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821 results on '"Pan, Xiaohong"'

8. Characterizing genetic transmission networks among newly diagnosed HIV-1 infected individuals in eastern China: 2012–2016

Author

Ding, Xiaobei, Chaillon, Antoine, Pan, Xiaohong, Zhang, Jiafeng, Zhong, Ping, He, Lin, Chen, Wanjun, Fan, Qin, Jiang, Jun, Luo, Mingyu, Xia, Yan, Guo, Zhihong, and Smith, Davey M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Sexual and Gender Minorities (SGM/LGBT*), Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, Genetics, Health Disparities, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, China, Genotype, HIV Infections, HIV Seropositivity, HIV-1, Homosexuality, Male, Humans, Male, Phylogeny, Sexual and Gender Minorities, General Science & Technology
Abstract

We aimed to elucidate the characteristics of HIV molecular epidemiology and identify transmission hubs in eastern China using genetic transmission network and lineage analyses. HIV-TRACE was used to infer putative relationships. Across the range of epidemiologically-plausible genetic distance (GD) thresholds (0.1-2.0%), a sensitivity analysis was performed to determine the optimal threshold, generating the maximum number of transmission clusters and providing reliable resolution without merging different small clusters into a single large cluster. Characteristics of genetically linked individuals were analyzed using logistic regression. Assortativity (shared characteristics) analysis was performed to infer shared attributes between putative partners. 1,993 persons living with HIV-1 were enrolled. The determined GD thresholds within subtypes CRF07_BC, CRF01_AE, and B were 0.5%, 1.2%, and 1.7%, respectively, and 826 of 1,993 (41.4%) sequences were linked with at least one other sequence, forming 188 transmission clusters of 2-80 sequences. Clustering rates for the main subtypes CRF01_AE, CRF07_BC, and B were 50.9% (523/1027), 34.2% (256/749), and 32.1% (25/78), respectively. Median cluster sizes of these subtypes were 2 (2-52, n = 523), 2 (2-80, n = 256), and 3 (2-6, n = 25), respectively. Subtypes in individuals diagnosed and residing in Hangzhou city (OR = 1.423, 95% CI: 1.168-1.734) and men who have sex with men (MSM) were more likely to cluster. Assortativity analysis revealed individuals were more likely to be genetically linked to individuals from the same age group (AIage = 0.090, P

Published
2022

42. Pulmonary Tuberculosis Complicated by Thrombotic Thrombocytopenic Purpura: A Case Report and Literature Review

Author

Zheng,Jun, Pan,Xiaohong, Jiang,Yiyun, Zheng,Jun, Pan,Xiaohong, and Jiang,Yiyun

Abstract

Jun Zheng,1 Xiaohong Pan,2 Yiyun Jiang3 1Department of Rehabilitation, Nanxing Health Service Center, Shangcheng, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Tuberculosis Care Unit, Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang, 310003, People’s Republic of China; 3Department of Comprehensive Surgery, Hangzhou Geriatric Hospital, Zhejiang, 310022, People’s Republic of ChinaCorrespondence: Yiyun Jiang, Department of Comprehensive Surgery, Hangzhou Geriatric Hospital, No. 50, Jingxin Road, Hangzhou, Zhejiang, 310022, People’s Republic of China, Tel +8615088664025, Email 458247254@qq.comAbstract: Thrombotic thrombocytopenic purpura is a rare but life-threatening emergency. Tuberculosis can have hematologic complications. However, concurrent tuberculosis and thrombotic thrombocytopenic purpura are extremely rare. In this study, we report a 53-year-old man who was initially treated for pulmonary tuberculosis but later developed weakness and an altered mental status. Laboratory tests revealed evidence of thrombocytopenia, acute renal insufficiency, and microangiopathic hemolytic anemia. Brain imaging identified intracranial hemorrhage. Further testing revealed low ADAMTS13 activity (1.8%) and positive anti-ADAMTS13 antibody, confirming the diagnosis of thrombotic thrombocytopenic purpura. The patient had a full recovery after anti-tuberculosis treatment, plasma exchange, and supportive care. We present this rare case and review previous relevant studies to remind clinicians about the potential connections between tuberculosis and thrombotic thrombocytopenic purpura. In patients with signs of severe thrombocytopenia and microangiopathic hemolysis, necessary diagnostic tests should be performed to eliminate the possibility of thrombotic thrombocytopenic purpura occurring concurrently with tuberculosis.Keywords: Thrombotic thrombocytopenic purpura, tuberculosis, case report, literature review

Published
2024

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