhang, Gangyu, additional, Jiang, Shan, additional, Ning, Yile, additional, Deng, Bo, additional, Pan, Xianmei, additional, Liu, Silin, additional, He, Yu, additional, Zhang, Lei, additional, Wan, Rentao, additional, Wu, Zhiming, additional, He, Qi, additional, Yin, Jiang, additional, Wang, Haibin, additional, and Li, Jing, additional

Published
2021
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13. Mechanosensitive Piezo1 Mediates Bone Fracture Repair by Promoting Angiogenesis Through Notch Signaling

Author

Chen, Peng, primary, Zhang, Gangyu, additional, Jiang, Shan, additional, Ning, Yile, additional, Deng, Bo, additional, Pan, Xianmei, additional, Liu, Silin, additional, He, Yu, additional, Zhang, Lei, additional, Wan, Rentao, additional, Wu, Zhiming, additional, He, Qi, additional, Yin, Jiang, additional, Wang, Haibin, additional, and Li, Jing, additional

Published
2021
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16. The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

Author

Chen, Peng, primary, Zhang, Gangyu, additional, Jiang, Shan, additional, Ning, Yile, additional, Deng, Bo, additional, Pan, Xianmei, additional, Liu, Silin, additional, He, Yu, additional, Zhang, Lei, additional, Wan, Rentao, additional, Wu, Zhiming, additional, He, Qi, additional, Yin, Jiang, additional, Wang, Haibin, additional, and Li, Jing, additional

Published
2019
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17. YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR.

Author

Pan, Xianmei, Wu, Bo, Fan, Xianglin, Xu, Guanghui, Ou, Caiwen, and Chen, Minsheng

Subjects
CARDIOVASCULAR diseases, UMBILICAL veins, ENDOTHELIAL cells
Abstract

Yes‐associated protein (YAP), a major effector of the Hippo signalling pathway, is widely implicated in vascular pathophysiology processes. Here, we identify a new role of YAP in the regulation of vascular senescence. The inhibition or deficiency and overexpression of YAP were performed in human umbilical vein endothelial cells (HUVECs) and isolated vascular tissues. Cellular and vascular senescence was assessed by analysis of the senescence‐associated β‐galactosidase (SA‐β‐gal) and expression of senescence markers P16, P21, P53, TERT and TRF1. We found that YAP was highly expressed in old vascular tissues, inhibition and knockdown of YAP decreased senescence, while overexpression of YAP increased the senescence in both HUVECs and vascular tissues. In addition, autophagic flux blockage and mTOR pathway activation were observed during YAP‐induced HUVECs and vascular senescence, which could be relieved by the inhibition and knockdown of YAP. Moreover, YAP‐promoted cellular and vascular senescence could be relieved by mTOR inhibition. Collectively, our findings indicate that YAP may serve as a potential therapeutic target for ageing‐associated cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2021
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18. β-Galactosidase instructed supramolecular hydrogelation for selective identification and removal of senescent cells.

Author

Xu, Tengyan, Cai, Yanbin, Zhong, Xinglong, Zhang, Le, Zheng, Debing, Gao, Zhengfeng, Pan, Xianmei, Wang, Fuqiang, Chen, Minsheng, and Yang, Zhimou

Subjects
GALACTOSIDASES, CELLULAR aging, ENDOTHELIAL cells, WOUND healing, CELLS, IDENTIFICATION
Abstract

The identification and removal of senescent cells is very important to improve human health and prolong life. In this study, we introduced a novel strategy of β-galactosidase (β-Gal) instructed peptide self-assembly to selectively form nanofibers and hydrogels in senescent cells. We demonstrated that the in situ formed nanofibers could alleviate endothelial cell senescence by reducing p53, p21, and p16INK4a expression levels. We also demonstrated that our strategy could selectively remove senescent endothelial cells by inducing cell apoptosis, with an increase in the BAX/BCL-2 ratio and caspase-3 expression. Our study reports the first example of enzyme-instructed self-assembly (EISA) by a sugar hydrolase, which may lead to the development of supramolecular nanomaterials for the diagnosis and treatment of many diseases, such as cancer, and for other applications, such as wound healing and senescence. [ABSTRACT FROM AUTHOR]

Published
2019
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