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Main observation and conclusion: A highly enantioselective palladium‐catalyzed intermolecular tandem Heck/Cacchi reaction of unactivated alkenes with ortho‐ethynylanilines was developed, which provides a powerful route to access a broad range of enantioenriched 2,3‐dihydrobenzofuran‐ or indoline‐substituted indoles bearing all‐carbon quaternary stereocenter of interest in pharmaceutical research. Its salient features include inherent atom‐ and step‐economy, high functional group tolerance, mild conditions, broad structural diversity together with excellent enantioselectivities. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "PPh3-Mediated Borylation of Arenediazonium Salts with Bis(pinacolato)diborane" by S. Chen and others, published in the periodical "Chemical Science" in 2014.

Despite much progress has been made in the asymmetric α-arylation reactions of cyclic ketones, lactones and lactams, the enantioselective α-arylation of acyclic carbonyl compounds lagged much behind due to the in situ generated Z/E-enolate intermediates leading to opposite enantiomers. Especially, the asymmetric α-arylation of acyclic aldehydes is a long-standing challenge, because of the highest activity among carbonyl compounds leading to various competitive side reactions. Herein we reported an efficient Pd-catalyzed asymmetric intermolecular α-arylation reaction of α-alkyl-α-aryl disubstituted aldehydes with aryl bromides, which provides a rapid access to chiral aldehydes bearing an α-all-carbon quaternary stereocenter in moderate to good yields with good er in most cases. In addition, a pair of enantiomers could be easily prepared with the use of the same ligand by exchanging the aryl groups of aldehyde and aryl bromide., (© 2021 Wiley-VCH GmbH.)

The first example of highly enantioselective fluoroarylation of gem-difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine (Sadphos) type ligand TY-Phos. N-Me-TY-Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily available starting materials, good yields, high enantioselectivities as well as broad substrate scope make this approach very practical and attractive. Notably, the asymmetric synthesis of an analogue of a biologically active molecule is also reported., (© 2020 Wiley-VCH GmbH.)