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124 results on '"Pan, Xufeng"'

6. Integrative Serum Metabolic Fingerprints Based Multi‐Modal Platforms for Lung Adenocarcinoma Early Detection and Pulmonary Nodule Classification

Author

Wang, Lin, primary, Zhang, Mengji, additional, Pan, Xufeng, additional, Zhao, Mingna, additional, Huang, Lin, additional, Hu, Xiaomeng, additional, Wang, Xueqing, additional, Qiao, Lihua, additional, Guo, Qiaomei, additional, Xu, Wanxing, additional, Qian, Wenli, additional, Xue, Tingjia, additional, Ye, Xiaodan, additional, Li, Ming, additional, Su, Haixiang, additional, Kuang, Yinglan, additional, Lu, Xing, additional, Ye, Xin, additional, Qian, Kun, additional, and Lou, Jiatao, additional

Published
2022
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23. Surgery performed at night by continuously working surgeons contributes to a higher incidence of intraoperative complications in video-assisted thoracoscopic pulmonary resection: a large monocentric retrospective study.

Author

Chen, Chunji, Zhang, Xiaofeng, Gu, Chang, Wang, Yiyang, Liu, Kun, Pan, Xufeng, Fu, Shijie, Fan, Limin, and Wang, Rui

Subjects
SURGICAL complications, NIGHT work, PROPENSITY score matching, CHEST endoscopic surgery, WORKING hours
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Our goal was to assess the influence of working hours and working at night on intraoperative complications on surgeons conducting video-assisted pulmonary resections. METHODS We identified all patients who underwent video-assisted thoracoscopic surgery (VATS) in Shanghai Chest Hospital from January 2015 to April 2017. Univariable and multivariable logistic analyses were used to analyse independent risk factors for intraoperative complications. A 1:4 propensity score matching analysis was conducted to verify those results. RESULTS A total of 15 767 patients who underwent VATS pulmonary resection were included in this study. Among them, 15 280 patients (96.1%) were operated on during daytime working hours and 487 (3.1%) at night. A total of 203 (1.3%) intraoperative complications occurred. Vascular injury was the main cause of intraoperative complications, accounting for 92.1% (187/203). Multivariable logistic regression indicated that age [odds ratio (OR) = 1.68, 95% confidence interval (CI) 1.43–1.98; P  < 0.001], gender (OR = 1.71, 95% CI 1.26–2.32; P  = 0.001), surgical experience (OR = 2.07, 95% CI 1.56–2.75; P  < 0.001), type of surgery (OR = 0.31, 95% CI 0.20–0.49; P  < 0.001) and operative periods (OR = 2.69, 95% CI 1.61–4.86; P  < 0.001) were independent predictors for intraoperative complications. The incidence of intraoperative complications during night-time surgery was significantly higher than that during daytime working hours. A 1:4 propensity score matching-based results verification showed that night-time surgery was still an independent risk factor after propensity score matching (OR = 2.76, 95% CI 1.47–5.15; P  = 0.002). CONCLUSIONS The incidence of intraoperative complications from VATS pulmonary resection performed during night hours was significantly higher than that performed during working hours. In the present labour environment, thoracic surgeons should avoid night-time surgery whenever possible. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Sialyltransferase ST3 GAL6 mediates the effect of micro RNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway.

Author

Sun, Mingming, Zhao, Xuzi, Liang, Leilei, Pan, Xufeng, Lv, Hao, and Zhao, Yongfu

Abstract

Aberrant sialylation profiles on the cell surface have been recognized for their potential diagnostic value in identifying the regulation of tumor properties in several cancers, including hepatocellular carcinoma ( HCC). Recently, increasing evidence has suggested that the deregulation of micro RNA (mi RNA) is a common feature in human cancers. In this study, we found obvious upregulation of sialyltransferase ST3 GAL6 both in HCC cell lines and in tissue samples. The altered expression of ST3 GAL6 was found to correlate with cell proliferation, migration, and invasion ability in HCC. Further investigation showed that miR-26a negatively regulated ST3 GAL6, inducing the suppression of cell proliferation, migration, and invasion in vitro. Moreover, we identified the protein kinase B/mammalian target of rapamycin (Akt/ mTOR) pathway as the target of ST3 GAL6 based on Western blot analysis. Analysis of a xenograft mouse model showed that miR-26a significantly reduced tumor growth by suppressing activation of the Akt/ mTOR pathway by directly targeting ST3 GAL6. In conclusion, these data indicate that ST3 GAL6 promotes cell growth, migration, and invasion and mediates the effect of miR-26a through the Akt/ mTOR signaling pathway in HCC. [ABSTRACT FROM AUTHOR]

Published
2017
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47. The application of wavelet transform and artificial neural networks in machinery fault diagnosis

Author

Li Xiaolei, Wu Yousheng, Pan Xufeng, and Sun Qiao

Subjects
Discrete wavelet transform, Lifting scheme, Computer science, business.industry, Feature vector, Second-generation wavelet transform, Stationary wavelet transform, Computer Science::Neural and Evolutionary Computation, Feature extraction, Wavelet transform, Cascade algorithm, Pattern recognition, Wavelet packet decomposition, Wavelet, Artificial intelligence, business
Abstract

The wavelet transform and artificial neural networks (ANNs) are briefly described. Then both of them are applied comprehensively to machinery fault diagnosis. The wavelet transform is used to pre-process data and extract feature vectors. ANNs are used to identify fault types. Using the wavelet transform, the dimension of the feature vector is greatly decreased and the noises are restrained as well. Thus the construction of the ANNs is simplified and the calculation speed is raised without lowering accuracy. For comparison, two types of features are extracted. Such a diagnosing measure is proved to be efficient by an experiment at the end of the paper.

Published
2002

50. Progress of Clinical Application for Ex Vivo Lung Perfusion (EVLP) in Lung Transplantation.

Author

Gu C, Pan X, and Shi J

Subjects
Humans, Lung Transplantation, Organ Preservation methods, Perfusion methods, Tissue Donors, Lung pathology, Lung surgery, Lung Diseases pathology, Lung Diseases surgery
Abstract

In recent years, medical advances make lung transplantation become a standard treatment for terminal lung diseases (such as emphysema, pulmonary fibrosis, pulmonary cystic fibrosis, and pulmonary arterial hypertension) that cannot be cured by drugs or surgery (Lund et al., J Heart Lung Transplant 34:1244, 2015). However, the current number of donor lungs that meet the transplant criteria is no longer sufficient for transplanting, causing some patients to die while waiting for a suitable lung. Current methods for improving the situation of shortage of lung transplant donors include the use of donation after cardiac death (DCD) donors, smoker donors, and Ex Vivo Lung Perfusion (EVLP). Among them, EVLP is a technique for extending lung preservation time and repairing lung injury in the field of lung transplantation. By continuously assessing and improving the function of marginal donor lungs, EVLP increases the number of lungs that meet the transplant criteria and, to some extent, alleviates the current situation of shortage of donor lungs. This chapter reviews the clinical application and research progress of EVLP in the field of lung transplantation.

Published
2020
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