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31. Five-Minute Cognitive Test as A New Quick Screening of Cognitive Impairment in The Elderly

Author

Zhang, Jie, Wang, Lijun, Deng, Xia, Fei, Guoqiang, Jin, Lirong, Pan, Xiaoli, Cai, Liuhan, Albano, Anthony D, and Zhong, Chunjiu

Subjects
Neurosciences, Brain Disorders, Dementia, Aging, Acquired Cognitive Impairment, Neurodegenerative, Clinical Research, Prevention, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Mental Health, Behavioral and Social Science, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Mental health, Neurological, Alzheimer’s disease, brief cognitive test, equipercentile equating method, mild cognitive impairment
Abstract

This study aims to develop a new evaluation method for quickly and conveniently screening cognitive impairment in the elderly. The five-minute cognitive test (FCT) was designed to capture deficits in five domains of cognitive abilities, including episodic memory, language fluency, time orientation, visuospatial function, and executive function. Subsequently, FCT efficiencies in differentiating normally cognitive ability from cognitive impairment were explored and compared with that of the Mini-Mental Status Evaluation (MMSE). Equipercentile equating method was utilized to create a crosswalk between scores of the FCT and MMSE. Further, the association of scores of the FCT and MMSE with hippocampal volumes was investigated. There were 241 subjects aged 60 years or above enrolled in this study, including 107 adults with cognitive abilities in normal range, 107 patients with mild cognitive impairment (MCI), and 27 patients with mild Alzheimer disease (AD). The AUC of FCT for detection of cognitive impairment (MCI and mild AD) was 0.885 (95% CI 0.838 to 0.922). The sensitivity and specificity of FCT for the diagnosis of cognitive impairment were 80.6% and 84.11 %, respectively. FCT's diagnostic performance was superior to that of MMSE in the same cohort. Mean completion time of FCT was 339.9 ± 67.7 seconds (5-6 min). In addition, a conversion table between scores on the FCT and MMSE was created. Further, the FCT scores were positively correlated with hippocampal volumes. The FCT is a novel, reliable, and valid cognitive screening test for the detection of dementia at early stages.

Published
2019

40. Drying kinetics and quality characteristics of exocarpium citreic grandis slices with hot air, vacuum, and microwave vacuum dryers.

Author

Li, Qiang, Pan, Xiaoli, Fan, Wenyan, Zhou, Ying, Liu, Yongfu, Yu, Wangxin, Li, Dongyu, Li, Wenyue, and Li, Weibin

Subjects
*MICROWAVE drying, *HONEYCOMB structures, *MANUFACTURING processes, *NARINGIN, *DIFFUSION coefficients
Abstract

The study investigates the impact of different drying methods on the selection of thin-layer drying kinetic models, parameters, and quality for Exocarpium Citreic Grandis. This study investigates the drying characteristics, index constituents content, and microscopic structures of Exocarpium Citreic Grandis slices, subjected to three drying techniques: HAD (at 50, 60, 70 ∘ C), VD (at 50, 60, 70 ∘ C), and MVD (at 1000, 1500, 2000W). A thin-layer drying kinetic model was established. The findings demonstrated that the drying process was primarily dominated by the falling rate phase. When the drying temperature was 70 ∘ C and the microwave power was 2000W, the HAD VD, and MVD took 120, 360, and 20 minutes respectively. By fitting six commonly used thin-layer drying models, it was discovered that the optimal mathematical models for HAD, VD, and MVD were the Page model, the Logarithmic model, and the Page model, respectively. The highest average R 2 values were 0.9963, 0.9965, and 0.9964, and the lowest average RMSE values were 0.01782, 0.01704, and 0.0174 respectively. The effective diffusion coefficient increased with the drying temperature and microwave power, with MVD having the maximum coefficient. As the temperature and microwave power increased, the contents of naringin and rhoifolin decreased. However, the naringin content in MVD was 23.05% and 45.71% higher compared to hot air and VD respectively. The cross-section of Exocarpium Citreic Grandis dried via microwave vacuum exhibited a porous honeycomb structure with uniformly distributed spaces and larger pores, reflecting an expansion effect. The HAD process also resulted in a honeycomb-like structure, but with smaller pores. The VD process resulted in a layered structure with significant cell collapse. Microwave vacuum drying demonstrates superior energy efficiency and product quality compared to hot air and vacuum drying methods. The study finds that microwave drying does not have a destructive impact on the active compounds of Exocarpium Citreic Grandis. To facilitate large-scale, continuous production, microwave drying can be practically applied in industrial processing. [ABSTRACT FROM AUTHOR]

Published
2024
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